THOP1 (thimet oligopeptidase 1)

Gene

• Entrez ID: 7064
• Gene name: Thimet oligopeptidase 1
• Gene symbol: THOP1
• Synonyms (NCBI Gene): EP24.15, MEPD_HUMAN, MP78, TOP
• Chromosome: 19
• Chromosome location: 19p13.3
• Summary: The protein encoded by this gene is a kininase that uses zinc as a cofactor. The encoded oligopeptidase cleaves cytosolic peptides, making them unavailable for display on antigen-presenting cells. This protein also cleaves neuropeptides under 20 aa in len

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT020122	hsa-miR-130b-3p	Sequencing	20371350
MIRT024285	hsa-miR-215-5p	Microarray	19074876
MIRT026106	hsa-miR-192-5p	Microarray	19074876
MIRT030367	hsa-miR-24-3p	Microarray	19748357
MIRT031093	hsa-miR-19b-3p	Sequencing	20371350
MIRT046579	hsa-miR-222-3p	CLASH	23622248
MIRT041826	hsa-miR-484	CLASH	23622248
MIRT041034	hsa-miR-505-3p	CLASH	23622248
MIRT040074	hsa-miR-615-3p	CLASH	23622248
MIRT039328	hsa-miR-425-5p	CLASH	23622248
MIRT036680	hsa-miR-935	CLASH	23622248
MIRT1423532	hsa-miR-130a	CLIP-seq
MIRT1423533	hsa-miR-130b	CLIP-seq
MIRT1423534	hsa-miR-1915	CLIP-seq
MIRT1423535	hsa-miR-301a	CLIP-seq
MIRT1423536	hsa-miR-301b	CLIP-seq
MIRT1423537	hsa-miR-3065-5p	CLIP-seq
MIRT1423538	hsa-miR-3152-3p	CLIP-seq
MIRT1423539	hsa-miR-3157-5p	CLIP-seq
MIRT1423540	hsa-miR-3620	CLIP-seq
MIRT1423541	hsa-miR-3666	CLIP-seq
MIRT1423542	hsa-miR-4269	CLIP-seq
MIRT1423543	hsa-miR-4295	CLIP-seq
MIRT1423544	hsa-miR-4473	CLIP-seq
MIRT1423545	hsa-miR-454	CLIP-seq
MIRT1423546	hsa-miR-4645-5p	CLIP-seq
MIRT1423547	hsa-miR-4671-3p	CLIP-seq
MIRT1423548	hsa-miR-4673	CLIP-seq
MIRT1423549	hsa-miR-4691-3p	CLIP-seq
MIRT1423550	hsa-miR-4722-3p	CLIP-seq
MIRT1423551	hsa-miR-4726-3p	CLIP-seq
MIRT1423549	hsa-miR-4691-3p	CLIP-seq
MIRT2461444	hsa-miR-1291	CLIP-seq
MIRT1423532	hsa-miR-130a	CLIP-seq
MIRT1423533	hsa-miR-130b	CLIP-seq
MIRT1423535	hsa-miR-301a	CLIP-seq
MIRT1423536	hsa-miR-301b	CLIP-seq
MIRT1423537	hsa-miR-3065-5p	CLIP-seq
MIRT1423541	hsa-miR-3666	CLIP-seq
MIRT1423543	hsa-miR-4295	CLIP-seq
MIRT1423544	hsa-miR-4473	CLIP-seq
MIRT1423545	hsa-miR-454	CLIP-seq
MIRT1423547	hsa-miR-4671-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000209	Process	Protein polyubiquitination	TAS
GO:0004222	Function	Metalloendopeptidase activity	IBA
GO:0004222	Function	Metalloendopeptidase activity	IEA
GO:0004222	Function	Metalloendopeptidase activity	TAS	7639763
GO:0005515	Function	Protein binding	IPI	32296183, 32814053
GO:0005737	Component	Cytoplasm	IEA
GO:0005758	Component	Mitochondrial intermembrane space	IBA
GO:0005829	Component	Cytosol	TAS
GO:0006508	Process	Proteolysis	IBA
GO:0006508	Process	Proteolysis	IEA
GO:0006518	Process	Peptide metabolic process	IBA
GO:0008233	Function	Peptidase activity	IEA
GO:0008237	Function	Metallopeptidase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 601117
• HGNC: 11793
• e!Ensembl: ENSG00000172009

Protein

• UniProt ID: P52888
• Protein name: Thimet oligopeptidase (EC 3.4.24.15) (Endopeptidase 24.15) (MP78)
• Protein function: Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation (PubMed:17251185, PubMed:7639763). Able to degrade the amyloid-beta precursor protein and generate amyloidogenic fragments
• PDB: 1S4B, 2O36
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01432	Peptidase_M3	227 → 677	Peptidase family M3	Family

• Sequence:

  MKPPAACAGDMADAASPCSVVNDLRWDLSAQQIEERTRELIEQTKRVYDQVGTQEFEDVS
  YESTLKALADVEVTYTVQRNILDFPQHVSPSKDIRTASTEADKKLSEFDVEMSMREDVYQ
  RIVWLQEKVQKDSLRPEAARYLERLIKLGRRNGLHLPRETQENIKRIKKKLSLLCIDFNK
  NLNEDTTFLPFTLQELGGLPEDFLNSLEKMEDGKLKVTLKYPHYFPLLKKCHVPETRRKV
  EEAFNCRCKEENCAILKELVTLRAQKSRLLGFHTHADYVLEMNMAKTSQTVATFLDELAQ
  KLKPLGEQERAVILELKRAECERRGLPFDGRIRAWDMRYYMNQVEETRYCVDQNLLKEYF
  PVQVVTHGLLGIYQELLGLAFHHEEGASAWHEDVRLYTARDAASGEVVGKFYLDLYPREG
  KYGHAACFGLQPGCLRQDGSRQIAIAAMVANFTKPTADAPSLLQHDEVETYFHEFGHVMH
  QLCSQAEFAMFSGTHVERDFVEAPSQMLENWVWEQEPLLRMSRHYRTGSAVPRELLEKLI
  ESRQANTGLFNLRQIVLAKVDQALHTQTDADPAEEYARLCQEILGVPATPGTNMPATFGH
  LAGGYDAQYYGYLWSEVYSMDMFHTRFKQEGVLNSKVGMDYRSCILRPGGSEDASAMLRR
  FLGRDPKQDAFLLSKGLQVGGCEPEPQVC

• Sequence length: 689

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
THOP1-related disorder	Likely benign	rs148139735	RCV003916827

Associations from Text Mining
Disease Name	Relationship Type	References
Alzheimer Disease	Associate	29847632, 40149871
Arthritis Rheumatoid	Associate	28148290
Carcinoma Non Small Cell Lung	Inhibit	25180910
Colorectal Neoplasms	Inhibit	34285715
Corneal Dystrophies Hereditary	Associate	14502125
Fatty Liver	Associate	38034016
Lymphatic Metastasis	Inhibit	25180910
Mitral Valve Insufficiency	Associate	30581499
Mouth Neoplasms	Associate	36142544
Parkinson Disease	Associate	38203854
Retinal Dystrophies	Associate	14502125