Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
7412
Gene name Gene Name - the full gene name approved by the HGNC.
Vascular cell adhesion molecule 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
VCAM1
Synonyms (NCBI Gene) Gene synonyms aliases
CD106, INCAM-100
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p21.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT004007 hsa-miR-200a-3p Microarray 17875710
MIRT004081 hsa-miR-126-3p Luciferase reporter assay, Western blot 18227515
MIRT004081 hsa-miR-126-3p Luciferase reporter assay, Western blot 18227515
MIRT020917 hsa-miR-155-5p qRT-PCR 21310411
MIRT004081 hsa-miR-126-3p Reporter assay;Other 18227515
Transcription factors
Transcription factor Regulation Reference
EP300 Activation 19281832
HDAC4 Activation 19281832
HOXA9 Unknown 22269951
IKBKB Repression 18600306
IRF1 Unknown 15265939;22182512
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001666 Process Response to hypoxia IEA
GO:0002102 Component Podosome IDA 15220135
GO:0002526 Process Acute inflammatory response IEA
GO:0002544 Process Chronic inflammatory response IEA
GO:0005178 Function Integrin binding IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
192225 12663 ENSG00000162692
Protein
UniProt ID P19320
Protein name Vascular cell adhesion protein 1 (V-CAM 1) (VCAM-1) (INCAM-100) (CD antigen CD106) [Cleaved into: Soluble Vascular Cell Adhesion Molecule-1]
Protein function Cell adhesion glycoprotein predominantly expressed on the surface of endothelial cells that plays an important role in immune surveillance and inflammation (PubMed:31310649). Acts as a major regulator of leukocyte adhesion to the endothelium thr
PDB 1IJ9 , 1VCA , 1VSC
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07679 I-set 25 112 Immunoglobulin I-set domain Domain
PF05790 C2-set 133 221 Immunoglobulin C2-set domain Domain
PF00047 ig 229 306 Immunoglobulin domain Domain
PF07679 I-set 314 400 Immunoglobulin I-set domain Domain
PF05790 C2-set 421 509 Immunoglobulin C2-set domain Domain
PF13927 Ig_3 515 583 Domain
PF07679 I-set 605 685 Immunoglobulin I-set domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue.
Sequence
Sequence length 739
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Multiple Sclerosis Multiple Sclerosis GWAS
Schizophrenia Schizophrenia GWAS
Prostate cancer Prostate cancer Together, these results show that PRRX2 is an oncogene and might play a role in the aggressiveness of PC within the DNPC population. GWAS, CBGDA
Associations from Text Mining
Disease Name Relationship Type References
3 Methylglutaconic Aciduria Type I Stimulate 15158909
Acidosis Stimulate 22110680
Acute Chest Syndrome Stimulate 10477680
Acute Chest Syndrome Associate 15114598
Acute Coronary Syndrome Associate 24524679, 40599142
Acute Pain Associate 15114598
Alzheimer Disease Stimulate 22801742, 33720880
Alzheimer Disease Associate 29359159, 31377428, 37762058
Amyloidosis Associate 11318968
Amyotrophic Lateral Sclerosis Inhibit 32586411