Gene Gene information from NCBI Gene database.
Entrez ID 6581
Gene name Solute carrier family 22 member 3
Gene symbol SLC22A3
Synonyms (NCBI Gene)
EMTEMTHOCT3
Chromosome 6
Chromosome location 6q25.3
Summary Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar c
miRNA miRNA information provided by mirtarbase database.
202
miRTarBase ID miRNA Experiments Reference
MIRT019444 hsa-miR-148b-3p Microarray 17612493
MIRT021441 hsa-miR-9-5p Microarray 17612493
MIRT022967 hsa-miR-124-3p Microarray 18668037
MIRT639284 hsa-miR-1272 HITS-CLIP 19536157
MIRT639283 hsa-miR-1322 HITS-CLIP 19536157
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
KLF8 Unknown 17671186
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
81
GO ID Ontology Definition Evidence Reference
GO:0001692 Process Histamine metabolic process TAS 23505051
GO:0005326 Function Neurotransmitter transmembrane transporter activity IDA 10196521, 16581093, 20858707
GO:0005326 Function Neurotransmitter transmembrane transporter activity IEA
GO:0005326 Function Neurotransmitter transmembrane transporter activity IMP 23505051
GO:0005515 Function Protein binding IPI 17474147
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
604842 10967 ENSG00000146477
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O75751
Protein name Solute carrier family 22 member 3 (Extraneuronal monoamine transporter) (EMT) (Organic cation transporter 3) (OCT3)
Protein function Electrogenic voltage-dependent transporter that mediates the transport of a variety of organic cations such as endogenous bioactive amines, cationic drugs and xenobiotics (PubMed:10196521, PubMed:10966924, PubMed:12538837, PubMed:17460754, PubMe
PDB 7ZH0 , 7ZH6 , 7ZHA
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07690 MFS_1 142 485 Major Facilitator Superfamily Family
Tissue specificity TISSUE SPECIFICITY: Expressed in liver (PubMed:10196521, PubMed:9933568). Expressed in intestine (PubMed:16263091, PubMed:20858707). Expressed in kidney in proximal tubular cells (PubMed:10966924). Expressed in placenta (PubMed:10966924, PubMed:9933568).
Sequence
Sequence length 556
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
1
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Pancreatic adenocarcinoma Benign rs2292334 RCV005922927
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 17805461
Arsenic Poisoning Associate 36436256
Cap Myopathy Associate 21820706
Carcinoma Hepatocellular Associate 22439694
Cardiovascular Diseases Associate 20665672, 27893421, 37948393
Colorectal Neoplasms Associate 23555006, 30561001, 33976257
Coronary Artery Disease Associate 27893421, 31870308, 32685059
Coronary Artery Disease Autosomal Dominant 1 Associate 22216278
Coronary Disease Associate 25561729
Death Associate 31874997