Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
79966
Gene name Gene Name - the full gene name approved by the HGNC.
Stearoyl-CoA desaturase 5
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SCD5
Synonyms (NCBI Gene) Gene synonyms aliases
ACOD4, DFNA79, FADS4, HSCD5, SCD2, SCD4
Disease Acronyms (UniProt) Disease acronyms from UniProt database
DFNA79, FADS4
Chromosome Chromosome number
4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4q21.22
Summary Summary of gene provided in NCBI Entrez Gene.
Stearoyl-CoA desaturase (SCD; EC 1.14.99.5) is an integral membrane protein of the endoplasmic reticulum that catalyzes the formation of monounsaturated fatty acids from saturated fatty acids. SCD may be a key regulator of energy metabolism with a role in
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT021675 hsa-miR-140-3p Sequencing 20371350
MIRT049021 hsa-miR-92a-3p CLASH 23622248
MIRT047892 hsa-miR-30c-5p CLASH 23622248
MIRT043059 hsa-miR-324-5p CLASH 23622248
MIRT718597 hsa-miR-141-3p HITS-CLIP 19536157
Transcription factors
Transcription factor Regulation Reference
EGR2 Repression 22510410
SREBF1 Activation 22510410
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004768 Function Stearoyl-CoA 9-desaturase activity IBA 21873635
GO:0004768 Function Stearoyl-CoA 9-desaturase activity IDA 15907797, 22745828
GO:0005506 Function Iron ion binding IBA 21873635
GO:0005789 Component Endoplasmic reticulum membrane IBA 21873635
GO:0005789 Component Endoplasmic reticulum membrane IDA 15907797
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
608370 21088 ENSG00000145284
Protein
UniProt ID Q86SK9
Protein name Stearoyl-CoA desaturase 5 (EC 1.14.19.1) (Acyl-CoA-desaturase 4) (HSCD5) (Stearoyl-CoA 9-desaturase) (Stearoyl-CoA desaturase 2)
Protein function Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00487 FA_desaturase 72 291 Fatty acid desaturase Domain
Tissue specificity TISSUE SPECIFICITY: Detected in fetal brain, and at lower levels in fetal kidney. Detected in adult brain and pancreas, and at lower levels in kidney and lung. Expressed in spiral ganglion cells and the organ of Corti of fetal cochlea (PubMed:31972369). {
Sequence
Sequence length 330
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Deafness hearing loss, autosomal dominant 79 GenCC
Diabetes Diabetes GWAS
Associations from Text Mining
Disease Name Relationship Type References
Arthritis Rheumatoid Inhibit 24816316
Breast Neoplasms Associate 26061164
Breast Neoplasms Inhibit 33903614, 37122728
Bronchiectasis Inhibit 40536885
Carcinoma Renal Cell Associate 31140607, 33221754, 37689589
Cholangiocarcinoma Associate 34871464
Diabetes Mellitus Associate 36292669
Diabetes Mellitus Type 2 Associate 36360309
Glioblastoma Associate 32392704
HIV Infections Associate 7527738