# GeDiPNet Cluster 102 -- Enriched Pathways -- generated 2026-10-07 21:41:41
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-07 03:30:09.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Thyroid hormone synthesis	KEGG	10	PAX8, SLC26A4, TSHR, TSHB, DUOX2, DUOXA2, IYD, SLC5A5, TPO, TG	75	35	45.75	7.847e-15	2.534e-12
Thyroxine biosynthesis	Reactome	5	TSHB, DUOX2, IYD, SLC5A5, TPO	7	35	245.10	3.263e-12	6.413e-10
Autoimmune thyroid disease	KEGG	5	TSHR, TSHB, TPO, TG, FASLG	54	35	31.77	4.455e-7	2.420e-5
Multifunctional anion exchangers	Reactome	2	SLC26A4, SLC26A7	9	35	76.25	2.932e-4	5.265e-3
Glycoprotein hormones	Reactome	2	TSHB, INHBB	12	35	57.19	5.347e-4	8.390e-3
Hormone ligand-binding receptors	Reactome	2	TSHR, TSHB	12	35	57.19	5.347e-4	8.390e-3
Defective SLC26A4 causes Pendred syndrome (PDS)	Reactome	1	SLC26A4	1	35	343.14	2.914e-3	3.012e-2
Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1)	Reactome	1	SLC5A5	1	35	343.14	2.914e-3	3.012e-2
G alpha (s) signalling events	Reactome	3	TSHR, TSHB, PDE1A	140	35	7.35	7.726e-3	5.831e-2
HSP90 chaperone cycle for steroid hormone receptors (SHR)	Reactome	2	TUBB1, FKBP4	55	35	12.48	1.112e-2	7.322e-2
Antagonism of Activin by Follistatin	Reactome	1	INHBB	4	35	85.79	1.161e-2	7.504e-2
HHAT G278V abrogates palmitoylation of Hh-Np	Reactome	1	SHH	4	35	85.79	1.161e-2	7.504e-2
Regulation of lipolysis in adipocytes	KEGG	2	TSHR, TSHB	59	35	11.63	1.272e-2	7.893e-2
FasL/ CD95L signaling	Reactome	1	FASLG	5	35	68.63	1.449e-2	8.530e-2
Long-term potentiation	KEGG	2	PPP3CA, GRIN2B	67	35	10.24	1.620e-2	9.123e-2