Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5792
Gene name Gene Name - the full gene name approved by the HGNC.
Protein tyrosine phosphatase receptor type F
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PTPRF
Synonyms (NCBI Gene) Gene synonyms aliases
BNAH2, LAR
Disease Acronyms (UniProt) Disease acronyms from UniProt database
BNAH2
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p34.2
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic tran
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs1131692054 TG>- Pathogenic Intron variant, coding sequence variant, frameshift variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT001340 hsa-miR-1-3p pSILAC 18668040
MIRT001340 hsa-miR-1-3p Proteomics;Other 18668040
MIRT035527 hsa-miR-24-3p Luciferase reporter assay 23418360
MIRT035527 hsa-miR-24-3p Luciferase reporter assay 23418360
MIRT046964 hsa-miR-221-3p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004725 Function Protein tyrosine phosphatase activity IBA 21873635
GO:0004725 Function Protein tyrosine phosphatase activity IDA 10338209
GO:0004725 Function Protein tyrosine phosphatase activity IMP 23358419
GO:0005001 Function Transmembrane receptor protein tyrosine phosphatase activity TAS 8995282
GO:0005886 Component Plasma membrane TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
179590 9670 ENSG00000142949
Protein
UniProt ID P10586
Protein name Receptor-type tyrosine-protein phosphatase F (EC 3.1.3.48) (Leukocyte common antigen related) (LAR)
Protein function Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity.; The first PTPase domain has enzymatic activity, while the second one seems t
PDB 1LAR , 2DJU , 2DN7 , 2EDX , 2EDY , 2YD5 , 2YD8 , 4N5U , 6KR4 , 6TPT , 6TPU , 6TPV , 6TPW
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07679 I-set 33 124 Immunoglobulin I-set domain Domain
PF07679 I-set 135 225 Immunoglobulin I-set domain Domain
PF07679 I-set 232 315 Immunoglobulin I-set domain Domain
PF00041 fn3 320 401 Fibronectin type III domain Domain
PF00041 fn3 415 500 Fibronectin type III domain Domain
PF00041 fn3 513 594 Fibronectin type III domain Domain
PF00041 fn3 608 696 Fibronectin type III domain Domain
PF00041 fn3 710 809 Fibronectin type III domain Domain
PF00041 fn3 823 903 Fibronectin type III domain Domain
PF00041 fn3 917 1000 Fibronectin type III domain Domain
PF00102 Y_phosphatase 1375 1606 Protein-tyrosine phosphatase Domain
PF00102 Y_phosphatase 1664 1897 Protein-tyrosine phosphatase Domain
Sequence
MAPEPAPGRTMVPLVPALVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEP
KPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSA
KLSV
LEEEQLPPGFPSIDMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPATS
NGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYV
RVRRVAPRFSIPPSS
QEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVA
ISSLGMIEATAQVTV
KALPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTE
GPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPS
EAVRARTGEQAPSSPPRRV
QARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLP
GITYSLRVLAFTAVGDGPPS
PTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPPQERI
IMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFT
PTIEAR
TAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVD
GISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPES
SPVLVRTDEDVPSGPPRKVEVEPL
NSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEESEDY
ETTISGLTPETTYSVTVAAYTTKGDGARS
KPKIVTTTGAVPGRPTMMISTTAMNTALLQW
HPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGL
GEE
FEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINS
QQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLS
PSIQSRTMPVEQVFAKNFRV
AAAMKTSVLLSWEVPDSYKSAVPFKILYNGQSVEVDGHSMRKLIADLQPNTEYSFVLMNR
GSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVRWFYIVVVPID
RVGGSMLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAAQLDVLPETFTL
GDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQQEEPE
MLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLN
YQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNR
YANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWE
QRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGS
SEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIV
IDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLE
AATCGHTEVPARNL
YAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTR
VCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTK
LREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQF
TDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMR
YEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALE
YLGSFDHYAT
Sequence length 1907
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Schizophrenia Schizophrenia GWAS
Attention Deficit Hyperactivity Disorder Attention Deficit Hyperactivity Disorder GWAS
Hypertension Hypertension GWAS
Associations from Text Mining
Disease Name Relationship Type References
Alternating hemiplegia of childhood Associate 32929364
Brain Diseases Associate 37446291
Breast Neoplasms Associate 19004008, 26336805
Carcinoma Hepatocellular Associate 12679910, 34969357
Carcinoma Non Small Cell Lung Associate 26291013
Endometrial Neoplasms Associate 37737665
Gallbladder Neoplasms Associate 35035811
Insulin Resistance Associate 23861770
Lung Neoplasms Associate 25638566
Melanoma Associate 35606887