Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs Transcription factors Other IDs
Entrez ID	6582
Gene name	Solute carrier family 22 member 2
Gene symbol	SLC22A2
Synonyms (NCBI Gene)	Oct-02
Chromosome	6
Chromosome location	6q25.3
Summary	Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar c

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miRTarBase ID	miRNA	Experiments	Reference
MIRT017635	hsa-miR-335-5p	Microarray	18185580
MIRT1354399	hsa-miR-3152-3p	CLIP-seq
MIRT1354400	hsa-miR-4724-5p	CLIP-seq
MIRT1354401	hsa-miR-4766-5p	CLIP-seq
MIRT1354402	hsa-miR-488	CLIP-seq
MIRT1354399	hsa-miR-3152-3p	CLIP-seq
MIRT2104826	hsa-miR-3622a-3p	CLIP-seq
MIRT2104827	hsa-miR-3622b-3p	CLIP-seq
MIRT2104828	hsa-miR-412	CLIP-seq
MIRT2104829	hsa-miR-4282	CLIP-seq
MIRT2104830	hsa-miR-4659a-3p	CLIP-seq
MIRT2104831	hsa-miR-4659b-3p	CLIP-seq
MIRT1354400	hsa-miR-4724-5p	CLIP-seq
MIRT2104832	hsa-miR-513a-3p	CLIP-seq

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Transcription factor	Regulation	Reference
USF1	Activation	17314196
USF1	Unknown	18508876

Show/Hide all (98)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005275	Function	Amine transmembrane transporter activity	IDA	9687576
GO:0005277	Function	Acetylcholine transmembrane transporter activity	IDA	15817714
GO:0005326	Function	Neurotransmitter transmembrane transporter activity	IDA	9687576, 16581093
GO:0005326	Function	Neurotransmitter transmembrane transporter activity	TAS
GO:0005886	Component	Plasma membrane	IDA	23137377
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	9260930
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006812	Process	Monoatomic cation transport	IEA
GO:0006836	Process	Neurotransmitter transport	IDA	9687576
GO:0006836	Process	Neurotransmitter transport	TAS
GO:0006837	Process	Serotonin transport	IDA	9687576, 16581093
GO:0007589	Process	Body fluid secretion	TAS	9260930
GO:0008504	Function	Monoamine transmembrane transporter activity	IDA	9687576, 12089365, 15212162, 16581093, 17072098, 17460754
GO:0008504	Function	Monoamine transmembrane transporter activity	IEA
GO:0008514	Function	Organic anion transmembrane transporter activity	IDA	11907186
GO:0009925	Component	Basal plasma membrane	IDA	35307651
GO:0009925	Component	Basal plasma membrane	IEA
GO:0015101	Function	Organic cation transmembrane transporter activity	EXP	19141712
GO:0015101	Function	Organic cation transmembrane transporter activity	IBA
GO:0015101	Function	Organic cation transmembrane transporter activity	IDA	9260930, 9687576, 12089365, 12538837, 16024787, 17460754, 21128598, 22806583, 24291757
GO:0015101	Function	Organic cation transmembrane transporter activity	IEA
GO:0015101	Function	Organic cation transmembrane transporter activity	IMP	23864433
GO:0015101	Function	Organic cation transmembrane transporter activity	TAS	9260930
GO:0015132	Function	Prostaglandin transmembrane transporter activity	IDA	11907186
GO:0015132	Function	Prostaglandin transmembrane transporter activity	IEA
GO:0015179	Function	L-amino acid transmembrane transporter activity	IMP	23864433
GO:0015214	Function	Pyrimidine nucleoside transmembrane transporter activity	IEA
GO:0015214	Function	Pyrimidine nucleoside transmembrane transporter activity	IMP	20477935
GO:0015220	Function	Choline transmembrane transporter activity	IDA	9687576
GO:0015234	Function	Thiamine transmembrane transporter activity	IDA	24961373
GO:0015489	Function	Putrescine transmembrane transporter activity	IDA	21128598
GO:0015489	Function	Putrescine transmembrane transporter activity	IEA
GO:0015562	Function	Efflux transmembrane transporter activity	IDA	9687576
GO:0015606	Function	Spermidine transmembrane transporter activity	ISS
GO:0015651	Function	Quaternary ammonium group transmembrane transporter activity	IDA	9260930
GO:0015695	Process	Organic cation transport	IBA
GO:0015695	Process	Organic cation transport	IDA	16024787
GO:0015695	Process	Organic cation transport	IDA	9687576, 22806583, 24291757
GO:0015695	Process	Organic cation transport	IMP	23864433
GO:0015695	Process	Organic cation transport	TAS	9260930
GO:0015697	Process	Quaternary ammonium group transport	IEA
GO:0015732	Process	Prostaglandin transport	IDA	11907186
GO:0015837	Process	Amine transport	IDA	9687576
GO:0015847	Process	Putrescine transport	IDA	21128598
GO:0015848	Process	Spermidine transport	ISS
GO:0015870	Process	Acetylcholine transport	IDA	15817714
GO:0015871	Process	Choline transport	IDA	9687576
GO:0015872	Process	Dopamine transport	IDA	16581093
GO:0015872	Process	Dopamine transport	ISS
GO:0015874	Process	Norepinephrine transport	IDA	9687576, 16581093
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	9260930
GO:0016323	Component	Basolateral plasma membrane	IEA
GO:0016323	Component	Basolateral plasma membrane	ISS
GO:0016324	Component	Apical plasma membrane	IDA	15817714, 20477935
GO:0016324	Component	Apical plasma membrane	IEA
GO:0019534	Function	Toxin transmembrane transporter activity	IDA	9687576, 22806583, 24291757
GO:0019534	Function	Toxin transmembrane transporter activity	IEA
GO:0019534	Function	Toxin transmembrane transporter activity	IMP	20477935
GO:0019534	Function	Toxin transmembrane transporter activity	ISS	30120945
GO:0022857	Function	Transmembrane transporter activity	IEA
GO:0042908	Process	Xenobiotic transport	IDA	9687576, 22806583, 24291757
GO:0042908	Process	Xenobiotic transport	IEA
GO:0042908	Process	Xenobiotic transport	IMP	20477935
GO:0042908	Process	Xenobiotic transport	ISS	30120945
GO:0042910	Function	Xenobiotic transmembrane transporter activity	IDA	12395288, 16394027
GO:0042910	Function	Xenobiotic transmembrane transporter activity	IEA
GO:0042910	Function	Xenobiotic transmembrane transporter activity	IMP	20477935
GO:0048241	Process	Epinephrine transport	IDA	16581093
GO:0048241	Process	Epinephrine transport	ISS
GO:0051608	Process	Histamine transport	IDA	16581093
GO:0051610	Process	Serotonin uptake	IDA	9687576
GO:0051610	Process	Serotonin uptake	IEA
GO:0051615	Process	Histamine uptake	IDA	9687576
GO:0051620	Process	Norepinephrine uptake	IDA	9687576
GO:0051620	Process	Norepinephrine uptake	TAS
GO:0055085	Process	Transmembrane transport	IEA
GO:0061459	Function	L-arginine transmembrane transporter activity	IMP	23864433
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0071934	Process	Thiamine transmembrane transport	IDA	24961373
GO:0071934	Process	Thiamine transmembrane transport	IEA
GO:0072530	Process	Purine-containing compound transmembrane transport	IEA
GO:0072530	Process	Purine-containing compound transmembrane transport	TAS
GO:0089718	Process	Amino acid import across plasma membrane	IMP	23864433
GO:0090494	Process	Dopamine uptake	IDA	9687576
GO:0090494	Process	Dopamine uptake	IEA
GO:0097638	Process	L-arginine import across plasma membrane	IMP	23864433
GO:0098793	Component	Presynapse	IEA
GO:0140115	Process	Export across plasma membrane	IDA	9687576
GO:0150104	Process	Transport across blood-brain barrier	NAS	26590417, 30280653
GO:1902475	Process	L-alpha-amino acid transmembrane transport	IMP	23864433
GO:1903711	Process	Spermidine transmembrane transport	IEA
GO:1903826	Process	L-arginine transmembrane transport	IEA
GO:1990748	Process	Cellular detoxification	IDA	9687576, 22806583, 24291757
GO:1990748	Process	Cellular detoxification	IEA
GO:1990748	Process	Cellular detoxification	IMP	20477935
GO:1990962	Process	Xenobiotic transport across blood-brain barrier	NAS	20477935

MIM	HGNC	e!Ensembl
602608	10966	ENSG00000112499

O15244

Protein name

Solute carrier family 22 member 2 (Organic cation transporter 2) (hOCT2)

Protein function

Electrogenic voltage-dependent transporter that mediates the transport of a variety of organic cations such as endogenous bioactive amines, cationic drugs and xenobiotics (PubMed:9260930, PubMed:9687576). Functions as a Na(+)-independent, bidire

PDB

8ET9

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00083	Sugar_tr	91 → 529	Sugar (and other) transporter	Family

Tissue specificity

TISSUE SPECIFICITY: Mainly expressed in kidney, in the cortex and medulla (PubMed:11912245, PubMed:12089365, PubMed:9260930). Localized in testis, mostly to peritubular myoid cells and Leydig cells and also detected along the basal membrane of Sertoli cel

Sequence

MPTTVDDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHRCRSPGVAELS
LRCGWSPAEELNYTVPGPGPAGEASPRQCRRYEVDWNQSTFDCVDPLASLDTNRSRLPLG
PCRDGWVYETPGSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCL
LTTVLINAAAGVLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGIF
YQVAYTVGLLVLAGVAYALPHWRWLQFTVSLPNFFFLLYYWCIPESPRWLISQNKNAEAM
RIIKHIAKKNGKSLPASLQRLRLEEETGKKLNPSFLDLVRTPQIRKHTMILMYNWFTSSV
LYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMVAGAACLA
SVFIPGDLQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSSMCDIGGII
TPFLVYRLTNIWLELPLMVFGVLGLVAGGLVLLLPETKGKALPETIEEAENMQRPRKNKE
KMIYLQVQKLDIPLN

Sequence length

555

Interactions

View interactions

SLC22A2 (solute carrier family 22 member 2)