Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs Other IDs Associated diseases
Entrez ID	7168
Gene name	Tropomyosin 1
Gene symbol	TPM1
Synonyms (NCBI Gene)	C15orf13CMD1YCMH3HEL-S-265HTM-alphaLVNC9TMSA
Chromosome	15
Chromosome location	15q22.2
Summary	This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha

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SNP ID	Visualize variation	Clinical significance	Consequence
rs104894501	G>A,C,T	Uncertain-significance, pathogenic	Coding sequence variant, stop gained, missense variant, genic upstream transcript variant, 5 prime UTR variant, intron variant
rs104894502	A>G,T	Not-provided, pathogenic	Non coding transcript variant, coding sequence variant, missense variant
rs104894503	G>A	Pathogenic	Non coding transcript variant, coding sequence variant, missense variant
rs104894504	T>C	Likely-pathogenic, pathogenic	Non coding transcript variant, coding sequence variant, missense variant, 5 prime UTR variant
rs104894505	G>A	Pathogenic-likely-pathogenic, pathogenic	Coding sequence variant, missense variant, genic upstream transcript variant, 5 prime UTR variant, intron variant
rs144045691	A>G	Uncertain-significance, conflicting-interpretations-of-pathogenicity	3 prime UTR variant, coding sequence variant, missense variant, non coding transcript variant, genic downstream transcript variant
rs199476305	G>C	Likely-pathogenic, not-provided	Genic upstream transcript variant, missense variant, intron variant, coding sequence variant, 5 prime UTR variant
rs199476306	C>T	Likely-pathogenic, uncertain-significance	Genic upstream transcript variant, missense variant, intron variant, coding sequence variant, 5 prime UTR variant
rs199476310	T>C	Likely-pathogenic, not-provided	Coding sequence variant, non coding transcript variant, 5 prime UTR variant, missense variant
rs199476311	G>A	Likely-pathogenic, pathogenic	Coding sequence variant, missense variant, non coding transcript variant
rs199476312	T>C	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Coding sequence variant, missense variant, non coding transcript variant
rs199476315	G>A	Pathogenic-likely-pathogenic, pathogenic	Coding sequence variant, non coding transcript variant, intron variant, missense variant
rs199476316	C>T	Likely-pathogenic, uncertain-significance, pathogenic	Coding sequence variant, missense variant, non coding transcript variant
rs199476317	G>A	Pathogenic	Coding sequence variant, missense variant, non coding transcript variant
rs199476319	A>G	Pathogenic, not-provided	Coding sequence variant, missense variant, non coding transcript variant
rs199476321	T>C	Conflicting-interpretations-of-pathogenicity, likely-pathogenic, uncertain-significance, pathogenic	Coding sequence variant, genic downstream transcript variant, intron variant, missense variant
rs397516363	G>A,T	Likely-pathogenic	Genic upstream transcript variant, missense variant, intron variant, coding sequence variant, 5 prime UTR variant
rs397516364	T>G	Likely-pathogenic	Coding sequence variant, missense variant, 5 prime UTR variant, genic upstream transcript variant
rs397516369	C>G	Likely-pathogenic, pathogenic	Coding sequence variant, non coding transcript variant, 5 prime UTR variant, missense variant
rs397516370	A>G	Likely-pathogenic	Coding sequence variant, non coding transcript variant, 5 prime UTR variant, missense variant
rs397516371	G>C	Likely-pathogenic	Coding sequence variant, missense variant, non coding transcript variant
rs397516372	C>G,T	Conflicting-interpretations-of-pathogenicity	Coding sequence variant, missense variant, non coding transcript variant
rs397516373	G>A	Likely-pathogenic, uncertain-significance, pathogenic	Coding sequence variant, missense variant, non coding transcript variant
rs397516376	C>T	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Coding sequence variant, missense variant, non coding transcript variant
rs397516386	C>T	Likely-pathogenic, uncertain-significance	Coding sequence variant, missense variant, non coding transcript variant
rs397516391	G>A,C,T	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Coding sequence variant, missense variant, 5 prime UTR variant, genic upstream transcript variant
rs397516486	C>G,T	Likely-pathogenic	Missense variant, intron variant, synonymous variant, coding sequence variant, non coding transcript variant
rs532254032	G>A	Likely-benign, conflicting-interpretations-of-pathogenicity, uncertain-significance	Non coding transcript variant, intron variant
rs727503518	G>A	Likely-pathogenic	Non coding transcript variant, coding sequence variant, missense variant
rs727504264	G>C	Likely-pathogenic	Non coding transcript variant, coding sequence variant, missense variant
rs727504290	G>C	Likely-pathogenic	Genic upstream transcript variant, coding sequence variant, missense variant, 5 prime UTR variant
rs727504389	A>T	Likely-pathogenic	Non coding transcript variant, coding sequence variant, missense variant
rs730881128	G>A	Conflicting-interpretations-of-pathogenicity	Genic downstream transcript variant, coding sequence variant, missense variant, intron variant
rs730881134	A>G,T	Likely-pathogenic	Non coding transcript variant, coding sequence variant, missense variant
rs730881136	T>A,G	Pathogenic, uncertain-significance	Non coding transcript variant, coding sequence variant, missense variant
rs730881140	A>G	Likely-pathogenic	Non coding transcript variant, coding sequence variant, missense variant, intron variant
rs730881146	G>A	Pathogenic, uncertain-significance	Splice donor variant, intron variant, genic upstream transcript variant
rs730881151	G>T	Uncertain-significance, likely-pathogenic	Genic upstream transcript variant, coding sequence variant, missense variant, 5 prime UTR variant
rs730881157	C>G	Pathogenic	Non coding transcript variant, coding sequence variant, missense variant, 5 prime UTR variant
rs730881159	G>A,T	Uncertain-significance, likely-pathogenic	Non coding transcript variant, coding sequence variant, missense variant, intron variant
rs730881160	A>C	Likely-pathogenic	Non coding transcript variant, coding sequence variant, missense variant
rs754664923	G>A	Likely-pathogenic	Non coding transcript variant, coding sequence variant, missense variant, 5 prime UTR variant
rs757577112	C>G,T	Likely-pathogenic, uncertain-significance	Missense variant, non coding transcript variant, 5 prime UTR variant, coding sequence variant
rs876657662	G>A	Likely-pathogenic	Missense variant, coding sequence variant, non coding transcript variant
rs879253758	G>A	Likely-pathogenic	Missense variant, coding sequence variant, non coding transcript variant
rs886037905	G>A,C	Likely-pathogenic	Synonymous variant, missense variant, coding sequence variant, non coding transcript variant
rs886039444	A>C	Uncertain-significance, likely-pathogenic	5 prime UTR variant, genic upstream transcript variant, coding sequence variant, missense variant
rs1064793284	G>C	Likely-pathogenic	Non coding transcript variant, 5 prime UTR variant, coding sequence variant, missense variant
rs1114167355	A>G	Likely-pathogenic	Non coding transcript variant, coding sequence variant, missense variant
rs1114167356	C>T	Likely-pathogenic	Non coding transcript variant, coding sequence variant, missense variant
rs1114167357	T>C	Likely-pathogenic	Splice donor variant, genic upstream transcript variant
rs1555408679	A>G	Uncertain-significance, likely-pathogenic	Missense variant, coding sequence variant, non coding transcript variant
rs1555409659	TACTCG>-	Likely-pathogenic	Splice acceptor variant, coding sequence variant, non coding transcript variant
rs1596303148	A>G	Likely-pathogenic	5 prime UTR variant, genic upstream transcript variant, missense variant, intron variant, coding sequence variant
rs1596386673	A>T	Likely-pathogenic	Coding sequence variant, non coding transcript variant, missense variant

366

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miRTarBase ID	miRNA	Experiments	Reference
MIRT001980	hsa-miR-21-5p	Luciferase reporter assayWestern blot	17363372
MIRT001980	hsa-miR-21-5p	Review	19935707
MIRT001980	hsa-miR-21-5p	Luciferase reporter assay	18270520
MIRT001980	hsa-miR-21-5p	Luciferase reporter assay	17363372
MIRT001980	hsa-miR-21-5p	Review	20130964
MIRT001980	hsa-miR-21-5p	Review	20026422
MIRT001980	hsa-miR-21-5p	Luciferase reporter assay	19253296
MIRT001327	hsa-miR-1-3p	pSILAC	18668040
MIRT001980	hsa-miR-21-5p	Luciferase reporter assay	21817107
MIRT001980	hsa-miR-21-5p	Luciferase reporter assay	21817107
MIRT021693	hsa-miR-133a-3p	Microarray	21396852
MIRT023135	hsa-miR-124-3p	Proteomics;Microarray	18668037
MIRT001327	hsa-miR-1-3p	Proteomics;Microarray	18668037
MIRT001327	hsa-miR-1-3p	Proteomics	18668040
MIRT025560	hsa-miR-34a-5p	Proteomics	21566225
MIRT025560	hsa-miR-34a-5p	Proteomics	21566225
MIRT025560	hsa-miR-34a-5p	Proteomics	21566225
MIRT001980	hsa-miR-21-5p	Microarray	18591254
MIRT001980	hsa-miR-21-5p	Western blot;qRT-PCR	17363372
MIRT053002	hsa-miR-10b-5p	Western blot	22766763
MIRT698095	hsa-miR-892a	HITS-CLIP	23313552
MIRT698094	hsa-miR-3174	HITS-CLIP	23313552
MIRT698093	hsa-miR-6761-3p	HITS-CLIP	23313552
MIRT698092	hsa-miR-6825-3p	HITS-CLIP	23313552
MIRT698091	hsa-miR-6831-3p	HITS-CLIP	23313552
MIRT698090	hsa-miR-1185-5p	HITS-CLIP	23313552
MIRT698089	hsa-miR-3679-5p	HITS-CLIP	23313552
MIRT698088	hsa-miR-3605-5p	HITS-CLIP	23313552
MIRT698087	hsa-miR-145-3p	HITS-CLIP	23313552
MIRT698086	hsa-miR-8064	HITS-CLIP	23313552
MIRT698085	hsa-miR-155-3p	HITS-CLIP	23313552
MIRT698084	hsa-miR-6828-3p	HITS-CLIP	23313552
MIRT698083	hsa-miR-6071	HITS-CLIP	23313552
MIRT698082	hsa-miR-3685	HITS-CLIP	23313552
MIRT698081	hsa-miR-497-5p	HITS-CLIP	23313552
MIRT698095	hsa-miR-892a	HITS-CLIP	23313552
MIRT698094	hsa-miR-3174	HITS-CLIP	23313552
MIRT698093	hsa-miR-6761-3p	HITS-CLIP	23313552
MIRT698092	hsa-miR-6825-3p	HITS-CLIP	23313552
MIRT698091	hsa-miR-6831-3p	HITS-CLIP	23313552
MIRT698090	hsa-miR-1185-5p	HITS-CLIP	23313552
MIRT698089	hsa-miR-3679-5p	HITS-CLIP	23313552
MIRT698088	hsa-miR-3605-5p	HITS-CLIP	23313552
MIRT698087	hsa-miR-145-3p	HITS-CLIP	23313552
MIRT698086	hsa-miR-8064	HITS-CLIP	23313552
MIRT698085	hsa-miR-155-3p	HITS-CLIP	23313552
MIRT698084	hsa-miR-6828-3p	HITS-CLIP	23313552
MIRT698083	hsa-miR-6071	HITS-CLIP	23313552
MIRT698082	hsa-miR-3685	HITS-CLIP	23313552
MIRT698081	hsa-miR-497-5p	HITS-CLIP	23313552
MIRT1449392	hsa-miR-1185	CLIP-seq
MIRT1449393	hsa-miR-1227	CLIP-seq
MIRT1449394	hsa-miR-1228	CLIP-seq
MIRT1449395	hsa-miR-1249	CLIP-seq
MIRT1449396	hsa-miR-1271	CLIP-seq
MIRT1449397	hsa-miR-1283	CLIP-seq
MIRT1449398	hsa-miR-140-3p	CLIP-seq
MIRT1449399	hsa-miR-219-5p	CLIP-seq
MIRT1449400	hsa-miR-2278	CLIP-seq
MIRT1449401	hsa-miR-297	CLIP-seq
MIRT1449402	hsa-miR-299-3p	CLIP-seq
MIRT1449403	hsa-miR-29a	CLIP-seq
MIRT1449404	hsa-miR-29b	CLIP-seq
MIRT1449405	hsa-miR-29c	CLIP-seq
MIRT1449406	hsa-miR-3119	CLIP-seq
MIRT1449407	hsa-miR-3144-5p	CLIP-seq
MIRT1449408	hsa-miR-3149	CLIP-seq
MIRT1449409	hsa-miR-3160-3p	CLIP-seq
MIRT1449410	hsa-miR-3182	CLIP-seq
MIRT1449411	hsa-miR-33a	CLIP-seq
MIRT1449412	hsa-miR-33b	CLIP-seq
MIRT1449413	hsa-miR-3591-5p	CLIP-seq
MIRT1449414	hsa-miR-3606	CLIP-seq
MIRT1449415	hsa-miR-3649	CLIP-seq
MIRT1449416	hsa-miR-375	CLIP-seq
MIRT1449417	hsa-miR-3917	CLIP-seq
MIRT1449418	hsa-miR-3973	CLIP-seq
MIRT1449419	hsa-miR-409-3p	CLIP-seq
MIRT1449420	hsa-miR-4445	CLIP-seq
MIRT1449421	hsa-miR-4477b	CLIP-seq
MIRT1449422	hsa-miR-4487	CLIP-seq
MIRT1449423	hsa-miR-4491	CLIP-seq
MIRT1449424	hsa-miR-4504	CLIP-seq
MIRT1449425	hsa-miR-4639-5p	CLIP-seq
MIRT1449426	hsa-miR-4645-3p	CLIP-seq
MIRT1449427	hsa-miR-4652-3p	CLIP-seq
MIRT1449428	hsa-miR-4657	CLIP-seq
MIRT1449429	hsa-miR-4659a-3p	CLIP-seq
MIRT1449430	hsa-miR-4659b-3p	CLIP-seq
MIRT1449431	hsa-miR-4677-3p	CLIP-seq
MIRT1449432	hsa-miR-4679	CLIP-seq
MIRT1449433	hsa-miR-4684-5p	CLIP-seq
MIRT1449434	hsa-miR-4716-3p	CLIP-seq
MIRT1449435	hsa-miR-4732-3p	CLIP-seq
MIRT1449436	hsa-miR-4778-3p	CLIP-seq
MIRT1449437	hsa-miR-4782-3p	CLIP-seq
MIRT1449438	hsa-miR-4790-3p	CLIP-seq
MIRT1449439	hsa-miR-4799-5p	CLIP-seq
MIRT1449440	hsa-miR-503	CLIP-seq
MIRT1449441	hsa-miR-508-3p	CLIP-seq
MIRT1449442	hsa-miR-513c	CLIP-seq
MIRT1449443	hsa-miR-514b-5p	CLIP-seq
MIRT1449444	hsa-miR-520d-5p	CLIP-seq
MIRT1449445	hsa-miR-520g	CLIP-seq
MIRT1449446	hsa-miR-520h	CLIP-seq
MIRT1449447	hsa-miR-524-5p	CLIP-seq
MIRT1449448	hsa-miR-542-3p	CLIP-seq
MIRT1449449	hsa-miR-548a-3p	CLIP-seq
MIRT1449450	hsa-miR-548a-5p	CLIP-seq
MIRT1449451	hsa-miR-548ab	CLIP-seq
MIRT1449452	hsa-miR-548ak	CLIP-seq
MIRT1449453	hsa-miR-548b-5p	CLIP-seq
MIRT1449454	hsa-miR-548c-5p	CLIP-seq
MIRT1449455	hsa-miR-548d-5p	CLIP-seq
MIRT1449456	hsa-miR-548e	CLIP-seq
MIRT1449457	hsa-miR-548f	CLIP-seq
MIRT1449458	hsa-miR-548h	CLIP-seq
MIRT1449459	hsa-miR-548i	CLIP-seq
MIRT1449460	hsa-miR-548j	CLIP-seq
MIRT1449461	hsa-miR-548n	CLIP-seq
MIRT1449462	hsa-miR-548t	CLIP-seq
MIRT1449463	hsa-miR-548w	CLIP-seq
MIRT1449464	hsa-miR-548y	CLIP-seq
MIRT1449465	hsa-miR-556-5p	CLIP-seq
MIRT1449466	hsa-miR-558	CLIP-seq
MIRT1449467	hsa-miR-559	CLIP-seq
MIRT1449468	hsa-miR-562	CLIP-seq
MIRT1449469	hsa-miR-567	CLIP-seq
MIRT1449470	hsa-miR-600	CLIP-seq
MIRT1449471	hsa-miR-653	CLIP-seq
MIRT1449472	hsa-miR-921	CLIP-seq
MIRT1449473	hsa-miR-96	CLIP-seq
MIRT1449399	hsa-miR-219-5p	CLIP-seq
MIRT1555139	hsa-miR-300	CLIP-seq
MIRT1555140	hsa-miR-381	CLIP-seq
MIRT1449420	hsa-miR-4445	CLIP-seq
MIRT1555141	hsa-miR-4528	CLIP-seq
MIRT1555142	hsa-miR-4666-3p	CLIP-seq
MIRT1449437	hsa-miR-4782-3p	CLIP-seq
MIRT1555143	hsa-miR-4789-5p	CLIP-seq
MIRT1449441	hsa-miR-508-3p	CLIP-seq
MIRT1449442	hsa-miR-513c	CLIP-seq
MIRT1449443	hsa-miR-514b-5p	CLIP-seq
MIRT1449449	hsa-miR-548a-3p	CLIP-seq
MIRT1449456	hsa-miR-548e	CLIP-seq
MIRT1449457	hsa-miR-548f	CLIP-seq
MIRT1555144	hsa-miR-587	CLIP-seq
MIRT1449392	hsa-miR-1185	CLIP-seq
MIRT2134402	hsa-miR-2355-5p	CLIP-seq
MIRT1449401	hsa-miR-297	CLIP-seq
MIRT1555139	hsa-miR-300	CLIP-seq
MIRT1449408	hsa-miR-3149	CLIP-seq
MIRT1449410	hsa-miR-3182	CLIP-seq
MIRT1449413	hsa-miR-3591-5p	CLIP-seq
MIRT1449414	hsa-miR-3606	CLIP-seq
MIRT2134403	hsa-miR-3679-3p	CLIP-seq
MIRT1555140	hsa-miR-381	CLIP-seq
MIRT1449419	hsa-miR-409-3p	CLIP-seq
MIRT2134404	hsa-miR-4286	CLIP-seq
MIRT2134405	hsa-miR-4446-5p	CLIP-seq
MIRT1555141	hsa-miR-4528	CLIP-seq
MIRT1449429	hsa-miR-4659a-3p	CLIP-seq
MIRT1449430	hsa-miR-4659b-3p	CLIP-seq
MIRT1555142	hsa-miR-4666-3p	CLIP-seq
MIRT1449436	hsa-miR-4778-3p	CLIP-seq
MIRT1555143	hsa-miR-4789-5p	CLIP-seq
MIRT1449438	hsa-miR-4790-3p	CLIP-seq
MIRT1449449	hsa-miR-548a-3p	CLIP-seq
MIRT1449456	hsa-miR-548e	CLIP-seq
MIRT1449457	hsa-miR-548f	CLIP-seq
MIRT1449469	hsa-miR-567	CLIP-seq
MIRT1555144	hsa-miR-587	CLIP-seq
MIRT2134406	hsa-miR-676	CLIP-seq
MIRT1449472	hsa-miR-921	CLIP-seq
MIRT2355679	hsa-miR-192	CLIP-seq
MIRT2355680	hsa-miR-215	CLIP-seq
MIRT1449399	hsa-miR-219-5p	CLIP-seq
MIRT2134402	hsa-miR-2355-5p	CLIP-seq
MIRT1449401	hsa-miR-297	CLIP-seq
MIRT1449402	hsa-miR-299-3p	CLIP-seq
MIRT1555139	hsa-miR-300	CLIP-seq
MIRT1449406	hsa-miR-3119	CLIP-seq
MIRT1449408	hsa-miR-3149	CLIP-seq
MIRT1449413	hsa-miR-3591-5p	CLIP-seq
MIRT1449414	hsa-miR-3606	CLIP-seq
MIRT2134403	hsa-miR-3679-3p	CLIP-seq
MIRT1555140	hsa-miR-381	CLIP-seq
MIRT2355681	hsa-miR-4269	CLIP-seq
MIRT2134404	hsa-miR-4286	CLIP-seq
MIRT2134405	hsa-miR-4446-5p	CLIP-seq
MIRT2355682	hsa-miR-4452	CLIP-seq
MIRT1449423	hsa-miR-4491	CLIP-seq
MIRT2355683	hsa-miR-4514	CLIP-seq
MIRT1555141	hsa-miR-4528	CLIP-seq
MIRT2355684	hsa-miR-4640-3p	CLIP-seq
MIRT1449428	hsa-miR-4657	CLIP-seq
MIRT1555142	hsa-miR-4666-3p	CLIP-seq
MIRT2355685	hsa-miR-4692	CLIP-seq
MIRT1449435	hsa-miR-4732-3p	CLIP-seq
MIRT2355686	hsa-miR-4742-5p	CLIP-seq
MIRT2355687	hsa-miR-4774-5p	CLIP-seq
MIRT1449437	hsa-miR-4782-3p	CLIP-seq
MIRT1555143	hsa-miR-4789-5p	CLIP-seq
MIRT1449439	hsa-miR-4799-5p	CLIP-seq
MIRT1449469	hsa-miR-567	CLIP-seq
MIRT1555144	hsa-miR-587	CLIP-seq
MIRT1449470	hsa-miR-600	CLIP-seq
MIRT1449472	hsa-miR-921	CLIP-seq
MIRT1449392	hsa-miR-1185	CLIP-seq
MIRT1449394	hsa-miR-1228	CLIP-seq
MIRT1449398	hsa-miR-140-3p	CLIP-seq
MIRT2355679	hsa-miR-192	CLIP-seq
MIRT2355680	hsa-miR-215	CLIP-seq
MIRT1449399	hsa-miR-219-5p	CLIP-seq
MIRT2134402	hsa-miR-2355-5p	CLIP-seq
MIRT1449401	hsa-miR-297	CLIP-seq
MIRT1449402	hsa-miR-299-3p	CLIP-seq
MIRT1449403	hsa-miR-29a	CLIP-seq
MIRT1449404	hsa-miR-29b	CLIP-seq
MIRT1449405	hsa-miR-29c	CLIP-seq
MIRT1555139	hsa-miR-300	CLIP-seq
MIRT1449407	hsa-miR-3144-5p	CLIP-seq
MIRT1449408	hsa-miR-3149	CLIP-seq
MIRT1449410	hsa-miR-3182	CLIP-seq
MIRT1449411	hsa-miR-33a	CLIP-seq
MIRT1449412	hsa-miR-33b	CLIP-seq
MIRT1449413	hsa-miR-3591-5p	CLIP-seq
MIRT1449414	hsa-miR-3606	CLIP-seq
MIRT2434302	hsa-miR-3622a-3p	CLIP-seq
MIRT2434303	hsa-miR-3622b-3p	CLIP-seq
MIRT1449415	hsa-miR-3649	CLIP-seq
MIRT2134403	hsa-miR-3679-3p	CLIP-seq
MIRT2434304	hsa-miR-3691-5p	CLIP-seq
MIRT1449416	hsa-miR-375	CLIP-seq
MIRT1555140	hsa-miR-381	CLIP-seq
MIRT2434305	hsa-miR-3936	CLIP-seq
MIRT1449418	hsa-miR-3973	CLIP-seq
MIRT2355681	hsa-miR-4269	CLIP-seq
MIRT2134404	hsa-miR-4286	CLIP-seq
MIRT1449420	hsa-miR-4445	CLIP-seq
MIRT2134405	hsa-miR-4446-5p	CLIP-seq
MIRT2355682	hsa-miR-4452	CLIP-seq
MIRT2434306	hsa-miR-4474-5p	CLIP-seq
MIRT1449421	hsa-miR-4477b	CLIP-seq
MIRT1449423	hsa-miR-4491	CLIP-seq
MIRT1449424	hsa-miR-4504	CLIP-seq
MIRT2355683	hsa-miR-4514	CLIP-seq
MIRT1555141	hsa-miR-4528	CLIP-seq
MIRT1449425	hsa-miR-4639-5p	CLIP-seq
MIRT2355684	hsa-miR-4640-3p	CLIP-seq
MIRT1449426	hsa-miR-4645-3p	CLIP-seq
MIRT1449427	hsa-miR-4652-3p	CLIP-seq
MIRT1449428	hsa-miR-4657	CLIP-seq
MIRT1449429	hsa-miR-4659a-3p	CLIP-seq
MIRT1449430	hsa-miR-4659b-3p	CLIP-seq
MIRT1555142	hsa-miR-4666-3p	CLIP-seq
MIRT1449431	hsa-miR-4677-3p	CLIP-seq
MIRT1449432	hsa-miR-4679	CLIP-seq
MIRT2355685	hsa-miR-4692	CLIP-seq
MIRT2434307	hsa-miR-4713-3p	CLIP-seq
MIRT1449434	hsa-miR-4716-3p	CLIP-seq
MIRT1449435	hsa-miR-4732-3p	CLIP-seq
MIRT2355686	hsa-miR-4742-5p	CLIP-seq
MIRT2434308	hsa-miR-4752	CLIP-seq
MIRT2434309	hsa-miR-4764-5p	CLIP-seq
MIRT2355687	hsa-miR-4774-5p	CLIP-seq
MIRT1449436	hsa-miR-4778-3p	CLIP-seq
MIRT1449437	hsa-miR-4782-3p	CLIP-seq
MIRT1555143	hsa-miR-4789-5p	CLIP-seq
MIRT1449441	hsa-miR-508-3p	CLIP-seq
MIRT1449442	hsa-miR-513c	CLIP-seq
MIRT1449443	hsa-miR-514b-5p	CLIP-seq
MIRT1449445	hsa-miR-520g	CLIP-seq
MIRT1449446	hsa-miR-520h	CLIP-seq
MIRT1449448	hsa-miR-542-3p	CLIP-seq
MIRT1449449	hsa-miR-548a-3p	CLIP-seq
MIRT1449450	hsa-miR-548a-5p	CLIP-seq
MIRT1449451	hsa-miR-548ab	CLIP-seq
MIRT1449452	hsa-miR-548ak	CLIP-seq
MIRT1449453	hsa-miR-548b-5p	CLIP-seq
MIRT1449454	hsa-miR-548c-5p	CLIP-seq
MIRT1449455	hsa-miR-548d-5p	CLIP-seq
MIRT1449456	hsa-miR-548e	CLIP-seq
MIRT1449457	hsa-miR-548f	CLIP-seq
MIRT1449458	hsa-miR-548h	CLIP-seq
MIRT1449459	hsa-miR-548i	CLIP-seq
MIRT1449460	hsa-miR-548j	CLIP-seq
MIRT1449461	hsa-miR-548n	CLIP-seq
MIRT1449462	hsa-miR-548t	CLIP-seq
MIRT1449463	hsa-miR-548w	CLIP-seq
MIRT1449464	hsa-miR-548y	CLIP-seq
MIRT1449467	hsa-miR-559	CLIP-seq
MIRT1449468	hsa-miR-562	CLIP-seq
MIRT1449469	hsa-miR-567	CLIP-seq
MIRT2434310	hsa-miR-581	CLIP-seq
MIRT1555144	hsa-miR-587	CLIP-seq
MIRT2434311	hsa-miR-643	CLIP-seq
MIRT1449471	hsa-miR-653	CLIP-seq
MIRT2134406	hsa-miR-676	CLIP-seq
MIRT1449472	hsa-miR-921	CLIP-seq
MIRT2649236	hsa-miR-105	CLIP-seq
MIRT2649237	hsa-miR-1207-3p	CLIP-seq
MIRT2649238	hsa-miR-124	CLIP-seq
MIRT2649239	hsa-miR-1254	CLIP-seq
MIRT2649240	hsa-miR-128	CLIP-seq
MIRT2649241	hsa-miR-149	CLIP-seq
MIRT2649242	hsa-miR-2467-3p	CLIP-seq
MIRT2649243	hsa-miR-3116	CLIP-seq
MIRT2649244	hsa-miR-3135b	CLIP-seq
MIRT1449410	hsa-miR-3182	CLIP-seq
MIRT2649245	hsa-miR-338-5p	CLIP-seq
MIRT2649246	hsa-miR-3670	CLIP-seq
MIRT2649247	hsa-miR-3678-3p	CLIP-seq
MIRT2649248	hsa-miR-3686	CLIP-seq
MIRT2649249	hsa-miR-3714	CLIP-seq
MIRT2649250	hsa-miR-3910	CLIP-seq
MIRT2649251	hsa-miR-3919	CLIP-seq
MIRT2649252	hsa-miR-3925-5p	CLIP-seq
MIRT2649253	hsa-miR-4302	CLIP-seq
MIRT2649254	hsa-miR-4434	CLIP-seq
MIRT2649255	hsa-miR-4516	CLIP-seq
MIRT2649256	hsa-miR-4521	CLIP-seq
MIRT2649257	hsa-miR-4531	CLIP-seq
MIRT1449425	hsa-miR-4639-5p	CLIP-seq
MIRT2649258	hsa-miR-4648	CLIP-seq
MIRT2649259	hsa-miR-4756-3p	CLIP-seq
MIRT2649260	hsa-miR-506	CLIP-seq
MIRT2649261	hsa-miR-550a	CLIP-seq
MIRT2649262	hsa-miR-589	CLIP-seq
MIRT2649263	hsa-miR-661	CLIP-seq
MIRT2649264	hsa-miR-760	CLIP-seq
MIRT2649265	hsa-miR-940	CLIP-seq
MIRT2649236	hsa-miR-105	CLIP-seq
MIRT2649237	hsa-miR-1207-3p	CLIP-seq
MIRT2649238	hsa-miR-124	CLIP-seq
MIRT2649239	hsa-miR-1254	CLIP-seq
MIRT2649240	hsa-miR-128	CLIP-seq
MIRT2693946	hsa-miR-1302	CLIP-seq
MIRT2649241	hsa-miR-149	CLIP-seq
MIRT2649242	hsa-miR-2467-3p	CLIP-seq
MIRT2649243	hsa-miR-3116	CLIP-seq
MIRT2649244	hsa-miR-3135b	CLIP-seq
MIRT1449410	hsa-miR-3182	CLIP-seq
MIRT2649245	hsa-miR-338-5p	CLIP-seq
MIRT2649246	hsa-miR-3670	CLIP-seq
MIRT2649247	hsa-miR-3678-3p	CLIP-seq
MIRT2649248	hsa-miR-3686	CLIP-seq
MIRT2649249	hsa-miR-3714	CLIP-seq
MIRT2649250	hsa-miR-3910	CLIP-seq
MIRT2649251	hsa-miR-3919	CLIP-seq
MIRT2649252	hsa-miR-3925-5p	CLIP-seq
MIRT2693947	hsa-miR-4298	CLIP-seq
MIRT2649253	hsa-miR-4302	CLIP-seq
MIRT2649254	hsa-miR-4434	CLIP-seq
MIRT2649255	hsa-miR-4516	CLIP-seq
MIRT2649256	hsa-miR-4521	CLIP-seq
MIRT2649257	hsa-miR-4531	CLIP-seq
MIRT1449425	hsa-miR-4639-5p	CLIP-seq
MIRT2649258	hsa-miR-4648	CLIP-seq
MIRT2649259	hsa-miR-4756-3p	CLIP-seq
MIRT2649260	hsa-miR-506	CLIP-seq
MIRT2649261	hsa-miR-550a	CLIP-seq
MIRT2649262	hsa-miR-589	CLIP-seq
MIRT2649263	hsa-miR-661	CLIP-seq
MIRT2649264	hsa-miR-760	CLIP-seq
MIRT2649265	hsa-miR-940	CLIP-seq

Show/Hide all (43)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001725	Component	Stress fiber	IDA	12686598
GO:0003065	Process	Positive regulation of heart rate by epinephrine	ISS	17556658
GO:0003779	Function	Actin binding	IEA
GO:0003779	Function	Actin binding	TAS	12686598
GO:0005200	Function	Structural constituent of cytoskeleton	TAS	12686598
GO:0005515	Function	Protein binding	IPI	16189514, 21516116, 25416956, 25910212, 26871637, 30021884, 32296183, 33961781
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0005856	Component	Cytoskeleton	TAS	16130169
GO:0005862	Component	Muscle thin filament tropomyosin	IEA
GO:0005862	Component	Muscle thin filament tropomyosin	TAS	8205619
GO:0005884	Component	Actin filament	IBA
GO:0006937	Process	Regulation of muscle contraction	TAS	3336363
GO:0007010	Process	Cytoskeleton organization	TAS	12686598
GO:0007015	Process	Actin filament organization	IBA
GO:0008016	Process	Regulation of heart contraction	TAS	8205619
GO:0008092	Function	Cytoskeletal protein binding	IPI	17987659
GO:0008307	Function	Structural constituent of muscle	TAS	8205619
GO:0008360	Process	Regulation of cell shape	IMP	21817107
GO:0015629	Component	Actin cytoskeleton	IDA
GO:0030017	Component	Sarcomere	TAS	16754800
GO:0030049	Process	Muscle filament sliding	ISS	11136687
GO:0030336	Process	Negative regulation of cell migration	ISS	15897890
GO:0031529	Process	Ruffle organization	ISS	15897890
GO:0032059	Component	Bleb	IMP	12686598
GO:0032587	Component	Ruffle membrane	IDA	12686598
GO:0034614	Process	Cellular response to reactive oxygen species	IEP	12686598
GO:0042060	Process	Wound healing	ISS	17721995
GO:0042802	Function	Identical protein binding	ISS
GO:0042803	Function	Protein homodimerization activity	ISS
GO:0045214	Process	Sarcomere organization	IMP	11273725
GO:0045785	Process	Positive regulation of cell adhesion	ISS	17721995
GO:0046982	Function	Protein heterodimerization activity	ISS
GO:0051015	Function	Actin filament binding	IBA
GO:0051015	Function	Actin filament binding	ISS
GO:0051496	Process	Positive regulation of stress fiber assembly	ISS	15897890
GO:0055010	Process	Ventricular cardiac muscle tissue morphogenesis	IMP	11136687
GO:0060048	Process	Cardiac muscle contraction	IBA
GO:0060048	Process	Cardiac muscle contraction	IMP	11136687
GO:1904706	Process	Negative regulation of vascular associated smooth muscle cell proliferation	IMP	21817107
GO:1904753	Process	Negative regulation of vascular associated smooth muscle cell migration	IMP	21817107

MIM	HGNC	e!Ensembl
191010	12010	ENSG00000140416

P09493

Protein name

Tropomyosin alpha-1 chain (Alpha-tropomyosin) (Tropomyosin-1)

Protein function

Binds to actin filaments in muscle and non-muscle cells (PubMed:23170982). Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction (PubMed:23170982). Smooth mu

PDB

3MUD , 5KHT , 6UT2 , 6X5Z , 7UTI , 7UTL , 8EFH , 8EFI , 8ENC , 8ZB7

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00261	Tropomyosin	48 → 284	Tropomyosin	Coiled-coil

Tissue specificity

TISSUE SPECIFICITY: Detected in primary breast cancer tissues but undetectable in normal breast tissues in Sudanese patients. Isoform 1 is expressed in adult and fetal skeletal muscle and cardiac tissues, with higher expression levels in the cardiac tissu

Sequence

MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKY
SEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAA
DESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAE
ERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDRYEEEIKVLSDKLKEAETRAE
FAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMTSI

Sequence length

284

Interactions

View interactions

1249

Show/Hide Causal Diseases (14)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Atrial septal defect 1	Likely pathogenic	rs1114167356	RCV000491210
Cardiomyopathy	Pathogenic; Likely pathogenic	rs104894503, rs199476315, rs199476316, rs397516373, rs397516386, rs397516363, rs1596386673, rs2031437544	RCV001170568 RCV003149576 RCV000144848 RCV000722121 RCV000159384 RCV000852460 RCV000852462 RCV001170563
Cardiovascular phenotype	Likely pathogenic; Pathogenic	rs754664923, rs104894503, rs104894504, rs199476305, rs199476306, rs199476315, rs199476316	RCV000242724 RCV000622165 RCV000619092 RCV004686570 RCV000619544 RCV002345253 RCV000617620
Dilated cardiomyopathy 1Y	Likely pathogenic; Pathogenic	rs2140963813, rs886037905, rs754664923, rs104894503, rs1206044252, rs199476316, rs199476317, rs199476311, rs397516373	RCV001594460 RCV000240649 RCV005208131 RCV001197088 RCV004017198 RCV001594373 RCV000850515 RCV001331475 RCV000679884
Effort-induced polymorphic ventricular tachycardia	Likely pathogenic	rs879253758	RCV000234880
Familial cardiomyopathy	Likely pathogenic; Pathogenic	rs397516373	RCV002470728
Hypertrophic cardiomyopathy	Pathogenic; Likely pathogenic	rs2140974070, rs730881131, rs727504264, rs2542806797, rs2140969490, rs754664923, rs104894502, rs104894503, rs104894504, rs2542431791, rs2140937964, rs199476305, rs199476306, rs199476315, rs199476316 View all (6 more)	RCV001379127 RCV001977264 RCV000154247 RCV002302138 RCV002310619 RCV002518731 RCV002513005 RCV000474684 RCV000211870 RCV003749986 RCV003749969 RCV000768494 RCV000229431 RCV002513229 RCV000526765 RCV000168063 RCV000695968 RCV003586127 RCV000498322 RCV000694039 RCV001236859 RCV001298950
Hypertrophic cardiomyopathy 1	Likely pathogenic	rs1596303148	RCV000989341
Hypertrophic cardiomyopathy 3	Likely pathogenic; Pathogenic	rs730881131, rs104894502, rs104894503, rs104894504, rs199476306, rs199476315, rs199476317, rs397516373	RCV003315264 RCV000013271 RCV000013272 RCV000013273 RCV002470718 RCV000578109 RCV000850515 RCV001334675
Left ventricular noncompaction 9	Likely pathogenic; Pathogenic	rs199476315, rs199476319, rs397516373	RCV000054795 RCV000054794 RCV000736013
Primary dilated cardiomyopathy	Likely pathogenic; Pathogenic	rs727504389, rs876657662, rs104894503, rs199476315, rs199476317, rs199476311, rs397516364, rs397516370, rs397516371, rs397516373	RCV000154548 RCV000221536 RCV005401283 RCV005401287 RCV000036354 RCV000036336 RCV000036318 RCV000036328 RCV000036330 RCV000036335
Primary familial hypertrophic cardiomyopathy	Pathogenic; Likely pathogenic	rs104894503, rs199476315, rs199476316	RCV000036340 RCV000208146 RCV000143959
Pulmonary atresia with intact ventricular septum	Likely pathogenic	rs1114167355	RCV000491526
TPM1-related disorder	Pathogenic; Likely pathogenic	rs199476317, rs2031437544	RCV005249998 RCV003396783

Show/Hide Unknown Diseases (12)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Dilated Cardiomyopathy, Dominant	Uncertain significance; Likely benign; Benign	rs886051321, rs138843544, rs747523720, rs17525848	RCV000317834 RCV000390726 RCV000384819 RCV000337233
Gastric cancer	Conflicting classifications of pathogenicity	rs202228866	RCV005888494
Hypertrophic cardiomyopathy 21	Uncertain significance	rs397516391	RCV003447482
Left ventricular noncompaction	Likely benign	rs371934474	RCV000624321
Left ventricular noncompaction cardiomyopathy	Uncertain significance; Conflicting classifications of pathogenicity	rs730881155, rs869025539, rs757577112	RCV000208256 RCV000208520 RCV000853182
Long QT syndrome	Conflicting classifications of pathogenicity	rs397516490	RCV005054144
Lung cancer	Benign; Likely benign	rs7668	RCV005893406
Paroxysmal familial ventricular fibrillation	Conflicting classifications of pathogenicity	rs397516490	RCV005054144
Sarcoma	Benign; Likely benign	rs7668	RCV005893405
See cases	Conflicting classifications of pathogenicity	rs730881151	RCV002252010
Tetralogy of Fallot	-	rs1114167357	RCV000491976
Uterine corpus endometrial carcinoma	Conflicting classifications of pathogenicity	rs199476322	RCV005888690

Show/Hide Text Mining Associations (49)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Apical Hypertrophic Cardiomyopathy	Associate	15556047, 29626422, 32882290
Arrhythmias Cardiac	Associate	29361520
Carcinoma Hepatocellular	Associate	34116652, 34850589
Carcinoma Squamous Cell	Associate	32991423
Cardiomegaly	Associate	12651045, 34319370
Cardiomyopathies	Associate	25548289, 29626422, 32882290, 35917600, 37569730
Cardiomyopathy Associated With Myopathy And Sudden Death	Associate	33642254
Cardiomyopathy Dilated	Associate	11106718, 15556047, 16043485, 20117437, 23147248, 25548289, 26400351, 31689804, 32882290, 33020181, 35176663, 35917600, 36739943, 37313752
Cardiomyopathy Familial Restrictive 1	Associate	32882290
Cardiomyopathy Hypertrophic	Associate	12679389, 16043485, 20117437, 21835320, 22447464, 23147248, 25548289, 26960954, 29361520, 29974557, 30775854, 32744700, 33642254, 34319370, 35917600 View all (6 more)
Cardiomyopathy Hypertrophic Familial	Associate	12651045, 15479242, 22958892, 7898523, 9060904, 9822100
Cardiomyopathy Restrictive	Associate	21823217, 32882290
Cardiomyopathy Right Ventricular Dilated	Associate	11106718
Cholangiocarcinoma	Associate	30390420
Clubfoot	Associate	21834041
Conduct Disorder	Associate	37569730
Death Sudden	Associate	20117437, 26960954, 8774330
Death Sudden Cardiac	Associate	36613463
Ductus Arteriosus Patent	Associate	32744700
familial dilated cardiomyopathy	Associate	11106718, 12651045, 20117437, 26873245
Familial Sudden Death	Associate	8774330
Fibrosis	Associate	9060904
Glycogen Storage Disease Type V	Inhibit	35563042
Heart Defects Congenital	Associate	28359939, 32744700
Heart Diseases	Associate	35917600
Heart Failure	Associate	11106718, 37313752
Hypertrophy	Associate	21229884, 34319370
Hypertrophy Left Ventricular	Associate	8774330, 9060904
Iron Deficiencies	Associate	37313752
Isolated Noncompaction of the Ventricular Myocardium	Associate	23147248, 35917600
LEOPARD Syndrome	Associate	15479242, 16043485
Muscle Weakness	Associate	18716557
Muscular Atrophy	Associate	35563042
Myopathies Nemaline	Associate	10051637, 18716557
Neoplasms	Associate	27108600
Neoplasms	Inhibit	28182650, 28276320, 30390420
Nephrosis Lipoid	Associate	18697798
Neuromuscular Diseases	Associate	37569730
Oral Submucous Fibrosis	Associate	34696938
Osteosarcoma	Associate	28276320
Rheumatic Heart Disease	Associate	24738046
Squamous Cell Carcinoma of Head and Neck	Associate	28182650
Tachycardia	Associate	35917600
Tachycardia Ventricular	Associate	29361520
Uterine Cervical Neoplasms	Associate	19367286
Vaginal Neoplasms	Associate	19367286
Venous Thromboembolism	Associate	26440977
Ventricular Dysfunction Left	Associate	32882290, 34319370, 35917600
Ventricular Remodeling	Associate	15556047

TPM1 (tropomyosin 1)