Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
10197
Gene name Gene Name - the full gene name approved by the HGNC.
Proteasome activator subunit 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PSME3
Synonyms (NCBI Gene) Gene synonyms aliases
HEL-S-283, Ki, PA28-gamma, PA28G, PA28gamma, REG-GAMMA
Chromosome Chromosome number
17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17q21.31
Summary Summary of gene provided in NCBI Entrez Gene.
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits a
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT004063 hsa-miR-7-5p Microarray 19073608
MIRT020956 hsa-miR-155-5p Proteomics 18668040
MIRT022991 hsa-miR-124-3p Proteomics;Microarray 18668037
MIRT004063 hsa-miR-7-5p Microarray;Other 19073608
MIRT030577 hsa-miR-24-3p Microarray 19748357
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000165 Process MAPK cascade TAS
GO:0000209 Process Protein polyubiquitination TAS
GO:0000502 Component Proteasome complex TAS 8811196
GO:0002039 Function P53 binding IDA 18309296
GO:0002223 Process Stimulatory C-type lectin receptor signaling pathway TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
605129 9570 ENSG00000131467
Protein
UniProt ID P61289
Protein name Proteasome activator complex subunit 3 (11S regulator complex subunit gamma) (REG-gamma) (Activator of multicatalytic protease subunit 3) (Ki nuclear autoantigen) (Proteasome activator 28 subunit gamma) (PA28g) (PA28gamma)
Protein function Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymot
PDB 7YQC , 7YQD
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02251 PA28_alpha 9 69 Proteasome activator pa28 alpha subunit Family
PF02252 PA28_beta 108 252 Proteasome activator pa28 beta subunit Family
Sequence
Sequence length 254
Interactions View interactions