SELE (selectin E)

Gene Gene information from NCBI Gene database.
Gene SNPs Transcription factors Other IDs Associated diseases
Entrez ID 6401
Gene name Selectin E
Gene symbol SELE
Synonyms (NCBI Gene)
CD62EELAMELAM1ESELLECAM2selectin-e
Chromosome 1
Chromosome location 1q24.2
Summary The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits st
miRNA miRNA information provided by mirtarbase database.
50
Gene SNPs Transcription factors Other IDs Associated diseases
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miRTarBase ID miRNA Experiments Reference
MIRT004019 hsa-miR-31-5p ImmunocytochemistryNorthern blotqRT-PCRWestern blot 19949084
MIRT005711 hsa-miR-17-5p Luciferase reporter assay 19949084
MIRT005712 hsa-miR-17-3p Luciferase reporter assay 19949084
MIRT005713 hsa-miR-155-5p Luciferase reporter assay 19949084
MIRT005714 hsa-miR-221-3p Luciferase reporter assay 19949084
Transcription factors Transcription factors information provided by TRRUST V2 database.
9
Gene SNPs Transcription factors Other IDs Associated diseases
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Transcription factor Regulation Reference
ATF3 Repression 10964678
HOXA9 Unknown 22269951
NFKB1 Activation 10946302;12408953;12885753;19422386
NFKB1 Unknown 8878392
REL Activation 12408953
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Gene SNPs Transcription factors Other IDs Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0002092 Process Positive regulation of receptor internalization IDA 9312078
GO:0002523 Process Leukocyte migration involved in inflammatory response TAS 18029551
GO:0002687 Process Positive regulation of leukocyte migration IEA
GO:0004888 Function Transmembrane signaling receptor activity IMP 12960351
GO:0005515 Function Protein binding IPI 18606703, 32814053
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene SNPs Transcription factors Other IDs Associated diseases
MIM HGNC e!Ensembl
131210 10718 ENSG00000007908
Protein Protein information from UniProt database.
Gene SNPs Transcription factors Other IDs Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P16581
Protein name E-selectin (CD62 antigen-like family member E) (Endothelial leukocyte adhesion molecule 1) (ELAM-1) (Leukocyte-endothelial cell adhesion molecule 2) (LECAM2) (CD antigen CD62E)
Protein function Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis. {ECO:0000269|PubMed:168
PDB 1ESL , 1G1T , 4C16 , 4CSY , 6EYI , 6EYJ , 6EYK , 8R5L , 8R5M
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00059 Lectin_C 29 → 140 Lectin C-type domain Domain
PF00008 EGF 143 → 173 EGF-like domain Domain
PF00084 Sushi 180 → 237 Sushi repeat (SCR repeat) Domain
PF00084 Sushi 242 → 299 Sushi repeat (SCR repeat) Domain
PF00084 Sushi 304 → 362 Sushi repeat (SCR repeat) Domain
PF00084 Sushi 367 → 425 Sushi repeat (SCR repeat) Domain
PF00084 Sushi 430 → 488 Sushi repeat (SCR repeat) Domain
PF00084 Sushi 493 → 547 Sushi repeat (SCR repeat) Domain
Sequence
Sequence length 610
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
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Gene SNPs Transcription factors Other IDs Associated diseases
Show/Hide Unknown Diseases (3)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Clear cell carcinoma of kidney Uncertain significance rs763174875 RCV005939188
Coronary artery disorder Benign rs3917406, rs5355 RCV002245536
RCV002245537
IgA nephropathy, susceptibility to Uncertain significance rs5368 RCV000018147
Show/Hide Text Mining Associations (200)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Acidosis Stimulate 22110680
Acrodermatitis Associate 12839559
Acute Coronary Syndrome Associate 18441195, 25147432, 29962384
Acute Kidney Injury Associate 16501492
Adenoma Associate 11231628, 12714632
Albuminuria Stimulate 31023084
Allergic Fungal Sinusitis Associate 24995349
Alopecia universalis Associate 7511865
Amyotrophic Lateral Sclerosis Associate 11054140, 18513389
Anemia Sickle Cell Stimulate 24551209