TAB3 (TGF-beta activated kinase 1 (MAP3K7) binding protein 3)
Gene | |
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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257397 |
Gene name
Gene Name - the full gene name approved by the HGNC.
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TGF-beta activated kinase 1 (MAP3K7) binding protein 3 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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TAB3 |
Synonyms (NCBI Gene)
Gene synonyms aliases
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MAP3K7IP3, NAP1 |
Chromosome
Chromosome number
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X |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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Xp21.2 |
Summary
Summary of gene provided in NCBI Entrez Gene.
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The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 |
miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein | |||||||||||
UniProt ID | Q8N5C8 | ||||||||||
Protein name | TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 3) (NF-kappa-B-activating protein 1) (TAK1-binding protein 3) (TAB-3) (TGF-beta-activated kinase 1-binding protein 3) | ||||||||||
Protein function | Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF) (PubMed:14633987, PubMed:14766965, PubMed:15327770, PubMed:22158 | ||||||||||
Family and domains |
Pfam
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Tissue specificity | TISSUE SPECIFICITY: Widely expressed. Constitutively overexpressed in certain tumor tissues. {ECO:0000269|PubMed:14670075}.; TISSUE SPECIFICITY: [Isoform 1]: Major transcript. {ECO:0000269|PubMed:14766965}.; TISSUE SPECIFICITY: [Isoform 2]: Minor transcri | ||||||||||
Sequence |
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Sequence length | 712 | ||||||||||
Interactions | View interactions |
Associated diseases
Disease information provided by ClinVar, GenCC, and GWAS databases.
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