Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs Other IDs Associated diseases
Entrez ID	6257
Gene name	Retinoid X receptor beta
Gene symbol	RXRB
Synonyms (NCBI Gene)	DAUDI6H-2RIIBPNR2B2RCoR-1RXR-betaRXRbeta
Chromosome	6
Chromosome location	6p21.32
Summary	This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). The encoded protein forms homodimers with the retinoic acid, thyroid hormone, and vitamin D receptor

276

Show/Hide all (276)

miRTarBase ID	miRNA	Experiments	Reference
MIRT004176	hsa-miR-197-3p	Microarray	16822819
MIRT004235	hsa-miR-346	Microarray	16822819
MIRT016771	hsa-miR-335-5p	Microarray	18185580
MIRT028819	hsa-miR-26b-5p	Microarray	19088304
MIRT051998	hsa-let-7b-5p	CLASH	23622248
MIRT049481	hsa-miR-92a-3p	CLASH	23622248
MIRT042213	hsa-miR-484	CLASH	23622248
MIRT610403	hsa-miR-412-3p	HITS-CLIP	23824327
MIRT610402	hsa-miR-6754-3p	HITS-CLIP	23824327
MIRT004176	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT610401	hsa-miR-6083	HITS-CLIP	23824327
MIRT610405	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT610404	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT610403	hsa-miR-412-3p	HITS-CLIP	23824327
MIRT610402	hsa-miR-6754-3p	HITS-CLIP	23824327
MIRT004176	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT610401	hsa-miR-6083	HITS-CLIP	23824327
MIRT628659	hsa-miR-6769a-3p	HITS-CLIP	23824327
MIRT610405	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT610404	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT610403	hsa-miR-412-3p	HITS-CLIP	23824327
MIRT610402	hsa-miR-6754-3p	HITS-CLIP	23824327
MIRT004176	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT610401	hsa-miR-6083	HITS-CLIP	23824327
MIRT610405	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT610404	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT610403	hsa-miR-412-3p	HITS-CLIP	23824327
MIRT610402	hsa-miR-6754-3p	HITS-CLIP	23824327
MIRT004176	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT610401	hsa-miR-6083	HITS-CLIP	23824327
MIRT610403	hsa-miR-412-3p	HITS-CLIP	23824327
MIRT610402	hsa-miR-6754-3p	HITS-CLIP	23824327
MIRT004176	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT610401	hsa-miR-6083	HITS-CLIP	23824327
MIRT628659	hsa-miR-6769a-3p	HITS-CLIP	23824327
MIRT610405	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT610404	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT610403	hsa-miR-412-3p	HITS-CLIP	23824327
MIRT610402	hsa-miR-6754-3p	HITS-CLIP	23824327
MIRT004176	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT610401	hsa-miR-6083	HITS-CLIP	23824327
MIRT610403	hsa-miR-412-3p	HITS-CLIP	23824327
MIRT610402	hsa-miR-6754-3p	HITS-CLIP	23824327
MIRT004176	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT610401	hsa-miR-6083	HITS-CLIP	23824327
MIRT610403	hsa-miR-412-3p	HITS-CLIP	23824327
MIRT610402	hsa-miR-6754-3p	HITS-CLIP	23824327
MIRT004176	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT610401	hsa-miR-6083	HITS-CLIP	23824327
MIRT610405	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT610404	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT610403	hsa-miR-412-3p	HITS-CLIP	23824327
MIRT610402	hsa-miR-6754-3p	HITS-CLIP	23824327
MIRT004176	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT610401	hsa-miR-6083	HITS-CLIP	23824327
MIRT488003	hsa-miR-320e	PAR-CLIP	23592263
MIRT488002	hsa-miR-4524b-3p	PAR-CLIP	23592263
MIRT488001	hsa-miR-4716-3p	PAR-CLIP	23592263
MIRT488000	hsa-miR-6794-5p	PAR-CLIP	23592263
MIRT487999	hsa-miR-6805-5p	PAR-CLIP	23592263
MIRT487998	hsa-miR-6732-5p	PAR-CLIP	23592263
MIRT487997	hsa-miR-3960	PAR-CLIP	23592263
MIRT487996	hsa-miR-8072	PAR-CLIP	23592263
MIRT487995	hsa-miR-6077	PAR-CLIP	23592263
MIRT487994	hsa-miR-4467	PAR-CLIP	23592263
MIRT487993	hsa-miR-3180	PAR-CLIP	23592263
MIRT487992	hsa-miR-3180-3p	PAR-CLIP	23592263
MIRT487990	hsa-miR-3196	PAR-CLIP	23592263
MIRT487991	hsa-miR-6816-5p	PAR-CLIP	23592263
MIRT487989	hsa-miR-1237-5p	PAR-CLIP	23592263
MIRT487988	hsa-miR-4488	PAR-CLIP	23592263
MIRT487987	hsa-miR-4697-5p	PAR-CLIP	23592263
MIRT487986	hsa-miR-328-5p	PAR-CLIP	23592263
MIRT487985	hsa-miR-6885-5p	PAR-CLIP	23592263
MIRT487984	hsa-miR-4278	PAR-CLIP	23592263
MIRT455426	hsa-miR-3173-3p	PAR-CLIP	23592263
MIRT455425	hsa-miR-6891-5p	PAR-CLIP	23592263
MIRT455424	hsa-miR-4418	PAR-CLIP	23592263
MIRT455423	hsa-miR-509-3-5p	PAR-CLIP	23592263
MIRT455422	hsa-miR-509-5p	PAR-CLIP	23592263
MIRT455421	hsa-miR-3158-5p	PAR-CLIP	23592263
MIRT455420	hsa-miR-4795-5p	PAR-CLIP	23592263
MIRT455419	hsa-miR-5002-3p	PAR-CLIP	23592263
MIRT455418	hsa-miR-7854-3p	PAR-CLIP	23592263
MIRT455417	hsa-miR-298	PAR-CLIP	23592263
MIRT455416	hsa-miR-3689d	PAR-CLIP	23592263
MIRT455414	hsa-miR-6851-5p	PAR-CLIP	23592263
MIRT455415	hsa-miR-3616-5p	PAR-CLIP	23592263
MIRT455413	hsa-miR-573	PAR-CLIP	23592263
MIRT610403	hsa-miR-412-3p	HITS-CLIP	23824327
MIRT610402	hsa-miR-6754-3p	HITS-CLIP	23824327
MIRT004176	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT610401	hsa-miR-6083	HITS-CLIP	23824327
MIRT610405	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT610404	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT610403	hsa-miR-412-3p	HITS-CLIP	23824327
MIRT610402	hsa-miR-6754-3p	HITS-CLIP	23824327
MIRT004176	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT610401	hsa-miR-6083	HITS-CLIP	23824327
MIRT628659	hsa-miR-6769a-3p	HITS-CLIP	23824327
MIRT610405	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT610404	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT610403	hsa-miR-412-3p	HITS-CLIP	23824327
MIRT610402	hsa-miR-6754-3p	HITS-CLIP	23824327
MIRT004176	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT610401	hsa-miR-6083	HITS-CLIP	23824327
MIRT610405	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT610404	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT610403	hsa-miR-412-3p	HITS-CLIP	23824327
MIRT610402	hsa-miR-6754-3p	HITS-CLIP	23824327
MIRT004176	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT610401	hsa-miR-6083	HITS-CLIP	23824327
MIRT610403	hsa-miR-412-3p	HITS-CLIP	23824327
MIRT610402	hsa-miR-6754-3p	HITS-CLIP	23824327
MIRT004176	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT610401	hsa-miR-6083	HITS-CLIP	23824327
MIRT628659	hsa-miR-6769a-3p	HITS-CLIP	23824327
MIRT610405	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT610404	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT610403	hsa-miR-412-3p	HITS-CLIP	23824327
MIRT610402	hsa-miR-6754-3p	HITS-CLIP	23824327
MIRT004176	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT610401	hsa-miR-6083	HITS-CLIP	23824327
MIRT610403	hsa-miR-412-3p	HITS-CLIP	23824327
MIRT610402	hsa-miR-6754-3p	HITS-CLIP	23824327
MIRT004176	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT610401	hsa-miR-6083	HITS-CLIP	23824327
MIRT610403	hsa-miR-412-3p	HITS-CLIP	23824327
MIRT610402	hsa-miR-6754-3p	HITS-CLIP	23824327
MIRT004176	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT610401	hsa-miR-6083	HITS-CLIP	23824327
MIRT610405	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT610404	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT610403	hsa-miR-412-3p	HITS-CLIP	23824327
MIRT610402	hsa-miR-6754-3p	HITS-CLIP	23824327
MIRT004176	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT610401	hsa-miR-6083	HITS-CLIP	23824327
MIRT488003	hsa-miR-320e	PAR-CLIP	23592263
MIRT488002	hsa-miR-4524b-3p	PAR-CLIP	23592263
MIRT488001	hsa-miR-4716-3p	PAR-CLIP	23592263
MIRT488000	hsa-miR-6794-5p	PAR-CLIP	23592263
MIRT487999	hsa-miR-6805-5p	PAR-CLIP	23592263
MIRT487998	hsa-miR-6732-5p	PAR-CLIP	23592263
MIRT487997	hsa-miR-3960	PAR-CLIP	23592263
MIRT487996	hsa-miR-8072	PAR-CLIP	23592263
MIRT487995	hsa-miR-6077	PAR-CLIP	23592263
MIRT487994	hsa-miR-4467	PAR-CLIP	23592263
MIRT487993	hsa-miR-3180	PAR-CLIP	23592263
MIRT487992	hsa-miR-3180-3p	PAR-CLIP	23592263
MIRT487990	hsa-miR-3196	PAR-CLIP	23592263
MIRT487991	hsa-miR-6816-5p	PAR-CLIP	23592263
MIRT487989	hsa-miR-1237-5p	PAR-CLIP	23592263
MIRT487988	hsa-miR-4488	PAR-CLIP	23592263
MIRT487987	hsa-miR-4697-5p	PAR-CLIP	23592263
MIRT487986	hsa-miR-328-5p	PAR-CLIP	23592263
MIRT487985	hsa-miR-6885-5p	PAR-CLIP	23592263
MIRT487984	hsa-miR-4278	PAR-CLIP	23592263
MIRT455426	hsa-miR-3173-3p	PAR-CLIP	23592263
MIRT455425	hsa-miR-6891-5p	PAR-CLIP	23592263
MIRT455424	hsa-miR-4418	PAR-CLIP	23592263
MIRT455423	hsa-miR-509-3-5p	PAR-CLIP	23592263
MIRT455422	hsa-miR-509-5p	PAR-CLIP	23592263
MIRT455421	hsa-miR-3158-5p	PAR-CLIP	23592263
MIRT455420	hsa-miR-4795-5p	PAR-CLIP	23592263
MIRT455419	hsa-miR-5002-3p	PAR-CLIP	23592263
MIRT455418	hsa-miR-7854-3p	PAR-CLIP	23592263
MIRT455417	hsa-miR-298	PAR-CLIP	23592263
MIRT455416	hsa-miR-3689d	PAR-CLIP	23592263
MIRT455414	hsa-miR-6851-5p	PAR-CLIP	23592263
MIRT455415	hsa-miR-3616-5p	PAR-CLIP	23592263
MIRT455413	hsa-miR-573	PAR-CLIP	23592263
MIRT1323443	hsa-miR-1225-3p	CLIP-seq
MIRT1323444	hsa-miR-1253	CLIP-seq
MIRT1323445	hsa-miR-1291	CLIP-seq
MIRT1323446	hsa-miR-146b-3p	CLIP-seq
MIRT1323447	hsa-miR-1825	CLIP-seq
MIRT1323448	hsa-miR-188-5p	CLIP-seq
MIRT1323449	hsa-miR-1910	CLIP-seq
MIRT1323450	hsa-miR-1913	CLIP-seq
MIRT1323451	hsa-miR-199a-5p	CLIP-seq
MIRT1323452	hsa-miR-199b-5p	CLIP-seq
MIRT1323453	hsa-miR-2116	CLIP-seq
MIRT1323454	hsa-miR-3151	CLIP-seq
MIRT1323455	hsa-miR-3153	CLIP-seq
MIRT1323456	hsa-miR-3173-5p	CLIP-seq
MIRT1323457	hsa-miR-324-3p	CLIP-seq
MIRT1323458	hsa-miR-339-5p	CLIP-seq
MIRT1323459	hsa-miR-3682-5p	CLIP-seq
MIRT1323460	hsa-miR-3909	CLIP-seq
MIRT1323461	hsa-miR-3919	CLIP-seq
MIRT1323462	hsa-miR-3922-5p	CLIP-seq
MIRT1323463	hsa-miR-3924	CLIP-seq
MIRT1323464	hsa-miR-3925-3p	CLIP-seq
MIRT1323465	hsa-miR-4268	CLIP-seq
MIRT1323466	hsa-miR-4302	CLIP-seq
MIRT1323467	hsa-miR-432	CLIP-seq
MIRT1323468	hsa-miR-4323	CLIP-seq
MIRT1323469	hsa-miR-4443	CLIP-seq
MIRT1323470	hsa-miR-4447	CLIP-seq
MIRT1323471	hsa-miR-4448	CLIP-seq
MIRT1323472	hsa-miR-4472	CLIP-seq
MIRT1323473	hsa-miR-450b-3p	CLIP-seq
MIRT1323474	hsa-miR-4671-5p	CLIP-seq
MIRT1323475	hsa-miR-4677-5p	CLIP-seq
MIRT1323476	hsa-miR-4691-5p	CLIP-seq
MIRT1323477	hsa-miR-4712-3p	CLIP-seq
MIRT1323478	hsa-miR-4717-5p	CLIP-seq
MIRT1323479	hsa-miR-4727-5p	CLIP-seq
MIRT1323480	hsa-miR-4753-5p	CLIP-seq
MIRT1323481	hsa-miR-4756-3p	CLIP-seq
MIRT1323482	hsa-miR-4764-5p	CLIP-seq
MIRT1323483	hsa-miR-4775	CLIP-seq
MIRT1323484	hsa-miR-4780	CLIP-seq
MIRT1323485	hsa-miR-486-5p	CLIP-seq
MIRT1323486	hsa-miR-488	CLIP-seq
MIRT1323487	hsa-miR-491-5p	CLIP-seq
MIRT1323488	hsa-miR-513a-5p	CLIP-seq
MIRT1323489	hsa-miR-623	CLIP-seq
MIRT1323490	hsa-miR-629	CLIP-seq
MIRT1323491	hsa-miR-659	CLIP-seq
MIRT1323492	hsa-miR-769-3p	CLIP-seq
MIRT1323493	hsa-miR-874	CLIP-seq
MIRT2096030	hsa-miR-101	CLIP-seq
MIRT2096031	hsa-miR-144	CLIP-seq
MIRT2096032	hsa-miR-2276	CLIP-seq
MIRT1323459	hsa-miR-3682-5p	CLIP-seq
MIRT2096033	hsa-miR-4747-5p	CLIP-seq
MIRT2096034	hsa-miR-627	CLIP-seq
MIRT2096035	hsa-miR-924	CLIP-seq
MIRT2096030	hsa-miR-101	CLIP-seq
MIRT2320319	hsa-miR-1226	CLIP-seq
MIRT2320320	hsa-miR-1256	CLIP-seq
MIRT2096031	hsa-miR-144	CLIP-seq
MIRT1323450	hsa-miR-1913	CLIP-seq
MIRT2320321	hsa-miR-1915	CLIP-seq
MIRT2320322	hsa-miR-197	CLIP-seq
MIRT2320323	hsa-miR-3127-5p	CLIP-seq
MIRT2320324	hsa-miR-3135b	CLIP-seq
MIRT2320325	hsa-miR-3150b-3p	CLIP-seq
MIRT1323455	hsa-miR-3153	CLIP-seq
MIRT1323457	hsa-miR-324-3p	CLIP-seq
MIRT2320326	hsa-miR-3652	CLIP-seq
MIRT1323459	hsa-miR-3682-5p	CLIP-seq
MIRT2320327	hsa-miR-3689a-3p	CLIP-seq
MIRT2320328	hsa-miR-3689c	CLIP-seq
MIRT2320329	hsa-miR-3918	CLIP-seq
MIRT2320330	hsa-miR-412	CLIP-seq
MIRT2320331	hsa-miR-4313	CLIP-seq
MIRT2320332	hsa-miR-4430	CLIP-seq
MIRT2320333	hsa-miR-4446-3p	CLIP-seq
MIRT2320334	hsa-miR-4453	CLIP-seq
MIRT2320335	hsa-miR-4476	CLIP-seq
MIRT2320336	hsa-miR-4492	CLIP-seq
MIRT2320337	hsa-miR-4493	CLIP-seq
MIRT2320338	hsa-miR-4498	CLIP-seq
MIRT2320339	hsa-miR-4538	CLIP-seq
MIRT2320340	hsa-miR-455-5p	CLIP-seq
MIRT2320341	hsa-miR-4646-5p	CLIP-seq
MIRT2320342	hsa-miR-4668-5p	CLIP-seq
MIRT2320343	hsa-miR-4685-5p	CLIP-seq
MIRT2320344	hsa-miR-4714-3p	CLIP-seq
MIRT2320345	hsa-miR-4720-5p	CLIP-seq
MIRT2320346	hsa-miR-4728-5p	CLIP-seq
MIRT2320347	hsa-miR-4763-5p	CLIP-seq
MIRT2320348	hsa-miR-4784	CLIP-seq
MIRT2320349	hsa-miR-4799-3p	CLIP-seq
MIRT2320350	hsa-miR-490-3p	CLIP-seq
MIRT2320351	hsa-miR-548k	CLIP-seq
MIRT2320352	hsa-miR-762	CLIP-seq
MIRT2320353	hsa-miR-765	CLIP-seq
MIRT1323450	hsa-miR-1913	CLIP-seq
MIRT2320321	hsa-miR-1915	CLIP-seq
MIRT1323457	hsa-miR-324-3p	CLIP-seq
MIRT2320343	hsa-miR-4685-5p	CLIP-seq
MIRT2320322	hsa-miR-197	CLIP-seq
MIRT2320330	hsa-miR-412	CLIP-seq

Show/Hide all (50)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000976	Function	Transcription cis-regulatory region binding	IEA
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA	12767074
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	12767074
GO:0001701	Process	In utero embryonic development	IEA
GO:0001893	Process	Maternal placenta development	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IEA
GO:0003707	Function	Nuclear steroid receptor activity	IEA
GO:0004879	Function	Nuclear receptor activity	IBA
GO:0004879	Function	Nuclear receptor activity	IDA	1662118, 7990953
GO:0005515	Function	Protein binding	IPI	16189514, 20195357, 20211142, 21988832, 25303530, 25416956, 25609649, 26871637, 28514442, 29892012, 31515488, 32296183, 33961781
GO:0005634	Component	Nucleus	IDA	7990953
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0007399	Process	Nervous system development	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0009755	Process	Hormone-mediated signaling pathway	ISS
GO:0009755	Process	Hormone-mediated signaling pathway	NAS	27011007
GO:0030154	Process	Cell differentiation	IBA
GO:0030501	Process	Positive regulation of bone mineralization	NAS	27184385
GO:0030518	Process	Nuclear receptor-mediated steroid hormone signaling pathway	IEA
GO:0031490	Function	Chromatin DNA binding	IEA
GO:0042789	Process	MRNA transcription by RNA polymerase II	ISS
GO:0042789	Process	MRNA transcription by RNA polymerase II	NAS	27011007
GO:0043565	Function	Sequence-specific DNA binding	IEA
GO:0044323	Function	Retinoic acid-responsive element binding	IBA
GO:0045893	Process	Positive regulation of DNA-templated transcription	IDA	1662118
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IBA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	12767074
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	ISS
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	NAS	27011007
GO:0046872	Function	Metal ion binding	IEA
GO:0048384	Process	Retinoic acid receptor signaling pathway	IBA
GO:0055012	Process	Ventricular cardiac muscle cell differentiation	IEA
GO:0060038	Process	Cardiac muscle cell proliferation	IEA
GO:0070564	Process	Positive regulation of vitamin D receptor signaling pathway	ISS
GO:0071300	Process	Cellular response to retinoic acid	IEA
GO:0090575	Component	RNA polymerase II transcription regulator complex	IBA
GO:0090575	Component	RNA polymerase II transcription regulator complex	IPI	25416956, 27011007
GO:0090575	Component	RNA polymerase II transcription regulator complex	ISS
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

MIM	HGNC	e!Ensembl
180246	10478	ENSG00000204231

P28702

Protein name

Retinoic acid receptor RXR-beta (Nuclear receptor subfamily 2 group B member 2) (Retinoid X receptor beta)

Protein function

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR

PDB

1H9U , 1UHL , 5HJP , 5I4V , 5KYA , 5KYJ , 7A78

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00105	zf-C4	203 → 272	Zinc finger, C4 type (two domains)	Domain
PF00104	Hormone_recep	331 → 513	Ligand-binding domain of nuclear hormone receptor	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in aortic endothelial cells (at protein level) (PubMed:28167758). Expressed in monocytes (PubMed:26463675). Expressed in a variety of tumor cell lines. {ECO:0000269|PubMed:26463675, ECO:0000269|PubMed:28167758, ECO:0000269|Pu

Sequence

MSWAARPPFLPQRHAAGQCGPVGVRKEMHCGVASRWRRRRPWLDPAAAAAAAVAGGEQQT
PEPEPGEAGRDGMGDSGRDSRSPDSSSPNPLPQGVPPPSPPGPPLPPSTAPSLGGSGAPP
PPPMPPPPLGSPFPVISSSMGSPGLPPPAPPGFSGPVSSPQINSTVSLPGGGSGPPEDVK
PPVLGVRGLHCPPPPGGPGAGKRLCAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYS
CRDNKDCTVDKRQRNRCQYCRYQKCLATGMKREAVQEERQRGKDKDGDGEGAGGAPEEMP
VDRILEAELAVEQKSDQGVEGPGGTGGSGSSPNDPVTNICQAADKQLFTLVEWAKRIPHF
SSLPLDDQVILLRAGWNELLIASFSHRSIDVRDGILLATGLHVHRNSAHSAGVGAIFDRV
LTELVSKMRDMRMDKTELGCLRAIILFNPDAKGLSNPSEVEVLREKVYASLETYCKQKYP
EQQGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQLA

Sequence length

533

Interactions

View interactions

Show/Hide Unknown Diseases (6)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Acute myeloid leukemia	Benign	rs186232872	RCV005936842
Cervical cancer	Benign	rs186232872	RCV005936843
Familial cancer of breast	Benign	rs186232872	RCV005936841
RXRB-related disorder	Benign; Likely benign	rs6531, rs186232872, rs61730281, rs2150679110, rs184921826, rs775312696, rs188577937, rs201700806, rs143154990	RCV003975833 RCV003906821 RCV003941788 RCV003917378 RCV003959145 RCV003932005 RCV003944636 RCV003983585 RCV003916033
Uterine corpus endometrial carcinoma	Benign	rs186232872	RCV005936845
Uveal melanoma	Benign	rs186232872	RCV005936844

Show/Hide Text Mining Associations (28)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma	Inhibit	12514092
Bile Duct Neoplasms	Associate	18375961
Breast Neoplasms	Associate	8384307
Carcinoma Basal Cell	Associate	12514092
Carcinoma Embryonal	Associate	1736309
Carcinoma Intraductal Noninfiltrating	Associate	11092983
Esophageal Squamous Cell Carcinoma	Associate	29098164
Eyelid Neoplasms	Associate	26503156
Gallstones	Associate	18375961
Granulomatosis with Polyangiitis	Associate	16526951, 19811264
Heart Diseases	Associate	29928977
Lung Neoplasms	Inhibit	19961602
Lymphoma Large B Cell Diffuse	Associate	21148756
Lymphoma Non Hodgkin	Associate	21148756
Melanoma	Associate	9228081
Mouth Neoplasms	Associate	24322297
Neoplasm Metastasis	Associate	24322297
Neoplasms	Associate	24322297
Neuroblastoma	Associate	11591367
Ossification of the posterior longitudinal ligament of the spine	Associate	10234570
Osteoarthritis	Associate	19217805
Ovarian Neoplasms	Associate	16012182
Pancreatic Neoplasms	Associate	29169171
Polycystic Kidney Autosomal Recessive	Associate	11092983
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	39465162
Prostatic Neoplasms	Associate	12514092
Sarcoidosis	Associate	16526951
Systemic Vasculitis	Associate	19811264

RXRB (retinoid X receptor beta)