Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs Other IDs Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	6383
Gene name Gene Name - the full gene name approved by the HGNC.	Syndecan 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	SDC2
Synonyms (NCBI Gene) Gene synonyms aliases	CD362, HSPG, HSPG1, SYND2
Chromosome Chromosome number	8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	8q22.1
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are req

Show/Hide all(205)

miRTarBase ID	miRNA	Experiments	Reference
MIRT468760	hsa-miR-495-3p	PAR-CLIP	23592263
MIRT468759	hsa-miR-5688	PAR-CLIP	23592263
MIRT468758	hsa-miR-7-1-3p	PAR-CLIP	23592263
MIRT468757	hsa-miR-7-2-3p	PAR-CLIP	23592263
MIRT468756	hsa-miR-3125	PAR-CLIP	23592263
MIRT468755	hsa-miR-3916	PAR-CLIP	23592263
MIRT468754	hsa-miR-6859-5p	PAR-CLIP	23592263
MIRT468753	hsa-miR-577	PAR-CLIP	23592263
MIRT468752	hsa-miR-4476	PAR-CLIP	23592263
MIRT468751	hsa-miR-6876-5p	PAR-CLIP	23592263
MIRT468750	hsa-miR-4436b-3p	PAR-CLIP	23592263
MIRT468749	hsa-miR-4632-5p	PAR-CLIP	23592263
MIRT468748	hsa-miR-6735-5p	PAR-CLIP	23592263
MIRT468747	hsa-miR-6879-5p	PAR-CLIP	23592263
MIRT468746	hsa-miR-7843-5p	PAR-CLIP	23592263
MIRT468745	hsa-miR-6847-5p	PAR-CLIP	23592263
MIRT468744	hsa-miR-3179	PAR-CLIP	23592263
MIRT468743	hsa-miR-3150b-3p	PAR-CLIP	23592263
MIRT468742	hsa-miR-4784	PAR-CLIP	23592263
MIRT468741	hsa-miR-3616-3p	PAR-CLIP	23592263
MIRT468740	hsa-miR-2467-3p	PAR-CLIP	23592263
MIRT468739	hsa-miR-3202	PAR-CLIP	23592263
MIRT468760	hsa-miR-495-3p	PAR-CLIP	23592263
MIRT468759	hsa-miR-5688	PAR-CLIP	23592263
MIRT468758	hsa-miR-7-1-3p	PAR-CLIP	23592263
MIRT468757	hsa-miR-7-2-3p	PAR-CLIP	23592263
MIRT468756	hsa-miR-3125	PAR-CLIP	23592263
MIRT468755	hsa-miR-3916	PAR-CLIP	23592263
MIRT468754	hsa-miR-6859-5p	PAR-CLIP	23592263
MIRT468753	hsa-miR-577	PAR-CLIP	23592263
MIRT468752	hsa-miR-4476	PAR-CLIP	23592263
MIRT468751	hsa-miR-6876-5p	PAR-CLIP	23592263
MIRT468750	hsa-miR-4436b-3p	PAR-CLIP	23592263
MIRT468749	hsa-miR-4632-5p	PAR-CLIP	23592263
MIRT468748	hsa-miR-6735-5p	PAR-CLIP	23592263
MIRT468747	hsa-miR-6879-5p	PAR-CLIP	23592263
MIRT468746	hsa-miR-7843-5p	PAR-CLIP	23592263
MIRT468745	hsa-miR-6847-5p	PAR-CLIP	23592263
MIRT468744	hsa-miR-3179	PAR-CLIP	23592263
MIRT468743	hsa-miR-3150b-3p	PAR-CLIP	23592263
MIRT468742	hsa-miR-4784	PAR-CLIP	23592263
MIRT468741	hsa-miR-3616-3p	PAR-CLIP	23592263
MIRT468740	hsa-miR-2467-3p	PAR-CLIP	23592263
MIRT468739	hsa-miR-3202	PAR-CLIP	23592263
MIRT1331299	hsa-miR-1271	CLIP-seq
MIRT1331300	hsa-miR-182	CLIP-seq
MIRT1331301	hsa-miR-3190	CLIP-seq
MIRT1331302	hsa-miR-3200-5p	CLIP-seq
MIRT1331303	hsa-miR-331-3p	CLIP-seq
MIRT1331304	hsa-miR-3622b-5p	CLIP-seq
MIRT1331305	hsa-miR-3646	CLIP-seq
MIRT1331306	hsa-miR-3647-3p	CLIP-seq
MIRT1331307	hsa-miR-3941	CLIP-seq
MIRT1331308	hsa-miR-4251	CLIP-seq
MIRT1331309	hsa-miR-4257	CLIP-seq
MIRT1331310	hsa-miR-4329	CLIP-seq
MIRT1331311	hsa-miR-4642	CLIP-seq
MIRT1331312	hsa-miR-4643	CLIP-seq
MIRT1331313	hsa-miR-466	CLIP-seq
MIRT1331314	hsa-miR-4670-3p	CLIP-seq
MIRT1331315	hsa-miR-4672	CLIP-seq
MIRT1331316	hsa-miR-4704-5p	CLIP-seq
MIRT1331317	hsa-miR-4719	CLIP-seq
MIRT1331318	hsa-miR-4728-3p	CLIP-seq
MIRT1331319	hsa-miR-4775	CLIP-seq
MIRT1331320	hsa-miR-4789-3p	CLIP-seq
MIRT1331321	hsa-miR-4789-5p	CLIP-seq
MIRT1331322	hsa-miR-494	CLIP-seq
MIRT1331323	hsa-miR-499a-5p	CLIP-seq
MIRT1331324	hsa-miR-561	CLIP-seq
MIRT1331325	hsa-miR-590-3p	CLIP-seq
MIRT1331326	hsa-miR-605	CLIP-seq
MIRT1331327	hsa-miR-628-5p	CLIP-seq
MIRT1331328	hsa-miR-642b	CLIP-seq
MIRT1331329	hsa-miR-885-3p	CLIP-seq
MIRT1331330	hsa-miR-96	CLIP-seq
MIRT1553262	hsa-miR-3148	CLIP-seq
MIRT1553263	hsa-miR-3149	CLIP-seq
MIRT1553264	hsa-miR-4496	CLIP-seq
MIRT1331316	hsa-miR-4704-5p	CLIP-seq
MIRT1553265	hsa-miR-4762-5p	CLIP-seq
MIRT1331319	hsa-miR-4775	CLIP-seq
MIRT1331321	hsa-miR-4789-5p	CLIP-seq
MIRT1553266	hsa-miR-4796-3p	CLIP-seq
MIRT1331325	hsa-miR-590-3p	CLIP-seq
MIRT1553267	hsa-miR-627	CLIP-seq
MIRT1331319	hsa-miR-4775	CLIP-seq
MIRT2322548	hsa-miR-103a	CLIP-seq
MIRT2322549	hsa-miR-107	CLIP-seq
MIRT2322550	hsa-miR-1184	CLIP-seq
MIRT2322551	hsa-miR-1205	CLIP-seq
MIRT2322552	hsa-miR-1283	CLIP-seq
MIRT2322553	hsa-miR-25	CLIP-seq
MIRT1553262	hsa-miR-3148	CLIP-seq
MIRT1553263	hsa-miR-3149	CLIP-seq
MIRT2322554	hsa-miR-3158-5p	CLIP-seq
MIRT2322555	hsa-miR-32	CLIP-seq
MIRT1331302	hsa-miR-3200-5p	CLIP-seq
MIRT2322556	hsa-miR-363	CLIP-seq
MIRT1331305	hsa-miR-3646	CLIP-seq
MIRT2322557	hsa-miR-367	CLIP-seq
MIRT2322558	hsa-miR-4307	CLIP-seq
MIRT1553264	hsa-miR-4496	CLIP-seq
MIRT2322559	hsa-miR-4666-3p	CLIP-seq
MIRT2322560	hsa-miR-4680-3p	CLIP-seq
MIRT1331317	hsa-miR-4719	CLIP-seq
MIRT2322561	hsa-miR-4781-3p	CLIP-seq
MIRT1331321	hsa-miR-4789-5p	CLIP-seq
MIRT1331322	hsa-miR-494	CLIP-seq
MIRT1553267	hsa-miR-627	CLIP-seq
MIRT1331328	hsa-miR-642b	CLIP-seq
MIRT2322562	hsa-miR-659	CLIP-seq
MIRT2322563	hsa-miR-767-5p	CLIP-seq
MIRT2322564	hsa-miR-891b	CLIP-seq
MIRT2322565	hsa-miR-9	CLIP-seq
MIRT2322566	hsa-miR-92a	CLIP-seq
MIRT2322567	hsa-miR-92b	CLIP-seq
MIRT2322552	hsa-miR-1283	CLIP-seq
MIRT2394131	hsa-miR-199a-3p	CLIP-seq
MIRT2394132	hsa-miR-199b-3p	CLIP-seq
MIRT2394133	hsa-miR-3129-5p	CLIP-seq
MIRT2394134	hsa-miR-936	CLIP-seq
MIRT2322552	hsa-miR-1283	CLIP-seq
MIRT2432940	hsa-miR-296-3p	CLIP-seq
MIRT1331305	hsa-miR-3646	CLIP-seq
MIRT1331306	hsa-miR-3647-3p	CLIP-seq
MIRT2432941	hsa-miR-3910	CLIP-seq
MIRT1331316	hsa-miR-4704-5p	CLIP-seq
MIRT1331317	hsa-miR-4719	CLIP-seq
MIRT1331321	hsa-miR-4789-5p	CLIP-seq
MIRT1331322	hsa-miR-494	CLIP-seq
MIRT2432942	hsa-miR-548an	CLIP-seq
MIRT1553267	hsa-miR-627	CLIP-seq
MIRT1331328	hsa-miR-642b	CLIP-seq
MIRT2440060	hsa-miR-3156-5p	CLIP-seq
MIRT1331305	hsa-miR-3646	CLIP-seq
MIRT1553264	hsa-miR-4496	CLIP-seq
MIRT1331317	hsa-miR-4719	CLIP-seq
MIRT1331322	hsa-miR-494	CLIP-seq
MIRT1553267	hsa-miR-627	CLIP-seq
MIRT1331328	hsa-miR-642b	CLIP-seq
MIRT2618679	hsa-miR-1245	CLIP-seq
MIRT2322552	hsa-miR-1283	CLIP-seq
MIRT2618680	hsa-miR-1321	CLIP-seq
MIRT2618681	hsa-miR-2277-3p	CLIP-seq
MIRT2432940	hsa-miR-296-3p	CLIP-seq
MIRT2618682	hsa-miR-300	CLIP-seq
MIRT2618683	hsa-miR-3117-5p	CLIP-seq
MIRT2618684	hsa-miR-3121-3p	CLIP-seq
MIRT1553262	hsa-miR-3148	CLIP-seq
MIRT1553263	hsa-miR-3149	CLIP-seq
MIRT2618685	hsa-miR-3154	CLIP-seq
MIRT1331301	hsa-miR-3190	CLIP-seq
MIRT1331305	hsa-miR-3646	CLIP-seq
MIRT2618686	hsa-miR-381	CLIP-seq
MIRT2432941	hsa-miR-3910	CLIP-seq
MIRT2618687	hsa-miR-3976	CLIP-seq
MIRT2618688	hsa-miR-4282	CLIP-seq
MIRT2618689	hsa-miR-4477b	CLIP-seq
MIRT1553264	hsa-miR-4496	CLIP-seq
MIRT2322559	hsa-miR-4666-3p	CLIP-seq
MIRT1331314	hsa-miR-4670-3p	CLIP-seq
MIRT2618690	hsa-miR-4695-3p	CLIP-seq
MIRT1331317	hsa-miR-4719	CLIP-seq
MIRT2618691	hsa-miR-4728-5p	CLIP-seq
MIRT2618692	hsa-miR-4739	CLIP-seq
MIRT2618693	hsa-miR-4756-5p	CLIP-seq
MIRT1331321	hsa-miR-4789-5p	CLIP-seq
MIRT1553266	hsa-miR-4796-3p	CLIP-seq
MIRT2618694	hsa-miR-4803	CLIP-seq
MIRT1331322	hsa-miR-494	CLIP-seq
MIRT2618695	hsa-miR-520d-5p	CLIP-seq
MIRT2618696	hsa-miR-520g	CLIP-seq
MIRT2618697	hsa-miR-520h	CLIP-seq
MIRT2618698	hsa-miR-524-5p	CLIP-seq
MIRT2432942	hsa-miR-548an	CLIP-seq
MIRT2618699	hsa-miR-548c-3p	CLIP-seq
MIRT2618700	hsa-miR-548n	CLIP-seq
MIRT2618701	hsa-miR-548t	CLIP-seq
MIRT1331324	hsa-miR-561	CLIP-seq
MIRT1553267	hsa-miR-627	CLIP-seq
MIRT1331328	hsa-miR-642b	CLIP-seq
MIRT2322562	hsa-miR-659	CLIP-seq
MIRT2322552	hsa-miR-1283	CLIP-seq
MIRT2618680	hsa-miR-1321	CLIP-seq
MIRT2618681	hsa-miR-2277-3p	CLIP-seq
MIRT2432940	hsa-miR-296-3p	CLIP-seq
MIRT1553262	hsa-miR-3148	CLIP-seq
MIRT1553263	hsa-miR-3149	CLIP-seq
MIRT2618685	hsa-miR-3154	CLIP-seq
MIRT1331305	hsa-miR-3646	CLIP-seq
MIRT2432941	hsa-miR-3910	CLIP-seq
MIRT2618689	hsa-miR-4477b	CLIP-seq
MIRT1553264	hsa-miR-4496	CLIP-seq
MIRT1331317	hsa-miR-4719	CLIP-seq
MIRT2618692	hsa-miR-4739	CLIP-seq
MIRT2618693	hsa-miR-4756-5p	CLIP-seq
MIRT1331322	hsa-miR-494	CLIP-seq
MIRT2432942	hsa-miR-548an	CLIP-seq
MIRT2618700	hsa-miR-548n	CLIP-seq
MIRT2618701	hsa-miR-548t	CLIP-seq
MIRT1331324	hsa-miR-561	CLIP-seq
MIRT1553267	hsa-miR-627	CLIP-seq
MIRT1331328	hsa-miR-642b	CLIP-seq
MIRT2322562	hsa-miR-659	CLIP-seq

Show/Hide all(17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	9660868, 11356864, 18093920, 22660413, 32296183, 32814053, 33961781
GO:0005788	Component	Endoplasmic reticulum lumen	TAS
GO:0005796	Component	Golgi lumen	TAS
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	TAS
GO:0007399	Process	Nervous system development	IEA
GO:0009986	Component	Cell surface	IBA
GO:0016020	Component	Membrane	IEA
GO:0016477	Process	Cell migration	IBA
GO:0030154	Process	Cell differentiation	IEA
GO:0030165	Function	PDZ domain binding	IPI	18256285
GO:0031012	Component	Extracellular matrix	HDA	27068509
GO:0042802	Function	Identical protein binding	IPI	18093920, 21988832
GO:0043202	Component	Lysosomal lumen	TAS
GO:0048813	Process	Dendrite morphogenesis	IBA
GO:0048814	Process	Regulation of dendrite morphogenesis	IEA
GO:0048814	Process	Regulation of dendrite morphogenesis	ISS

MIM	HGNC	e!Ensembl
142460	10659	ENSG00000169439

Protein

UniProt ID

P34741

Protein name

Syndecan-2 (SYND2) (Fibroglycan) (Heparan sulfate proteoglycan core protein) (HSPG) (CD antigen CD362)

Protein function

Cell surface proteoglycan which regulates dendritic arbor morphogenesis.

PDB

6ITH

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01034	Syndecan	138 → 199	Syndecan domain	Family

Sequence

MRRAWILLTLGLVACVSAESRAELTSDKDMYLDNSSIEEASGVYPIDDDDYASASGSGAD
EDVESPELTTSRPLPKILLTSAAPKVETTTLNIQNKIPAQTKSPEETDKEKVHLSDSERK
MDPAEEDTNVYTEKHSDSLFKRTEVLAAVIAGGVIGFLFAIFLILLLVYRMRKKDEGSYD
LGERKPSSAAYQKAPTKEFYA

Sequence length

201

Interactions

View interactions

Show/Hide Unknown Diseases (2)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Insomnia	Insomnia	N/A	N/A	GWAS
Stress Disorder	Post-traumatic stress disorder	N/A	N/A	GWAS

Show/Hide Text Mining Associations (57)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenocarcinoma	Associate	23327652, 34397867
Adenocarcinoma of Lung	Associate	30106131
Adenoma	Associate	28058013, 28753106, 36203138
Adenoma	Stimulate	29730903
Adenoma Villous	Associate	29730903
Adenomatous Polyps	Associate	29225717
Arrest of spermatogenesis	Associate	39285301
Arthritis	Associate	17545191
Azoospermia	Associate	39285301
Breast Neoplasms	Associate	19383343, 23327652, 24357546, 25623282
Colonic Neoplasms	Associate	12055189, 31337828
Colorectal Neoplasms	Associate	12055189, 23747112, 24485021, 28700744, 28753106, 29225717, 29730903, 29945573, 30876480, 31089394, 31407497, 31707342, 33126908, 33393623, 33504902 View all (18 more)
Colorectal Neoplasms	Stimulate	23705906
Diabetes Gestational	Associate	32111749
Dyslipidemias	Associate	24278138
Fibrosarcoma	Associate	22745764, 23297089
Glioblastoma	Associate	35702951
Head and Neck Neoplasms	Associate	25935541
Heart Diseases	Associate	32174066
Hepatitis C Chronic	Associate	27693511
Hyperlipidemias	Associate	24278138
Infections	Associate	27223085
Infertility Male	Associate	39285301
Inflammation	Associate	18032547
Iron Overload	Associate	32174066
Keratoconus	Associate	31467338
Kidney Diseases	Associate	18032547
Leukemia Myeloid Acute	Associate	17035092
Liver Failure	Associate	24736615
Lymphangioleiomyomatosis	Associate	23867796
Lymphatic Metastasis	Stimulate	24927672, 31707342
Melanoma	Associate	19696445
Mesothelioma	Associate	35127947
Multiple Myeloma	Associate	16732320
Neoplasm Invasiveness	Associate	24927672
Neoplasm Metastasis	Associate	22745764, 31707342, 34229299, 34397867, 36810912
Neoplasm Metastasis	Stimulate	24927672
Neoplasms	Associate	20930391, 22471946, 22745764, 23705906, 23747112, 24927672, 29225717, 31089394, 32793117, 34397867, 36181793, 36510988, 37419119, 37496999
Neoplasms	Inhibit	34382948
Neurofibromatosis Familial Spinal	Stimulate	37217626
Pancreatic Neoplasms	Associate	22471946, 9802880
Papillomavirus Infections	Associate	37358427
Polycystic Ovary Syndrome	Associate	35794640
Polyposis Syndrome Hereditary Mixed 1	Associate	28753106
Polyps	Associate	29225717, 29730903, 36203138
Precancerous Conditions	Associate	29730903, 37881109, 40307680
Prostatic Neoplasms	Associate	21317913, 34445387
Retinal Dysplasia	Associate	29730903
Squamous Cell Carcinoma of Head and Neck	Associate	35358652
Squamous Intraepithelial Lesions	Associate	37410084
Stomach Neoplasms	Associate	33178362, 37419119, 37496999
Thyroid Cancer Papillary	Associate	33521130
Thyroid Neoplasms	Associate	32793117
Triple Negative Breast Neoplasms	Stimulate	25623282
Uterine Cervical Neoplasms	Associate	37410084
Uterine Cervicitis	Associate	27223085
Uveal melanoma	Associate	35426938

SDC2 (syndecan 2)