Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6776
Gene name Gene Name - the full gene name approved by the HGNC.
Signal transducer and activator of transcription 5A
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
STAT5A
Synonyms (NCBI Gene) Gene synonyms aliases
MGF, STAT5
Chromosome Chromosome number
17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17q21.2
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that tran
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT000018 hsa-miR-222-3p qRT-PCR, Luciferase reporter assay, Western blot 20489169
MIRT023082 hsa-miR-124-3p Microarray 18668037
MIRT438254 hsa-miR-221-3p Luciferase reporter assay 24736554
MIRT000018 hsa-miR-222-3p Luciferase reporter assay 24736554
MIRT000018 hsa-miR-222-3p Luciferase reporter assay 24736554
Transcription factors
Transcription factor Regulation Reference
PPARA Unknown 21542777
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000785 Component Chromatin ISA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA 21873635
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA 21873635
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific ISA
GO:0001938 Process Positive regulation of endothelial cell proliferation IMP 20489169
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
601511 11366 ENSG00000126561
Protein
UniProt ID P42229
Protein name Signal transducer and activator of transcription 5A
Protein function Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated F
PDB 7TVA , 7TVB , 7UBT , 7UC6 , 7UC7
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02865 STAT_int 2 124 STAT protein, protein interaction domain Domain
PF01017 STAT_alpha 141 324 STAT protein, all-alpha domain Family
PF02864 STAT_bind 336 469 STAT protein, DNA binding domain Domain
PF00017 SH2 589 670 SH2 domain Domain
Sequence
Sequence length 794
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Inflammatory Bowel Disease Inflammatory Bowel Disease GWAS
Asthma Asthma GWAS
Associations from Text Mining
Disease Name Relationship Type References
Achondroplasia Associate 19802676
Adenocarcinoma of Lung Associate 32686362
Alzheimer Disease Associate 32854783, 33239300
Anemia Aplastic Associate 33586472
Anemia Refractory with Excess of Blasts Stimulate 11027834
Aortic Aneurysm Abdominal Associate 21493888, 21764069, 25993293
Aortic Aneurysm Familial Abdominal 1 Associate 21493888
Arthritis Rheumatoid Associate 25164131, 27629845, 31167762, 31181818, 32998457, 33362761, 35887269, 36726974
Arthritis Rheumatoid Stimulate 35706043
Ascites Associate 34359872