Gene Gene information from NCBI Gene database.
Entrez ID 6233
Gene name Ribosomal protein S27a
Gene symbol RPS27A
Synonyms (NCBI Gene)
CEP80HEL112S27AUBA80UBCUBCEP1UBCEP80eS31
Chromosome 2
Chromosome location 2p16.1
Summary Ubiquitin, a highly conserved protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome, is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin fused to an unrelated p
miRNA miRNA information provided by mirtarbase database.
850
miRTarBase ID miRNA Experiments Reference
MIRT050798 hsa-miR-17-5p CLASH 23622248
MIRT050094 hsa-miR-26a-5p CLASH 23622248
MIRT047980 hsa-miR-30c-5p CLASH 23622248
MIRT046242 hsa-miR-23b-3p CLASH 23622248
MIRT046153 hsa-miR-30b-5p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
49
GO ID Ontology Definition Evidence Reference
GO:0002181 Process Cytoplasmic translation IC 23636399
GO:0002181 Process Cytoplasmic translation NAS 25901680
GO:0003723 Function RNA binding HDA 22658674, 22681889
GO:0003735 Function Structural constituent of ribosome HDA 15883184
GO:0003735 Function Structural constituent of ribosome IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
191343 10417 ENSG00000143947
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P62979
Protein name Ubiquitin-ribosomal protein eS31 fusion protein (Ubiquitin carboxyl extension protein 80) [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31 (40S ribosomal protein S27a)]
Protein function [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys re
PDB 2KHW , 2KOX , 2KTF , 2KWU , 2KWV , 2L0F , 2L0T , 2XK5 , 3AXC , 3I3T , 3K9P , 3N30 , 3N32 , 3NHE , 3NOB , 3NS8 , 3PHD , 3PHW , 3TBL , 3VDZ , 4R62 , 4UG0 , 4V6X , 5A2Q , 5AJ0 , 5FLX , 5LKS , 5T2C , 5WVO , 5YDK , 6DC6 , 6FEC , 6G18 , 6G51 , 6G53 , 6G5H , 6G5I , 6IP5 , 6IP6 , 6IP8 , 6J99 , 6KFP , 6KG6 , 6KIU , 6KIV , 6KIW , 6OLE , 6OLF , 6OLG , 6OLI , 6OLZ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00240 ubiquitin 3 74 Ubiquitin family Domain
PF01599 Ribosomal_S27 102 147 Ribosomal protein S27a Domain
Sequence
Sequence length 156
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
4
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Familial cancer of breast Benign rs6545480 RCV005915903
Familial pancreatic carcinoma Benign rs118100576 RCV005905932
Hepatocellular carcinoma Benign rs118100576 RCV005905931
Uterine corpus endometrial carcinoma Uncertain significance rs369415573 RCV005930897
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 32673827
Alzheimer Disease Associate 34326892, 36195955, 36405716
Breast Neoplasms Associate 32444848
Carcinoma Hepatocellular Associate 22258406, 36378050
Colonic Diseases Associate 8541345
Colorectal Neoplasms Associate 8541345
Diabetic Nephropathies Associate 29532746
Diabetic Retinopathy Associate 35154512
Inflammation Associate 35154512
Leukemia Associate 26942564