# GeDiPNet Cluster 1 -- Enriched GO Terms (Biological Process) -- generated 2026-10-08 23:32:06
# GO term enrichment: Biological Process terms (gene2go, human/tax_id=9606 only), upper-tail hypergeometric test, fold enrichment = (overlap / cluster gene count) / (term gene count / universe size), Benjamini-Hochberg FDR-corrected. Top 15 terms per cluster by q-value. See scripts/build_cluster_go_enrichment.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-09 03:23:08.
GO Term	GO ID	Overlap Genes	Overlap Gene Names	Term Gene Count	Cluster Gene Count	Fold Enrichment	P-value	FDR Q-value
immune response	GO:0006955	71	HLA-DPA1, HLA-DPB1, HLA-DQA1, CD40LG, HLA-DQB1, HLA-DRA, HLA-DRB1, B2M, FCGR3A, JAK2, TLR4, STAT4	543	743	3.29	5.882e-19	7.827e-16
peptide antigen assembly with MHC class II protein complex	GO:0002503	14	HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, B2M, HLA-DOB, HLA-DQB2, HLA-DRB5, HLA-DOA, HLA-DMA	16	743	22.01	2.442e-18	2.960e-15
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	GO:0002504	13	HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DOB, HLA-DQB2, HLA-DRB5, HLA-DOA, HLA-DMA, HLA-DMB	15	743	21.80	5.469e-17	5.432e-14
positive regulation of T cell activation	GO:0050870	20	HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, B2M, HLA-DOB, HLA-DQB2, HLA-DRB5, HLA-DOA, CCL2	45	743	11.18	9.430e-17	9.060e-14
cellular response to lipopolysaccharide	GO:0071222	33	B2M, CD40, JAK2, TLR4, ZFP36, NOS2, DAB2IP, ABCB1, CD86, CXCL8, NOD2, IL1B	187	743	4.44	4.880e-13	2.341e-10
positive regulation of immune response	GO:0050778	16	HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, B2M, HLA-DOB, HLA-DQB2, HLA-DRB5, HLA-DOA, IFNL3	40	743	10.06	8.568e-13	3.919e-10
antigen processing and presentation of exogenous peptide antigen via MHC class II	GO:0019886	14	HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, B2M, HLA-DOB, HLA-DQB2, HLA-DRB5, HLA-DOA, HLA-DMA	31	743	11.36	3.095e-12	1.273e-9
positive regulation of cell population proliferation	GO:0008284	57	PRTN3, TSC22D1, GRK5, TSHR, IL23R, JAK2, NPY, VEGFA, IL2, TNC, BMP4, EDN1	532	743	2.69	9.792e-12	3.612e-9
regulation of cell population proliferation	GO:0042127	32	NF1, STAT4, NOS2, EMILIN2, DNMT1, TBX19, AGT, PLAU, ARG1, CXCL10, CXCL11, CXCL9	201	743	4.00	1.917e-11	6.648e-9
antigen processing and presentation	GO:0019882	16	HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DOB, HLA-DQB2, HLA-DRB5, HLA-B, HLA-C, HLA-DOA	48	743	8.38	2.282e-11	7.722e-9
phosphatidylinositol 3-kinase/protein kinase B signal transduction	GO:0043491	21	CD40, FCGR3A, NF1, EDN1, MAPKAP1, BTN2A2, BANK1, PTEN, PDPK1, PIK3CA, PIK3CB, PIK3CD	92	743	5.74	5.856e-11	1.818e-8
response to nicotine	GO:0035094	14	TACR1, EDN1, CHRNA3, CHRNA5, GABBR1, HMOX1, CHRNA1, MMP2, BCL2, PENK, ND4, IL13	40	743	8.80	1.941e-10	5.318e-8
immune system process	GO:0002376	79	HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, B2M, CD40, FCGR3A, HP, IL23R, JAK2	943	743	2.11	2.520e-10	6.677e-8
positive regulation of interleukin-12 production	GO:0032735	14	CD40LG, CD40, IL23R, SYK, TLR4, TLR2, SCIMP, AGER, IFNG, TLR9, TNFSF4, LTB	43	743	8.19	5.867e-10	1.408e-7
inflammatory response	GO:0006954	49	AZU1, CD40LG, CRP, CD40, HP, IL23R, TLR4, PTGER3, EPG5, NOS2, TACR1, CYBB	467	743	2.64	6.028e-10	1.441e-7