Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs Transcription factors Other IDs Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	6581
Gene name Gene Name - the full gene name approved by the HGNC.	Solute carrier family 22 member 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	SLC22A3
Synonyms (NCBI Gene) Gene synonyms aliases	EMT, EMTH, OCT3
Chromosome Chromosome number	6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	6q25.3
Summary Summary of gene provided in NCBI Entrez Gene.	Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar c

Show/Hide all(202)

miRTarBase ID	miRNA	Experiments	Reference
MIRT019444	hsa-miR-148b-3p	Microarray	17612493
MIRT021441	hsa-miR-9-5p	Microarray	17612493
MIRT022967	hsa-miR-124-3p	Microarray	18668037
MIRT639284	hsa-miR-1272	HITS-CLIP	19536157
MIRT639283	hsa-miR-1322	HITS-CLIP	19536157
MIRT639282	hsa-miR-4639-3p	HITS-CLIP	19536157
MIRT639281	hsa-miR-519d-5p	HITS-CLIP	19536157
MIRT639280	hsa-miR-5695	HITS-CLIP	19536157
MIRT639279	hsa-miR-515-5p	HITS-CLIP	19536157
MIRT639278	hsa-miR-519e-5p	HITS-CLIP	19536157
MIRT639284	hsa-miR-1272	HITS-CLIP	19536157
MIRT639283	hsa-miR-1322	HITS-CLIP	19536157
MIRT639282	hsa-miR-4639-3p	HITS-CLIP	19536157
MIRT639281	hsa-miR-519d-5p	HITS-CLIP	19536157
MIRT639280	hsa-miR-5695	HITS-CLIP	19536157
MIRT639279	hsa-miR-515-5p	HITS-CLIP	19536157
MIRT639278	hsa-miR-519e-5p	HITS-CLIP	19536157
MIRT639284	hsa-miR-1272	HITS-CLIP	19536157
MIRT639283	hsa-miR-1322	HITS-CLIP	19536157
MIRT639282	hsa-miR-4639-3p	HITS-CLIP	19536157
MIRT639281	hsa-miR-519d-5p	HITS-CLIP	19536157
MIRT639280	hsa-miR-5695	HITS-CLIP	19536157
MIRT639279	hsa-miR-515-5p	HITS-CLIP	19536157
MIRT639278	hsa-miR-519e-5p	HITS-CLIP	19536157
MIRT713248	hsa-miR-4494	HITS-CLIP	19536157
MIRT713247	hsa-miR-499b-5p	HITS-CLIP	19536157
MIRT713246	hsa-miR-4330	HITS-CLIP	19536157
MIRT713245	hsa-miR-130b-5p	HITS-CLIP	19536157
MIRT713244	hsa-miR-4753-3p	HITS-CLIP	19536157
MIRT639284	hsa-miR-1272	HITS-CLIP	19536157
MIRT639283	hsa-miR-1322	HITS-CLIP	19536157
MIRT639282	hsa-miR-4639-3p	HITS-CLIP	19536157
MIRT639281	hsa-miR-519d-5p	HITS-CLIP	19536157
MIRT639280	hsa-miR-5695	HITS-CLIP	19536157
MIRT639279	hsa-miR-515-5p	HITS-CLIP	19536157
MIRT639278	hsa-miR-519e-5p	HITS-CLIP	19536157
MIRT666311	hsa-miR-545-3p	HITS-CLIP	23824327
MIRT666310	hsa-miR-23a-5p	HITS-CLIP	23824327
MIRT666309	hsa-miR-23b-5p	HITS-CLIP	23824327
MIRT666307	hsa-miR-4291	HITS-CLIP	23824327
MIRT666308	hsa-miR-452-3p	HITS-CLIP	23824327
MIRT666306	hsa-miR-3940-5p	HITS-CLIP	23824327
MIRT666305	hsa-miR-4507	HITS-CLIP	23824327
MIRT666304	hsa-miR-6839-3p	HITS-CLIP	23824327
MIRT639284	hsa-miR-1272	HITS-CLIP	23824327
MIRT639283	hsa-miR-1322	HITS-CLIP	23824327
MIRT639282	hsa-miR-4639-3p	HITS-CLIP	23824327
MIRT639281	hsa-miR-519d-5p	HITS-CLIP	23824327
MIRT639280	hsa-miR-5695	HITS-CLIP	23824327
MIRT639279	hsa-miR-515-5p	HITS-CLIP	23824327
MIRT639278	hsa-miR-519e-5p	HITS-CLIP	23824327
MIRT639284	hsa-miR-1272	HITS-CLIP	23824327
MIRT639283	hsa-miR-1322	HITS-CLIP	23824327
MIRT639282	hsa-miR-4639-3p	HITS-CLIP	23824327
MIRT639281	hsa-miR-519d-5p	HITS-CLIP	23824327
MIRT639280	hsa-miR-5695	HITS-CLIP	23824327
MIRT639279	hsa-miR-515-5p	HITS-CLIP	23824327
MIRT639278	hsa-miR-519e-5p	HITS-CLIP	23824327
MIRT639284	hsa-miR-1272	HITS-CLIP	19536157
MIRT639283	hsa-miR-1322	HITS-CLIP	19536157
MIRT639282	hsa-miR-4639-3p	HITS-CLIP	19536157
MIRT639281	hsa-miR-519d-5p	HITS-CLIP	19536157
MIRT639280	hsa-miR-5695	HITS-CLIP	19536157
MIRT639279	hsa-miR-515-5p	HITS-CLIP	19536157
MIRT639278	hsa-miR-519e-5p	HITS-CLIP	19536157
MIRT639284	hsa-miR-1272	HITS-CLIP	19536157
MIRT639283	hsa-miR-1322	HITS-CLIP	19536157
MIRT639282	hsa-miR-4639-3p	HITS-CLIP	19536157
MIRT639281	hsa-miR-519d-5p	HITS-CLIP	19536157
MIRT639280	hsa-miR-5695	HITS-CLIP	19536157
MIRT639279	hsa-miR-515-5p	HITS-CLIP	19536157
MIRT639278	hsa-miR-519e-5p	HITS-CLIP	19536157
MIRT639284	hsa-miR-1272	HITS-CLIP	19536157
MIRT639283	hsa-miR-1322	HITS-CLIP	19536157
MIRT639282	hsa-miR-4639-3p	HITS-CLIP	19536157
MIRT639281	hsa-miR-519d-5p	HITS-CLIP	19536157
MIRT639280	hsa-miR-5695	HITS-CLIP	19536157
MIRT639279	hsa-miR-515-5p	HITS-CLIP	19536157
MIRT639278	hsa-miR-519e-5p	HITS-CLIP	19536157
MIRT713248	hsa-miR-4494	HITS-CLIP	19536157
MIRT713247	hsa-miR-499b-5p	HITS-CLIP	19536157
MIRT713246	hsa-miR-4330	HITS-CLIP	19536157
MIRT713245	hsa-miR-130b-5p	HITS-CLIP	19536157
MIRT713244	hsa-miR-4753-3p	HITS-CLIP	19536157
MIRT639284	hsa-miR-1272	HITS-CLIP	19536157
MIRT639283	hsa-miR-1322	HITS-CLIP	19536157
MIRT639282	hsa-miR-4639-3p	HITS-CLIP	19536157
MIRT639281	hsa-miR-519d-5p	HITS-CLIP	19536157
MIRT639280	hsa-miR-5695	HITS-CLIP	19536157
MIRT639279	hsa-miR-515-5p	HITS-CLIP	19536157
MIRT639278	hsa-miR-519e-5p	HITS-CLIP	19536157
MIRT666311	hsa-miR-545-3p	HITS-CLIP	23824327
MIRT666310	hsa-miR-23a-5p	HITS-CLIP	23824327
MIRT666309	hsa-miR-23b-5p	HITS-CLIP	23824327
MIRT666307	hsa-miR-4291	HITS-CLIP	23824327
MIRT666308	hsa-miR-452-3p	HITS-CLIP	23824327
MIRT666306	hsa-miR-3940-5p	HITS-CLIP	23824327
MIRT666305	hsa-miR-4507	HITS-CLIP	23824327
MIRT666304	hsa-miR-6839-3p	HITS-CLIP	23824327
MIRT639284	hsa-miR-1272	HITS-CLIP	23824327
MIRT639283	hsa-miR-1322	HITS-CLIP	23824327
MIRT639282	hsa-miR-4639-3p	HITS-CLIP	23824327
MIRT639281	hsa-miR-519d-5p	HITS-CLIP	23824327
MIRT639280	hsa-miR-5695	HITS-CLIP	23824327
MIRT639279	hsa-miR-515-5p	HITS-CLIP	23824327
MIRT639278	hsa-miR-519e-5p	HITS-CLIP	23824327
MIRT639284	hsa-miR-1272	HITS-CLIP	23824327
MIRT639283	hsa-miR-1322	HITS-CLIP	23824327
MIRT639282	hsa-miR-4639-3p	HITS-CLIP	23824327
MIRT639281	hsa-miR-519d-5p	HITS-CLIP	23824327
MIRT639280	hsa-miR-5695	HITS-CLIP	23824327
MIRT639279	hsa-miR-515-5p	HITS-CLIP	23824327
MIRT639278	hsa-miR-519e-5p	HITS-CLIP	23824327
MIRT1354481	hsa-miR-1227	CLIP-seq
MIRT1354482	hsa-miR-124	CLIP-seq
MIRT1354483	hsa-miR-1257	CLIP-seq
MIRT1354484	hsa-miR-1287	CLIP-seq
MIRT1354485	hsa-miR-134	CLIP-seq
MIRT1354486	hsa-miR-1825	CLIP-seq
MIRT1354487	hsa-miR-199a-5p	CLIP-seq
MIRT1354488	hsa-miR-199b-5p	CLIP-seq
MIRT1354489	hsa-miR-2276	CLIP-seq
MIRT1354490	hsa-miR-3118	CLIP-seq
MIRT1354491	hsa-miR-3135	CLIP-seq
MIRT1354492	hsa-miR-3135b	CLIP-seq
MIRT1354493	hsa-miR-3163	CLIP-seq
MIRT1354494	hsa-miR-3194-3p	CLIP-seq
MIRT1354495	hsa-miR-335	CLIP-seq
MIRT1354496	hsa-miR-33a	CLIP-seq
MIRT1354497	hsa-miR-33b	CLIP-seq
MIRT1354498	hsa-miR-3908	CLIP-seq
MIRT1354499	hsa-miR-3942-5p	CLIP-seq
MIRT1354500	hsa-miR-3974	CLIP-seq
MIRT1354501	hsa-miR-410	CLIP-seq
MIRT1354502	hsa-miR-4252	CLIP-seq
MIRT1354503	hsa-miR-4275	CLIP-seq
MIRT1354504	hsa-miR-4436a	CLIP-seq
MIRT1354505	hsa-miR-4459	CLIP-seq
MIRT1354506	hsa-miR-4474-5p	CLIP-seq
MIRT1354507	hsa-miR-4700-3p	CLIP-seq
MIRT1354508	hsa-miR-4703-5p	CLIP-seq
MIRT1354509	hsa-miR-4708-3p	CLIP-seq
MIRT1354510	hsa-miR-4738-3p	CLIP-seq
MIRT1354511	hsa-miR-4766-3p	CLIP-seq
MIRT1354512	hsa-miR-4766-5p	CLIP-seq
MIRT1354513	hsa-miR-4772-3p	CLIP-seq
MIRT1354514	hsa-miR-4786-5p	CLIP-seq
MIRT1354515	hsa-miR-499a-5p	CLIP-seq
MIRT1354516	hsa-miR-506	CLIP-seq
MIRT1354517	hsa-miR-517b	CLIP-seq
MIRT1354518	hsa-miR-548a-3p	CLIP-seq
MIRT1354519	hsa-miR-548c-3p	CLIP-seq
MIRT1354520	hsa-miR-548e	CLIP-seq
MIRT1354521	hsa-miR-548f	CLIP-seq
MIRT1354522	hsa-miR-548l	CLIP-seq
MIRT1354523	hsa-miR-548n	CLIP-seq
MIRT1354524	hsa-miR-582-3p	CLIP-seq
MIRT1354525	hsa-miR-875-3p	CLIP-seq
MIRT1354526	hsa-miR-943	CLIP-seq
MIRT1354492	hsa-miR-3135b	CLIP-seq
MIRT1553714	hsa-miR-3612	CLIP-seq
MIRT1553715	hsa-miR-3652	CLIP-seq
MIRT1553716	hsa-miR-3660	CLIP-seq
MIRT1553717	hsa-miR-4430	CLIP-seq
MIRT1553718	hsa-miR-4443	CLIP-seq
MIRT1553719	hsa-miR-4505	CLIP-seq
MIRT1553720	hsa-miR-4526	CLIP-seq
MIRT1553721	hsa-miR-4645-3p	CLIP-seq
MIRT1553722	hsa-miR-647	CLIP-seq
MIRT1553723	hsa-miR-650	CLIP-seq
MIRT2104876	hsa-miR-19a	CLIP-seq
MIRT2104877	hsa-miR-19b	CLIP-seq
MIRT1354489	hsa-miR-2276	CLIP-seq
MIRT2104878	hsa-miR-3140-3p	CLIP-seq
MIRT1354494	hsa-miR-3194-3p	CLIP-seq
MIRT2104879	hsa-miR-3650	CLIP-seq
MIRT2104880	hsa-miR-4307	CLIP-seq
MIRT2104881	hsa-miR-4315	CLIP-seq
MIRT2104882	hsa-miR-4716-5p	CLIP-seq
MIRT2104883	hsa-miR-4790-5p	CLIP-seq
MIRT2329572	hsa-miR-142-5p	CLIP-seq
MIRT2329573	hsa-miR-181a	CLIP-seq
MIRT2329574	hsa-miR-181b	CLIP-seq
MIRT2329575	hsa-miR-181c	CLIP-seq
MIRT2329576	hsa-miR-181d	CLIP-seq
MIRT2104876	hsa-miR-19a	CLIP-seq
MIRT2104877	hsa-miR-19b	CLIP-seq
MIRT2329577	hsa-miR-3158-5p	CLIP-seq
MIRT2329578	hsa-miR-340	CLIP-seq
MIRT2329579	hsa-miR-3686	CLIP-seq
MIRT2329580	hsa-miR-4262	CLIP-seq
MIRT2329581	hsa-miR-4652-3p	CLIP-seq
MIRT2329582	hsa-miR-4777-3p	CLIP-seq
MIRT2329583	hsa-miR-513b	CLIP-seq
MIRT2329584	hsa-miR-520d-5p	CLIP-seq
MIRT2329585	hsa-miR-524-5p	CLIP-seq
MIRT2394649	hsa-miR-1238	CLIP-seq
MIRT2394650	hsa-miR-3942-3p	CLIP-seq
MIRT2690966	hsa-miR-3919	CLIP-seq
MIRT2690967	hsa-miR-3925-5p	CLIP-seq
MIRT2690968	hsa-miR-4468	CLIP-seq
MIRT2690969	hsa-miR-4792	CLIP-seq

Transcription factors

Show/Hide all(1)

Transcription factor	Regulation	Reference
KLF8	Unknown	17671186

Show/Hide all(35)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001692	Process	Histamine metabolic process	TAS	23505051
GO:0005326	Function	Neurotransmitter transmembrane transporter activity	IDA	20858707
GO:0005326	Function	Neurotransmitter transmembrane transporter activity	IMP	23505051
GO:0005330	Function	Dopamine:sodium symporter activity	IEA
GO:0005515	Function	Protein binding	IPI	17474147
GO:0005886	Component	Plasma membrane	IDA	20858707, 23137377
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	TAS	9933568
GO:0006836	Process	Neurotransmitter transport	IDA	20858707
GO:0006855	Process	Drug transmembrane transport	TAS
GO:0008504	Function	Monoamine transmembrane transporter activity	IDA	20858707
GO:0008504	Function	Monoamine transmembrane transporter activity	IMP	23505051
GO:0008514	Function	Organic anion transmembrane transporter activity	ISS
GO:0015101	Function	Organic cation transmembrane transporter activity	IDA	10966924, 16024787, 22806583, 24291757
GO:0015101	Function	Organic cation transmembrane transporter activity	TAS
GO:0015651	Function	Quaternary ammonium group transmembrane transporter activity	IDA	10966924, 20858707
GO:0015695	Process	Organic cation transport	IDA	10966924, 16024787, 22806583, 24291757
GO:0015697	Process	Quaternary ammonium group transport	IDA	10966924, 20858707
GO:0015711	Process	Organic anion transport	ISS
GO:0015718	Process	Monocarboxylic acid transport	IEA
GO:0015844	Process	Monoamine transport	IMP	23505051
GO:0016020	Component	Membrane	TAS	9933568
GO:0019534	Function	Toxin transmembrane transporter activity	IDA	22806583, 24291757
GO:0032098	Process	Regulation of appetite	IEA
GO:0042908	Process	Xenobiotic transport	IDA	20858707, 22806583, 24291757
GO:0043025	Component	Neuronal cell body	IEA
GO:0051610	Process	Serotonin uptake	IDA	20858707
GO:0051615	Process	Histamine uptake	IDA	20858707
GO:0051615	Process	Histamine uptake	IMP	23505051
GO:0051620	Process	Norepinephrine uptake	IDA	20858707
GO:0051625	Process	Epinephrine uptake	IDA	20858707
GO:0090494	Process	Dopamine uptake	IDA	20858707
GO:0098793	Component	Presynapse	IEA
GO:0150104	Process	Transport across blood-brain barrier	NAS	26590417, 30280653
GO:1901998	Process	Toxin transport	IDA	22806583, 24291757

MIM	HGNC	e!Ensembl
604842	10967	ENSG00000146477

Protein

UniProt ID

O75751

Protein name

Solute carrier family 22 member 3 (Extraneuronal monoamine transporter) (EMT) (Organic cation transporter 3) (OCT3)

Protein function

Electrogenic voltage-dependent transporter that mediates the transport of a variety of organic cations such as endogenous bioactive amines, cationic drugs and xenobiotics (PubMed:10196521, PubMed:10966924, PubMed:12538837, PubMed:17460754, PubMe

PDB

7ZH0 , 7ZH6 , 7ZHA

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07690	MFS_1	142 → 485	Major Facilitator Superfamily	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in liver (PubMed:10196521, PubMed:9933568). Expressed in intestine (PubMed:16263091, PubMed:20858707). Expressed in kidney in proximal tubular cells (PubMed:10966924). Expressed in placenta (PubMed:10966924, PubMed:9933568).

Sequence

MPSFDEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYWCRGPSAAALA
ERCGWSPEEEWNRTAPASRGPEPPERRGRCQRYLLEAANDSASATSALSCADPLAAFPNR
SAPLVPCRGGWRYAQAHSTIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLGYAADRYG
RIVIYLLSCLGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQRR
IVGIVIQMFFTLGIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVVPESPRWLITRKK
GDKALQILRRIAKCNGKYLSSNYSEITVTDEEVSNPSFLDLVRTPQMRKCTLILMFAWFT
SAVVYQGLVMRLGIIGGNLYIDFFISGVVELPGALLILLTIERLGRRLPFAASNIVAGVA
CLVTAFLPEGIAWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFG
GIIAPFLLFRLAAVWLELPLIIFGILASICGGLVMLLPETKGIALPETVDDVEKLGSPHS
CKCGRNKKTPVSRSHL

Sequence length

556

Interactions

View interactions

Show/Hide Unknown Diseases (10)

Disease term	Disease name	Evidence	Source
Unknown
Diabetes	Diabetes		GWAS
Prostate cancer	Prostate cancer	Together, these results show that PRRX2 is an oncogene and might play a role in the aggressiveness of PC within the DNPC population.	GWAS, CBGDA
Coronary artery disease	Coronary artery disease		GWAS
Colorectal Cancer	Colorectal Cancer	In summary, our data strongly demonstrated that upregulation of GRB7 conferred MEKi resistance in CRC cells with KRAS mutations by mediating RTK signaling through the recruitment of PLK1.	GWAS, CBGDA
Lung adenocarcinoma	Lung adenocarcinoma	Validation that loss of Tgfbr2 results in more aggressive and T cell-excluded KP lung tumors	GWAS, CBGDA
Metabolic Syndrome	Metabolic Syndrome		GWAS
Myocardial Infarction	Myocardial Infarction		GWAS
Coronary Heart Disease	Coronary Heart Disease		GWAS
Barrett esophagus	Barrett esophagus		GWAS
Duodenal Ulcer	Duodenal Ulcer		GWAS

Show/Hide Text Mining Associations (30)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenocarcinoma of Lung	Associate	17805461
Arsenic Poisoning	Associate	36436256
Cap Myopathy	Associate	21820706
Carcinoma Hepatocellular	Associate	22439694
Cardiovascular Diseases	Associate	20665672, 27893421, 37948393
Colorectal Neoplasms	Associate	23555006, 30561001, 33976257
Coronary Artery Disease	Associate	27893421, 31870308, 32685059
Coronary Artery Disease Autosomal Dominant 1	Associate	22216278
Coronary Disease	Associate	25561729
Death	Associate	31874997
Diabetes Mellitus	Associate	21900290, 28947922
Esophageal Neoplasms	Associate	28743982, 30416380
Esophageal Squamous Cell Carcinoma	Inhibit	30416380
Inflammation	Associate	25561729
Leukemia	Associate	36461046
Leukemia Myeloid Acute	Associate	36461046
Multiple Myeloma	Associate	21820706
Myelodysplastic Syndromes	Associate	36461046
Myocardial Infarction	Associate	21493818
Neoplasm Metastasis	Associate	28272475
Neoplasms	Associate	20025723, 22439694, 22730461, 28743982, 36461046
Obesity	Associate	28947922, 39766774
Overweight	Associate	39766774
Pancreatic Neoplasms	Associate	28272475, 31874997, 37604837
Prostatic Neoplasms	Associate	19318432, 19336566, 20651075, 21538423, 21820706, 22730461, 29266682, 33509203, 36254631
Prostatic Neoplasms	Inhibit	22231567
Prostatic Neoplasms Castration Resistant	Inhibit	36254631
Prostatitis	Associate	22231567
Pulmonary Disease Chronic Obstructive	Associate	30111857
Stomach Neoplasms	Associate	26383524

SLC22A3 (solute carrier family 22 member 3)