Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs Other IDs Associated diseases
Entrez ID	5797
Gene name	Protein tyrosine phosphatase receptor type M
Gene symbol	PTPRM
Synonyms (NCBI Gene)	PTPRL1R-PTP-MURPTPMRPTPUhR-PTPu
Chromosome	18
Chromosome location	18p11.23
Summary	The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic tran

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miRTarBase ID	miRNA	Experiments	Reference
MIRT018602	hsa-miR-335-5p	Microarray	18185580
MIRT054104	hsa-miR-205-5p	ImmunohistochemistryLuciferase reporter assayMicroarrayQRTPCR	23497265
MIRT654619	hsa-miR-1264	HITS-CLIP	23824327
MIRT654618	hsa-miR-4461	HITS-CLIP	23824327
MIRT654617	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT654615	hsa-miR-1253	HITS-CLIP	23824327
MIRT654614	hsa-miR-6770-5p	HITS-CLIP	23824327
MIRT654613	hsa-miR-452-3p	HITS-CLIP	23824327
MIRT654612	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT654611	hsa-miR-580-3p	HITS-CLIP	23824327
MIRT654610	hsa-miR-450b-5p	HITS-CLIP	23824327
MIRT654609	hsa-miR-507	HITS-CLIP	23824327
MIRT654608	hsa-miR-557	HITS-CLIP	23824327
MIRT654619	hsa-miR-1264	HITS-CLIP	23824327
MIRT654618	hsa-miR-4461	HITS-CLIP	23824327
MIRT654616	hsa-miR-1279	HITS-CLIP	23824327
MIRT654617	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT654615	hsa-miR-1253	HITS-CLIP	23824327
MIRT654614	hsa-miR-6770-5p	HITS-CLIP	23824327
MIRT654613	hsa-miR-452-3p	HITS-CLIP	23824327
MIRT654612	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT654611	hsa-miR-580-3p	HITS-CLIP	23824327
MIRT654610	hsa-miR-450b-5p	HITS-CLIP	23824327
MIRT654609	hsa-miR-507	HITS-CLIP	23824327
MIRT654608	hsa-miR-557	HITS-CLIP	23824327
MIRT654607	hsa-miR-3680-3p	HITS-CLIP	23824327
MIRT654619	hsa-miR-1264	HITS-CLIP	23824327
MIRT654618	hsa-miR-4461	HITS-CLIP	23824327
MIRT654617	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT654615	hsa-miR-1253	HITS-CLIP	23824327
MIRT654614	hsa-miR-6770-5p	HITS-CLIP	23824327
MIRT654613	hsa-miR-452-3p	HITS-CLIP	23824327
MIRT654612	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT654611	hsa-miR-580-3p	HITS-CLIP	23824327
MIRT654610	hsa-miR-450b-5p	HITS-CLIP	23824327
MIRT654609	hsa-miR-507	HITS-CLIP	23824327
MIRT654608	hsa-miR-557	HITS-CLIP	23824327
MIRT654619	hsa-miR-1264	HITS-CLIP	23824327
MIRT654618	hsa-miR-4461	HITS-CLIP	23824327
MIRT654616	hsa-miR-1279	HITS-CLIP	23824327
MIRT654617	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT654615	hsa-miR-1253	HITS-CLIP	23824327
MIRT654614	hsa-miR-6770-5p	HITS-CLIP	23824327
MIRT654613	hsa-miR-452-3p	HITS-CLIP	23824327
MIRT654612	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT654611	hsa-miR-580-3p	HITS-CLIP	23824327
MIRT654610	hsa-miR-450b-5p	HITS-CLIP	23824327
MIRT654609	hsa-miR-507	HITS-CLIP	23824327
MIRT654608	hsa-miR-557	HITS-CLIP	23824327
MIRT654607	hsa-miR-3680-3p	HITS-CLIP	23824327
MIRT2081294	hsa-miR-103a	CLIP-seq
MIRT2081295	hsa-miR-107	CLIP-seq
MIRT2081296	hsa-miR-15a	CLIP-seq
MIRT2081297	hsa-miR-15b	CLIP-seq
MIRT2081298	hsa-miR-16	CLIP-seq
MIRT2081299	hsa-miR-195	CLIP-seq
MIRT2081300	hsa-miR-424	CLIP-seq
MIRT2081301	hsa-miR-4310	CLIP-seq
MIRT2081302	hsa-miR-497	CLIP-seq
MIRT2604709	hsa-miR-1206	CLIP-seq
MIRT2604710	hsa-miR-221	CLIP-seq
MIRT2604711	hsa-miR-222	CLIP-seq
MIRT2604712	hsa-miR-365	CLIP-seq
MIRT2604713	hsa-miR-3690	CLIP-seq
MIRT2604714	hsa-miR-375	CLIP-seq
MIRT2604715	hsa-miR-3941	CLIP-seq
MIRT2604716	hsa-miR-3978	CLIP-seq
MIRT2604717	hsa-miR-4254	CLIP-seq
MIRT2604718	hsa-miR-4540	CLIP-seq
MIRT2604719	hsa-miR-4643	CLIP-seq
MIRT2604720	hsa-miR-466	CLIP-seq
MIRT2604721	hsa-miR-4672	CLIP-seq
MIRT2604722	hsa-miR-4729	CLIP-seq
MIRT2604723	hsa-miR-4789-3p	CLIP-seq
MIRT2604724	hsa-miR-485-3p	CLIP-seq
MIRT2604725	hsa-miR-491-3p	CLIP-seq
MIRT2604726	hsa-miR-548a-5p	CLIP-seq
MIRT2604727	hsa-miR-548ab	CLIP-seq
MIRT2604728	hsa-miR-548ak	CLIP-seq
MIRT2604729	hsa-miR-548b-5p	CLIP-seq
MIRT2604730	hsa-miR-548c-5p	CLIP-seq
MIRT2604731	hsa-miR-548d-5p	CLIP-seq
MIRT2604732	hsa-miR-548h	CLIP-seq
MIRT2604733	hsa-miR-548i	CLIP-seq
MIRT2604734	hsa-miR-548j	CLIP-seq
MIRT2604735	hsa-miR-548k	CLIP-seq
MIRT2604736	hsa-miR-548l	CLIP-seq
MIRT2604737	hsa-miR-548w	CLIP-seq
MIRT2604738	hsa-miR-548y	CLIP-seq
MIRT2604739	hsa-miR-556-3p	CLIP-seq
MIRT2604740	hsa-miR-559	CLIP-seq
MIRT2604741	hsa-miR-656	CLIP-seq
MIRT2604742	hsa-miR-875-3p	CLIP-seq
MIRT2604709	hsa-miR-1206	CLIP-seq
MIRT2604713	hsa-miR-3690	CLIP-seq
MIRT2604714	hsa-miR-375	CLIP-seq
MIRT2604715	hsa-miR-3941	CLIP-seq
MIRT2604717	hsa-miR-4254	CLIP-seq
MIRT2604718	hsa-miR-4540	CLIP-seq
MIRT2604719	hsa-miR-4643	CLIP-seq
MIRT2604720	hsa-miR-466	CLIP-seq
MIRT2604721	hsa-miR-4672	CLIP-seq
MIRT2604722	hsa-miR-4729	CLIP-seq
MIRT2604723	hsa-miR-4789-3p	CLIP-seq
MIRT2604724	hsa-miR-485-3p	CLIP-seq
MIRT2604742	hsa-miR-875-3p	CLIP-seq

Show/Hide all (40)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001937	Process	Negative regulation of endothelial cell proliferation	IMP	18566238
GO:0004721	Function	Phosphoprotein phosphatase activity	IEA
GO:0004725	Function	Protein tyrosine phosphatase activity	IBA
GO:0004725	Function	Protein tyrosine phosphatase activity	IDA	8393854, 17965016, 18566238
GO:0004725	Function	Protein tyrosine phosphatase activity	IEA
GO:0005001	Function	Transmembrane receptor protein tyrosine phosphatase activity	IDA	10809770
GO:0005001	Function	Transmembrane receptor protein tyrosine phosphatase activity	IEA
GO:0005515	Function	Protein binding	IPI	9531566, 11278757, 16380380
GO:0005737	Component	Cytoplasm	IDA	16380380
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	NAS	1655529
GO:0005911	Component	Cell-cell junction	IDA	10753936
GO:0005911	Component	Cell-cell junction	IDA	15491993, 16380380
GO:0005912	Component	Adherens junction	IDA	17965016
GO:0007155	Process	Cell adhesion	IEA
GO:0007156	Process	Homophilic cell adhesion via plasma membrane adhesion molecules	IDA	8393854
GO:0007156	Process	Homophilic cell adhesion via plasma membrane adhesion molecules	IEA
GO:0007165	Process	Signal transduction	IBA
GO:0007165	Process	Signal transduction	IDA	15080886
GO:0009410	Process	Response to xenobiotic stimulus	IDA	18566238
GO:0010596	Process	Negative regulation of endothelial cell migration	IMP	18566238
GO:0010828	Process	Positive regulation of D-glucose transmembrane transport	IDA	10753936
GO:0010829	Process	Negative regulation of D-glucose transmembrane transport	IDA	21998202
GO:0010842	Process	Retina layer formation	IMP	14623235
GO:0016020	Component	Membrane	IEA
GO:0016525	Process	Negative regulation of angiogenesis	IMP	18566238
GO:0016787	Function	Hydrolase activity	IEA
GO:0016791	Function	Phosphatase activity	IDA	10753936
GO:0030027	Component	Lamellipodium	IDA	15706045
GO:0030336	Process	Negative regulation of cell migration	IEA
GO:0031175	Process	Neuron projection development	IBA
GO:0031175	Process	Neuron projection development	IDA	16380380
GO:0031175	Process	Neuron projection development	IMP	17276081
GO:0031290	Process	Retinal ganglion cell axon guidance	IDA	15080886
GO:0042802	Function	Identical protein binding	IPI	10809770
GO:0045296	Function	Cadherin binding	IDA	9531566
GO:0045296	Function	Cadherin binding	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	15491993
GO:1904659	Process	D-glucose transmembrane transport	TAS	12556481

MIM	HGNC	e!Ensembl
176888	9675	ENSG00000173482

P28827

Protein name

Receptor-type tyrosine-protein phosphatase mu (Protein-tyrosine phosphatase mu) (R-PTP-mu) (EC 3.1.3.48)

Protein function

Receptor protein-tyrosine phosphatase that mediates homotypic cell-cell interactions and plays a role in adipogenic differentiation via modulation of p120 catenin/CTNND1 phosphorylation (PubMed:10753936, PubMed:17761881). Promotes CTNND1 dephosp

PDB

1RPM , 2C9A , 2V5Y , 8A16 , 8A17

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00629	MAM	27 → 183	MAM domain, meprin/A5/mu	Domain
PF00047	ig	189 → 274	Immunoglobulin domain	Domain
PF00041	fn3	283 → 366	Fibronectin type III domain	Domain
PF00041	fn3	488 → 575	Fibronectin type III domain	Domain
PF18861	PTP_tm	611 → 768	Transmembrane domain of protein tyrosine phosphatase, receptor type J	Family
PF00102	Y_phosphatase	923 → 1153	Protein-tyrosine phosphatase	Domain
PF00102	Y_phosphatase	1213 → 1447	Protein-tyrosine phosphatase	Domain

Sequence

MRGLGTCLATLAGLLLTAAGETFSGGCLFDEPYSTCGYSQSEGDDFNWEQVNTLTKPTSD
PWMPSGSFMLVNASGRPEGQRAHLLLPQLKENDTHCIDFHYFVSSKSNSPPGLLNVYVKV
NNGPLGNPIWNISGDPTRTWNRAELAISTFWPNFYQVIFEVITSGHQGYLAIDEVKVLGH
PCTRTPHFLRIQNVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRR
FIASFNVVNTTKRDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWI
QLNANSINGDGPIVAREVEYCTASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGE
GGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYC
YQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDED
LPGAVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVS
KLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQT
DNTVTVMLKPAHSRGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYY
FAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQVA
TKGAATPKPVPEPEKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKETMSST
RQEMTVMVNSMDKSYAEQGTNCDEAFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSVPNSY
YPDETHTMASDTSSLVQSHTYKKREPADVPYQTGQLHPAIRVADLLQHITQMKCAEGYGF
KEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYID
GYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEIYK
DIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQV
KSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQT
EEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLNMVTPTL
RVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGESSNYINAALMDSYKQPSAFIVT
QHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQLCPQYWPENGVHRHGPIQVEFVSADLE
EDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNG
GEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKF
CYEVALEYLNSG

Sequence length

1452

Interactions

View interactions

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Familial cancer of breast	Likely benign	rs147989230	RCV005933497
PTPRM-related disorder	Likely benign; Benign	rs375393712, rs34831755, rs61737158, rs593950, rs594742, rs202017391, rs113690903, rs2230601, rs147695315, rs752156618, rs143759203, rs3744983, rs78499397, rs755740975, rs142773706 View all (16 more)	RCV003909505 RCV003929703 RCV003904117 RCV003979677 RCV003979861 RCV003912114 RCV003977219 RCV003984508 RCV003933896 RCV003943955 RCV003963914 RCV003962105 RCV003941695 RCV003947129 RCV003969332 RCV003969339 RCV003922038 RCV003931928 RCV003932081 RCV003932192 RCV003936896 RCV003954639 RCV003979006 RCV003979139 RCV003982186 RCV003959431 RCV003969786 RCV003925968 RCV003915949 RCV003916257 RCV003902980
Thymoma	Benign	rs147695315	RCV005933148
Thyroid cancer, nonmedullary, 1	Benign	rs147695315	RCV005933149

Show/Hide Text Mining Associations (21)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma	Associate	26683690
Astrocytoma	Associate	27586084
Breast Neoplasms	Inhibit	23185569
Carcinogenesis	Associate	22968929, 25910225
Carcinoma Ovarian Epithelial	Inhibit	37403117
Colonic Neoplasms	Inhibit	25910225
Colorectal Neoplasms	Associate	22968929, 25910225
Glioblastoma	Associate	27586084, 34225581
Leukemia Myeloid Acute	Associate	27784745
Lupus Erythematosus Systemic	Associate	30685201
Lymphatic Metastasis	Stimulate	32826853
Medulloblastoma	Associate	32056145
Neoplasms	Associate	23185569, 32826853, 37403117
Neoplasms	Inhibit	25910225, 34397405
Oral Submucous Fibrosis	Associate	36966276
Ovarian Neoplasms	Inhibit	37403117
Pancreatic Intraductal Neoplasms	Associate	22355676
Polyposis Syndrome Hereditary Mixed 1	Associate	25910225
Sex Chromosome Aberrations	Associate	28771244
Squamous Cell Carcinoma of Head and Neck	Associate	36966276
Uterine Cervical Neoplasms	Stimulate	32826853

PTPRM (protein tyrosine phosphatase receptor type M)