Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
9252
Gene name Gene Name - the full gene name approved by the HGNC.
Ribosomal protein S6 kinase A5
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
RPS6KA5
Synonyms (NCBI Gene) Gene synonyms aliases
MSK1, MSPK1, RLPK
Chromosome Chromosome number
14
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
14q32.11
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT004504 hsa-miR-148a-3p qRT-PCR, Luciferase reporter assay, Western blot 20406806
MIRT004504 hsa-miR-148a-3p qRT-PCR, Luciferase reporter assay, Western blot 20406806
MIRT004504 hsa-miR-148a-3p qRT-PCR, Luciferase reporter assay, Western blot 20406806
MIRT022082 hsa-miR-128-3p Sequencing 20371350
MIRT004504 hsa-miR-148a-3p Reporter assay 20406806
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000287 Function Magnesium ion binding IEA
GO:0001818 Process Negative regulation of cytokine production TAS 18508628
GO:0002223 Process Stimulatory C-type lectin receptor signaling pathway TAS
GO:0004672 Function Protein kinase activity IDA 9873047
GO:0004674 Function Protein serine/threonine kinase activity IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
603607 10434 ENSG00000100784
Protein
UniProt ID O75582
Protein name Ribosomal protein S6 kinase alpha-5 (S6K-alpha-5) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 5) (Nuclear mitogen- and stress-activated protein kinase 1) (RSK-like protein kinase) (RSKL)
Protein function Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to
PDB 1VZO , 3KN5 , 3KN6 , 7UP4 , 7UP5 , 7UP6 , 7UP7 , 7UP8
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase 49 318 Protein kinase domain Domain
PF00433 Pkinase_C 339 377 Protein kinase C terminal domain Family
PF00069 Pkinase 427 687 Protein kinase domain Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed with high levels in heart, brain and placenta. Less abundant in lung, kidney and liver. {ECO:0000269|PubMed:9687510, ECO:0000269|PubMed:9873047}.
Sequence
MEEEGGSSGGAAGTSADGGDGGEQLLTVKHELRTANLTGHAEKVGIENFELLKVLGTGAY
GKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYA
FQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKL
ENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWS
LGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKK
RLGCGPRDADEIKEHLFF
QKINWDDLAAKKVPAPFKPVIRDELDVSNFAEEFTEMDPTYS
PAALPQSSEKLFQGYSF
VAPSILFKRNAAVIDPLQFHMGVERPGVTNVARSAMMKDSPFY
QHYDLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEGHPN
IVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGV
VHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYD
ESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEA
KDLIQGLLTVDPNKRLKMSGLRYNEWL
QDGSQLSSNPLMTPDILGSSGAAVHTCVKATFH
AFNKYKREGFCLQNVDKAPLAKRRKMKKTSTSTETRSSSSESSHSSSSHSHGKTTPTKTL
QPSNPADSNNPETLFQFSDSVA
Sequence length 802
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Multiple Sclerosis Multiple Sclerosis GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Associate 36829221
Arthritis Psoriatic Stimulate 16543895
Breast Neoplasms Associate 23292247, 23675462, 27390128, 29327245
Carcinogenesis Associate 25958199
Cell Transformation Viral Associate 20382163
Colonic Neoplasms Associate 34060286
Colorectal Neoplasms Associate 34060286
Death Associate 29327245
Ganglioglioma Associate 24374956
Hyperglycemia Stimulate 36930661