RASIP1 (Ras interacting protein 1)

Gene Gene information from NCBI Gene database.
Gene SNPs Other IDs Associated diseases
Entrez ID 54922
Gene name Ras interacting protein 1
Gene symbol RASIP1
Synonyms (NCBI Gene)
RAIN
Chromosome 19
Chromosome location 19q13.33
miRNA miRNA information provided by mirtarbase database.
3
Gene SNPs Other IDs Associated diseases
Show/Hide all (3)
miRTarBase ID miRNA Experiments Reference
MIRT018491 hsa-miR-335-5p Microarray 18185580
MIRT022870 hsa-miR-124-3p Microarray 18668037
MIRT029847 hsa-miR-26b-5p Microarray 19088304
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
26
Gene SNPs Other IDs Associated diseases
Show/Hide all (26)
GO ID Ontology Definition Evidence Reference
GO:0001525 Process Angiogenesis IBA
GO:0001525 Process Angiogenesis IEA
GO:0001525 Process Angiogenesis ISS
GO:0001570 Process Vasculogenesis IEA
GO:0001570 Process Vasculogenesis ISS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene SNPs Other IDs Associated diseases
MIM HGNC e!Ensembl
609623 24716 ENSG00000105538
Protein Protein information from UniProt database.
Gene SNPs Other IDs Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q5U651
Protein name Ras-interacting protein 1 (Rain)
Protein function Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endot
PDB 5KHO , 5KHQ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00788 RA 144 → 259 Ras association (RalGDS/AF-6) domain Domain
PF01843 DIL 770 → 877 DIL domain Family
Tissue specificity TISSUE SPECIFICITY: Highly expressed in heart. Detected at lower levels in placenta and pancreas. {ECO:0000269|PubMed:15031288}.
Sequence 
MLSGERKEGGSPRFGKLHLPVGLWINSPRKQLAKLGRRWPSAASVKSSSSDTGSRSSEPL
PPPPPHVELRRVGAVKAAGGASGSRAKRISQLFRGSGTGTTGSSGAGGPGTPGGAQRWAS
EKKLPELAAGVAPEPPLATRATAPPGVLKIFGAGLASGANYKSVLATARSTARELVAEAL
ERYGLAGSPGGGPGESSCVDAFALCDALGRPAAAGVGSGEWRAEHLRVLGDSERPLLVQE
LWRARPGWARRFELRGREEARRLEQEAFGAADSEGTGAPSWRPQKNRSRAASGGAALASP
GPGTGSGAPAGSGGKERSENLSLRRSVSELSLQGRRRRQQERRQQALSMAPGAADAQIGT
ADPGDFDQLTQCLIQAPSNRPYFLLLQGYQDAQDFVVYVMTREQHVFGRGGNSSGRGGSP
APYVDTFLNAPDILPRHCTVRAGPEHPAMVRPSRGAPVTHNGCLLLREAELHPGDLLGLG
EHFLFMYKDPRTGGSGPARPPWLPARPGATPPGPGWAFSCRLCGRGLQERGEALAAYLDG
REPVLRFRPREEEALLGEIVRAAAAGSGDLPPLGPATLLALCVQHSARELELGHLPRLLG
RLARLIKEAVWEKIKEIGDRQPENHPEGVPEVPLTPEAVSVELRPLMLWMANTTELLSFV
QEKVLEMEKEADQEDPQLCNDLELCDEAMALLDEVIMCTFQQSVYYLTKTLYSTLPALLD
SNPFTAGAELPGPGAELGAMPPGLRPTLGVFQAALELTSQCELHPDLVSQTFGYLFFFSN
ASLLNSLMERGQGRPFYQWSRAVQIRTNLDLVLDWLQGAGLGDIATEFFRKLSMAVNLLC
VPRTSLLKASWSSLRTDHPTLTPAQLHHLLSHYQLGPGRGPPAAWDPPPAEREAVDTGDI
FESFSSHPPLILPLGSSRLRLTGPVTDDALHRELRRLRRLLWDLEQQELPANYRHGPPVA
TSP
Sequence length 963
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
2
Gene SNPs Other IDs Associated diseases
Show/Hide Unknown Diseases (1)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
RASIP1-related disorder Likely benign rs34800326, rs144734317 RCV003927334
RCV003936947
Show/Hide Text Mining Associations (11)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 26356813
Breast Neoplasms Stimulate 31624086
Cardiovascular Diseases Associate 21060863
Cerebral Infarction Associate 24846872
COVID 19 Associate 37662924
Floating harbor syndrome Associate 27934915
Lung Neoplasms Associate 36967521
Lymphoma Large B Cell Diffuse Associate 36967521
Neoplasms Associate 31624086, 36967521
Squamous Cell Carcinoma of Head and Neck Associate 24675808