Gene Gene information from NCBI Gene database.
Entrez ID 6517
Gene name Solute carrier family 2 member 4
Gene symbol SLC2A4
Synonyms (NCBI Gene)
GLUT4
Chromosome 17
Chromosome location 17p13.1
Summary This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. In the absence of insulin, this integral membrane protein is seque
miRNA miRNA information provided by mirtarbase database.
337
miRTarBase ID miRNA Experiments Reference
MIRT006559 hsa-miR-223-3p FlowImmunoblotImmunofluorescenceImmunohistochemistryImmunoprecipitaionIn situ hybridizationLuciferase reporter assayNorthern blotqRT-PCR 20080987
MIRT019111 hsa-miR-335-5p Microarray 18185580
MIRT038921 hsa-miR-92a-1-5p CLASH 23622248
MIRT053085 hsa-miR-93-5p Luciferase reporter assayqRT-PCRWestern blot 23493574
MIRT611339 hsa-miR-548ac HITS-CLIP 23824327
Transcription factors Transcription factors information provided by TRRUST V2 database.
7
Transcription factor Regulation Reference
HDAC4 Unknown 23899560
HDAC5 Repression 22991226
HDAC5 Unknown 23899560
MEF2A Activation 14630949;18198354
MEF2A Unknown 15294043
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
83
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 19478182, 25910212, 33961781
GO:0005737 Component Cytoplasm IEA
GO:0005768 Component Endosome IEA
GO:0005771 Component Multivesicular body IEA
GO:0005802 Component Trans-Golgi network IDA 12467732
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
138190 11009 ENSG00000181856
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P14672
Protein name Solute carrier family 2, facilitated glucose transporter member 4 (Glucose transporter type 4, insulin-responsive) (GLUT-4)
Protein function Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation. Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracel
PDB 7WSM , 7WSN
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00083 Sugar_tr 27 483 Sugar (and other) transporter Family
Tissue specificity TISSUE SPECIFICITY: Skeletal and cardiac muscles; brown and white fat.
Sequence
Sequence length 509
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
9
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Cervical cancer Likely benign rs8192702 RCV005929452
Familial cancer of breast Likely benign rs8192702 RCV005929450
Gastric cancer Likely benign rs8192702 RCV005929454
Lung cancer Likely benign rs8192702 RCV005929457
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Breast Neoplasms Associate 10950817, 34488531, 34525987
Carcinogenesis Associate 33570246
Carcinoma Non Small Cell Lung Associate 31180527, 37549925
Cardiomegaly Stimulate 22028857
Cardiomyopathy Hypertrophic Associate 32455814
Colorectal Neoplasms Associate 29504525
Coronary Disease Associate 35468725
Dental Caries Associate 31261961
Diabetes Gestational Stimulate 27981520
Diabetes Gestational Associate 30805369, 35532201, 35712865