Gene Gene information from NCBI Gene database.
Entrez ID 7525
Gene name YES proto-oncogene 1, Src family tyrosine kinase
Gene symbol YES1
Synonyms (NCBI Gene)
HsT441P61-YESYesc-yes
Chromosome 18
Chromosome location 18p11.32
Summary This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a c
miRNA miRNA information provided by mirtarbase database.
922
miRTarBase ID miRNA Experiments Reference
MIRT000627 hsa-miR-145-5p qRT-PCRLuciferase reporter assayWestern blotMicroarray 20098684
MIRT000627 hsa-miR-145-5p Luciferase reporter assay 20098684
MIRT000263 hsa-miR-17-5p Luciferase reporter assay 19734348
MIRT000627 hsa-miR-145-5p Review 20144549
MIRT005569 hsa-miR-519a-3p ImmunoblotLuciferase reporter assayqRT-PCR 21274007
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
NANOG Activation 22378194
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
52
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0001784 Function Phosphotyrosine residue binding IEA
GO:0001784 Function Phosphotyrosine residue binding IPI 20624904
GO:0002862 Process Negative regulation of inflammatory response to antigenic stimulus IEA
GO:0002862 Process Negative regulation of inflammatory response to antigenic stimulus TAS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
164880 12841 ENSG00000176105
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P07947
Protein name Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes)
Protein function Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGFR, PDG
PDB 2HDA
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00018 SH3_1 97 144 SH3 domain Domain
PF00017 SH2 158 240 SH2 domain Domain
PF07714 PK_Tyr_Ser-Thr 277 526 Protein tyrosine and serine/threonine kinase Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in the epithelial cells of renal proximal tubules and stomach as well as hematopoietic cells in the bone marrow and spleen in the fetal tissues. In adult, expressed in epithelial cells of the renal proximal tubules and presen
Sequence
Sequence length 543
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
5
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Cervical cancer Likely benign rs117449313 RCV005929497
Gastric cancer Likely benign rs117449313 RCV005929498
Lung cancer Likely benign rs117449313 RCV005929500
Malignant tumor of esophagus Likely benign rs117449313 RCV005929496
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Carcinoma Associate 19318475
Carcinoma Squamous Cell Associate 20796316
Colorectal Neoplasms Associate 24323901
Melanoma Associate 20796316
Neoplasms Associate 12138090, 12620106, 20796316
Skin Neoplasms Associate 20796316
Squamous Cell Carcinoma of Head and Neck Associate 12771142