Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs Other IDs
Entrez ID	11069
Gene name	Rap guanine nucleotide exchange factor 4
Gene symbol	RAPGEF4
Synonyms (NCBI Gene)	CAMP-GEFIICGEF2EPACEPAC 2EPAC2Nbla00496
Chromosome	2
Chromosome location	2q31.1

Show/Hide all (52)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018141	hsa-miR-335-5p	Microarray	18185580
MIRT027613	hsa-miR-98-5p	Microarray	19088304
MIRT029706	hsa-miR-26b-5p	Microarray	19088304
MIRT156411	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT156404	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT156411	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT156401	hsa-miR-17-5p	HITS-CLIP	22473208
MIRT156417	hsa-miR-20b-5p	HITS-CLIP	22473208
MIRT156406	hsa-miR-93-5p	HITS-CLIP	22473208
MIRT156424	hsa-miR-519d-3p	HITS-CLIP	22473208
MIRT156402	hsa-miR-19a-3p	HITS-CLIP	22473208
MIRT156403	hsa-miR-19b-3p	HITS-CLIP	22473208
MIRT156404	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT1290845	hsa-miR-106a	CLIP-seq
MIRT1290846	hsa-miR-106b	CLIP-seq
MIRT1290847	hsa-miR-130a	CLIP-seq
MIRT1290848	hsa-miR-130b	CLIP-seq
MIRT1290849	hsa-miR-17	CLIP-seq
MIRT1290850	hsa-miR-19a	CLIP-seq
MIRT1290851	hsa-miR-19b	CLIP-seq
MIRT1290852	hsa-miR-20a	CLIP-seq
MIRT1290853	hsa-miR-20b	CLIP-seq
MIRT1290854	hsa-miR-301a	CLIP-seq
MIRT1290855	hsa-miR-301b	CLIP-seq
MIRT1290856	hsa-miR-3666	CLIP-seq
MIRT1290857	hsa-miR-4295	CLIP-seq
MIRT1290858	hsa-miR-454	CLIP-seq
MIRT1290859	hsa-miR-488	CLIP-seq
MIRT1290860	hsa-miR-519a	CLIP-seq
MIRT1290861	hsa-miR-519b-3p	CLIP-seq
MIRT1290862	hsa-miR-519c-3p	CLIP-seq
MIRT1290863	hsa-miR-519d	CLIP-seq
MIRT1290864	hsa-miR-93	CLIP-seq
MIRT2086496	hsa-miR-1265	CLIP-seq
MIRT2086497	hsa-miR-1266	CLIP-seq
MIRT2086498	hsa-miR-1273e	CLIP-seq
MIRT2086499	hsa-miR-129-5p	CLIP-seq
MIRT2086500	hsa-miR-3664-3p	CLIP-seq
MIRT2086501	hsa-miR-4518	CLIP-seq
MIRT2086502	hsa-miR-4764-5p	CLIP-seq
MIRT2086496	hsa-miR-1265	CLIP-seq
MIRT2086497	hsa-miR-1266	CLIP-seq
MIRT2086498	hsa-miR-1273e	CLIP-seq
MIRT2086499	hsa-miR-129-5p	CLIP-seq
MIRT2086500	hsa-miR-3664-3p	CLIP-seq
MIRT2086501	hsa-miR-4518	CLIP-seq
MIRT2086502	hsa-miR-4764-5p	CLIP-seq
MIRT2607976	hsa-miR-3681	CLIP-seq
MIRT2607977	hsa-miR-3924	CLIP-seq
MIRT2607978	hsa-miR-410	CLIP-seq
MIRT2607979	hsa-miR-4460	CLIP-seq
MIRT2607980	hsa-miR-4727-3p	CLIP-seq

Show/Hide all (38)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0002250	Process	Adaptive immune response	IEA
GO:0002250	Process	Adaptive immune response	TAS
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	EXP	15334074, 16076873
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IBA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IEA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	ISS
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	TAS	9856955
GO:0005515	Function	Protein binding	IPI	11438518, 24722188, 25416956, 32296183, 32814053
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	TAS
GO:0006887	Process	Exocytosis	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS	9856955
GO:0007188	Process	Adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IEA
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IEA
GO:0007264	Process	Small GTPase-mediated signal transduction	IEA
GO:0007265	Process	Ras protein signal transduction	IBA
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	10777494
GO:0017156	Process	Calcium-ion regulated exocytosis	IEA
GO:0017157	Process	Regulation of exocytosis	IEA
GO:0030073	Process	Insulin secretion	IEA
GO:0030552	Function	CAMP binding	IEA
GO:0030552	Function	CAMP binding	ISS
GO:0030552	Function	CAMP binding	TAS
GO:0030674	Function	Protein-macromolecule adaptor activity	IEA
GO:0031267	Function	Small GTPase binding	IEA
GO:0031267	Function	Small GTPase binding	ISS
GO:0032024	Process	Positive regulation of insulin secretion	IEA
GO:0035556	Process	Intracellular signal transduction	IEA
GO:0046879	Process	Hormone secretion	IEA
GO:0050796	Process	Regulation of insulin secretion	IEA
GO:0050796	Process	Regulation of insulin secretion	TAS
GO:0098686	Component	Hippocampal mossy fiber to CA3 synapse	IEA
GO:0098693	Process	Regulation of synaptic vesicle cycle	IEA

MIM	HGNC	e!Ensembl
606058	16626	ENSG00000091428

Q8WZA2

Protein name

Rap guanine nucleotide exchange factor 4 (Exchange factor directly activated by cAMP 2) (Exchange protein directly activated by cAMP 2) (EPAC 2) (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII)

Protein function

Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2 (By similarit

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00027	cNMP_binding	61 → 150	Cyclic nucleotide-binding domain	Domain
PF00610	DEP	220 → 289	Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)	Domain
PF00027	cNMP_binding	375 → 459	Cyclic nucleotide-binding domain	Domain
PF00618	RasGEF_N	499 → 605	RasGEF N-terminal motif	Domain
PF00617	RasGEF	775 → 952	RasGEF domain	Family

Tissue specificity

TISSUE SPECIFICITY: Predominantly expressed in brain and adrenal gland. Isoform 2 is expressed in liver. Isoform 1 is expressed in liver at very low levels.

Sequence

MVAAHAAHSSSSAEWIACLDKRPLERSSEDVDIIFTRLKEVKAFEKFHPNLLHQICLCGY
YENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGESILDN
TPRHATIVTRESSELLRIEQKDFKALWEKYRQYMAGLLAPPYGVMETGSNNDRIPDKENT
PLIEPHVPLRPANTITKVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTE
LVDWMMQQTPCVHSRTQAVGMWQVLLEDGVLNHVDQEHHFQDKYLFYRFLDDEHEDAPLP
TEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHL
STTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDD
FGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKV
PAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHCVF
MPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMA
FLEEFYVSVSDDARMIAALKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQK
RQPIRGSDEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSGEGLIIVKMSSGGEK
VVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQM
TIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKR
VQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLM
DPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTART
VRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP

Sequence length

1011

Interactions

View interactions

RAPGEF4 (Rap guanine nucleotide exchange factor 4)