# GeDiPNet Cluster 1 -- Top Shared Genes -- generated 2026-10-10 05:35:59
# Curated genes (disease_gdp) linked to 2 or more of this cluster's member diseases, most widely shared first. Data as of: 2026-10-10 03:15:01.
Gene	Member Diseases Linked	Cluster Size	Linked Diseases
HLA-DQA1	45	110	Anti-neutrophil antibody associated vasculitis; Antiphospholipid syndrome; Arthritis; Autoimmune musculoskeletal system disorder; Autoimmune polyendocrine syndrome; Benign hereditary chorea; Bouillaud’s disease; Bronchitis; Bullous pemphigoid; Cartilage disease; Central nervous system non-hodgkin lymphoma; Cervical intraepithelial neoplasia; Chorea; Cold paroxysmal hemoglobinuria; Collagenous colitis; Cryoglobulinemia; Cutaneous lupus erythematosus; Diabetic nephropathy type 1; Esophageal achalasia; Gastroparesis; Hemoglobinuria paroxysmal; Henoch schoenlein purpura; Immune system disease; Interstitial cystitis; Latent autoimmune diabetes in adults; Lupus nephritis; Lymphedema; Lymphoma; Membranous glomerulonephritis; Myasthenia gravis; Narcolepsy; Nasopharyngeal neoplasms; Obstructive asthma; Ocular sarcoidosis; Oropharyngeal neoplasms; Paroxysmal nocturnal hemoglobinuria; Pemphigus; Pemphigus vulgaris; Rosacea; Sinusitis; Skeletal system disease; Thyroiditis; Uveomeningoencephalitic syndrome; Vogt-koyanagi-harada disease; Wheat allergic reaction
HLA-DQB1	45	110	Acute disseminated encephalomyelitis; Antiphospholipid syndrome; Apolipoprotein b hypobetalipoproteinemia; Arthritis; Autoimmune pancreatitis; Autoimmune polyendocrine syndrome; Benign hereditary chorea; Benign mucous membrane pemphigoid; Benign mucous membrane pemphigoid with ocular involvement; Bouillaud’s disease; Bronchitis; Bullous pemphigoid; Cervical intraepithelial neoplasia; Chorea; Churg-strauss syndrome; Cold paroxysmal hemoglobinuria; Diabetic nephropathy type 1; Duodenitis; Esophageal achalasia; Gastritis; Gastroparesis; Head and neck cancer; Hemoglobinuria paroxysmal; Henoch schoenlein purpura; Interstitial cystitis; Latent autoimmune diabetes in adults; Lupus nephritis; Lymphoma; Myasthenia gravis; Narcolepsy; Nasopharyngeal neoplasms; Obstructive asthma; Ocular sarcoidosis; Optic neuritis; Oral cavity carcinoma; Oropharyngeal neoplasms; Osteomyelitis; Paroxysmal nocturnal hemoglobinuria; Pemphigus; Pemphigus vulgaris; Respiratory system neoplasm; Thyrotoxic periodic paralysis; Tongue cancer; Tonsil cancer; Uveomeningoencephalitic syndrome
HLA-DRB1	45	110	Acute disseminated encephalomyelitis; Anti-glomerular basement membrane disease; Antiphospholipid syndrome; Aortic arch syndrome; Autoimmune musculoskeletal system disorder; Autoimmune polyendocrine syndrome; Autoimmune pulmonary alveolar proteinosis; Benign hereditary chorea; Benign mucous membrane pemphigoid; Benign mucous membrane pemphigoid with ocular involvement; Bouillaud’s disease; Bullous pemphigoid; Cartilage disease; Central nervous system non-hodgkin lymphoma; Chorea; Congenital pulmonary artery atresia; Cryoglobulinemia; Cutaneous lupus erythematosus; Follicular lymphoma; Gastritis; Giant cell arteritis; Heerfordt syndrome; Henoch schoenlein purpura; Immune system disease; Interstitial cystitis; Lupus nephritis; Lymphedema; Lymphoma; Membranous glomerulonephritis; Myasthenia gravis; Narcolepsy; Nasopharyngeal neoplasms; Optic neuritis; Oropharyngeal neoplasms; Pemphigus; Pemphigus vulgaris; Pulmonary alveolar proteinosis; Rosacea; Sinusitis; Skeletal system disease; Thromboangiitis obliterans; Thyroiditis; Uveomeningoencephalitic syndrome; Vogt-koyanagi-harada disease; Wheat allergic reaction
HLA-B	10	110	Aortic arch syndrome; Cervical intraepithelial neoplasia; Diffuse large b-cell lymphoma; Giant cell arteritis; Immune system disease; Membranous glomerulonephritis; Myasthenia gravis; Nasopharyngeal neoplasms; Oral cavity carcinoma; Sinusitis
C3	8	110	atypical hemolytic-uremic syndrome with C3 anomaly; Cold paroxysmal hemoglobinuria; Hemoglobinuria paroxysmal; Henoch schoenlein purpura; Lupus nephritis; Membranous glomerulonephritis; Paroxysmal nocturnal hemoglobinuria; Pemphigus
HLA-DRA	7	110	Antiphospholipid syndrome; Bullous pemphigoid; Henoch schoenlein purpura; Hepatitis c induced liver cirrhosis; Interstitial cystitis; Oral cavity carcinoma; Pemphigus vulgaris
IRF4	7	110	Central nervous system non-hodgkin lymphoma; Diffuse large b-cell lymphoma; Lymphoma; Membranous glomerulonephritis; Respiratory system neoplasm; Rosacea; Waldenstrom macroglobulinemia
PTPN22	7	110	Diabetic nephropathy type 1; Giant cell arteritis; Immune system disease; Latent autoimmune diabetes in adults; Myasthenia gravis; Uveomeningoencephalitic syndrome; Vogt-koyanagi-harada disease
HLA-DQB3	6	110	Anti-neutrophil antibody associated vasculitis; Henoch schoenlein purpura; Interstitial cystitis; Narcolepsy; Pemphigus vulgaris; Thiopurine immunosuppressant-induced pancreatitis
HLA-DRB5	6	110	Acute disseminated encephalomyelitis; Bullous pemphigoid; Central nervous system non-hodgkin lymphoma; Henoch schoenlein purpura; Myasthenia gravis; Pulmonary alveolar proteinosis
C6ORF15	5	110	Immune system disease; Membranous glomerulonephritis; Myasthenia gravis; Nasopharyngeal neoplasms; Thyrotoxic periodic paralysis
CTLA4	5	110	Anti-glomerular basement membrane disease; Immune system disease; Latent autoimmune diabetes in adults; Lupus nephritis; Myasthenia gravis
FAS	5	110	Diffuse large b-cell lymphoma; Lupus nephritis; Myasthenia gravis; Uveomeningoencephalitic syndrome; Vogt-koyanagi-harada disease
FCGR3A	5	110	Anti-glomerular basement membrane disease; Arthritis; Giant cell arteritis; Lupus nephritis; Primary immunodeficiency with defective natural killer cell cytotoxicity
HLA-DPB1	5	110	Anti-glomerular basement membrane disease; Anti-neutrophil antibody associated vasculitis; Gastroparesis; Myasthenia gravis; Narcolepsy
CLPTM1L	4	110	Cervical intraepithelial neoplasia; Head and neck cancer; Nasopharyngeal neoplasms; Oral cavity carcinoma
EXOC2	4	110	Central nervous system non-hodgkin lymphoma; Diffuse large b-cell lymphoma; Lymphoma; Waldenstrom macroglobulinemia
STAT4	4	110	Autoimmune musculoskeletal system disorder; Disabling pansclerotic morphea of childhood; Immune system disease; Uveomeningoencephalitic syndrome
TERT	4	110	Head and neck cancer; Nasopharyngeal neoplasms; Osteomyelitis; Tongue cancer
ATXN2	3	110	Immune system disease; Latent autoimmune diabetes in adults; Myasthenia gravis
BACH2	3	110	Central nervous system non-hodgkin lymphoma; immunodeficiency 60; Latent autoimmune diabetes in adults
BCL2	3	110	Diffuse large b-cell lymphoma; Follicular lymphoma; Lymphoma
C5	3	110	Cold paroxysmal hemoglobinuria; Hemoglobinuria paroxysmal; Paroxysmal nocturnal hemoglobinuria
CCL2	3	110	Giant cell arteritis; Henoch schoenlein purpura; Lupus nephritis
CDKN2A	3	110	Diffuse large b-cell lymphoma; Lymphoma; Nasopharyngeal neoplasms
CRP	3	110	Antiphospholipid syndrome; Arthritis; Lupus nephritis
HLA-A	3	110	Aortic arch syndrome; Parapsoriasis; Thromboangiitis obliterans
HLA-DOB	3	110	Bullous pemphigoid; Interstitial cystitis; Lymphoma
HLA-DPA1	3	110	Anti-neutrophil antibody associated vasculitis; Interstitial cystitis; Ocular sarcoidosis
HLA-DQB2	3	110	Bullous pemphigoid; Interstitial cystitis; Lymphoma
IL2	3	110	Aortic arch syndrome; Bullous pemphigoid; Pemphigus
ITGAM	3	110	Autoimmune musculoskeletal system disorder; Cutaneous lupus erythematosus; Lupus nephritis
MC1R	3	110	Blepharitis; Respiratory system neoplasm; Rosacea
MMP2	3	110	Giant cell arteritis; Lupus nephritis; Nasopharyngeal neoplasms
MOG	3	110	Narcolepsy; Nasopharyngeal neoplasms; Optic neuritis
MYD88	3	110	Diffuse large b-cell lymphoma; Lymphoma; Waldenstrom macroglobulinemia
NOTCH4	3	110	Cryoglobulinemia; Interstitial cystitis; Lupus nephritis
PDE2A	3	110	Chorea; Intellectual developmental disorder seizures movement; Oral cavity carcinoma
PIGA	3	110	Cold paroxysmal hemoglobinuria; Hemoglobinuria paroxysmal; Paroxysmal nocturnal hemoglobinuria
PIGT	3	110	Cold paroxysmal hemoglobinuria; Hemoglobinuria paroxysmal; Paroxysmal nocturnal hemoglobinuria
TLR4	3	110	Arthritis; Dysbiosis; Giant cell arteritis
VPS13A	3	110	Benign hereditary chorea; Chorea; Choreoacanthocytosis
ABCA3	2	110	Pulmonary alveolar proteinosis; Pulmonary surfactant metabolism dysfunction
ABCB1	2	110	Cryoglobulinemia; Diffuse large b-cell lymphoma
ABCG8	2	110	Duodenitis; Gastritis
ADCY5	2	110	Benign hereditary chorea; Chorea
ADH1B	2	110	Oral cavity carcinoma; Respiratory system neoplasm
AIRE	2	110	Autoimmune polyendocrine syndrome; Hypoparathyroidism
ARPC1B	2	110	Gastritis; platelet abnormalities with eosinophilia and immune-mediated inflammatory disease
ATP4B	2	110	Autoimmune gastritis; Gastritis
ATP6AP1	2	110	congenital disorder of glycosylation type II; Lymphoma
B2M	2	110	Arthritis; Diffuse large b-cell lymphoma
BTNL2	2	110	Hepatitis c induced liver cirrhosis; Membranous glomerulonephritis
CA2	2	110	Autoimmune pancreatitis; autosomal recessive osteopetrosis 3
CACNA2D2	2	110	Benign hereditary chorea; Chorea
CAMK2D	2	110	Bronchitis; Neurodevelopmental disorder with dilated cardiomyopathy
CASP14	2	110	Bronchial disease; Bronchitis
CAST	2	110	Peeling skin syndrome with leukonychia and acral punctate keratoses; Pemphigus
CAT	2	110	Diffuse large b-cell lymphoma; Optic neuritis
CD207	2	110	Birbeck granule deficiency; Narcolepsy
CD40	2	110	Arthritis; Pemphigus
CD40LG	2	110	Antiphospholipid syndrome; Lupus nephritis
CD86	2	110	Diffuse large b-cell lymphoma; Henoch schoenlein purpura
CDH18	2	110	Antiphospholipid syndrome; Gastritis
CDKN2B	2	110	Lymphoma; Nasopharyngeal neoplasms
CEP43	2	110	Immune system disease; Myasthenia gravis
CFB	2	110	Membranous glomerulonephritis; Myasthenia gravis
CHRNA1	2	110	Immune system disease; Myasthenia gravis
COL11A2	2	110	Cartilage disease; Interstitial cystitis
COL14A1	2	110	Gastritis; Keratosis palmoplantaris papulosa
COL2A1	2	110	Arthritis; Cartilage disease
CSF2	2	110	Lymphoma; Pulmonary alveolar proteinosis
CSF2RA	2	110	Pulmonary alveolar proteinosis; Pulmonary surfactant metabolism dysfunction
CSF2RB	2	110	Pulmonary alveolar proteinosis; Pulmonary surfactant metabolism dysfunction
CXCL8	2	110	Bullous pemphigoid; Gastritis
CYP2A6	2	110	Bronchitis; Nasopharyngeal neoplasms
DDX6	2	110	Immune system disease; Lymphoma
EBF1	2	110	Blepharitis; Lymphoma
EGFR	2	110	Nasopharyngeal neoplasms; Ocular sarcoidosis
ELMO1	2	110	Autonomic nervous system disease; Immune system disease
EPG5	2	110	Bronchial disease; Vici syndrome
EXOC6	2	110	Diffuse large b-cell lymphoma; Follicular lymphoma
EZH2	2	110	Diffuse large b-cell lymphoma; Lymphoma
FAM76B	2	110	Immune system disease; Myasthenia gravis
FCGR2A	2	110	Giant cell arteritis; Lupus nephritis
FKBPL	2	110	Interstitial cystitis; Membranous glomerulonephritis
FRMD4A	2	110	Antiphospholipid syndrome; Ocular sarcoidosis
FTO	2	110	Oral cavity carcinoma; Osteomyelitis
GABRA3	2	110	Thyrotoxic periodic paralysis; X-linked epilepsy with or without intellectual disability and dysmorphic features
GATA2	2	110	Cartilage disease; Lymphedema
GRB7	2	110	Immune system disease; Myasthenia gravis
GSTM1	2	110	Gastritis; Optic neuritis
HLA-C	2	110	Interstitial cystitis; Sinusitis
HLA-DOA	2	110	Interstitial cystitis; Ocular sarcoidosis
HOMEZ	2	110	Bronchial disease; Bronchitis
HSD17B10	2	110	Chorea; hsd10 mitochondrial disease
IFNA2	2	110	Lymphoma; Uveomeningoencephalitic syndrome
IFNAR1	2	110	immunodeficiency 106, susceptibility to viral infections; Narcolepsy
IFNG	2	110	Giant cell arteritis; Lupus nephritis
IKZF1	2	110	Lymphoma; Rosacea
IKZF3	2	110	Immune system disease; Myasthenia gravis
IL23R	2	110	Arthritis; Vogt-koyanagi-harada disease
IMPDH1	2	110	IMPDH1-related retinopathy; Thyroiditis
KCNMB2	2	110	Cutaneous lupus erythematosus; Diabetic nephropathy type 1
KCTD1	2	110	Ocular sarcoidosis; scalp-ear-nipple syndrome
KIZ	2	110	KIZ-related retinopathy; Lupus nephritis
KMT2D	2	110	Diffuse large b-cell lymphoma; Lymphoma
LRMDA	2	110	Ocular sarcoidosis; Thyrotoxic periodic paralysis
MAGI3	2	110	Immune system disease; Myasthenia gravis
MATR3	2	110	distal myopathy with vocal cord weakness; Vogt-koyanagi-harada disease
MBL2	2	110	Giant cell arteritis; Lupus nephritis
MET	2	110	Lymphedema; Sinusitis
MICA	2	110	Cervical intraepithelial neoplasia; Thyroiditis
MMP9	2	110	Giant cell arteritis; Lupus nephritis
MUC21	2	110	Apolipoprotein b hypobetalipoproteinemia; Cutaneous lupus erythematosus
MUCL3	2	110	Interstitial cystitis; Membranous glomerulonephritis
NCOA5	2	110	Diffuse large b-cell lymphoma; Follicular lymphoma
NKX2-1	2	110	Benign hereditary chorea; Chorea
NOS2	2	110	Aortic arch syndrome; Bronchial disease
P2RY11	2	110	Cataplexy and narcolepsy; Narcolepsy
PDCD1	2	110	Lupus nephritis; Narcolepsy
PFKFB3	2	110	Latent autoimmune diabetes in adults; Ocular sarcoidosis
POMC	2	110	Immune system disease; Myasthenia gravis
PON1	2	110	Henoch schoenlein purpura; Lymphoma
PPAN	2	110	Cataplexy and narcolepsy; Narcolepsy
PPAN-P2RY11	2	110	Cataplexy and narcolepsy; Narcolepsy
PPP1R10	2	110	Interstitial cystitis; Pemphigus vulgaris
PPP2R5E	2	110	Bronchial disease; Bronchitis
PPT2	2	110	Interstitial cystitis; Membranous glomerulonephritis
PRRC2A	2	110	Apolipoprotein b hypobetalipoproteinemia; Membranous glomerulonephritis
PSORS1C1	2	110	Cutaneous lupus erythematosus; Membranous glomerulonephritis
PTCRA	2	110	immunodeficiency 126, susceptibility to; Ocular sarcoidosis
PTGER3	2	110	Benign mucous membrane pemphigoid; Benign mucous membrane pemphigoid with ocular involvement
RNF39	2	110	Immune system disease; Myasthenia gravis
RTN4IP1	2	110	Chorea; optic atrophy 10 with or without ataxia, intellectual disability, and seizures
SFMBT2	2	110	Immune system disease; Myasthenia gravis
SFTA2	2	110	Interstitial cystitis; Membranous glomerulonephritis
SFTPB	2	110	Pulmonary alveolar proteinosis; Pulmonary surfactant metabolism dysfunction
SFTPC	2	110	Pulmonary alveolar proteinosis; Pulmonary surfactant metabolism dysfunction
SOD2	2	110	Diffuse large b-cell lymphoma; Optic neuritis
SYK	2	110	Arthritis; Diffuse large b-cell lymphoma
TAFA5	2	110	Lymphedema; Ocular sarcoidosis
TBX18	2	110	Immune system disease; Myasthenia gravis
TBX19	2	110	Congenital isolated acth deficiency; Duodenitis
TEKTL1	2	110	Bronchial disease; Bronchitis
TNFRSF11A	2	110	Immune system disease; Myasthenia gravis
TNIP1	2	110	Immune system disease; Myasthenia gravis
TRIM39	2	110	Cutaneous lupus erythematosus; Interstitial cystitis
TRIM39-RPP21	2	110	Cutaneous lupus erythematosus; Interstitial cystitis
TRPM1	2	110	Immune system disease; Myasthenia gravis
TSBP1	2	110	Hepatitis c induced liver cirrhosis; Membranous glomerulonephritis
TSHR	2	110	Antiphospholipid syndrome; Thyroiditis
TSLP	2	110	Churg-strauss syndrome; Sinusitis
VARS1	2	110	Interstitial cystitis; neurodevelopmental disorder with microcephaly, seizures, and cortical atrophy
WHR1	2	110	Bullous pemphigoid; Membranous glomerulonephritis
ZBTB46	2	110	Osteomyelitis; Parenchymal hematoma
ZFHX3	2	110	Bronchial disease; Thyrotoxic periodic paralysis
ZNF365	2	110	Narcolepsy; Uric acid urolithiasis