Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs Transcription factors Other IDs
Entrez ID	6615
Gene name	Snail family transcriptional repressor 1
Gene symbol	SNAI1
Synonyms (NCBI Gene)	SLUGH2SNASNAHSNAILSNAIL1dJ710H13.1
Chromosome	20
Chromosome location	20q13.13
Summary	The Drosophila embryonic protein snail is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. The nuclear protein encoded by this gene is structurally similar to the Drosophila snail protein,

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Show/Hide all (281)

miRTarBase ID	miRNA	Experiments	Reference
MIRT004651	hsa-miR-204-5p	Luciferase reporter assay	20056717
MIRT006760	hsa-miR-30a-5p	Luciferase reporter assayqRT-PCRWestern blot	21633953
MIRT006760	hsa-miR-30a-5p	Luciferase reporter assayqRT-PCRWestern blot	21633953
MIRT006761	hsa-miR-30b-5p	Luciferase reporter assayqRT-PCRWestern blot	21633953
MIRT006761	hsa-miR-30b-5p	Luciferase reporter assayqRT-PCRWestern blot	21633953
MIRT006762	hsa-miR-30c-5p	Luciferase reporter assayqRT-PCRWestern blot	21633953
MIRT006762	hsa-miR-30c-5p	Luciferase reporter assayqRT-PCRWestern blot	21633953
MIRT006763	hsa-miR-30d-5p	Luciferase reporter assayqRT-PCRWestern blot	21633953
MIRT006763	hsa-miR-30d-5p	Luciferase reporter assayqRT-PCRWestern blot	21633953
MIRT006764	hsa-miR-30e-5p	Luciferase reporter assayqRT-PCRWestern blot	21633953
MIRT006764	hsa-miR-30e-5p	Luciferase reporter assayqRT-PCRWestern blot	21633953
MIRT007098	hsa-miR-153-3p	Luciferase reporter assayqRT-PCRWestern blot	23188671
MIRT018418	hsa-miR-335-5p	Microarray	18185580
MIRT022882	hsa-miR-124-3p	Microarray	18668037
MIRT029897	hsa-miR-26b-5p	Microarray	19088304
MIRT052946	hsa-miR-34a-5p	HCT-15 and H1299"	22134354
MIRT052946	hsa-miR-34a-5p	HCT-15 and H1299"	22134354
MIRT052947	hsa-miR-34b-3p	HCT-15 and H1299"	22134354
MIRT052952	hsa-miR-34c-5p	HCT-15 and H1299"	22134354
MIRT052946	hsa-miR-34a-5p	Luciferase reporter assayWestern blot	22134354
MIRT007098	hsa-miR-153-3p	ImmunohistochemistryqRT-PCRWestern blot	25678802
MIRT006760	hsa-miR-30a-5p	ImmunohistochemistryLuciferase reporter assayQRTPCRWestern blot	24954667
MIRT006760	hsa-miR-30a-5p	ImmunofluorescenceLuciferase reporter assayMicroarrayqRT-PCRWestern blot	23831330
MIRT006760	hsa-miR-30a-5p	ImmunofluorescenceLuciferase reporter assayMicroarrayqRT-PCRWestern blot	23831330
MIRT437836	hsa-miR-506-3p	ImmunofluorescenceImmunohistochemistryIn situ hybridizationLuciferase reporter assayMicroarrayqRT-PCRWestern blot	23410973
MIRT438895	hsa-miR-203a-3p	ChIP-seqImmunofluorescenceLuciferase reporter assayMicroarrayqRT-PCRWestern blot	23447531
MIRT438532	hsa-miR-199a-5p	Luciferase reporter assayWestern blot	25041364
MIRT438532	hsa-miR-199a-5p	Luciferase reporter assayWestern blot	25041364
MIRT438532	hsa-miR-199a-5p	Luciferase reporter assayWestern blot	25041364
MIRT438532	hsa-miR-199a-5p	Luciferase reporter assayWestern blot	25041364
MIRT438895	hsa-miR-203a-3p	ChIP-seqImmunofluorescenceLuciferase reporter assayMicroarrayqRT-PCRWestern blot	23447531
MIRT438532	hsa-miR-199a-5p	Luciferase reporter assayWestern blot	25041364
MIRT438532	hsa-miR-199a-5p	Luciferase reporter assayWestern blot	25041364
MIRT438532	hsa-miR-199a-5p	Luciferase reporter assayWestern blot	25041364
MIRT438532	hsa-miR-199a-5p	Luciferase reporter assayWestern blot	25041364
MIRT052946	hsa-miR-34a-5p	Luciferase reporter assayWestern blot	28145431
MIRT052946	hsa-miR-34a-5p	Luciferase reporter assayWestern blot	28145431
MIRT007098	hsa-miR-153-3p	Luciferase reporter assayqRT-PCRWestern blot	26232914
MIRT007098	hsa-miR-153-3p	Luciferase reporter assayqRT-PCRWestern blot	26232914
MIRT007098	hsa-miR-153-3p	Luciferase reporter assayqRT-PCRWestern blot	28400282
MIRT007098	hsa-miR-153-3p	Luciferase reporter assayqRT-PCRWestern blot	28400282
MIRT006762	hsa-miR-30c-5p	Luciferase reporter assayWestern blot	28222434
MIRT006762	hsa-miR-30c-5p	Luciferase reporter assayWestern blot	28222434
MIRT006760	hsa-miR-30a-5p	Luciferase reporter assayWestern blot	28222434
MIRT006760	hsa-miR-30a-5p	Luciferase reporter assayWestern blot	28222434
MIRT732075	hsa-miR-22-3p	Luciferase reporter assayMicroarrayqRT-PCRWestern blot	26610210
MIRT732075	hsa-miR-22-3p	Luciferase reporter assayMicroarrayqRT-PCRWestern blot	26610210
MIRT004651	hsa-miR-204-5p	Luciferase reporter assayqRT-PCRWestern blot	26729198
MIRT004651	hsa-miR-204-5p	Luciferase reporter assayqRT-PCRWestern blot	26729198
MIRT006606	hsa-miR-30a-5p	FlowqRT-PCRWestern blot	27212164
MIRT052946	hsa-miR-34a-5p	MicroarrayqRT-PCR	33675467
MIRT006760	hsa-miR-30a-5p	qRT-PCRWestern blotting	31772711
MIRT734646	hsa-miR-199b-5p	Luciferase reporter assayqRT-PCR	31705138
MIRT737572	hsa-miR-30a-3p	Western blottingqRT-PCR	31772711
MIRT737577	hsa-miR-29b-3p	MicroarrayImmunofluorescenceqRT-PCR	31482255
MIRT756063	hsa-miR-370-3p	Luciferase reporter assayWestern blottingqRT-PCREMSA	36083239
MIRT1374756	hsa-miR-1228	CLIP-seq
MIRT1374757	hsa-miR-1236	CLIP-seq
MIRT1374758	hsa-miR-1253	CLIP-seq
MIRT1374759	hsa-miR-1470	CLIP-seq
MIRT1374760	hsa-miR-22	CLIP-seq
MIRT1374761	hsa-miR-296-5p	CLIP-seq
MIRT1374762	hsa-miR-3151	CLIP-seq
MIRT1374763	hsa-miR-3187-3p	CLIP-seq
MIRT1374764	hsa-miR-34a	CLIP-seq
MIRT1374765	hsa-miR-3614-5p	CLIP-seq
MIRT1374766	hsa-miR-3664-3p	CLIP-seq
MIRT1374767	hsa-miR-4286	CLIP-seq
MIRT1374768	hsa-miR-4290	CLIP-seq
MIRT1374769	hsa-miR-4433	CLIP-seq
MIRT1374770	hsa-miR-4459	CLIP-seq
MIRT1374771	hsa-miR-4469	CLIP-seq
MIRT1374772	hsa-miR-4488	CLIP-seq
MIRT1374773	hsa-miR-4493	CLIP-seq
MIRT1374774	hsa-miR-449a	CLIP-seq
MIRT1374775	hsa-miR-449b	CLIP-seq
MIRT1374776	hsa-miR-4529-5p	CLIP-seq
MIRT1374777	hsa-miR-4640-5p	CLIP-seq
MIRT1374778	hsa-miR-4667-3p	CLIP-seq
MIRT1374779	hsa-miR-4697-5p	CLIP-seq
MIRT1374780	hsa-miR-4726-5p	CLIP-seq
MIRT1374781	hsa-miR-4731-5p	CLIP-seq
MIRT1374782	hsa-miR-4747-5p	CLIP-seq
MIRT1374783	hsa-miR-4757-5p	CLIP-seq
MIRT1374784	hsa-miR-4768-3p	CLIP-seq
MIRT1374785	hsa-miR-4779	CLIP-seq
MIRT1374786	hsa-miR-4795-5p	CLIP-seq
MIRT1374787	hsa-miR-486-3p	CLIP-seq
MIRT1374788	hsa-miR-502-5p	CLIP-seq
MIRT1374789	hsa-miR-510	CLIP-seq
MIRT1374790	hsa-miR-544b	CLIP-seq
MIRT1374791	hsa-miR-635	CLIP-seq
MIRT1374792	hsa-miR-637	CLIP-seq
MIRT1374762	hsa-miR-3151	CLIP-seq
MIRT2111556	hsa-miR-3165	CLIP-seq
MIRT1374786	hsa-miR-4795-5p	CLIP-seq
MIRT1374787	hsa-miR-486-3p	CLIP-seq
MIRT2334629	hsa-miR-1197	CLIP-seq
MIRT2334630	hsa-miR-1324	CLIP-seq
MIRT2334631	hsa-miR-204	CLIP-seq
MIRT2334632	hsa-miR-211	CLIP-seq
MIRT2334633	hsa-miR-2114	CLIP-seq
MIRT2334634	hsa-miR-2467-3p	CLIP-seq
MIRT1374761	hsa-miR-296-5p	CLIP-seq
MIRT1374765	hsa-miR-3614-5p	CLIP-seq
MIRT2334635	hsa-miR-3942-3p	CLIP-seq
MIRT1374767	hsa-miR-4286	CLIP-seq
MIRT2334636	hsa-miR-4514	CLIP-seq
MIRT2334637	hsa-miR-4645-5p	CLIP-seq
MIRT2334638	hsa-miR-4673	CLIP-seq
MIRT2334639	hsa-miR-4692	CLIP-seq
MIRT1374761	hsa-miR-296-5p	CLIP-seq
MIRT1374765	hsa-miR-3614-5p	CLIP-seq
MIRT1374767	hsa-miR-4286	CLIP-seq
MIRT1374791	hsa-miR-635	CLIP-seq
MIRT1374756	hsa-miR-1228	CLIP-seq
MIRT2440590	hsa-miR-128	CLIP-seq
MIRT2440591	hsa-miR-1281	CLIP-seq
MIRT2440592	hsa-miR-1291	CLIP-seq
MIRT2334630	hsa-miR-1324	CLIP-seq
MIRT2334631	hsa-miR-204	CLIP-seq
MIRT2440593	hsa-miR-2053	CLIP-seq
MIRT2334632	hsa-miR-211	CLIP-seq
MIRT2334633	hsa-miR-2114	CLIP-seq
MIRT2440594	hsa-miR-27a	CLIP-seq
MIRT2440595	hsa-miR-27b	CLIP-seq
MIRT1374762	hsa-miR-3151	CLIP-seq
MIRT2440596	hsa-miR-3680	CLIP-seq
MIRT2334635	hsa-miR-3942-3p	CLIP-seq
MIRT2440597	hsa-miR-4265	CLIP-seq
MIRT2440598	hsa-miR-4283	CLIP-seq
MIRT2440599	hsa-miR-4292	CLIP-seq
MIRT2440600	hsa-miR-4296	CLIP-seq
MIRT2440601	hsa-miR-4322	CLIP-seq
MIRT2440602	hsa-miR-4447	CLIP-seq
MIRT2440603	hsa-miR-4472	CLIP-seq
MIRT2440604	hsa-miR-4489	CLIP-seq
MIRT2440605	hsa-miR-4715-3p	CLIP-seq
MIRT2440606	hsa-miR-4798-3p	CLIP-seq
MIRT2440607	hsa-miR-491-5p	CLIP-seq
MIRT1374788	hsa-miR-502-5p	CLIP-seq
MIRT1374790	hsa-miR-544b	CLIP-seq
MIRT2440608	hsa-miR-885-5p	CLIP-seq
MIRT2460070	hsa-miR-1287	CLIP-seq
MIRT2460071	hsa-miR-2110	CLIP-seq
MIRT2460072	hsa-miR-3074-5p	CLIP-seq
MIRT2460073	hsa-miR-3135b	CLIP-seq
MIRT2460074	hsa-miR-3667-3p	CLIP-seq
MIRT2460075	hsa-miR-370	CLIP-seq
MIRT2460076	hsa-miR-4271	CLIP-seq
MIRT2460077	hsa-miR-4487	CLIP-seq
MIRT2460078	hsa-miR-4633-3p	CLIP-seq
MIRT2460079	hsa-miR-4667-5p	CLIP-seq
MIRT2460080	hsa-miR-4700-5p	CLIP-seq
MIRT2460081	hsa-miR-4725-3p	CLIP-seq
MIRT1374781	hsa-miR-4731-5p	CLIP-seq
MIRT1374782	hsa-miR-4747-5p	CLIP-seq
MIRT2628652	hsa-miR-1227	CLIP-seq
MIRT1374756	hsa-miR-1228	CLIP-seq
MIRT2440590	hsa-miR-128	CLIP-seq
MIRT2440591	hsa-miR-1281	CLIP-seq
MIRT2440592	hsa-miR-1291	CLIP-seq
MIRT2628653	hsa-miR-1294	CLIP-seq
MIRT2334630	hsa-miR-1324	CLIP-seq
MIRT2334631	hsa-miR-204	CLIP-seq
MIRT2440593	hsa-miR-2053	CLIP-seq
MIRT2334632	hsa-miR-211	CLIP-seq
MIRT2334633	hsa-miR-2114	CLIP-seq
MIRT1374760	hsa-miR-22	CLIP-seq
MIRT2440594	hsa-miR-27a	CLIP-seq
MIRT2440595	hsa-miR-27b	CLIP-seq
MIRT2628654	hsa-miR-3130-3p	CLIP-seq
MIRT1374762	hsa-miR-3151	CLIP-seq
MIRT2111556	hsa-miR-3165	CLIP-seq
MIRT2628655	hsa-miR-3184	CLIP-seq
MIRT2628656	hsa-miR-3650	CLIP-seq
MIRT2440596	hsa-miR-3680	CLIP-seq
MIRT2628657	hsa-miR-3929	CLIP-seq
MIRT2334635	hsa-miR-3942-3p	CLIP-seq
MIRT2628658	hsa-miR-423-5p	CLIP-seq
MIRT2628659	hsa-miR-4261	CLIP-seq
MIRT2440597	hsa-miR-4265	CLIP-seq
MIRT2440598	hsa-miR-4283	CLIP-seq
MIRT2440599	hsa-miR-4292	CLIP-seq
MIRT2440600	hsa-miR-4296	CLIP-seq
MIRT2628660	hsa-miR-4316	CLIP-seq
MIRT2440601	hsa-miR-4322	CLIP-seq
MIRT2628661	hsa-miR-4419b	CLIP-seq
MIRT2440602	hsa-miR-4447	CLIP-seq
MIRT2628662	hsa-miR-4455	CLIP-seq
MIRT1374770	hsa-miR-4459	CLIP-seq
MIRT2440603	hsa-miR-4472	CLIP-seq
MIRT2628663	hsa-miR-4478	CLIP-seq
MIRT2440604	hsa-miR-4489	CLIP-seq
MIRT2628664	hsa-miR-4651	CLIP-seq
MIRT2628665	hsa-miR-4695-5p	CLIP-seq
MIRT2440605	hsa-miR-4715-3p	CLIP-seq
MIRT2440606	hsa-miR-4798-3p	CLIP-seq
MIRT2628666	hsa-miR-485-5p	CLIP-seq
MIRT2440607	hsa-miR-491-5p	CLIP-seq
MIRT1374788	hsa-miR-502-5p	CLIP-seq
MIRT1374790	hsa-miR-544b	CLIP-seq
MIRT2628667	hsa-miR-552	CLIP-seq
MIRT2628668	hsa-miR-608	CLIP-seq
MIRT1374792	hsa-miR-637	CLIP-seq
MIRT2628669	hsa-miR-764	CLIP-seq
MIRT2440608	hsa-miR-885-5p	CLIP-seq
MIRT2628652	hsa-miR-1227	CLIP-seq
MIRT1374756	hsa-miR-1228	CLIP-seq
MIRT2691545	hsa-miR-1254	CLIP-seq
MIRT2440590	hsa-miR-128	CLIP-seq
MIRT2440591	hsa-miR-1281	CLIP-seq
MIRT2440592	hsa-miR-1291	CLIP-seq
MIRT2628653	hsa-miR-1294	CLIP-seq
MIRT2334630	hsa-miR-1324	CLIP-seq
MIRT2691546	hsa-miR-137	CLIP-seq
MIRT2334631	hsa-miR-204	CLIP-seq
MIRT2440593	hsa-miR-2053	CLIP-seq
MIRT2334632	hsa-miR-211	CLIP-seq
MIRT2334633	hsa-miR-2114	CLIP-seq
MIRT1374760	hsa-miR-22	CLIP-seq
MIRT2691547	hsa-miR-25	CLIP-seq
MIRT2440594	hsa-miR-27a	CLIP-seq
MIRT2440595	hsa-miR-27b	CLIP-seq
MIRT2691548	hsa-miR-3116	CLIP-seq
MIRT2628654	hsa-miR-3130-3p	CLIP-seq
MIRT1374762	hsa-miR-3151	CLIP-seq
MIRT2111556	hsa-miR-3165	CLIP-seq
MIRT1374763	hsa-miR-3187-3p	CLIP-seq
MIRT2691549	hsa-miR-32	CLIP-seq
MIRT2691550	hsa-miR-346	CLIP-seq
MIRT2691551	hsa-miR-363	CLIP-seq
MIRT2628656	hsa-miR-3650	CLIP-seq
MIRT2691552	hsa-miR-367	CLIP-seq
MIRT2440596	hsa-miR-3680	CLIP-seq
MIRT2691553	hsa-miR-378g	CLIP-seq
MIRT2628657	hsa-miR-3929	CLIP-seq
MIRT2334635	hsa-miR-3942-3p	CLIP-seq
MIRT2628659	hsa-miR-4261	CLIP-seq
MIRT2440597	hsa-miR-4265	CLIP-seq
MIRT2440598	hsa-miR-4283	CLIP-seq
MIRT2440599	hsa-miR-4292	CLIP-seq
MIRT2440600	hsa-miR-4296	CLIP-seq
MIRT2628660	hsa-miR-4316	CLIP-seq
MIRT2440601	hsa-miR-4322	CLIP-seq
MIRT2691554	hsa-miR-4330	CLIP-seq
MIRT2628661	hsa-miR-4419b	CLIP-seq
MIRT2691555	hsa-miR-4437	CLIP-seq
MIRT2440602	hsa-miR-4447	CLIP-seq
MIRT2628662	hsa-miR-4455	CLIP-seq
MIRT1374770	hsa-miR-4459	CLIP-seq
MIRT2440603	hsa-miR-4472	CLIP-seq
MIRT2628663	hsa-miR-4478	CLIP-seq
MIRT2691556	hsa-miR-4481	CLIP-seq
MIRT2440604	hsa-miR-4489	CLIP-seq
MIRT2691557	hsa-miR-4494	CLIP-seq
MIRT2691558	hsa-miR-4508	CLIP-seq
MIRT1374776	hsa-miR-4529-5p	CLIP-seq
MIRT2628664	hsa-miR-4651	CLIP-seq
MIRT2691559	hsa-miR-4674	CLIP-seq
MIRT2628665	hsa-miR-4695-5p	CLIP-seq
MIRT2440605	hsa-miR-4715-3p	CLIP-seq
MIRT2691560	hsa-miR-4727-5p	CLIP-seq
MIRT2691561	hsa-miR-4745-5p	CLIP-seq
MIRT1374782	hsa-miR-4747-5p	CLIP-seq
MIRT2691562	hsa-miR-4769-3p	CLIP-seq
MIRT2440606	hsa-miR-4798-3p	CLIP-seq
MIRT2628666	hsa-miR-485-5p	CLIP-seq
MIRT2440607	hsa-miR-491-5p	CLIP-seq
MIRT2691563	hsa-miR-499a-5p	CLIP-seq
MIRT1374788	hsa-miR-502-5p	CLIP-seq
MIRT1374790	hsa-miR-544b	CLIP-seq
MIRT2628667	hsa-miR-552	CLIP-seq
MIRT2691564	hsa-miR-554	CLIP-seq
MIRT2628668	hsa-miR-608	CLIP-seq
MIRT1374792	hsa-miR-637	CLIP-seq
MIRT2691565	hsa-miR-661	CLIP-seq
MIRT2628669	hsa-miR-764	CLIP-seq
MIRT2440608	hsa-miR-885-5p	CLIP-seq
MIRT2691566	hsa-miR-92a	CLIP-seq
MIRT2691567	hsa-miR-92b	CLIP-seq

Show/Hide all (13)

Transcription factor	Regulation	Reference
CREB1	Repression	15955695
ESRRA	Repression	15955695
HMGA2	Unknown	22241470
HOXA10	Repression	16424022
ID2	Activation	22551584
MTA1	Activation	18719363
MTA3	Repression	23510993
NFKB1	Activation	17665043;18477483
NFKB1	Unknown	19538137
PARP1	Repression	21577210
RELA	Activation	17665043;18477483
RELA	Unknown	19538137
SNAI1	Unknown	16617148

Show/Hide all (77)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IDA	11912130
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IMP	15314165
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	ISS
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA	11912130
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IEA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0001227	Function	DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA
GO:0001227	Function	DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA	11912130, 20562920
GO:0001227	Function	DNA-binding transcription repressor activity, RNA polymerase II-specific	IEA
GO:0001649	Process	Osteoblast differentiation	IEA
GO:0001649	Process	Osteoblast differentiation	IEP	20128911
GO:0001650	Component	Fibrillar center	IDA
GO:0001707	Process	Mesoderm formation	IEA
GO:0001707	Process	Mesoderm formation	ISS
GO:0001837	Process	Epithelial to mesenchymal transition	IDA	16096638
GO:0001837	Process	Epithelial to mesenchymal transition	IEA
GO:0001837	Process	Epithelial to mesenchymal transition	ISS
GO:0003180	Process	Aortic valve morphogenesis	IEA
GO:0003180	Process	Aortic valve morphogenesis	TAS	20951801
GO:0003198	Process	Epithelial to mesenchymal transition involved in endocardial cushion formation	IEA
GO:0003198	Process	Epithelial to mesenchymal transition involved in endocardial cushion formation	ISS
GO:0003198	Process	Epithelial to mesenchymal transition involved in endocardial cushion formation	TAS	20951801
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	15448698, 16096638, 18331720, 19411070, 19955572, 20385133, 20389281, 20562920, 21577210, 23644467, 24209753, 25203322, 25314079, 25416956, 31515488, 32296183, 33961781
GO:0005634	Component	Nucleus	IDA	15448698, 19955572, 23288509, 24209753, 25893292
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005721	Component	Pericentric heterochromatin	IDA	24239292
GO:0005721	Component	Pericentric heterochromatin	IEA
GO:0005737	Component	Cytoplasm	IDA	15448698, 19955572, 24209753
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS
GO:0005829	Component	Cytosol	IDA
GO:0006355	Process	Regulation of DNA-templated transcription	IBA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IEA
GO:0007219	Process	Notch signaling pathway	IEA
GO:0007219	Process	Notch signaling pathway	ISS
GO:0007219	Process	Notch signaling pathway	TAS	20951801
GO:0007498	Process	Mesoderm development	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0010631	Process	Epithelial cell migration	IEA
GO:0010718	Process	Positive regulation of epithelial to mesenchymal transition	IEA
GO:0010718	Process	Positive regulation of epithelial to mesenchymal transition	IMP	20018240, 23288509
GO:0010718	Process	Positive regulation of epithelial to mesenchymal transition	ISS
GO:0010718	Process	Positive regulation of epithelial to mesenchymal transition	TAS	17072303
GO:0010957	Process	Negative regulation of vitamin D biosynthetic process	IDA	19502595
GO:0010957	Process	Negative regulation of vitamin D biosynthetic process	IEA
GO:0019900	Function	Kinase binding	IPI	15448698
GO:0030335	Process	Positive regulation of cell migration	IEA
GO:0030335	Process	Positive regulation of cell migration	IMP	15314165, 20018240
GO:0031069	Process	Hair follicle morphogenesis	IEA
GO:0043518	Process	Negative regulation of DNA damage response, signal transduction by p53 class mediator	IEA
GO:0043518	Process	Negative regulation of DNA damage response, signal transduction by p53 class mediator	IMP	15314165
GO:0043565	Function	Sequence-specific DNA binding	IEA
GO:0045892	Process	Negative regulation of DNA-templated transcription	IEA
GO:0045893	Process	Positive regulation of DNA-templated transcription	IEA
GO:0045893	Process	Positive regulation of DNA-templated transcription	IMP	20018240
GO:0046872	Function	Metal ion binding	IEA
GO:0048762	Process	Mesenchymal cell differentiation	IEA
GO:0060021	Process	Roof of mouth development	IEA
GO:0060070	Process	Canonical Wnt signaling pathway	IMP	17072303
GO:0060536	Process	Cartilage morphogenesis	IEA
GO:0060707	Process	Trophoblast giant cell differentiation	IEA
GO:0060806	Process	Negative regulation of cell differentiation involved in embryonic placenta development	IEA
GO:0060972	Process	Left/right pattern formation	IEA
GO:0070828	Process	Heterochromatin organization	IEA
GO:0070828	Process	Heterochromatin organization	ISS
GO:0070888	Function	E-box binding	IDA	11912130
GO:0070888	Function	E-box binding	IEA
GO:1902230	Process	Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	IEA
GO:1902230	Process	Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	IMP	15314165
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536
GO:2000810	Process	Regulation of bicellular tight junction assembly	IEA
GO:2000810	Process	Regulation of bicellular tight junction assembly	IMP	15314165

MIM	HGNC	e!Ensembl
604238	11128	ENSG00000124216

O95863

Protein name

Zinc finger protein SNAI1 (Protein snail homolog 1) (Protein sna)

Protein function

Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration (PubMed:10655587, PubMed:15647282, PubMed:20389281, PubMed:20562920, PubMed:2195

PDB

2Y48 , 3W5K , 3ZMT , 4QLI , 8BOX , 8F59 , 8FDV , 8FJ7

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13912	zf-C2H2_6	153 → 177		Domain
PF00096	zf-C2H2	180 → 202	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	208 → 230	Zinc finger, C2H2 type	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in a variety of tissues with the highest expression in kidney. Expressed in mesenchymal and epithelial cell lines. {ECO:0000269|PubMed:10655587}.

Sequence

MPRSFLVRKPSDPNRKPNYSELQDSNPEFTFQQPYDQAHLLAAIPPPEILNPTASLPMLI
WDSVLAPQAQPIAWASLRLQESPRVAELTSLSDEDSGKGSQPPSPPSPAPSSFSSTSVSS
LEAEAYAAFPGLGQVPKQLAQLSEAKDLQARKAFNCKYCNKEYLSLGALKMHIRSHTLPC
VCGTCGKAFSRPWLLQGHVRTHTGEKPFSCPHCSRAFADRSNLRAHLQTHSDVKKYQCQA
CARTFSRMSLLHKHQESGCSGCPR

Sequence length

264

Interactions

View interactions

SNAI1 (snail family transcriptional repressor 1)