Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5795
Gene name Gene Name - the full gene name approved by the HGNC.
Protein tyrosine phosphatase receptor type J
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PTPRJ
Synonyms (NCBI Gene) Gene synonyms aliases
CD148, DEP1, HPTP eta, HPTPeta, R-PTP-ETA, R-PTP-J, SCC1, THC10
Disease Acronyms (UniProt) Disease acronyms from UniProt database
THC10
Chromosome Chromosome number
11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
11p11.2
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic tra
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs1566734 A>C Pathogenic Missense variant, coding sequence variant, non coding transcript variant
rs121434507 C>T Pathogenic Coding sequence variant, non coding transcript variant, missense variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT001514 hsa-miR-155-5p pSILAC 18668040
MIRT006477 hsa-miR-328-3p qRT-PCR, Western blot 22564856
MIRT006477 hsa-miR-328-3p qRT-PCR, Western blot 22564856
MIRT006477 hsa-miR-328-3p qRT-PCR, Western blot 22564856
MIRT006477 hsa-miR-328-3p qRT-PCR, Western blot 22564856
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001772 Component Immunological synapse IDA 12913111
GO:0004725 Function Protein tyrosine phosphatase activity IBA 21873635
GO:0004725 Function Protein tyrosine phosphatase activity IDA 9531590, 10821867, 12913111, 18348712, 18936167, 19332538
GO:0004725 Function Protein tyrosine phosphatase activity IMP 9780142, 12475979
GO:0004725 Function Protein tyrosine phosphatase activity TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
600925 9673 ENSG00000149177
Protein
UniProt ID Q12913
Protein name Receptor-type tyrosine-protein phosphatase eta (Protein-tyrosine phosphatase eta) (R-PTP-eta) (EC 3.1.3.48) (Density-enhanced phosphatase 1) (DEP-1) (HPTP eta) (Protein-tyrosine phosphatase receptor type J) (R-PTP-J) (CD antigen CD148)
Protein function Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2 (PubMed:10821867, PubMed:12062403, PubMed:12370829, PubMed:1247597
PDB 2CFV , 2DLE , 2NZ6 , 7U01 , 7U08
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00041 fn3 120 199 Fibronectin type III domain Domain
PF00041 fn3 368 445 Fibronectin type III domain Domain
PF18861 PTP_tm 835 1000 Transmembrane domain of protein tyrosine phosphatase, receptor type J Family
PF00102 Y_phosphatase 1065 1297 Protein-tyrosine phosphatase Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in the promyelocytic cell line HL-60, the granulocyte-macrophage colony-stimulating factor-dependent leukemic cell line F-36P, and the IL3 and erythropoietin-dependent leukemic cell line F-36E. Expressed predominantly in epit
Sequence
MKPAAREARLPPRSPGLRWALPLLLLLLRLGQILCAGGTPSPIPDPSVATVATGENGITQ
ISSTAESFHKQNGTGTPQVETNTSEDGESSGANDSLRTPEQGSNGTDGASQKTPSSTGPS
PVFDIKAVSISPTNVILTWKSNDTAASEYKYVVKHKMENEKTITVVHQPWCNITGLRPAT
SYVFSITPGIGNETWGDPR
VIKVITEPIPVSDLRVALTGVRKAALSWSNGNGTASCRVLL
ESIGSHEELTQDSRLQVNISGLKPGVQYNINPYLLQSNKTKGDPLGTEGGLDASNTERSR
AGSPTAPVHDESLVGPVDPSSGQQSRDTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAI
EFRTNAIQVFDVTAVNISATSLTLIWKVSDNESSSNYTYKIHVAGETDSSNLNVSEPRAV
IPGLRSSTFYNITVCPVLGDIEGTP
GFLQVHTPPVPVSDFRVTVVSTTEIGLAWSSHDAE
SFQMHITQEGAGNSRVEITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRTVP
SAVFDIHVVYVTTTEMWLDWKSPDGASEYVYHLVIESKHGSNHTSTYDKAITLQGLIPGT
LYNITISPEVDHVWGDPNSTAQYTRPSNVSNIDVSTNTTAATLSWQNFDDASPTYSYCLL
IEKAGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQVGDGIKSLEPGRKSFCTDPA
SMASFDCEVVPKEPALVLKWTCPPGANAGFELEVSSGAWNNATHLESCSSENGTEYRTEV
TYLNFSTSYNISITTVSCGKMAAPTRNTCTTGITDPPPPDGSPNITSVSHNSVKVKFSGF
EASHGPIKAYAVILTTGEAGHPSADVLKYTYEDFKKGASDTYVTYLIRTEEKGRSQSLSE
VLKYEIDVGNESTTLGYYNGKLEPLGSYRACVAGFTNITFHPQNKGLIDGAESYVSFSRY
SDAVSLPQDPGVICGAVFGCIFGALVIVTVGGFIFWRKKR
KDAKNNEVSFSQIKPKKSKL
IRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDIS
RVKLSVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTK
CVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHF
TSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIE
NENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLD
IVRSQKDSKVDLIYQNTTAMTIY
ENLAPVTTFGKTNGYIA
Sequence length 1337
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Colorectal Cancer colorectal cancer, hereditary nonpolyposis colon cancer In summary, our data strongly demonstrated that upregulation of GRB7 conferred MEKi resistance in CRC cells with KRAS mutations by mediating RTK signaling through the recruitment of PLK1. GenCC, CBGDA
Thrombocytopenia thrombocytopenia 10 GenCC
Hypertension Hypertension GWAS
Neuroticism Neuroticism GWAS
Associations from Text Mining
Disease Name Relationship Type References
Asthma Associate 39380119
Breast Neoplasms Associate 12475979, 9115287
Cachexia Associate 27879288
Carcinogenesis Associate 20823296, 22076464
Carcinoma Renal Cell Associate 23007793
Carcinoma Squamous Cell Associate 34791835
Carcinoma Squamous Cell Inhibit 35791609
Colorectal Neoplasms Associate 16258161, 24338422, 28031238
Esophageal Neoplasms Inhibit 26694178
Esophageal Squamous Cell Carcinoma Associate 26694178, 36578050