Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6400
Gene name Gene Name - the full gene name approved by the HGNC.
SEL1L adaptor subunit of SYVN1 ubiquitin ligase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SEL1L
Synonyms (NCBI Gene) Gene synonyms aliases
Hrd3, NEDGSAF, NEDHGFA, PRO1063, SEL1-LIKE, SEL1L1
Disease Acronyms (UniProt) Disease acronyms from UniProt database
NEDGSAF, NEDHGFA
Chromosome Chromosome number
14
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
14q31.1
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is part of a protein complex required for the retrotranslocation or dislocation of misfolded proteins from the endoplasmic reticulum lumen to the cytosol, where they are degraded by the proteasome in a ubiquitin-dependent
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT005008 hsa-miR-125b-5p Microarray 17891175
MIRT018739 hsa-miR-335-5p Microarray 18185580
MIRT054478 hsa-miR-155-5p Luciferase reporter assay, qRT-PCR, Western blot 23661430
MIRT529750 hsa-miR-548ac PAR-CLIP 22012620
MIRT529749 hsa-miR-548bb-3p PAR-CLIP 22012620
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000836 Component Hrd1p ubiquitin ligase complex TAS 21454652, 23710284
GO:0000839 Component Hrd1p ubiquitin ligase ERAD-L complex IBA 21873635
GO:0000839 Component Hrd1p ubiquitin ligase ERAD-L complex IMP 26471130
GO:0004842 Function Ubiquitin-protein transferase activity IBA 21873635
GO:0005515 Function Protein binding IPI 18264092, 18502753, 18711132, 19135427, 19524542, 19706418, 22119785, 26471130, 26551274, 28514442, 28827405, 31477895
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
602329 10717 ENSG00000071537
Protein
UniProt ID Q9UBV2
Protein name Protein sel-1 homolog 1 (Suppressor of lin-12-like protein 1) (Sel-1L)
Protein function Plays a role in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:16186509, PubMed:29997207, PubMe
PDB 8KES , 8KET , 8KEV
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00040 fn2 127 168 Fibronectin type II domain Domain
PF08238 Sel1 183 218 Sel1 repeat Repeat
PF08238 Sel1 219 254 Sel1 repeat Repeat
PF08238 Sel1 373 409 Sel1 repeat Repeat
PF08238 Sel1 410 446 Sel1 repeat Repeat
PF08238 Sel1 447 482 Sel1 repeat Repeat
PF08238 Sel1 483 518 Sel1 repeat Repeat
PF08238 Sel1 627 662 Sel1 repeat Repeat
PF08238 Sel1 664 698 Sel1 repeat Repeat
Tissue specificity TISSUE SPECIFICITY: Highly expressed in pancreas.
Sequence
MRVRIGLTLLLCAVLLSLASASSDEEGSQDESLDSKTTLTSDESVKDHTTAGRVVAGQIF
LDSEESELESSIQEEEDSLKSQEGESVTEDISFLESPNPENKDYEEPKKVRKPALTAIEG
TAHGEPCHFPFLFLDKEYDECTSDGREDGRLWCATTYDYKADEKWGFCETEEEAAKRRQM
QEAEMMYQTGMKILNGSNKKSQKREAYRYLQKAASMNHTKALERVSYALLFGDYLPQNIQ
AAREMFEKLTEEGS
PKGQTALGFLYASGLGVNSSQAKALVYYTFGALGGNLIAHMVLGYR
YWAGIGVLQSCESALTHYRLVANHVASDISLTGGSVVQRIRLPDEVENPGMNSGMLEEDL
IQYYQFLAEKGDVQAQVGLGQLHLHGGRGVEQNHQRAFDYFNLAANAGNSHAMAFLGKMY
SEGSDIVPQSNETALHYFKKAADMGN
PVGQSGLGMAYLYGRGVQVNYDLALKYFQKAAEQ
GW
VDGQLQLGSMYYNGIGVKRDYKQALKYFNLASQGGHILAFYNLAQMHASGTGVMRSCH
TAVELFKNVCERGRWSERLMTAYNSYKDGDYNAAVIQYLLLAEQGYEVAQSNAAFILDQR
EASIVGENETYPRALLHWNRAASQGYTVARIKLGDYHFYGFGTDVDYETAFIHYRLASEQ
QH
SAQAMFNLGYMHEKGLGIKQDIHLAKRFYDMAAEASPDAQVPVFLALCKLGVVYFLQY
IRETNIRDMFTQLDMDQLLGPEWDLYLMTIIALLLGTVIAYRQRQHQDMPAPRPPGPRPA
PPQQEGPPEQQPPQ
Sequence length 794
Interactions View interactions