STK11 (serine/threonine kinase 11)

Gene

• Entrez ID: 6794
• Gene name: Serine/threonine kinase 11
• Gene symbol: STK11
• Synonyms (NCBI Gene): LKB1, PJS, hLKB1
• Disease Acronyms (UniProt): PJS
• Chromosome: 19
• Chromosome location: 19p13.3
• Summary: This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs2075607	G>A,C,T	Likely-benign, conflicting-interpretations-of-pathogenicity, benign	Intron variant
rs9282859	C>G,T	Likely-benign, benign, pathogenic	Synonymous variant, stop gained, coding sequence variant
rs112675807	G>A,C,T	Pathogenic	Splice acceptor variant
rs121913315	G>A,T	Pathogenic-likely-pathogenic, pathogenic, likely-pathogenic	Coding sequence variant, missense variant
rs121913316	A>T	Likely-pathogenic	Coding sequence variant, missense variant
rs121913317	G>A,T	Uncertain-significance, likely-pathogenic	Stop gained, coding sequence variant, missense variant
rs121913319	G>-,GG	Pathogenic	Coding sequence variant, frameshift variant
rs121913320	TTTG>-	Pathogenic	Coding sequence variant, frameshift variant
rs121913321	CC>-,C,CCC	Pathogenic	Coding sequence variant, frameshift variant
rs121913322	C>A,G,T	Likely-benign, benign-likely-benign, likely-pathogenic, conflicting-interpretations-of-pathogenicity, uncertain-significance	Coding sequence variant, missense variant
rs121913323	C>G,T	Likely-pathogenic, pathogenic, uncertain-significance	Stop gained, coding sequence variant, missense variant
rs121913324	C>T	Pathogenic, likely-pathogenic	Coding sequence variant, stop gained
rs121913325	G>A	Likely-pathogenic	Coding sequence variant, stop gained
rs137853075	C>A,T	Likely-benign, pathogenic	Synonymous variant, coding sequence variant, stop gained
rs137853076	A>G,T	Pathogenic	Stop gained, coding sequence variant, missense variant
rs137853077	T>C	Pathogenic-likely-pathogenic, likely-pathogenic	Coding sequence variant, missense variant
rs137853078	G>A	Pathogenic	Coding sequence variant, missense variant
rs137853079	C>A,G,T	Likely-benign, pathogenic	Synonymous variant, coding sequence variant, stop gained
rs137853080	T>G	Pathogenic	Coding sequence variant, missense variant
rs137853081	G>C,T	Pathogenic	Coding sequence variant, missense variant
rs137853082	G>A,C,T	Pathogenic, likely-pathogenic	Coding sequence variant, missense variant, stop gained
rs137853083	C>G,T	Likely-benign, pathogenic	Synonymous variant, coding sequence variant, stop gained
rs137854584	G>T	Pathogenic	Coding sequence variant, stop gained
rs148830698	G>A,T	Uncertain-significance, conflicting-interpretations-of-pathogenicity	Missense variant, coding sequence variant
rs199681533	C>A,G,T	Likely-benign, conflicting-interpretations-of-pathogenicity	Missense variant, synonymous variant, coding sequence variant
rs200078204	C>A,T	Likely-benign, conflicting-interpretations-of-pathogenicity, uncertain-significance	Missense variant, coding sequence variant
rs200824447	C>A,T	Likely-benign, conflicting-interpretations-of-pathogenicity	Synonymous variant, coding sequence variant
rs202011521	G>A	Conflicting-interpretations-of-pathogenicity, benign-likely-benign, benign	Synonymous variant, coding sequence variant
rs368466538	C>A,G,T	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Missense variant, synonymous variant, coding sequence variant
rs370222210	G>A	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Missense variant, coding sequence variant
rs370976710	G>A,C,T	Likely-benign, benign, conflicting-interpretations-of-pathogenicity	Synonymous variant, coding sequence variant
rs371264852	G>A,T	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Missense variant, coding sequence variant
rs372329880	C>A,T	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Missense variant, coding sequence variant
rs372511774	C>T	Likely-benign, benign, conflicting-interpretations-of-pathogenicity	Synonymous variant, coding sequence variant
rs373167735	C>T	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Intron variant
rs376069854	C>T	Likely-benign, conflicting-interpretations-of-pathogenicity	Synonymous variant, coding sequence variant
rs376280361	G>A,C	Pathogenic, uncertain-significance	Missense variant, coding sequence variant
rs397518440	C>-	Pathogenic	Coding sequence variant, frameshift variant
rs397518441	->T	Pathogenic	Coding sequence variant, frameshift variant
rs397518442	C>-	Pathogenic	Coding sequence variant, frameshift variant
rs397518443	AA>-,A	Pathogenic	Coding sequence variant, frameshift variant
rs398123405	G>A,T	Uncertain-significance, pathogenic	Stop gained, coding sequence variant, missense variant
rs398123406	G>C,T	Pathogenic	Splice acceptor variant
rs532889728	G>A	Benign, conflicting-interpretations-of-pathogenicity	Coding sequence variant, synonymous variant
rs552610464	G>A	Conflicting-interpretations-of-pathogenicity	5 prime UTR variant
rs553752236	G>A	Likely-benign, uncertain-significance, conflicting-interpretations-of-pathogenicity	Missense variant, coding sequence variant
rs556651007	G>A,T	Likely-benign, uncertain-significance, conflicting-interpretations-of-pathogenicity	Synonymous variant, missense variant, coding sequence variant
rs558040549	C>A,T	Uncertain-significance, conflicting-interpretations-of-pathogenicity	Missense variant, coding sequence variant
rs565993396	A>G	Uncertain-significance, conflicting-interpretations-of-pathogenicity	Missense variant, coding sequence variant
rs567202367	C>A,T	Conflicting-interpretations-of-pathogenicity, uncertain-significance, likely-benign	Intron variant
rs587776656	G>-	Pathogenic	Frameshift variant, coding sequence variant
rs587776657	TCGG>-	Pathogenic	Frameshift variant, coding sequence variant
rs587776658	G>A	Pathogenic	Splice acceptor variant
rs587776659	TG>-	Pathogenic	Frameshift variant, coding sequence variant
rs587776660	TCCGGCAGC>-	Pathogenic	Inframe indel, coding sequence variant
rs587776661	G>-	Pathogenic	Frameshift variant, coding sequence variant
rs587778695	C>A,T	Conflicting-interpretations-of-pathogenicity, uncertain-significance, not-provided	Coding sequence variant, missense variant
rs587780009	G>A,C	Conflicting-interpretations-of-pathogenicity, uncertain-significance, likely-benign	Intron variant
rs587780013	G>A	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Intron variant
rs587781537	C>A,G,T	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Stop gained, coding sequence variant, missense variant
rs587781633	A>G	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Coding sequence variant, missense variant
rs587781856	A>-	Pathogenic	Frameshift variant, coding sequence variant
rs587782018	G>C,T	Pathogenic	Splice donor variant
rs587782259	C>T	Conflicting-interpretations-of-pathogenicity, likely-benign, benign	3 prime UTR variant
rs587782364	G>A	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Coding sequence variant, missense variant
rs587782424	TG>-	Pathogenic	Frameshift variant, coding sequence variant
rs727504171	T>G	Likely-pathogenic	Coding sequence variant, missense variant
rs727504172	A>C,T	Pathogenic	Splice acceptor variant
rs730881958	TCATCGGCAAGT>-	Pathogenic	Inframe indel, coding sequence variant
rs730881959	GCAGGAGGGCCGT>-	Pathogenic	Frameshift variant, coding sequence variant
rs730881961	C>A,T	Benign, conflicting-interpretations-of-pathogenicity, likely-benign	Synonymous variant, coding sequence variant
rs730881963	G>A,C	Benign, conflicting-interpretations-of-pathogenicity, likely-benign	Synonymous variant, coding sequence variant, missense variant
rs730881969	C>A,T	Likely-benign, pathogenic	Synonymous variant, stop gained, coding sequence variant
rs730881970	C>A,T	Uncertain-significance, pathogenic	Stop gained, coding sequence variant, missense variant
rs730881972	G>C,T	Likely-pathogenic	Coding sequence variant, missense variant
rs730881973	C>A,G	Uncertain-significance, pathogenic	Coding sequence variant, missense variant
rs730881976	C>A,G	Likely-pathogenic, pathogenic	Stop gained, coding sequence variant, missense variant
rs730881979	G>A	Pathogenic	Coding sequence variant, missense variant
rs755126393	A>G	Conflicting-interpretations-of-pathogenicity, likely-benign	Synonymous variant, coding sequence variant
rs755746417	G>A	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Intron variant
rs759090799	ATGAA>-	Conflicting-interpretations-of-pathogenicity, uncertain-significance, likely-benign	Splice acceptor variant, intron variant
rs759284466	C>T	Conflicting-interpretations-of-pathogenicity, uncertain-significance	5 prime UTR variant
rs760399253	C>G,T	Pathogenic	Coding sequence variant, synonymous variant, stop gained
rs764244639	C>G,T	Uncertain-significance, conflicting-interpretations-of-pathogenicity	Missense variant, coding sequence variant
rs764449808	A>G	Likely-pathogenic	Missense variant, coding sequence variant
rs767565606	C>T	Conflicting-interpretations-of-pathogenicity, likely-benign	Coding sequence variant, synonymous variant
rs768058962	C>G,T	Uncertain-significance, conflicting-interpretations-of-pathogenicity	Missense variant, coding sequence variant
rs774072752	G>T	Benign-likely-benign, uncertain-significance, conflicting-interpretations-of-pathogenicity	5 prime UTR variant
rs774100153	C>G,T	Conflicting-interpretations-of-pathogenicity, likely-benign	Missense variant, coding sequence variant, synonymous variant
rs775595174	G>A,C,T	Uncertain-significance, pathogenic	Missense variant, coding sequence variant, stop gained
rs778376925	C>A,G,T	Likely-benign, pathogenic	Synonymous variant, coding sequence variant, stop gained
rs786200991	->G	Pathogenic	Frameshift variant, coding sequence variant
rs786201090	C>T	Likely-pathogenic, pathogenic	Missense variant, coding sequence variant
rs786201213	C>A,T	Likely-pathogenic, likely-benign, pathogenic	Synonymous variant, coding sequence variant, stop gained
rs786201349	C>G,T	Likely-benign, pathogenic	Synonymous variant, coding sequence variant, stop gained
rs786202134	C>A,G,T	Likely-pathogenic	Missense variant, synonymous variant, coding sequence variant
rs786203624	T>-	Pathogenic	Frameshift variant, coding sequence variant
rs786205864	->C	Pathogenic	Frameshift variant, coding sequence variant
rs863224448	G>A	Likely-pathogenic	Splice acceptor variant
rs863224669	C>T	Conflicting-interpretations-of-pathogenicity, uncertain-significance, likely-benign	Intron variant
rs864622488	G>A,T	Likely-pathogenic, pathogenic	Missense variant, coding sequence variant, stop gained
rs864622707	T>-	Pathogenic	Frameshift variant, coding sequence variant
rs876658584	A>G	Pathogenic	Splice acceptor variant
rs876661012	->A	Pathogenic	Coding sequence variant, stop gained
rs878853247	G>C,T	Likely-pathogenic	Missense variant, coding sequence variant
rs878853984	C>T	Conflicting-interpretations-of-pathogenicity, likely-benign	Synonymous variant, coding sequence variant
rs878853985	C>T	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Synonymous variant, coding sequence variant
rs886037859	A>G	Conflicting-interpretations-of-pathogenicity, pathogenic-likely-pathogenic	Missense variant, coding sequence variant
rs886037926	A>G	Likely-pathogenic	Missense variant, coding sequence variant
rs886039554	G>T	Likely-pathogenic, pathogenic	Splice donor variant
rs886041996	A>-	Pathogenic	Frameshift variant, coding sequence variant
rs927999961	T>-,TT	Conflicting-interpretations-of-pathogenicity	5 prime UTR variant
rs1057517830	G>A	Pathogenic	Splice acceptor variant
rs1057518830	CTG>-	Likely-pathogenic	Coding sequence variant, inframe deletion
rs1057519858	G>T	Likely-pathogenic	Coding sequence variant, missense variant
rs1057520017	C>T	Likely-pathogenic	Coding sequence variant, missense variant
rs1057520018	T>C	Likely-pathogenic, likely-benign	Coding sequence variant, missense variant
rs1057520038	G>A	Likely-pathogenic	Coding sequence variant, missense variant
rs1057520039	C>G,T	Pathogenic, likely-pathogenic	Coding sequence variant, missense variant, stop gained
rs1057520040	A>G	Likely-pathogenic	Coding sequence variant, missense variant
rs1057520041	T>A	Likely-pathogenic	Coding sequence variant, missense variant
rs1057520042	G>C	Likely-pathogenic	Coding sequence variant, missense variant
rs1057520379	C>A,G	Likely-pathogenic	Coding sequence variant, missense variant
rs1057520606	G>T	Pathogenic	Coding sequence variant, stop gained
rs1057524439	T>C	Likely-pathogenic	Coding sequence variant, missense variant
rs1060499956	G>A	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Intron variant
rs1060499958	T>C	Pathogenic, likely-pathogenic, uncertain-significance	Coding sequence variant, missense variant
rs1060499960	ACCGGTGG>-	Pathogenic	Coding sequence variant, frameshift variant
rs1060499961	C>-	Pathogenic	Coding sequence variant, frameshift variant
rs1060503786	C>T	Conflicting-interpretations-of-pathogenicity, likely-benign	Coding sequence variant, synonymous variant
rs1064793427	C>-	Pathogenic	Coding sequence variant, frameshift variant
rs1064794805	A>C,G	Likely-pathogenic, uncertain-significance	Coding sequence variant, missense variant
rs1085307466	C>T	Pathogenic	Coding sequence variant, stop gained
rs1131690916	ATGGGGGACCTG>-	Likely-pathogenic	Coding sequence variant, inframe deletion
rs1131690917	GGG>-,G,GGGG	Pathogenic, likely-pathogenic, uncertain-significance	Coding sequence variant, frameshift variant, inframe deletion
rs1131690920	G>A	Pathogenic, likely-pathogenic	Splice donor variant
rs1131690921	G>T	Pathogenic	Splice donor variant
rs1131690922	->ACCT	Pathogenic	Coding sequence variant, frameshift variant
rs1131690923	C>T	Pathogenic	Coding sequence variant, stop gained
rs1131690924	T>-	Pathogenic	Coding sequence variant, frameshift variant
rs1131690925	C>T	Pathogenic	Coding sequence variant, stop gained
rs1131690926	C>-	Pathogenic	Coding sequence variant, frameshift variant
rs1131690929	->A	Pathogenic	Coding sequence variant, frameshift variant
rs1131690930	->C	Pathogenic	Coding sequence variant, frameshift variant
rs1131690931	A>C	Likely-pathogenic	Splice acceptor variant
rs1131690933	->GAAGC	Pathogenic	Coding sequence variant, frameshift variant
rs1131690934	A>G	Pathogenic	Splice acceptor variant
rs1131690935	GGTTCTCCATCCGGCAGA>-	Likely-pathogenic	Coding sequence variant, inframe deletion
rs1131690936	GGTG>-	Pathogenic	Coding sequence variant, frameshift variant
rs1131690938	A>T	Likely-pathogenic, uncertain-significance	Coding sequence variant, missense variant
rs1131690939	G>-,GG	Pathogenic	Coding sequence variant, frameshift variant
rs1131690940	C>T	Pathogenic	Coding sequence variant, stop gained
rs1131690941	T>C	Likely-pathogenic	Splice donor variant
rs1131690944	A>G	Likely-pathogenic	Splice acceptor variant
rs1131690945	C>T	Pathogenic	Coding sequence variant, stop gained
rs1131690946	->C	Pathogenic	Coding sequence variant, frameshift variant
rs1131690947	C>-	Pathogenic	Coding sequence variant, stop gained
rs1131690948	G>-	Pathogenic	Coding sequence variant, frameshift variant
rs1131690949	->G	Pathogenic	Coding sequence variant, frameshift variant
rs1131690950	G>A,C	Pathogenic	Splice donor variant
rs1131690951	A>G	Pathogenic	Splice donor variant
rs1131690952	->A	Pathogenic	Coding sequence variant, frameshift variant
rs1131690953	CCTGCTGGGGGA>-	Likely-pathogenic, uncertain-significance	Coding sequence variant, inframe deletion
rs1407794756	C>T	Conflicting-interpretations-of-pathogenicity	Intron variant
rs1471868090	C>A,T	Conflicting-interpretations-of-pathogenicity, likely-benign	Coding sequence variant, synonymous variant
rs1555734904	G>-	Pathogenic	Frameshift variant, coding sequence variant
rs1555735001	->AC	Pathogenic	Frameshift variant, coding sequence variant
rs1555735008	C>-	Pathogenic	Coding sequence variant, stop gained
rs1555735014	C>-	Pathogenic, likely-pathogenic	Frameshift variant, coding sequence variant
rs1555735080	GTAAGTA>-	Likely-pathogenic	Intron variant, coding sequence variant, splice donor variant
rs1555737444	C>-	Pathogenic	Frameshift variant, coding sequence variant
rs1555737480	T>C	Likely-pathogenic	Splice donor variant
rs1555737814	GT>-	Pathogenic	Frameshift variant, coding sequence variant
rs1555737830	G>A	Uncertain-significance, conflicting-interpretations-of-pathogenicity	Coding sequence variant, missense variant
rs1555738205	C>G,T	Pathogenic, likely-benign	Coding sequence variant, stop gained, synonymous variant
rs1555738219	->GGACATCA	Pathogenic	Frameshift variant, coding sequence variant
rs1555738319	G>A	Likely-pathogenic	Splice acceptor variant
rs1555738475	G>-	Pathogenic	Frameshift variant, coding sequence variant
rs1555738656	->GA	Pathogenic	Frameshift variant, coding sequence variant
rs1555738667	C>-	Pathogenic	Coding sequence variant, stop gained
rs1555738683	T>AC	Pathogenic	Frameshift variant, coding sequence variant
rs1555738723	A>-	Likely-pathogenic	Frameshift variant, coding sequence variant
rs1555738863	CCAAG>-	Pathogenic	Frameshift variant, coding sequence variant
rs1555738874	->TCCATCC	Pathogenic	Frameshift variant, coding sequence variant
rs1555738899	CA>TCC	Pathogenic	Frameshift variant, coding sequence variant
rs1568689930	->C	Pathogenic	Frameshift variant, coding sequence variant
rs1568689994	CT>-	Pathogenic	Frameshift variant, coding sequence variant
rs1568690161	->T	Pathogenic	Frameshift variant, coding sequence variant
rs1568690546	TAA>-	Likely-pathogenic	Intron variant, splice donor variant
rs1568708275	C>T	Conflicting-interpretations-of-pathogenicity	Coding sequence variant, synonymous variant
rs1568708382	G>A	Uncertain-significance, likely-pathogenic	Coding sequence variant, missense variant
rs1568709203	->TACAAGTT	Likely-pathogenic	Frameshift variant, coding sequence variant
rs1568710381	G>A	Uncertain-significance, pathogenic	Coding sequence variant, missense variant
rs1599915131	TGCTGGACTCGGAGACGCTGTGCAGGAGG>-	Pathogenic	Frameshift variant, coding sequence variant
rs1599915235	A>-	Pathogenic	Frameshift variant, coding sequence variant
rs1599924500	TCCTCTCTGTCCCAGGG>-	Likely-pathogenic	Intron variant, coding sequence variant, splice acceptor variant
rs1599925303	G>T	Pathogenic	Coding sequence variant, stop gained
rs1599926521	G>-	Pathogenic	Frameshift variant, coding sequence variant
rs1599927564	->TGTA	Pathogenic	Frameshift variant, coding sequence variant
rs1599927573	->C	Pathogenic	Frameshift variant, coding sequence variant
rs1599927589	G>-	Pathogenic	Frameshift variant, coding sequence variant
rs1599927622	T>-	Pathogenic	Frameshift variant, coding sequence variant
rs1599927645	A>-	Pathogenic	Frameshift variant, coding sequence variant
rs1599927689	->ACTGTGG	Pathogenic	Frameshift variant, coding sequence variant
rs1599928360	G>-	Likely-pathogenic	Coding sequence variant, splice donor variant
rs1599929258	TGGTTCCGGA>CC	Pathogenic	Frameshift variant, coding sequence variant
rs1599929264	G>-	Pathogenic	Frameshift variant, coding sequence variant
rs1599929328	C>-	Pathogenic	Frameshift variant, coding sequence variant
rs1599929335	A>-	Pathogenic	Frameshift variant, coding sequence variant
rs1599929339	->T	Pathogenic	Frameshift variant, coding sequence variant
rs1599929369	AC>-	Likely-pathogenic	Frameshift variant, coding sequence variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT020252	hsa-miR-130b-3p	Sequencing	20371350
MIRT028122	hsa-miR-93-5p	Sequencing	20371350
MIRT050817	hsa-miR-17-5p	CLASH	23622248
MIRT052942	hsa-miR-199a-3p	Luciferase reporter assay, Western blot	22265968
MIRT052942	hsa-miR-199a-3p	Luciferase reporter assay, Western blot	22265968
MIRT570514	hsa-miR-7-5p	PAR-CLIP	20371350
MIRT570513	hsa-miR-3141	PAR-CLIP	20371350
MIRT570512	hsa-miR-873-5p	PAR-CLIP	20371350
MIRT570511	hsa-miR-4767	PAR-CLIP	20371350
MIRT492157	hsa-miR-149-3p	PAR-CLIP	20371350
MIRT492156	hsa-miR-4728-5p	PAR-CLIP	20371350
MIRT492154	hsa-miR-6785-5p	PAR-CLIP	20371350
MIRT492155	hsa-miR-6883-5p	PAR-CLIP	20371350
MIRT492161	hsa-miR-4446-3p	PAR-CLIP	23592263
MIRT492160	hsa-miR-6890-3p	PAR-CLIP	23592263
MIRT492159	hsa-miR-4721	PAR-CLIP	23592263
MIRT492158	hsa-miR-604	PAR-CLIP	23592263
MIRT492157	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT492156	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT492154	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT492155	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT492153	hsa-miR-6829-5p	PAR-CLIP	23592263
MIRT492152	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT492151	hsa-miR-4723-5p	PAR-CLIP	23592263
MIRT492150	hsa-miR-5698	PAR-CLIP	23592263
MIRT492149	hsa-miR-6870-5p	PAR-CLIP	23592263
MIRT492148	hsa-miR-7111-5p	PAR-CLIP	23592263
MIRT492146	hsa-miR-6795-5p	PAR-CLIP	23592263
MIRT492147	hsa-miR-6887-5p	PAR-CLIP	23592263
MIRT028122	hsa-miR-93-5p	Luciferase reporter assay	28382150
MIRT028122	hsa-miR-93-5p	Luciferase reporter assay	28382150
MIRT028122	hsa-miR-93-5p	Luciferase reporter assay	28382150
MIRT028122	hsa-miR-93-5p	Luciferase reporter assay	28382150
MIRT570514	hsa-miR-7-5p	PAR-CLIP	20371350
MIRT570513	hsa-miR-3141	PAR-CLIP	20371350
MIRT570512	hsa-miR-873-5p	PAR-CLIP	20371350
MIRT570511	hsa-miR-4767	PAR-CLIP	20371350
MIRT492157	hsa-miR-149-3p	PAR-CLIP	20371350
MIRT492156	hsa-miR-4728-5p	PAR-CLIP	20371350
MIRT492154	hsa-miR-6785-5p	PAR-CLIP	20371350
MIRT492155	hsa-miR-6883-5p	PAR-CLIP	20371350
MIRT492161	hsa-miR-4446-3p	PAR-CLIP	23592263
MIRT492160	hsa-miR-6890-3p	PAR-CLIP	23592263
MIRT492159	hsa-miR-4721	PAR-CLIP	23592263
MIRT492158	hsa-miR-604	PAR-CLIP	23592263
MIRT492157	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT492156	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT492154	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT492155	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT492153	hsa-miR-6829-5p	PAR-CLIP	23592263
MIRT492152	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT492151	hsa-miR-4723-5p	PAR-CLIP	23592263
MIRT492150	hsa-miR-5698	PAR-CLIP	23592263
MIRT492149	hsa-miR-6870-5p	PAR-CLIP	23592263
MIRT492148	hsa-miR-7111-5p	PAR-CLIP	23592263
MIRT492146	hsa-miR-6795-5p	PAR-CLIP	23592263
MIRT492147	hsa-miR-6887-5p	PAR-CLIP	23592263
MIRT1397196	hsa-miR-1255a	CLIP-seq
MIRT1397197	hsa-miR-1255b	CLIP-seq
MIRT1397198	hsa-miR-1299	CLIP-seq
MIRT1397199	hsa-miR-1470	CLIP-seq
MIRT1397200	hsa-miR-1471	CLIP-seq
MIRT1397201	hsa-miR-1908	CLIP-seq
MIRT1397202	hsa-miR-2115	CLIP-seq
MIRT1397203	hsa-miR-3130-3p	CLIP-seq
MIRT1397204	hsa-miR-3177-3p	CLIP-seq
MIRT1397205	hsa-miR-3663-5p	CLIP-seq
MIRT1397206	hsa-miR-3676	CLIP-seq
MIRT1397207	hsa-miR-3682-3p	CLIP-seq
MIRT1397208	hsa-miR-4433	CLIP-seq
MIRT1397209	hsa-miR-4459	CLIP-seq
MIRT1397210	hsa-miR-4479	CLIP-seq
MIRT1397211	hsa-miR-4768-3p	CLIP-seq
MIRT1397212	hsa-miR-4782-5p	CLIP-seq
MIRT1397213	hsa-miR-4793-3p	CLIP-seq
MIRT1397214	hsa-miR-516b	CLIP-seq
MIRT1397215	hsa-miR-663	CLIP-seq
MIRT1397216	hsa-miR-767-5p	CLIP-seq
MIRT2118976	hsa-miR-1205	CLIP-seq
MIRT2118977	hsa-miR-1291	CLIP-seq
MIRT1397199	hsa-miR-1470	CLIP-seq
MIRT2118978	hsa-miR-1909	CLIP-seq
MIRT2118979	hsa-miR-3173-5p	CLIP-seq
MIRT1397199	hsa-miR-1470	CLIP-seq
MIRT2341278	hsa-miR-532-3p	CLIP-seq
MIRT2341279	hsa-miR-662	CLIP-seq
MIRT2692231	hsa-miR-4484	CLIP-seq
MIRT2692232	hsa-miR-4740-3p	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
NFYA	Unknown	22412893
NFYB	Unknown	22412893
NKX2-1	Repression	23995788
NR1H4	Activation	22265968
SP1	Unknown	22412893;23995788
STAT3	Unknown	24913037
STAT5A	Unknown	24913037

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000287	Function	Magnesium ion binding	IDA	12805220
GO:0001558	Process	Regulation of cell growth	ISS
GO:0001894	Process	Tissue homeostasis	IEA
GO:0001944	Process	Vasculature development	ISS
GO:0002039	Function	P53 binding	IDA	11430832
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	11430832, 12805220, 19892943
GO:0004674	Function	Protein serine/threonine kinase activity	TAS
GO:0005515	Function	Protein binding	IPI	12595760, 12753905, 12805220, 14676191, 17216128, 19274086, 19513107, 19892943, 20562859, 22575644, 22939624, 24362629, 25036637, 25241761, 25329316, 25852190, 26479318, 28514442
GO:0005524	Function	ATP binding	IDA	12805220
GO:0005634	Component	Nucleus	IDA	12805220, 18854309
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IDA	11430832, 12805220, 17216128, 18854309
GO:0005739	Component	Mitochondrion	IDA	11430832
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	ISS
GO:0005829	Component	Cytosol	TAS
GO:0006468	Process	Protein phosphorylation	IDA	12805220, 25329316
GO:0006470	Process	Protein dephosphorylation	IMP	15731909
GO:0006914	Process	Autophagy	IEA
GO:0006974	Process	Cellular response to DNA damage stimulus	IMP	25329316
GO:0007050	Process	Cell cycle arrest	IDA	12805220, 17216128
GO:0007050	Process	Cell cycle arrest	TAS
GO:0007283	Process	Spermatogenesis	IEA
GO:0007409	Process	Axonogenesis	IEA
GO:0008285	Process	Negative regulation of cell population proliferation	IMP	17216128, 25329316
GO:0010212	Process	Response to ionizing radiation	ISS
GO:0010508	Process	Positive regulation of autophagy	IMP	23878245
GO:0016020	Component	Membrane	ISS
GO:0030010	Process	Establishment of cell polarity	IMP	24643070
GO:0030010	Process	Establishment of cell polarity	ISS
GO:0030275	Function	LRR domain binding	IEA
GO:0030295	Function	Protein kinase activator activity	IDA	19892943
GO:0030308	Process	Negative regulation of cell growth	ISS
GO:0030511	Process	Positive regulation of transforming growth factor beta receptor signaling pathway	IMP	18311138
GO:0032147	Process	Activation of protein kinase activity	IMP	15731909
GO:0042593	Process	Glucose homeostasis	ISS
GO:0043276	Process	Anoikis	IMP	19622832
GO:0045059	Process	Positive thymic T cell selection	IEA
GO:0046777	Process	Protein autophosphorylation	IDA	11430832
GO:0048814	Process	Regulation of dendrite morphogenesis	IEA
GO:0050772	Process	Positive regulation of axonogenesis	IEA
GO:0050852	Process	T cell receptor signaling pathway	IEA
GO:0051645	Process	Golgi localization	IEA
GO:0051896	Process	Regulation of protein kinase B signaling	IEA
GO:0060070	Process	Canonical Wnt signaling pathway	IEA
GO:0060770	Process	Negative regulation of epithelial cell proliferation involved in prostate gland development	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0071493	Process	Cellular response to UV-B	IDA	25329316
GO:0072332	Process	Intrinsic apoptotic signaling pathway by p53 class mediator	IDA	11430832
GO:0090090	Process	Negative regulation of canonical Wnt signaling pathway	IMP	15731909
GO:0097484	Process	Dendrite extension	IEA
GO:0106310	Function	Protein serine kinase activity	IEA
GO:0106311	Function	Protein threonine kinase activity	IEA
GO:0120163	Process	Negative regulation of cold-induced thermogenesis	ISS	27461402
GO:1900182	Process	Positive regulation of protein localization to nucleus	IEA
GO:1901610	Process	Positive regulation of vesicle transport along microtubule	IMP	24643070
GO:1901796	Process	Regulation of signal transduction by p53 class mediator	TAS
GO:1904262	Process	Negative regulation of TORC1 signaling	IMP	23878245

Other IDs

• MIM: 602216
• HGNC: 11389
• e!Ensembl: ENSG00000118046

Protein

• UniProt ID: Q15831
• Protein name: Serine/threonine-protein kinase STK11 (EC 2.7.11.1) (Liver kinase B1) (LKB1) (hLKB1) (Renal carcinoma antigen NY-REN-19)
• Protein function: Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage respo
• PDB: 2WTK, 4ZDR, 5WXN, 8VSU
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00069	Pkinase	49 → 309	Protein kinase domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitously expressed. Strongest expression in testis and fetal liver.
• Sequence:

  MEVVDPQQLGMFTEGELMSVGMDTFIHRIDSTEVIYQPRRKRAKLIGKYLMGDLLGEGSY
  GKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHKNVIQLVDVLYNE
  EKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPG
  NLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPPEIANGLDTFSGFKVDIWS
  AGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSDLLKGMLEYEPAKRFSI
  RQIRQHSWFRKKHPPAEAPVPIPPSPDTKDRWRSMTVVPYLEDLHGADEDEDLFDIEDDI
  IYTQDFTVPGQVPEEEASHNGQRRGLPKAVCMNGTEAAQLSTKSRAEGRAPNPARKACSA
  SSKIRRLSACKQQ

• Sequence length: 433

Associated diseases

Unknown
Disease term	Disease name	Evidence	References	Source
Ovarian cancer	familial ovarian cancer	Conditional KD of IL6 in the OCCA xenograft model delays tumor growth		GenCC, CBGDA
Pancreatic Carcinoma	familial pancreatic carcinoma			GenCC
Diabetes	Diabetes			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Abdominal Injuries	Associate	20497868
ACTH Secreting Pituitary Adenoma	Associate	27615706
Adenocarcinoma	Associate	10079245, 11389158, 14511408, 23287851, 26317919, 29219616, 29370903, 30885352, 30978501, 31407221, 31988001
Adenocarcinoma Mucinous	Associate	12533684, 31243107, 34103667, 38369337
Adenocarcinoma of Lung	Associate	10079245, 17711506, 19347029, 20559149, 21159649, 21532627, 22460425, 22590557, 24236184, 24419424, 25465874, 25695224, 26066407, 26069186, 26829311, 26864623, 26917230, 27151654, 27687306, 28336552, 28376202, 28884744, 30075702, 30185829, 32396674, 32442617, 32931935, 33264619, 34045189, 34450259, 34654720, 34735498, 34740862, 34849607, 35543335, 36163168, 37100205, 37506141, 37968341, 37996064, 38428265
Adenoma	Associate	19955943, 31248021
Adenoma Liver Cell	Associate	35961004
Adenomatous Polyposis Coli	Associate	21940722
Angioedemas Hereditary	Associate	37495171
Anodontia	Associate	28911955
Apnea	Associate	35768580
Arthritis Rheumatoid	Associate	36759597, 37174663
Astrocytoma	Associate	15367334
Atherosclerosis	Associate	36627571
Azoospermia	Associate	35849255
Birt Hogg Dube Syndrome	Associate	34031471
Breast Neoplasms	Associate	11064676, 12865922, 18794113, 19369417, 19483724, 20418665, 21294903, 22562547, 23155392, 23409019, 24498881, 24830819, 24913037, 25178656, 26534844, 26877155, 28011157, 28071670, 28407996, 28419251, 28550065, 28891274, 29566768, 30054559, 30289978, 31206626, 33560870, 34299313, 34866136, 39226054, 40523834
Bronchiolitis Obliterans Syndrome	Inhibit	34859569, 39228019
Cafe au Lait Spots	Associate	33147782
Calcinosis Cutis	Associate	32657779, 32881920
Carcinogenesis	Associate	10362809, 16407837, 22801477, 25633809, 28720067, 28813465, 29370903, 32396674, 33149122, 33219302, 34921839, 9708796
Carcinogenesis	Inhibit	25674212, 26877155
Carcinoma Ductal	Associate	34810298
Carcinoma Hepatocellular	Associate	22168747, 23679304, 33082400, 33219302, 35961004, 37787988
Carcinoma Large Cell	Associate	26317919, 26960398, 29535388, 30978501, 33031101
Carcinoma Non Small Cell Lung	Associate	17384680, 18594528, 19258070, 20193846, 21749859, 23178462, 25634010, 25769882, 26027660, 26506235, 26625312, 26847819, 26960398, 27266881, 28034771, 29118262, 29642873, 30514331, 30626603, 30710424, 30885352, 30896962, 31200821, 31389598, 31659111, 32312757, 32396674, 32467099, 32606052, 32871843, 33537171, 33744718, 34518295, 34654720, 34849607, 35598205, 35747993, 35753125, 35792876, 36220070, 36239337, 36459496, 36603171, 37069542, 37100205, 37349576, 37495171, 37506141, 37838086, 37921939, 38159439, 38183584, 38428265, 39308524, 39541774, 40007122, 40591555
Carcinoma Non Small Cell Lung	Inhibit	21532627
Carcinoma Ovarian Epithelial	Associate	26068970
Carcinoma Pancreatic Ductal	Associate	26015068, 26887594, 35752568, 36978154, 38086003
Carcinoma Papillary	Associate	37369462
Carcinoma Renal Cell	Associate	25179843, 25969368
Carcinoma Squamous Cell	Associate	21191146, 22768234, 24810493, 25738363, 28145643, 29980281, 32345599, 35621648, 35709927
Cell Transformation Neoplastic	Associate	34193159
Cheyne Stokes Respiration	Associate	35768580
Cholangiocarcinoma	Associate	26056085, 26517522, 34810298, 37369462
Cholangiocarcinoma	Inhibit	32653521, 35856436
Colonic Neoplasms	Associate	31243107
Colonic Polyps	Associate	23399955
Colorectal Neoplasms	Associate	10429655, 10896921, 20622004, 22168747, 26797410, 29141581, 29307989, 29967336, 30913862, 37116137, 9708796
Congenital Hyperinsulinism	Associate	20357370
Coronary Artery Disease	Associate	28349069
Death	Associate	30913862, 33264619, 37495171, 39709652
Diabetes Gestational	Associate	23706335
Diabetes Mellitus	Associate	23706335, 26345094
Diabetes Mellitus Type 2	Associate	28349069
Disease Resistance	Associate	35157996
Drug Related Side Effects and Adverse Reactions	Associate	17212587, 19258070
Early Onset Glaucoma	Associate	33264619
Endometrial Neoplasms	Inhibit	22635025
Endometrial Neoplasms	Associate	25042259, 26027660, 31308508, 36140779
Epilepsy	Associate	24260271
Esophageal Neoplasms	Associate	24022664
Esophageal Neoplasms	Inhibit	29370903
Esophageal Squamous Cell Carcinoma	Associate	35463992, 37080995
Fibrosis	Associate	36276641
Gallbladder Neoplasms	Associate	24508317, 32045060, 32839463
Ganglioneuroma	Associate	23399955
Gastrointestinal Diseases	Associate	26430231, 35189935
Gastrointestinal Hemorrhage	Associate	20497868
Gastrointestinal Neoplasms	Associate	10353780, 10429655, 12865922, 16407375, 32396674, 32799895
Genetic Diseases Inborn	Associate	10079245, 31712642
Genomic Instability	Associate	36044718
Glassy cell carcinoma of the cervix	Associate	12533684
Glioma	Associate	25399650, 26488897
Glucagonoma	Associate	28921546
Glycogen Storage Disease IB	Associate	35961004
Glycogen Storage Disease Type II	Associate	35961004
Glycogen Storage Disease Type IV	Associate	25695224
Gout	Associate	33493135
Granulosa Cell Tumor	Associate	10389980
Granulosa cell tumor of the ovary	Associate	10389980
Guillain Barre Syndrome	Associate	36139470
Gynecomastia	Associate	24037887
Hamartoma	Associate	10201537, 10389980, 10429655, 11733352, 14726968, 20939895, 32390703, 9708796
Hamartoma Syndrome Multiple	Associate	25208626, 29496690, 36011318, 9708796
Head and Neck Neoplasms	Associate	32911741
Hematologic Neoplasms	Associate	25846811
Hematuria Benign Familial	Associate	23679304
Hepatoblastoma	Associate	34828353
Hereditary Breast and Ovarian Cancer Syndrome	Associate	25178656, 29496690, 30623411, 33646313, 37563628, 39684258
Hypercapnia	Associate	35768580
Hyperpigmentation	Associate	17921699
Hyperplasia	Associate	23027127
Hypoventilation	Associate	35768580
Hypoxia	Associate	35768580
Hypoxia	Inhibit	39228019
Hypoxia Brain	Associate	35768580
Infections	Associate	28813465
Infertility Male	Associate	31418107
Inflammation	Associate	20622004, 21150337, 33493135, 36627571, 37172591, 37174663
Intestinal Obstruction	Associate	37377590
Intestinal Polyposis	Associate	23399955
Intestinal Polyps	Associate	10362809, 27721366
Intussusception	Associate	20497868, 26607058, 29685139, 37377590
Keratoacanthoma	Associate	26319365
Laryngeal Neoplasms	Associate	17641416
Lead Poisoning Nervous System	Associate	27705915
Leiomyoma	Associate	27748285
Leukemia	Associate	24705122
Leukemia Lymphoma Adult T Cell	Associate	23577667
Leukemia Myeloid Acute	Associate	25846811, 28882949
Leukemia Myeloid Acute	Inhibit	39369651
Lip Hamartomatous	Associate	33147782
Liver Failure	Inhibit	22265968
Lung Diseases	Associate	24285539, 31292535
Lung Neoplasms	Associate	17384680, 17711506, 20010869, 21150337, 21532627, 24236184, 24285539, 24419424, 25042259, 25465874, 25477232, 26420428, 26625312, 26701889, 26864623, 28205554, 28720067, 28813465, 29089357, 30297358, 30297789, 30626603, 31697874, 32396674, 32945133, 33013881, 33264619, 33268447, 34016959, 35543335, 35621648, 35709927, 36150391, 36220070, 36459496, 39955067
Lung Neoplasms	Inhibit	29138862
Lymphatic Metastasis	Inhibit	17641416
Lymphoma Non Hodgkin	Associate	24998186
Melanoma	Associate	10201537, 20193846, 25349262, 25846811, 28870692
Meningeal Carcinomatosis	Associate	27721366
Mesothelioma Malignant	Associate	25514803
Microsatellite Instability	Associate	37838086
Mouth Diseases	Associate	21940722
Multiple Sclerosis	Associate	25694554, 34371271
Multiple Sclerosis Relapsing Remitting	Associate	34371271
Neoplasm Metastasis	Associate	17641416, 20418665, 25178656, 25179843, 25224251, 25349262, 25695224, 27756406, 28700115, 32374727, 32657779
Neoplasm Metastasis	Inhibit	26015068, 35856436
Neoplasm Recurrence Local	Associate	33527763
Neoplasms	Associate	10079245, 10201537, 10362809, 10429655, 11389158, 12865922, 14511408, 14726968, 16344569, 16407375, 16407837, 16707622, 17921699, 19340305, 19369417, 19513107, 19892943, 20010869, 20082550, 20193846, 20559149, 20939895, 21159649, 21191146, 21281788, 21749859, 22168747, 22590557, 22722266, 22735790, 23027127, 24260271, 24285539, 25208626, 25224251, 25404506, 25490678, 25607951, 25738363, 25960268, 26477306, 26506235, 26625312, 26717043, 26864623, 27151654, 27687306, 27894106, 27923066, 28205554, 28336552, 28619094, 28869103, 29053726, 29141581, 29169176, 29219616, 29245219, 29415725, 29571084, 29973599, 30092773, 30297789, 30582752, 30626603, 30913862, 30997723, 31072341, 31243107, 31257110, 31634668, 31855952, 31983282, 32068166, 32467099, 32573125, 32668413, 32677196, 32778095, 32799895, 32866624, 32871843, 32887687, 32929052, 33013881, 33149122, 33264619, 33270827, 33534223, 33744718, 34193159, 34674268, 34735498, 34740862, 34849607, 35091439, 35189935, 35666960, 35753125, 36140779, 36163168, 36220070, 36355420, 36529447, 36578081, 37062002, 37080995, 37172591, 37174663, 37369462, 37460928, 37495171, 37968341, 37988950, 39369651, 39955067, 40340749, 9708796
Neoplasms	Inhibit	10389980, 10896921, 11733352, 16189157, 17928927, 18794113, 19258070, 19347029, 19483724, 20418665, 21118512, 21532627, 22168747, 22460425, 22635025, 22801477, 23287851, 23584481, 24022664, 24025358, 24792998, 25042259, 25179843, 25349262, 25674212, 25695224, 25769882, 25960268, 26056085, 26068970, 26392535, 26517522, 26877155, 26917230, 27077911, 27141100, 27705915, 27748285, 27974177, 28034771, 28071670, 28376202, 28443499, 28483946, 28632727, 28700115, 28921546, 29106388, 29138862, 29245219, 29370903, 29996110, 30185829, 31697874, 31712642, 32345599, 32396674, 32911741, 33147782, 34016959, 34654720, 34859569, 35017636, 35856436, 36077459, 36207323, 36459496, 36661676, 37506141, 39228019
Neoplastic Syndromes Hereditary	Associate	23584481
Neuroendocrine Tumors	Stimulate	33031101
Neuroendocrine Tumors	Associate	39346064
Nose Diseases	Associate	16775120
Obesity	Associate	22635025
Optic Atrophy Autosomal Dominant	Associate	37495171
Osteoblastoma	Associate	28632727
Osteosarcoma	Inhibit	28632727
Osteosarcoma	Associate	29496690
Ovarian Neoplasms	Associate	10201537, 10389980, 10429654, 26068970, 31464709, 33560870, 35017636
Ovarian Neoplasms	Inhibit	24022664, 29257268
Pancreatic Intraductal Neoplasms	Associate	11733352, 36578081
Pancreatic Neoplasms	Associate	10079245, 10362809, 11733352, 14511408, 20193846, 25479140, 26098869, 27615706, 30538291, 30997723, 32354656
Papilloma Inverted	Associate	29779136
Parkinson Disease	Stimulate	31234232
Parkinson Disease	Associate	31234232, 33552685
Parovarian Cyst	Associate	33534223
Pelvic Inflammatory Disease	Associate	33534223
Peutz Jeghers Syndrome	Associate	10079245, 10201537, 10353780, 10362809, 10389980, 10429654, 10429655, 10623683, 10780518, 10896921, 11039077, 11389158, 11430832, 11445556, 11733352, 12533684, 12865922, 14511408, 14726968, 15121768, 15756273, 16189157, 16344569, 16407375, 16582077, 16648371, 16775120, 16882735, 17010210, 17384680, 17711506, 17921699, 17924967, 18495044, 19330929, 19369417, 19615099, 19892943, 19908348, 19955943, 20082550, 20497868, 20939895, 21118512, 21572398, 21829227, 21940722, 22118009, 22160729, 22168747, 23399955, 23426006, 23584481, 23718779, 24037887, 24260271, 25042259, 25208626, 25519740, 25694554, 26430231, 26607058, 27004004, 27705915, 27721366, 27821076, 27894106, 28231849, 28869103, 29141581, 29245219, 29371475, 29685139, 29720104, 30092773, 31072341, 31107726, 31257110, 31308508, 31545393, 31712642, 32390703, 32396674, 32462036, 32573125, 32668413, 32756735, 32799895, 33147782, 33244976, 33534223, 34080793, 34103092, 34754157, 35189935, 36011318, 36550395, 36578081, 37377590, 37392704, 38036954, 38626741, 39603093, 39955067, 9708796, 9837816
Pigmentation Disorders	Associate	10389980, 29685139
Pituitary Neoplasms	Associate	27615706
Pneumothorax	Associate	34031471
Polycystic Ovary Syndrome	Associate	18000088
Polyneuropathies	Associate	36139470
Polypoidal Choroidal Vasculopathy	Associate	32677196
Polyposis Syndrome Hereditary Mixed 1	Associate	11215281
Polyps	Associate	17921699, 23399955, 26607058, 28231849, 32799895
Primary Graft Dysfunction	Inhibit	39228019
Prodromal Symptoms	Associate	30913862
Prostatic Neoplasms	Inhibit	25674212, 26616116
Rectal Neoplasms	Associate	20622004
Retinal Dysplasia	Associate	19340305
Sarcoma Ewing	Associate	27077911
Sertoli Cell Tumor	Associate	22160729
Sex Cord Gonadal Stromal Tumors	Associate	10623683, 19955943
Sezary Syndrome	Associate	30518812
Signs and Symptoms	Associate	15121768
Small Cell Lung Carcinoma	Associate	36044718, 37062002
Spinocerebellar Degenerations	Associate	34754157
Squamous Cell Carcinoma of Head and Neck	Associate	16407837, 25234657, 25871473, 33527763
Stomach Neoplasms	Associate	10429655, 19615099, 22723903, 25372287, 26182300, 31308508, 31855952, 31949278, 36484990
Sveinsson Chorioretinal Atrophy	Associate	32931935
Tertiary Lymphoid Structures	Associate	17641416
Thyroid cancer medullary	Associate	26295973
Thyroid Neoplasms	Associate	38165228
Triple Negative Breast Neoplasms	Associate	33314633
Tuberous Sclerosis 1	Associate	18794113
Turcot syndrome	Associate	37838086
Uterine Cervical Dysplasia	Associate	25738363
Uterine Cervical Neoplasms	Associate	17212587, 19340305, 20193846, 22735790, 24390348, 27581326, 32345599
Uterine Cervical Neoplasms	Inhibit	24792998, 25155037
Uterine Cervicitis	Associate	24285539
Uveal melanoma	Associate	37647867, 37966164
Virilism	Associate	20357370, 21575951
Wilms Tumor	Associate	40340749
Wounds and Injuries	Associate	22265968