Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
7525
Gene name Gene Name - the full gene name approved by the HGNC.
YES proto-oncogene 1, Src family tyrosine kinase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
YES1
Synonyms (NCBI Gene) Gene synonyms aliases
HsT441, P61-YES, Yes, c-yes
Chromosome Chromosome number
18
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
18p11.32
Summary Summary of gene provided in NCBI Entrez Gene.
This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a c
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT000627 hsa-miR-145-5p qRT-PCR, Luciferase reporter assay, Western blot, Microarray 20098684
MIRT000627 hsa-miR-145-5p Luciferase reporter assay 20098684
MIRT000263 hsa-miR-17-5p Luciferase reporter assay 19734348
MIRT000627 hsa-miR-145-5p Review 20144549
MIRT005569 hsa-miR-519a-3p Immunoblot, Luciferase reporter assay, qRT-PCR 21274007
Transcription factors
Transcription factor Regulation Reference
NANOG Activation 22378194
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001784 Function Phosphotyrosine residue binding IPI 20624904
GO:0004713 Function Protein tyrosine kinase activity EXP 1381360, 9799234, 11448999, 12923167, 18697750
GO:0004713 Function Protein tyrosine kinase activity IBA 21873635
GO:0004713 Function Protein tyrosine kinase activity TAS
GO:0004715 Function Non-membrane spanning protein tyrosine kinase activity IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
164880 12841 ENSG00000176105
Protein
UniProt ID P07947
Protein name Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes)
Protein function Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGFR, PDG
PDB 2HDA
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00018 SH3_1 97 144 SH3 domain Domain
PF00017 SH2 158 240 SH2 domain Domain
PF07714 PK_Tyr_Ser-Thr 277 526 Protein tyrosine and serine/threonine kinase Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in the epithelial cells of renal proximal tubules and stomach as well as hematopoietic cells in the bone marrow and spleen in the fetal tissues. In adult, expressed in epithelial cells of the renal proximal tubules and presen
Sequence
Sequence length 543
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Hypertension Hypertension GWAS
Associations from Text Mining
Disease Name Relationship Type References
Carcinoma Associate 19318475
Carcinoma Squamous Cell Associate 20796316
Colorectal Neoplasms Associate 24323901
Melanoma Associate 20796316
Neoplasms Associate 12138090, 12620106, 20796316
Skin Neoplasms Associate 20796316
Squamous Cell Carcinoma of Head and Neck Associate 12771142