Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
7171
Gene name Gene Name - the full gene name approved by the HGNC.
Tropomyosin 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TPM4
Synonyms (NCBI Gene) Gene synonyms aliases
BDPLT25, HEL-S-108
Disease Acronyms (UniProt) Disease acronyms from UniProt database
BDPLT25
Chromosome Chromosome number
19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
19p13.12-p13.11
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT002782 hsa-miR-1-3p pSILAC 18668040
MIRT002782 hsa-miR-1-3p Microarray 15685193
MIRT002782 hsa-miR-1-3p Proteomics;Microarray 18668037
MIRT002782 hsa-miR-1-3p Proteomics 18668040
MIRT002782 hsa-miR-1-3p Microarray 15685193
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001649 Process Osteoblast differentiation HDA 16210410
GO:0001725 Component Stress fiber IDA 16236705
GO:0005509 Function Calcium ion binding NAS 1836432
GO:0005515 Function Protein binding IPI 24407287, 28330616, 32296183
GO:0005829 Component Cytosol TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
600317 12013 ENSG00000167460
Protein
UniProt ID P67936
Protein name Tropomyosin alpha-4 chain (TM30p1) (Tropomyosin-4)
Protein function Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by int
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00261 Tropomyosin 12 248 Tropomyosin Coiled-coil
Tissue specificity TISSUE SPECIFICITY: Detected in cardiac tissue and platelets, the form found in cardiac tissue is a higher molecular weight than the form found in platelets. Expressed at higher levels in the platelets of hypertensive patients with cardiac hypertrophy tha
Sequence
Sequence length 248
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Macrothrombocytopenia autosomal dominant macrothrombocytopenia GenCC
Oligodendroglioma Oligodendroglioma GWAS
Associations from Text Mining
Disease Name Relationship Type References
Alzheimer Disease Associate 36672180
Brain Diseases Associate 36672180
Breast Neoplasms Associate 23812729
Carcinogenesis Associate 17131471, 21119665
Carcinoma Ductal Breast Associate 23812729
Carcinoma Ductal Breast Inhibit 28431393
Carcinoma Hepatocellular Associate 32363617, 33390785, 34850589, 37328795
Carcinoma Renal Cell Associate 15953868
Cardiovascular Diseases Associate 27649540
Colonic Neoplasms Associate 34575979