Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5787
Gene name Gene Name - the full gene name approved by the HGNC.
Protein tyrosine phosphatase receptor type B
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PTPRB
Synonyms (NCBI Gene) Gene synonyms aliases
HPTP-BETA, HPTPB, PTPB, R-PTP-BETA, VEPTP
Chromosome Chromosome number
12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12q15
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic tran
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT022308 hsa-miR-124-3p Microarray 18668037
MIRT053404 hsa-miR-629-5p Microarray 23807165
MIRT641056 hsa-miR-5582-3p HITS-CLIP 23824327
MIRT641054 hsa-miR-3606-3p HITS-CLIP 23824327
MIRT641055 hsa-miR-513a-3p HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001525 Process Angiogenesis IBA 21873635
GO:0005001 Function Transmembrane receptor protein tyrosine phosphatase activity TAS 2170109
GO:0005515 Function Protein binding IPI 12840032, 12907755, 16101282, 19167335, 19451274, 28065597, 31980649
GO:0005886 Component Plasma membrane TAS
GO:0005887 Component Integral component of plasma membrane TAS 2170109
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
176882 9665 ENSG00000127329
Protein
UniProt ID P23467
Protein name Receptor-type tyrosine-protein phosphatase beta (Protein-tyrosine phosphatase beta) (R-PTP-beta) (EC 3.1.3.48) (Vascular endothelial protein tyrosine phosphatase) (VE-PTP)
Protein function Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and
PDB 2AHS , 2H02 , 2H03 , 2H04 , 2HC1 , 2HC2 , 2I3R , 2I3U , 2I4E , 2I4G , 2I4H , 2I5X , 8JBN , 8JBY
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00041 fn3 24 103 Fibronectin type III domain Domain
PF00041 fn3 112 194 Fibronectin type III domain Domain
PF00041 fn3 290 368 Fibronectin type III domain Domain
PF00041 fn3 378 460 Fibronectin type III domain Domain
PF00041 fn3 468 547 Fibronectin type III domain Domain
PF00041 fn3 555 633 Fibronectin type III domain Domain
PF00041 fn3 644 725 Fibronectin type III domain Domain
PF00041 fn3 732 812 Fibronectin type III domain Domain
PF00041 fn3 819 899 Fibronectin type III domain Domain
PF00041 fn3 908 986 Fibronectin type III domain Domain
PF00041 fn3 996 1077 Fibronectin type III domain Domain
PF00041 fn3 1086 1165 Fibronectin type III domain Domain
PF00041 fn3 1174 1252 Fibronectin type III domain Domain
PF00041 fn3 1262 1344 Fibronectin type III domain Domain
PF00041 fn3 1356 1435 Fibronectin type III domain Domain
PF18861 PTP_tm 1473 1643 Transmembrane domain of protein tyrosine phosphatase, receptor type J Family
PF00102 Y_phosphatase 1727 1962 Protein-tyrosine phosphatase Domain
Sequence
MLSHGAGLALWITLSLLQTGLAEPERCNFTLAESKASSHSVSIQWRILGSPCNFSLIYSS
DTLGAALCPTFRIDNTTYGCNLQDLQAGTIYNFRIISLDEERT
VVLQTDPLPPARFGVSK
EKTTSTSLHVWWTPSSGKVTSYEVQLFDENNQKIQGVQIQESTSWNEYTFFNLTAGSKYN
IAITAVSGGKRSFS
VYTNGSTVPSPVKDIGISTKANSLLISWSHGSGNVERYRLMLMDKG
ILVHGGVVDKHATSYAFHGLTPGYLYNLTVMTEAAGLQNYRWKLVRTAPMEVSNLKVTND
GSLTSLKVKWQRPPGNVDSYNITLSHKGTIKESRVLAPWITETHFKELVPGRLYQVTVSC
VSGELSAQ
KMAVGRTFPDKVANLEANNNGRMRSLVVSWSPPAGDWEQYRILLFNDSVVLL
NITVGKEETQYVMDDTGLVPGRQYEVEVIVESGNLKNSER
CQGRTVPLAVLQLRVKHANE
TSLSIMWQTPVAEWEKYIISLADRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISG
DLKNSSS
VKGRTVPAQVTDLHVANQGMTSSLFTNWTQAQGDVEFYQVLLIHENVVIKNES
ISSETSRYSFHSLKSGSLYSVVVTTVSGGISSR
QVVVEGRTVPSSVSGVTVNNSGRNDYL
SVSWLLAPGDVDNYEVTLSHDGKVVQSLVIAKSVRECSFSSLTPGRLYTVTITTRSGKYE
NHSFS
QERTVPDKVQGVSVSNSARSDYLRVSWVHATGDFDHYEVTIKNKNNFIQTKSIPK
SENECVFVQLVPGRLYSVTVTTKSGQYEANEQ
GNGRTIPEPVKDLTLRNRSTEDLHVTWS
GANGDVDQYEIQLLFNDMKVFPPFHLVNTATEYRFTSLTPGRQYKILVLTISGDVQQSA
F
IEGFTVPSAVKNIHISPNGATDSLTVNWTPGGGDVDSYTVSAFRHSQKVDSQTIPKHVFE
HTFHRLEAGEQYQIMIASVSGSLKNQ
INVVGRTVPASVQGVIADNAYSSYSLIVSWQKAA
GVAERYDILLLTENGILLRNTSEPATTKQHKFEDLTPGKKYKIQILTVSGGLFSKEA
QTE
GRTVPAAVTDLRITENSTRHLSFRWTASEGELSWYNIFLYNPDGNLQERAQVDPLVQSFS
FQNLLQGRMYKMVIVTHSGELSNES
FIFGRTVPASVSHLRGSNRNTTDSLWFNWSPASGD
FDFYELILYNPNGTKKENWKDKDLTEWRFQGLVPGRKYVLWVVTHSGDLSNK
VTAESRTA
PSPPSLMSFADIANTSLAITWKGPPDWTDYNDFELQWLPRDALTVFNPYNNRKSEGRIVY
GLRPGRSYQFNVKTVSGDSWKTYS
KPIFGSVRTKPDKIQNLHCRPQNSTAIACSWIPPDS
DFDGYSIECRKMDTQEVEFSRKLEKEKSLLNIMMLVPHKRYLVSIKVQSAGMTSE
VVEDS
TITMIDRPPPPPPHIRVNEKDVLISKSSINFTVNCSWFSDTNGAVKYFTVVVREADGSDE
LKPEQQHPLPSYLEYRHNASIRVYQTNYFASKCAENPNSNSKSFNIKLGAEMESLGGKCD
PTQQKFCDGPLKPHTAYRISIRAFTQLFDEDLKEFTKPLYSDTFFSLPITTESEPLFGAI
EGVSAGLFLIGMLVAVVALLICR
QKVSHGRERPSARLSIRRDRPLSVHLNLGQKGNRKTS
CPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYD
ATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVM
VTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAHRLI
RHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRI
LQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRD
VLRARKLRSEQENPLFPI
YENVNPEYHRDPVYSRH
Sequence length 1997
Interactions View interactions