Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs Other IDs Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	57154
Gene name Gene Name - the full gene name approved by the HGNC.	SMAD specific E3 ubiquitin protein ligase 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	SMURF1
Synonyms (NCBI Gene) Gene synonyms aliases	-
Chromosome Chromosome number	7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	7q22.1
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. This protein plays a key roll in the regulation of cell motility, cell signalling, and cell polarity. Alternative s

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miRTarBase ID	miRNA	Experiments	Reference
MIRT006796	hsa-miR-17-5p	Luciferase reporter assay, qRT-PCR, Western blot	21898695
MIRT042442	hsa-miR-424-5p	CLASH	23622248
MIRT054756	hsa-miR-497-5p	Luciferase reporter assay, Immunohistochemistry, Western blot	24858688
MIRT054796	hsa-miR-15b-5p	Luciferase reporter assay, qRT-PCR, Western blot	24435757
MIRT726482	hsa-miR-15a-5p	HITS-CLIP	22473208
MIRT054796	hsa-miR-15b-5p	HITS-CLIP	22473208
MIRT726481	hsa-miR-16-5p	HITS-CLIP	22473208
MIRT726480	hsa-miR-195-5p	HITS-CLIP	22473208
MIRT733838	hsa-miR-424-3p	qRT-PCR	31571913
MIRT734903	hsa-miR-516a-5p	Luciferase reporter assay, Western blotting, Immunoprecipitaion (IP), Immunohistochemistry (IHC), qRT-PCR	33377649
MIRT736112	hsa-miR-503-5p	Luciferase reporter assay, Western blotting, qRT-PCR, Flow cytometry, ELISA	33872218
MIRT1374243	hsa-miR-103b	CLIP-seq
MIRT1374244	hsa-miR-1178	CLIP-seq
MIRT1374245	hsa-miR-1208	CLIP-seq
MIRT1374246	hsa-miR-1226	CLIP-seq
MIRT1374247	hsa-miR-1287	CLIP-seq
MIRT1374248	hsa-miR-1292	CLIP-seq
MIRT1374249	hsa-miR-1299	CLIP-seq
MIRT1374250	hsa-miR-1323	CLIP-seq
MIRT1374251	hsa-miR-133a	CLIP-seq
MIRT1374252	hsa-miR-133b	CLIP-seq
MIRT1374253	hsa-miR-1343	CLIP-seq
MIRT1374254	hsa-miR-137	CLIP-seq
MIRT1374255	hsa-miR-138	CLIP-seq
MIRT1374256	hsa-miR-144	CLIP-seq
MIRT1374257	hsa-miR-145	CLIP-seq
MIRT1374258	hsa-miR-153	CLIP-seq
MIRT1374259	hsa-miR-15a	CLIP-seq
MIRT1374260	hsa-miR-15b	CLIP-seq
MIRT1374261	hsa-miR-16	CLIP-seq
MIRT1374262	hsa-miR-194	CLIP-seq
MIRT1374263	hsa-miR-195	CLIP-seq
MIRT1374264	hsa-miR-2052	CLIP-seq
MIRT1374265	hsa-miR-2113	CLIP-seq
MIRT1374266	hsa-miR-219-1-3p	CLIP-seq
MIRT1374267	hsa-miR-22	CLIP-seq
MIRT1374268	hsa-miR-2392	CLIP-seq
MIRT1374269	hsa-miR-25	CLIP-seq
MIRT1374270	hsa-miR-296-5p	CLIP-seq
MIRT1374271	hsa-miR-3074-5p	CLIP-seq
MIRT1374272	hsa-miR-3124-3p	CLIP-seq
MIRT1374273	hsa-miR-3148	CLIP-seq
MIRT1374274	hsa-miR-3153	CLIP-seq
MIRT1374275	hsa-miR-3157-5p	CLIP-seq
MIRT1374276	hsa-miR-3158-3p	CLIP-seq
MIRT1374277	hsa-miR-3176	CLIP-seq
MIRT1374278	hsa-miR-3180-5p	CLIP-seq
MIRT1374279	hsa-miR-3184	CLIP-seq
MIRT1374280	hsa-miR-32	CLIP-seq
MIRT1374281	hsa-miR-323-3p	CLIP-seq
MIRT1374282	hsa-miR-34b	CLIP-seq
MIRT1374283	hsa-miR-3591-5p	CLIP-seq
MIRT1374284	hsa-miR-3614-3p	CLIP-seq
MIRT1374285	hsa-miR-3616-3p	CLIP-seq
MIRT1374286	hsa-miR-3617	CLIP-seq
MIRT1374287	hsa-miR-3622a-3p	CLIP-seq
MIRT1374288	hsa-miR-3622b-3p	CLIP-seq
MIRT1374289	hsa-miR-363	CLIP-seq
MIRT1374290	hsa-miR-3646	CLIP-seq
MIRT1374291	hsa-miR-3649	CLIP-seq
MIRT1374292	hsa-miR-3652	CLIP-seq
MIRT1374293	hsa-miR-3654	CLIP-seq
MIRT1374294	hsa-miR-3657	CLIP-seq
MIRT1374295	hsa-miR-3659	CLIP-seq
MIRT1374296	hsa-miR-3662	CLIP-seq
MIRT1374297	hsa-miR-367	CLIP-seq
MIRT1374298	hsa-miR-3674	CLIP-seq
MIRT1374299	hsa-miR-3685	CLIP-seq
MIRT1374300	hsa-miR-3688-5p	CLIP-seq
MIRT1374301	hsa-miR-370	CLIP-seq
MIRT1374302	hsa-miR-376c	CLIP-seq
MIRT1374303	hsa-miR-380	CLIP-seq
MIRT1374304	hsa-miR-384	CLIP-seq
MIRT1374305	hsa-miR-3922-3p	CLIP-seq
MIRT1374306	hsa-miR-3927	CLIP-seq
MIRT1374307	hsa-miR-3942-5p	CLIP-seq
MIRT1374308	hsa-miR-3977	CLIP-seq
MIRT1374309	hsa-miR-3978	CLIP-seq
MIRT1374310	hsa-miR-423-5p	CLIP-seq
MIRT1374311	hsa-miR-424	CLIP-seq
MIRT1374312	hsa-miR-4252	CLIP-seq
MIRT1374313	hsa-miR-4276	CLIP-seq
MIRT1374314	hsa-miR-4293	CLIP-seq
MIRT1374315	hsa-miR-4299	CLIP-seq
MIRT1374316	hsa-miR-4307	CLIP-seq
MIRT1374317	hsa-miR-4420	CLIP-seq
MIRT1374318	hsa-miR-4430	CLIP-seq
MIRT1374319	hsa-miR-4446-3p	CLIP-seq
MIRT1374320	hsa-miR-4464	CLIP-seq
MIRT1374321	hsa-miR-4470	CLIP-seq
MIRT1374322	hsa-miR-4471	CLIP-seq
MIRT1374323	hsa-miR-448	CLIP-seq
MIRT1374324	hsa-miR-4495	CLIP-seq
MIRT1374325	hsa-miR-4505	CLIP-seq
MIRT1374326	hsa-miR-452	CLIP-seq
MIRT1374327	hsa-miR-4520a-3p	CLIP-seq
MIRT1374328	hsa-miR-4523	CLIP-seq
MIRT1374329	hsa-miR-4524	CLIP-seq
MIRT1374330	hsa-miR-4527	CLIP-seq
MIRT1374331	hsa-miR-4533	CLIP-seq
MIRT1374332	hsa-miR-4638-3p	CLIP-seq
MIRT1374333	hsa-miR-4646-5p	CLIP-seq
MIRT1374334	hsa-miR-4655-5p	CLIP-seq
MIRT1374335	hsa-miR-4656	CLIP-seq
MIRT1374336	hsa-miR-4658	CLIP-seq
MIRT1374337	hsa-miR-4668-5p	CLIP-seq
MIRT1374338	hsa-miR-4669	CLIP-seq
MIRT1374339	hsa-miR-4676-3p	CLIP-seq
MIRT1374340	hsa-miR-4677-3p	CLIP-seq
MIRT1374341	hsa-miR-4688	CLIP-seq
MIRT1374342	hsa-miR-4691-3p	CLIP-seq
MIRT1374343	hsa-miR-4694-5p	CLIP-seq
MIRT1374344	hsa-miR-4698	CLIP-seq
MIRT1374345	hsa-miR-4703-5p	CLIP-seq
MIRT1374346	hsa-miR-4705	CLIP-seq
MIRT1374347	hsa-miR-4710	CLIP-seq
MIRT1374348	hsa-miR-4718	CLIP-seq
MIRT1374349	hsa-miR-4721	CLIP-seq
MIRT1374350	hsa-miR-4731-5p	CLIP-seq
MIRT1374351	hsa-miR-4733-3p	CLIP-seq
MIRT1374352	hsa-miR-4747-5p	CLIP-seq
MIRT1374353	hsa-miR-4748	CLIP-seq
MIRT1374354	hsa-miR-4764-5p	CLIP-seq
MIRT1374355	hsa-miR-4773	CLIP-seq
MIRT1374356	hsa-miR-4792	CLIP-seq
MIRT1374357	hsa-miR-4795-5p	CLIP-seq
MIRT1374358	hsa-miR-489	CLIP-seq
MIRT1374359	hsa-miR-495	CLIP-seq
MIRT1374360	hsa-miR-497	CLIP-seq
MIRT1374361	hsa-miR-503	CLIP-seq
MIRT1374362	hsa-miR-5096	CLIP-seq
MIRT1374363	hsa-miR-513a-5p	CLIP-seq
MIRT1374364	hsa-miR-514	CLIP-seq
MIRT1374365	hsa-miR-514b-3p	CLIP-seq
MIRT1374366	hsa-miR-516a-3p	CLIP-seq
MIRT1374367	hsa-miR-520d-5p	CLIP-seq
MIRT1374368	hsa-miR-524-5p	CLIP-seq
MIRT1374369	hsa-miR-548ac	CLIP-seq
MIRT1374370	hsa-miR-548ae	CLIP-seq
MIRT1374371	hsa-miR-548aj	CLIP-seq
MIRT1374372	hsa-miR-548am	CLIP-seq
MIRT1374373	hsa-miR-548d-3p	CLIP-seq
MIRT1374374	hsa-miR-548o	CLIP-seq
MIRT1374375	hsa-miR-548x	CLIP-seq
MIRT1374376	hsa-miR-548z	CLIP-seq
MIRT1374377	hsa-miR-571	CLIP-seq
MIRT1374378	hsa-miR-574-5p	CLIP-seq
MIRT1374379	hsa-miR-596	CLIP-seq
MIRT1374380	hsa-miR-597	CLIP-seq
MIRT1374381	hsa-miR-599	CLIP-seq
MIRT1374382	hsa-miR-626	CLIP-seq
MIRT1374383	hsa-miR-641	CLIP-seq
MIRT1374384	hsa-miR-646	CLIP-seq
MIRT1374385	hsa-miR-661	CLIP-seq
MIRT1374386	hsa-miR-760	CLIP-seq
MIRT1374387	hsa-miR-875-3p	CLIP-seq
MIRT1374388	hsa-miR-92a	CLIP-seq
MIRT1374389	hsa-miR-92b	CLIP-seq
MIRT1374390	hsa-miR-103a	CLIP-seq
MIRT1374391	hsa-miR-105	CLIP-seq
MIRT1374392	hsa-miR-106a	CLIP-seq
MIRT1374393	hsa-miR-106b	CLIP-seq
MIRT1374394	hsa-miR-107	CLIP-seq
MIRT1374395	hsa-miR-10a	CLIP-seq
MIRT1374396	hsa-miR-10b	CLIP-seq
MIRT1374244	hsa-miR-1178	CLIP-seq
MIRT1374397	hsa-miR-1207-3p	CLIP-seq
MIRT1374245	hsa-miR-1208	CLIP-seq
MIRT1374398	hsa-miR-1267	CLIP-seq
MIRT1374399	hsa-miR-1273g	CLIP-seq
MIRT1374250	hsa-miR-1323	CLIP-seq
MIRT1374253	hsa-miR-1343	CLIP-seq
MIRT1374254	hsa-miR-137	CLIP-seq
MIRT1374400	hsa-miR-142-5p	CLIP-seq
MIRT1374258	hsa-miR-153	CLIP-seq
MIRT1374259	hsa-miR-15a	CLIP-seq
MIRT1374260	hsa-miR-15b	CLIP-seq
MIRT1374261	hsa-miR-16	CLIP-seq
MIRT1374401	hsa-miR-17	CLIP-seq
MIRT1374402	hsa-miR-1913	CLIP-seq
MIRT1374262	hsa-miR-194	CLIP-seq
MIRT1374263	hsa-miR-195	CLIP-seq
MIRT1374403	hsa-miR-196a	CLIP-seq
MIRT1374404	hsa-miR-196b	CLIP-seq
MIRT1374405	hsa-miR-203	CLIP-seq
MIRT1374264	hsa-miR-2052	CLIP-seq
MIRT1374406	hsa-miR-20a	CLIP-seq
MIRT1374407	hsa-miR-20b	CLIP-seq
MIRT1374265	hsa-miR-2113	CLIP-seq
MIRT1374269	hsa-miR-25	CLIP-seq
MIRT1374270	hsa-miR-296-5p	CLIP-seq
MIRT1374271	hsa-miR-3074-5p	CLIP-seq
MIRT1374408	hsa-miR-3121-3p	CLIP-seq
MIRT1374278	hsa-miR-3180-5p	CLIP-seq
MIRT1374409	hsa-miR-3186-5p	CLIP-seq
MIRT1374410	hsa-miR-3187-3p	CLIP-seq
MIRT1374280	hsa-miR-32	CLIP-seq
MIRT1374411	hsa-miR-324-3p	CLIP-seq
MIRT1374412	hsa-miR-340	CLIP-seq
MIRT1374282	hsa-miR-34b	CLIP-seq
MIRT1374413	hsa-miR-3609	CLIP-seq
MIRT1374286	hsa-miR-3617	CLIP-seq
MIRT1374289	hsa-miR-363	CLIP-seq
MIRT1374290	hsa-miR-3646	CLIP-seq
MIRT1374293	hsa-miR-3654	CLIP-seq
MIRT1374296	hsa-miR-3662	CLIP-seq
MIRT1374414	hsa-miR-3664-5p	CLIP-seq
MIRT1374297	hsa-miR-367	CLIP-seq
MIRT1374301	hsa-miR-370	CLIP-seq
MIRT1374303	hsa-miR-380	CLIP-seq
MIRT1374307	hsa-miR-3942-5p	CLIP-seq
MIRT1374311	hsa-miR-424	CLIP-seq
MIRT1374415	hsa-miR-4267	CLIP-seq
MIRT1374313	hsa-miR-4276	CLIP-seq
MIRT1374315	hsa-miR-4299	CLIP-seq
MIRT1374416	hsa-miR-431	CLIP-seq
MIRT1374417	hsa-miR-4423-5p	CLIP-seq
MIRT1374418	hsa-miR-4456	CLIP-seq
MIRT1374320	hsa-miR-4464	CLIP-seq
MIRT1374419	hsa-miR-4475	CLIP-seq
MIRT1374323	hsa-miR-448	CLIP-seq
MIRT1374420	hsa-miR-4484	CLIP-seq
MIRT1374324	hsa-miR-4495	CLIP-seq
MIRT1374421	hsa-miR-4519	CLIP-seq
MIRT1374326	hsa-miR-452	CLIP-seq
MIRT1374327	hsa-miR-4520a-3p	CLIP-seq
MIRT1374422	hsa-miR-4522	CLIP-seq
MIRT1374329	hsa-miR-4524	CLIP-seq
MIRT1374423	hsa-miR-4529-5p	CLIP-seq
MIRT1374331	hsa-miR-4533	CLIP-seq
MIRT1374332	hsa-miR-4638-3p	CLIP-seq
MIRT1374339	hsa-miR-4676-3p	CLIP-seq
MIRT1374344	hsa-miR-4698	CLIP-seq
MIRT1374345	hsa-miR-4703-5p	CLIP-seq
MIRT1374346	hsa-miR-4705	CLIP-seq
MIRT1374424	hsa-miR-4713-3p	CLIP-seq
MIRT1374348	hsa-miR-4718	CLIP-seq
MIRT1374425	hsa-miR-4719	CLIP-seq
MIRT1374426	hsa-miR-4727-5p	CLIP-seq
MIRT1374352	hsa-miR-4747-5p	CLIP-seq
MIRT1374353	hsa-miR-4748	CLIP-seq
MIRT1374427	hsa-miR-4796-3p	CLIP-seq
MIRT1374428	hsa-miR-486-5p	CLIP-seq
MIRT1374359	hsa-miR-495	CLIP-seq
MIRT1374360	hsa-miR-497	CLIP-seq
MIRT1374361	hsa-miR-503	CLIP-seq
MIRT1374363	hsa-miR-513a-5p	CLIP-seq
MIRT1374429	hsa-miR-513b	CLIP-seq
MIRT1374430	hsa-miR-519d	CLIP-seq
MIRT1374431	hsa-miR-539	CLIP-seq
MIRT1374432	hsa-miR-543	CLIP-seq
MIRT1374433	hsa-miR-544	CLIP-seq
MIRT1374434	hsa-miR-545	CLIP-seq
MIRT1374369	hsa-miR-548ac	CLIP-seq
MIRT1374370	hsa-miR-548ae	CLIP-seq
MIRT1374435	hsa-miR-548ah	CLIP-seq
MIRT1374371	hsa-miR-548aj	CLIP-seq
MIRT1374372	hsa-miR-548am	CLIP-seq
MIRT1374436	hsa-miR-548an	CLIP-seq
MIRT1374373	hsa-miR-548d-3p	CLIP-seq
MIRT1374437	hsa-miR-548m	CLIP-seq
MIRT1374374	hsa-miR-548o	CLIP-seq
MIRT1374438	hsa-miR-548p	CLIP-seq
MIRT1374439	hsa-miR-548q	CLIP-seq
MIRT1374375	hsa-miR-548x	CLIP-seq
MIRT1374376	hsa-miR-548z	CLIP-seq
MIRT1374440	hsa-miR-556-5p	CLIP-seq
MIRT1374441	hsa-miR-563	CLIP-seq
MIRT1374442	hsa-miR-580	CLIP-seq
MIRT1374443	hsa-miR-587	CLIP-seq
MIRT1374379	hsa-miR-596	CLIP-seq
MIRT1374381	hsa-miR-599	CLIP-seq
MIRT1374444	hsa-miR-610	CLIP-seq
MIRT1374383	hsa-miR-641	CLIP-seq
MIRT1374384	hsa-miR-646	CLIP-seq
MIRT1374445	hsa-miR-659	CLIP-seq
MIRT1374446	hsa-miR-9	CLIP-seq
MIRT1374388	hsa-miR-92a	CLIP-seq
MIRT1374389	hsa-miR-92b	CLIP-seq
MIRT1374447	hsa-miR-93	CLIP-seq
MIRT1374448	hsa-miR-1228	CLIP-seq
MIRT1374449	hsa-miR-1285	CLIP-seq
MIRT1374250	hsa-miR-1323	CLIP-seq
MIRT1374251	hsa-miR-133a	CLIP-seq
MIRT1374252	hsa-miR-133b	CLIP-seq
MIRT1374254	hsa-miR-137	CLIP-seq
MIRT1374255	hsa-miR-138	CLIP-seq
MIRT1374258	hsa-miR-153	CLIP-seq
MIRT1374259	hsa-miR-15a	CLIP-seq
MIRT1374260	hsa-miR-15b	CLIP-seq
MIRT1374261	hsa-miR-16	CLIP-seq
MIRT1374450	hsa-miR-1908	CLIP-seq
MIRT1374262	hsa-miR-194	CLIP-seq
MIRT1374263	hsa-miR-195	CLIP-seq
MIRT1374451	hsa-miR-2467-3p	CLIP-seq
MIRT1374269	hsa-miR-25	CLIP-seq
MIRT1374270	hsa-miR-296-5p	CLIP-seq
MIRT1374452	hsa-miR-3064-5p	CLIP-seq
MIRT1374453	hsa-miR-3065-5p	CLIP-seq
MIRT1374272	hsa-miR-3124-3p	CLIP-seq
MIRT1374276	hsa-miR-3158-3p	CLIP-seq
MIRT1374454	hsa-miR-3158-5p	CLIP-seq
MIRT1374455	hsa-miR-3187-5p	CLIP-seq
MIRT1374280	hsa-miR-32	CLIP-seq
MIRT1374456	hsa-miR-329	CLIP-seq
MIRT1374285	hsa-miR-3616-3p	CLIP-seq
MIRT1374457	hsa-miR-362-3p	CLIP-seq
MIRT1374289	hsa-miR-363	CLIP-seq
MIRT1374290	hsa-miR-3646	CLIP-seq
MIRT1374458	hsa-miR-3656	CLIP-seq
MIRT1374296	hsa-miR-3662	CLIP-seq
MIRT1374297	hsa-miR-367	CLIP-seq
MIRT1374299	hsa-miR-3685	CLIP-seq
MIRT1374300	hsa-miR-3688-5p	CLIP-seq
MIRT1374459	hsa-miR-378g	CLIP-seq
MIRT1374303	hsa-miR-380	CLIP-seq
MIRT1374304	hsa-miR-384	CLIP-seq
MIRT1374307	hsa-miR-3942-5p	CLIP-seq
MIRT1374311	hsa-miR-424	CLIP-seq
MIRT1374314	hsa-miR-4293	CLIP-seq
MIRT1374315	hsa-miR-4299	CLIP-seq
MIRT1374316	hsa-miR-4307	CLIP-seq
MIRT1374460	hsa-miR-4313	CLIP-seq
MIRT1374319	hsa-miR-4446-3p	CLIP-seq
MIRT1374461	hsa-miR-4447	CLIP-seq
MIRT1374462	hsa-miR-4472	CLIP-seq
MIRT1374323	hsa-miR-448	CLIP-seq
MIRT1374463	hsa-miR-4486	CLIP-seq
MIRT1374324	hsa-miR-4495	CLIP-seq
MIRT1374329	hsa-miR-4524	CLIP-seq
MIRT1374330	hsa-miR-4527	CLIP-seq
MIRT1374331	hsa-miR-4533	CLIP-seq
MIRT1374335	hsa-miR-4656	CLIP-seq
MIRT1374464	hsa-miR-4668-3p	CLIP-seq
MIRT1374343	hsa-miR-4694-5p	CLIP-seq
MIRT1374344	hsa-miR-4698	CLIP-seq
MIRT1374345	hsa-miR-4703-5p	CLIP-seq
MIRT1374347	hsa-miR-4710	CLIP-seq
MIRT1374349	hsa-miR-4721	CLIP-seq
MIRT1374352	hsa-miR-4747-5p	CLIP-seq
MIRT1374465	hsa-miR-4768-5p	CLIP-seq
MIRT1374356	hsa-miR-4792	CLIP-seq
MIRT1374359	hsa-miR-495	CLIP-seq
MIRT1374360	hsa-miR-497	CLIP-seq
MIRT1374361	hsa-miR-503	CLIP-seq
MIRT1374369	hsa-miR-548ac	CLIP-seq
MIRT1374370	hsa-miR-548ae	CLIP-seq
MIRT1374371	hsa-miR-548aj	CLIP-seq
MIRT1374372	hsa-miR-548am	CLIP-seq
MIRT1374373	hsa-miR-548d-3p	CLIP-seq
MIRT1374374	hsa-miR-548o	CLIP-seq
MIRT1374375	hsa-miR-548x	CLIP-seq
MIRT1374376	hsa-miR-548z	CLIP-seq
MIRT1374466	hsa-miR-604	CLIP-seq
MIRT1374467	hsa-miR-612	CLIP-seq
MIRT1374468	hsa-miR-644	CLIP-seq
MIRT1374384	hsa-miR-646	CLIP-seq
MIRT1374469	hsa-miR-647	CLIP-seq
MIRT1374470	hsa-miR-663	CLIP-seq
MIRT1374386	hsa-miR-760	CLIP-seq
MIRT1374471	hsa-miR-767-3p	CLIP-seq
MIRT1374388	hsa-miR-92a	CLIP-seq
MIRT1374389	hsa-miR-92b	CLIP-seq
MIRT1374271	hsa-miR-3074-5p	CLIP-seq
MIRT2111440	hsa-miR-1262	CLIP-seq
MIRT1374452	hsa-miR-3064-5p	CLIP-seq
MIRT1374271	hsa-miR-3074-5p	CLIP-seq
MIRT1374408	hsa-miR-3121-3p	CLIP-seq
MIRT2111441	hsa-miR-3140-3p	CLIP-seq
MIRT1374454	hsa-miR-3158-5p	CLIP-seq
MIRT1374278	hsa-miR-3180-5p	CLIP-seq
MIRT1374281	hsa-miR-323-3p	CLIP-seq
MIRT1374301	hsa-miR-370	CLIP-seq
MIRT1374329	hsa-miR-4524	CLIP-seq
MIRT2111442	hsa-miR-4701-3p	CLIP-seq
MIRT1374359	hsa-miR-495	CLIP-seq
MIRT1374466	hsa-miR-604	CLIP-seq
MIRT1374384	hsa-miR-646	CLIP-seq
MIRT1374469	hsa-miR-647	CLIP-seq
MIRT1374446	hsa-miR-9	CLIP-seq
MIRT1374384	hsa-miR-646	CLIP-seq
MIRT1374244	hsa-miR-1178	CLIP-seq
MIRT1374245	hsa-miR-1208	CLIP-seq
MIRT2334536	hsa-miR-1238	CLIP-seq
MIRT2334537	hsa-miR-125a-3p	CLIP-seq
MIRT2111440	hsa-miR-1262	CLIP-seq
MIRT2334538	hsa-miR-1264	CLIP-seq
MIRT1374247	hsa-miR-1287	CLIP-seq
MIRT2334539	hsa-miR-1293	CLIP-seq
MIRT2334540	hsa-miR-1302	CLIP-seq
MIRT1374250	hsa-miR-1323	CLIP-seq
MIRT1374253	hsa-miR-1343	CLIP-seq
MIRT1374254	hsa-miR-137	CLIP-seq
MIRT1374258	hsa-miR-153	CLIP-seq
MIRT1374259	hsa-miR-15a	CLIP-seq
MIRT1374260	hsa-miR-15b	CLIP-seq
MIRT1374261	hsa-miR-16	CLIP-seq
MIRT1374262	hsa-miR-194	CLIP-seq
MIRT1374263	hsa-miR-195	CLIP-seq
MIRT2334541	hsa-miR-19a	CLIP-seq
MIRT2334542	hsa-miR-19b	CLIP-seq
MIRT1374265	hsa-miR-2113	CLIP-seq
MIRT2334543	hsa-miR-214	CLIP-seq
MIRT1374268	hsa-miR-2392	CLIP-seq
MIRT1374269	hsa-miR-25	CLIP-seq
MIRT2334544	hsa-miR-2681	CLIP-seq
MIRT1374270	hsa-miR-296-5p	CLIP-seq
MIRT1374271	hsa-miR-3074-5p	CLIP-seq
MIRT2334545	hsa-miR-3115	CLIP-seq
MIRT2334546	hsa-miR-3122	CLIP-seq
MIRT1374272	hsa-miR-3124-3p	CLIP-seq
MIRT1374277	hsa-miR-3176	CLIP-seq
MIRT1374279	hsa-miR-3184	CLIP-seq
MIRT2334547	hsa-miR-3199	CLIP-seq
MIRT1374280	hsa-miR-32	CLIP-seq
MIRT1374281	hsa-miR-323-3p	CLIP-seq
MIRT2334548	hsa-miR-323b-3p	CLIP-seq
MIRT2334549	hsa-miR-342-3p	CLIP-seq
MIRT1374282	hsa-miR-34b	CLIP-seq
MIRT1374284	hsa-miR-3614-3p	CLIP-seq
MIRT1374286	hsa-miR-3617	CLIP-seq
MIRT2334550	hsa-miR-3619-5p	CLIP-seq
MIRT1374289	hsa-miR-363	CLIP-seq
MIRT1374290	hsa-miR-3646	CLIP-seq
MIRT1374291	hsa-miR-3649	CLIP-seq
MIRT1374292	hsa-miR-3652	CLIP-seq
MIRT1374296	hsa-miR-3662	CLIP-seq
MIRT1374297	hsa-miR-367	CLIP-seq
MIRT1374300	hsa-miR-3688-5p	CLIP-seq
MIRT1374301	hsa-miR-370	CLIP-seq
MIRT2334551	hsa-miR-377	CLIP-seq
MIRT1374303	hsa-miR-380	CLIP-seq
MIRT2334552	hsa-miR-3913-3p	CLIP-seq
MIRT2334553	hsa-miR-3913-5p	CLIP-seq
MIRT1374305	hsa-miR-3922-3p	CLIP-seq
MIRT2334554	hsa-miR-3934	CLIP-seq
MIRT1374307	hsa-miR-3942-5p	CLIP-seq
MIRT1374308	hsa-miR-3977	CLIP-seq
MIRT1374310	hsa-miR-423-5p	CLIP-seq
MIRT1374311	hsa-miR-424	CLIP-seq
MIRT1374312	hsa-miR-4252	CLIP-seq
MIRT1374313	hsa-miR-4276	CLIP-seq
MIRT2334555	hsa-miR-4291	CLIP-seq
MIRT2334556	hsa-miR-4298	CLIP-seq
MIRT2334557	hsa-miR-4300	CLIP-seq
MIRT1374318	hsa-miR-4430	CLIP-seq
MIRT2334558	hsa-miR-4450	CLIP-seq
MIRT1374323	hsa-miR-448	CLIP-seq
MIRT2334559	hsa-miR-4483	CLIP-seq
MIRT1374324	hsa-miR-4495	CLIP-seq
MIRT2334560	hsa-miR-4513	CLIP-seq
MIRT1374421	hsa-miR-4519	CLIP-seq
MIRT1374328	hsa-miR-4523	CLIP-seq
MIRT1374329	hsa-miR-4524	CLIP-seq
MIRT1374331	hsa-miR-4533	CLIP-seq
MIRT1374341	hsa-miR-4688	CLIP-seq
MIRT2334561	hsa-miR-4690-3p	CLIP-seq
MIRT1374342	hsa-miR-4691-3p	CLIP-seq
MIRT2334562	hsa-miR-4691-5p	CLIP-seq
MIRT1374344	hsa-miR-4698	CLIP-seq
MIRT2111442	hsa-miR-4701-3p	CLIP-seq
MIRT1374345	hsa-miR-4703-5p	CLIP-seq
MIRT1374346	hsa-miR-4705	CLIP-seq
MIRT1374348	hsa-miR-4718	CLIP-seq
MIRT2334563	hsa-miR-4725-5p	CLIP-seq
MIRT2334564	hsa-miR-4740-5p	CLIP-seq
MIRT1374352	hsa-miR-4747-5p	CLIP-seq
MIRT2334565	hsa-miR-4777-5p	CLIP-seq
MIRT2334566	hsa-miR-4786-5p	CLIP-seq
MIRT1374358	hsa-miR-489	CLIP-seq
MIRT1374359	hsa-miR-495	CLIP-seq
MIRT1374360	hsa-miR-497	CLIP-seq
MIRT1374361	hsa-miR-503	CLIP-seq
MIRT2334567	hsa-miR-504	CLIP-seq
MIRT1374366	hsa-miR-516a-3p	CLIP-seq
MIRT2334568	hsa-miR-518d-5p	CLIP-seq
MIRT2334569	hsa-miR-519b-5p	CLIP-seq
MIRT2334570	hsa-miR-519c-5p	CLIP-seq
MIRT2334571	hsa-miR-520c-5p	CLIP-seq
MIRT2334572	hsa-miR-526a	CLIP-seq
MIRT1374369	hsa-miR-548ac	CLIP-seq
MIRT1374370	hsa-miR-548ae	CLIP-seq
MIRT1374371	hsa-miR-548aj	CLIP-seq
MIRT1374372	hsa-miR-548am	CLIP-seq
MIRT1374373	hsa-miR-548d-3p	CLIP-seq
MIRT1374374	hsa-miR-548o	CLIP-seq
MIRT1374375	hsa-miR-548x	CLIP-seq
MIRT1374376	hsa-miR-548z	CLIP-seq
MIRT1374379	hsa-miR-596	CLIP-seq
MIRT1374383	hsa-miR-641	CLIP-seq
MIRT1374384	hsa-miR-646	CLIP-seq
MIRT1374385	hsa-miR-661	CLIP-seq
MIRT2334573	hsa-miR-761	CLIP-seq
MIRT2334574	hsa-miR-764	CLIP-seq
MIRT2334575	hsa-miR-769-5p	CLIP-seq
MIRT2334576	hsa-miR-920	CLIP-seq
MIRT2334577	hsa-miR-922	CLIP-seq
MIRT1374388	hsa-miR-92a	CLIP-seq
MIRT1374389	hsa-miR-92b	CLIP-seq
MIRT1374259	hsa-miR-15a	CLIP-seq
MIRT1374260	hsa-miR-15b	CLIP-seq
MIRT1374261	hsa-miR-16	CLIP-seq
MIRT1374263	hsa-miR-195	CLIP-seq
MIRT1374454	hsa-miR-3158-5p	CLIP-seq
MIRT1374301	hsa-miR-370	CLIP-seq
MIRT1374311	hsa-miR-424	CLIP-seq
MIRT1374329	hsa-miR-4524	CLIP-seq
MIRT1374360	hsa-miR-497	CLIP-seq
MIRT1374361	hsa-miR-503	CLIP-seq
MIRT1374384	hsa-miR-646	CLIP-seq
MIRT2442676	hsa-miR-1207-5p	CLIP-seq
MIRT2442677	hsa-miR-1909	CLIP-seq
MIRT1374451	hsa-miR-2467-3p	CLIP-seq
MIRT1374279	hsa-miR-3184	CLIP-seq
MIRT2442678	hsa-miR-3622b-5p	CLIP-seq
MIRT1374292	hsa-miR-3652	CLIP-seq
MIRT1374310	hsa-miR-423-5p	CLIP-seq
MIRT2442679	hsa-miR-4253	CLIP-seq
MIRT1374318	hsa-miR-4430	CLIP-seq
MIRT1374325	hsa-miR-4505	CLIP-seq
MIRT1374341	hsa-miR-4688	CLIP-seq
MIRT2442680	hsa-miR-4763-3p	CLIP-seq
MIRT2442681	hsa-miR-486-3p	CLIP-seq
MIRT2442676	hsa-miR-1207-5p	CLIP-seq
MIRT2628578	hsa-miR-1224-3p	CLIP-seq
MIRT2111440	hsa-miR-1262	CLIP-seq
MIRT2628579	hsa-miR-1265	CLIP-seq
MIRT2442677	hsa-miR-1909	CLIP-seq
MIRT1374451	hsa-miR-2467-3p	CLIP-seq
MIRT2628580	hsa-miR-3151	CLIP-seq
MIRT1374279	hsa-miR-3184	CLIP-seq
MIRT2628581	hsa-miR-3619-3p	CLIP-seq
MIRT2442678	hsa-miR-3622b-5p	CLIP-seq
MIRT1374292	hsa-miR-3652	CLIP-seq
MIRT2628582	hsa-miR-3714	CLIP-seq
MIRT2334552	hsa-miR-3913-3p	CLIP-seq
MIRT1374310	hsa-miR-423-5p	CLIP-seq
MIRT2442679	hsa-miR-4253	CLIP-seq
MIRT2628583	hsa-miR-4427	CLIP-seq
MIRT1374318	hsa-miR-4430	CLIP-seq
MIRT1374461	hsa-miR-4447	CLIP-seq
MIRT1374462	hsa-miR-4472	CLIP-seq
MIRT2628584	hsa-miR-4488	CLIP-seq
MIRT1374325	hsa-miR-4505	CLIP-seq
MIRT2628585	hsa-miR-4520b-3p	CLIP-seq
MIRT2628586	hsa-miR-4529-3p	CLIP-seq
MIRT2628587	hsa-miR-4535	CLIP-seq
MIRT2628588	hsa-miR-455-5p	CLIP-seq
MIRT2628589	hsa-miR-4680-3p	CLIP-seq
MIRT1374341	hsa-miR-4688	CLIP-seq
MIRT2628590	hsa-miR-4697-5p	CLIP-seq
MIRT2111442	hsa-miR-4701-3p	CLIP-seq
MIRT2628591	hsa-miR-4708-3p	CLIP-seq
MIRT2442680	hsa-miR-4763-3p	CLIP-seq
MIRT1374354	hsa-miR-4764-5p	CLIP-seq
MIRT2628592	hsa-miR-4776-5p	CLIP-seq
MIRT2442681	hsa-miR-486-3p	CLIP-seq
MIRT1374358	hsa-miR-489	CLIP-seq
MIRT2628593	hsa-miR-491-5p	CLIP-seq
MIRT2628594	hsa-miR-642b	CLIP-seq
MIRT2691535	hsa-miR-1202	CLIP-seq
MIRT2442676	hsa-miR-1207-5p	CLIP-seq
MIRT2691536	hsa-miR-1286	CLIP-seq
MIRT2442677	hsa-miR-1909	CLIP-seq
MIRT1374451	hsa-miR-2467-3p	CLIP-seq
MIRT1374279	hsa-miR-3184	CLIP-seq
MIRT2691537	hsa-miR-3194-5p	CLIP-seq
MIRT2442678	hsa-miR-3622b-5p	CLIP-seq
MIRT1374292	hsa-miR-3652	CLIP-seq
MIRT2691538	hsa-miR-3918	CLIP-seq
MIRT2691539	hsa-miR-3972	CLIP-seq
MIRT1374310	hsa-miR-423-5p	CLIP-seq
MIRT2442679	hsa-miR-4253	CLIP-seq
MIRT1374318	hsa-miR-4430	CLIP-seq
MIRT1374325	hsa-miR-4505	CLIP-seq
MIRT2691540	hsa-miR-4512	CLIP-seq
MIRT2691541	hsa-miR-4685-5p	CLIP-seq
MIRT1374341	hsa-miR-4688	CLIP-seq
MIRT2691542	hsa-miR-4722-5p	CLIP-seq
MIRT1374426	hsa-miR-4727-5p	CLIP-seq
MIRT2691543	hsa-miR-4757-5p	CLIP-seq
MIRT2442680	hsa-miR-4763-3p	CLIP-seq
MIRT2691544	hsa-miR-4769-3p	CLIP-seq
MIRT2442681	hsa-miR-486-3p	CLIP-seq

Show/Hide all(57)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000209	Process	Protein polyubiquitination	IDA	11278251, 19937093
GO:0004842	Function	Ubiquitin-protein transferase activity	IDA	10458166, 19937093
GO:0004842	Function	Ubiquitin-protein transferase activity	IEA
GO:0005160	Function	Transforming growth factor beta receptor binding	IPI	12151385
GO:0005515	Function	Protein binding	IPI	15231748, 19914168, 19937093, 20580715, 20621832, 20937913, 21382345, 21572392, 21708152, 22020285, 22921829, 23032291, 25249323, 32814053
GO:0005543	Function	Phospholipid binding	TAS	22020285
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	11278251, 12151385, 21572392
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	IGI	22020285
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA	12151385
GO:0005886	Component	Plasma membrane	IEA
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IDA	10458166, 11278251, 12151385, 19937093
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IEA
GO:0006611	Process	Protein export from nucleus	IDA	11278251
GO:0007398	Process	Ectoderm development	IEA
GO:0007398	Process	Ectoderm development	TAS	10458166
GO:0016020	Component	Membrane	IEA
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0030154	Process	Cell differentiation	IDA	10458166
GO:0030154	Process	Cell differentiation	IEA
GO:0030424	Component	Axon	IEA
GO:0030509	Process	BMP signaling pathway	IDA	21572392
GO:0030512	Process	Negative regulation of transforming growth factor beta receptor signaling pathway	IDA	11278251, 12151385
GO:0030512	Process	Negative regulation of transforming growth factor beta receptor signaling pathway	IEA
GO:0030512	Process	Negative regulation of transforming growth factor beta receptor signaling pathway	IMP	21791611
GO:0030514	Process	Negative regulation of BMP signaling pathway	IBA
GO:0030514	Process	Negative regulation of BMP signaling pathway	IDA	27214554
GO:0030514	Process	Negative regulation of BMP signaling pathway	TAS	10458166
GO:0032801	Process	Receptor catabolic process	IDA	12151385
GO:0032926	Process	Negative regulation of activin receptor signaling pathway	IDA	16720724
GO:0043025	Component	Neuronal cell body	IEA
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IBA
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IDA	11278251
GO:0045773	Process	Positive regulation of axon extension	IEA
GO:0046332	Function	SMAD binding	IBA
GO:0046332	Function	SMAD binding	IEA
GO:0060071	Process	Wnt signaling pathway, planar cell polarity pathway	IEA
GO:0060071	Process	Wnt signaling pathway, planar cell polarity pathway	TAS
GO:0061630	Function	Ubiquitin protein ligase activity	IBA
GO:0061630	Function	Ubiquitin protein ligase activity	IDA	11278251, 12151385
GO:0061630	Function	Ubiquitin protein ligase activity	IEA
GO:0061630	Function	Ubiquitin protein ligase activity	TAS
GO:0061736	Process	Engulfment of target by autophagosome	IMP	22020285
GO:0061753	Process	Substrate localization to autophagosome	IMP	22020285
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0070411	Function	I-SMAD binding	IPI	11278251, 12151385, 16720724
GO:0070412	Function	R-SMAD binding	IPI	11278251
GO:0070697	Function	Activin receptor binding	IPI	16720724
GO:0071211	Process	Protein targeting to vacuole involved in autophagy	IMP	22020285
GO:0072659	Process	Protein localization to plasma membrane	IDA	12151385
GO:0072659	Process	Protein localization to plasma membrane	TAS	22020285
GO:1903861	Process	Positive regulation of dendrite extension	IDA	23999003
GO:2000060	Process	Positive regulation of ubiquitin-dependent protein catabolic process	IMP	21454619

MIM	HGNC	e!Ensembl
605568	16807	ENSG00000198742

Protein

UniProt ID

Q9HCE7

Protein name

E3 ubiquitin-protein ligase SMURF1 (hSMURF1) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF1) (SMAD ubiquitination regulatory factor 1) (SMAD-specific E3 ubiquitin-protein ligase 1)

Protein function

E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent p

PDB

2LAZ , 2LB0 , 2LB1 , 2LTX , 3PYC

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00168	C2	13 → 115	C2 domain	Domain
PF00397	WW	236 → 265	WW domain	Domain
PF00397	WW	308 → 337	WW domain	Domain
PF00632	HECT	449 → 757	HECT-domain (ubiquitin-transferase)	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in melanocytes (PubMed:23999003). {ECO:0000269|PubMed:23999003}.

Sequence

MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDP
KWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCK
LNPSDTDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENEGTVYEDSGPGRPLSCFMEEPA
PYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEGY
EQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIPGGDAAFLYEFLLQGHTSEPRDLNSV
NCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPS
EGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMR
PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSS
INPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLV
WILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGI
EAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVR
WFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLP
KAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE

Sequence length

757

Interactions

View interactions

Show/Hide Unknown Diseases (3)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Crohn Disease	Crohn's disease	N/A	N/A	GWAS
Inflammatory Bowel Disease	Inflammatory bowel disease	N/A	N/A	GWAS
Ulcerative colitis	Ulcerative colitis	N/A	N/A	GWAS

Show/Hide Text Mining Associations (32)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Acidosis Renal Tubular	Associate	39349238
Adenocarcinoma	Associate	33506581
Bone Diseases	Associate	24828823
Bone Diseases Metabolic	Associate	24828823
Brain Neoplasms	Associate	34614303
Breast Neoplasms	Associate	18927080, 23184937, 24241683, 32462972
Carcinogenesis	Associate	25249323, 32462972, 34614303
Carcinoma Hepatocellular	Associate	24089522, 25311538
Cell Transformation Neoplastic	Inhibit	25471937
Cell Transformation Neoplastic	Associate	28321604
Coronavirus Infections	Associate	33968364
Fibrosis	Associate	37091902, 37169841
Glioblastoma	Associate	34614303
Glioma	Associate	28321604
Hemangioma Cavernous Central Nervous System	Associate	19318350
Idiopathic Pulmonary Fibrosis	Associate	35203313
Left sided gallbladder	Associate	29089047
Lumbar Stenosis Familial	Stimulate	37091902
Neoplasm Metastasis	Associate	25631036, 30244247
Neoplasms	Associate	18927080, 20621832, 25249323, 25471937, 25631036, 28321604, 33506581
Oncogene Addiction	Associate	17233815
Osteoarthritis	Associate	33090007
Ovarian Neoplasms	Associate	31004081
Pancreatic Neoplasms	Associate	16036106, 17233815, 18380791, 24041470
Precancerous Conditions	Associate	24089522
Prostatic Neoplasms	Associate	25631036
Renal Insufficiency	Associate	24997640
Sarcoidosis	Associate	35203313
Squamous Cell Carcinoma of Head and Neck	Associate	25471937
Thyroid Neoplasms	Associate	30244247
Tuberculosis Meningeal	Associate	33711518
Urinary Bladder Neoplasms	Associate	35731212

SMURF1 (SMAD specific E3 ubiquitin protein ligase 1)