# GeDiPNet Cluster 101 -- Enriched Pathways -- generated 2026-10-07 07:11:39
# Pathway enrichment: KEGG + Reactome, upper-tail hypergeometric test, Benjamini-Hochberg FDR-corrected. Fold enrichment = (overlap / cluster gene count) / (pathway gene count / universe size). Top 15 pathways per cluster by q-value. See scripts/build_cluster_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-07 03:30:09.
Pathway	Source	Overlap Genes	Overlap Gene Names	Pathway Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
Amoebiasis	KEGG	5	ARG1, GNA11, GNAS, IFNG, TNF	103	26	22.42	2.399e-6	1.032e-4
Hormone signaling	KEGG	6	GNA11, GCG, OPRM1, POMC, GNAS, PTH	219	26	12.66	5.825e-6	2.147e-4
ADORA2B mediated anti-inflammatory cytokines production	Reactome	5	GCG, GPBAR1, POMC, GNAS, PTH	128	26	18.04	6.989e-6	2.486e-4
G alpha (s) signalling events	Reactome	5	GCG, GPBAR1, POMC, GNAS, PTH	140	26	16.50	1.082e-5	3.586e-4
Opioid Signalling	Reactome	2	OPRM1, POMC	3	26	307.95	1.350e-5	4.307e-4
Necroptosis	KEGG	5	TRPM7, IFNA2, IFNG, TNF, TNFRSF10A	159	26	14.53	2.006e-5	5.995e-4
Aldosterone synthesis and secretion	KEGG	4	GNA11, POMC, ATP2B1, GNAS	98	26	18.85	5.430e-5	1.368e-3
Chagas disease	KEGG	4	GNA11, GNAS, IFNG, TNF	103	26	17.94	6.597e-5	1.598e-3
Parathyroid hormone synthesis, secretion and action	KEGG	4	CASR, GNA11, GNAS, PTH	115	26	16.07	1.014e-4	2.278e-3
Natural killer cell mediated cytotoxicity	KEGG	4	IFNA2, IFNG, TNF, TNFRSF10A	133	26	13.89	1.779e-4	3.570e-3
Endocrine and other factor-regulated calcium reabsorption	KEGG	3	ATP2B1, GNAS, PTH	53	26	26.15	1.964e-4	3.848e-3
Hepatitis C	KEGG	4	EIF2AK4, IFNA2, IFNG, TNF	159	26	11.62	3.523e-4	6.085e-3
Cortisol synthesis and secretion	KEGG	3	GNA11, POMC, GNAS	65	26	21.32	3.599e-4	6.183e-3
Influenza A	KEGG	4	IFNA2, IFNG, TNF, TNFRSF10A	173	26	10.68	4.853e-4	7.785e-3
Herpes simplex virus 1 infection	KEGG	4	EIF2AK4, IFNA2, IFNG, TNF	182	26	10.15	5.876e-4	9.035e-3