PSMD9 (proteasome 26S subunit, non-ATPase 9)

Gene

• Entrez ID: 5715
• Gene name: Proteasome 26S subunit, non-ATPase 9
• Gene symbol: PSMD9
• Synonyms (NCBI Gene): Rpn4, p27
• Chromosome: 12
• Chromosome location: 12q24.31
• Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits a

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT020196	hsa-miR-130b-3p	Sequencing	20371350
MIRT021122	hsa-miR-186-5p	Sequencing	20371350
MIRT025995	hsa-miR-148a-3p	Sequencing	20371350
MIRT031151	hsa-miR-19b-3p	Sequencing	20371350
MIRT032262	hsa-let-7b-5p	Proteomics	18668040
MIRT682705	hsa-miR-508-5p	HITS-CLIP	23706177
MIRT682704	hsa-miR-6849-3p	HITS-CLIP	23706177
MIRT682703	hsa-miR-6742-3p	HITS-CLIP	23706177
MIRT682702	hsa-miR-766-3p	HITS-CLIP	23706177
MIRT682701	hsa-miR-4793-3p	HITS-CLIP	23706177
MIRT682700	hsa-miR-6776-5p	HITS-CLIP	23706177
MIRT682699	hsa-miR-661	HITS-CLIP	23706177
MIRT682698	hsa-miR-4504	HITS-CLIP	23706177
MIRT682696	hsa-miR-6512-3p	HITS-CLIP	23706177
MIRT682697	hsa-miR-6720-5p	HITS-CLIP	23706177
MIRT682695	hsa-miR-7703	HITS-CLIP	23706177
MIRT682694	hsa-miR-1262	HITS-CLIP	23706177
MIRT682693	hsa-miR-4701-3p	HITS-CLIP	23706177
MIRT682692	hsa-miR-6736-5p	HITS-CLIP	23706177
MIRT682691	hsa-miR-1273a	HITS-CLIP	23706177
MIRT682690	hsa-miR-1273g-3p	HITS-CLIP	23706177
MIRT682705	hsa-miR-508-5p	HITS-CLIP	23706177
MIRT682704	hsa-miR-6849-3p	HITS-CLIP	23706177
MIRT682703	hsa-miR-6742-3p	HITS-CLIP	23706177
MIRT682702	hsa-miR-766-3p	HITS-CLIP	23706177
MIRT682701	hsa-miR-4793-3p	HITS-CLIP	23706177
MIRT682700	hsa-miR-6776-5p	HITS-CLIP	23706177
MIRT682699	hsa-miR-661	HITS-CLIP	23706177
MIRT682698	hsa-miR-4504	HITS-CLIP	23706177
MIRT682696	hsa-miR-6512-3p	HITS-CLIP	23706177
MIRT682697	hsa-miR-6720-5p	HITS-CLIP	23706177
MIRT682695	hsa-miR-7703	HITS-CLIP	23706177
MIRT682694	hsa-miR-1262	HITS-CLIP	23706177
MIRT682693	hsa-miR-4701-3p	HITS-CLIP	23706177
MIRT682692	hsa-miR-6736-5p	HITS-CLIP	23706177
MIRT682691	hsa-miR-1273a	HITS-CLIP	23706177
MIRT682690	hsa-miR-1273g-3p	HITS-CLIP	23706177
MIRT1270695	hsa-miR-101	CLIP-seq
MIRT1270696	hsa-miR-10a	CLIP-seq
MIRT1270697	hsa-miR-10b	CLIP-seq
MIRT1270698	hsa-miR-1278	CLIP-seq
MIRT1270699	hsa-miR-1283	CLIP-seq
MIRT1270700	hsa-miR-1305	CLIP-seq
MIRT1270701	hsa-miR-141	CLIP-seq
MIRT1270702	hsa-miR-1587	CLIP-seq
MIRT1270703	hsa-miR-200a	CLIP-seq
MIRT1270704	hsa-miR-2110	CLIP-seq
MIRT1270705	hsa-miR-24	CLIP-seq
MIRT1270706	hsa-miR-3178	CLIP-seq
MIRT1270707	hsa-miR-330-3p	CLIP-seq
MIRT1270708	hsa-miR-335	CLIP-seq
MIRT1270709	hsa-miR-339-5p	CLIP-seq
MIRT1270710	hsa-miR-3611	CLIP-seq
MIRT1270711	hsa-miR-3613-3p	CLIP-seq
MIRT1270712	hsa-miR-3646	CLIP-seq
MIRT1270713	hsa-miR-3925-3p	CLIP-seq
MIRT1270714	hsa-miR-4270	CLIP-seq
MIRT1270715	hsa-miR-4271	CLIP-seq
MIRT1270716	hsa-miR-4284	CLIP-seq
MIRT1270717	hsa-miR-4421	CLIP-seq
MIRT1270718	hsa-miR-4441	CLIP-seq
MIRT1270719	hsa-miR-4486	CLIP-seq
MIRT1270720	hsa-miR-4492	CLIP-seq
MIRT1270721	hsa-miR-4498	CLIP-seq
MIRT1270722	hsa-miR-4505	CLIP-seq
MIRT1270723	hsa-miR-451b	CLIP-seq
MIRT1270724	hsa-miR-4656	CLIP-seq
MIRT1270725	hsa-miR-4667-5p	CLIP-seq
MIRT1270726	hsa-miR-4675	CLIP-seq
MIRT1270727	hsa-miR-4679	CLIP-seq
MIRT1270728	hsa-miR-4684-5p	CLIP-seq
MIRT1270729	hsa-miR-4696	CLIP-seq
MIRT1270730	hsa-miR-4700-5p	CLIP-seq
MIRT1270731	hsa-miR-4715-3p	CLIP-seq
MIRT1270732	hsa-miR-4725-3p	CLIP-seq
MIRT1270733	hsa-miR-4725-5p	CLIP-seq
MIRT1270734	hsa-miR-4741	CLIP-seq
MIRT1270735	hsa-miR-498	CLIP-seq
MIRT1270736	hsa-miR-504	CLIP-seq
MIRT1270737	hsa-miR-505	CLIP-seq
MIRT1270738	hsa-miR-570	CLIP-seq
MIRT1270739	hsa-miR-583	CLIP-seq
MIRT1270740	hsa-miR-593	CLIP-seq
MIRT1270741	hsa-miR-758	CLIP-seq
MIRT1270742	hsa-miR-762	CLIP-seq
MIRT1270743	hsa-miR-766	CLIP-seq
MIRT1270695	hsa-miR-101	CLIP-seq
MIRT2079581	hsa-miR-1225-3p	CLIP-seq
MIRT2079582	hsa-miR-1233	CLIP-seq
MIRT2079583	hsa-miR-1273e	CLIP-seq
MIRT2079584	hsa-miR-1288	CLIP-seq
MIRT2079585	hsa-miR-3074-3p	CLIP-seq
MIRT2079586	hsa-miR-3169	CLIP-seq
MIRT2079587	hsa-miR-3200-5p	CLIP-seq
MIRT2079588	hsa-miR-3714	CLIP-seq
MIRT2079589	hsa-miR-4266	CLIP-seq
MIRT2079590	hsa-miR-4281	CLIP-seq
MIRT2079591	hsa-miR-4303	CLIP-seq
MIRT2079592	hsa-miR-4433	CLIP-seq
MIRT2079593	hsa-miR-4459	CLIP-seq
MIRT1270727	hsa-miR-4679	CLIP-seq
MIRT2079594	hsa-miR-4695-5p	CLIP-seq
MIRT2079595	hsa-miR-4722-5p	CLIP-seq
MIRT2079596	hsa-miR-4779	CLIP-seq
MIRT2079597	hsa-miR-635	CLIP-seq
MIRT2079598	hsa-miR-651	CLIP-seq
MIRT2079599	hsa-miR-665	CLIP-seq
MIRT1270743	hsa-miR-766	CLIP-seq
MIRT2079600	hsa-miR-890	CLIP-seq
MIRT2079601	hsa-miR-940	CLIP-seq
MIRT1270695	hsa-miR-101	CLIP-seq
MIRT2079581	hsa-miR-1225-3p	CLIP-seq
MIRT2305907	hsa-miR-1228	CLIP-seq
MIRT2079582	hsa-miR-1233	CLIP-seq
MIRT2079583	hsa-miR-1273e	CLIP-seq
MIRT1270698	hsa-miR-1278	CLIP-seq
MIRT2079584	hsa-miR-1288	CLIP-seq
MIRT2305908	hsa-miR-130a	CLIP-seq
MIRT2305909	hsa-miR-130b	CLIP-seq
MIRT2305910	hsa-miR-140-3p	CLIP-seq
MIRT2305911	hsa-miR-148a	CLIP-seq
MIRT2305912	hsa-miR-148b	CLIP-seq
MIRT2305913	hsa-miR-152	CLIP-seq
MIRT1270702	hsa-miR-1587	CLIP-seq
MIRT2305914	hsa-miR-185	CLIP-seq
MIRT2305915	hsa-miR-19a	CLIP-seq
MIRT2305916	hsa-miR-19b	CLIP-seq
MIRT1270705	hsa-miR-24	CLIP-seq
MIRT2305917	hsa-miR-301a	CLIP-seq
MIRT2305918	hsa-miR-301b	CLIP-seq
MIRT2305919	hsa-miR-3120-3p	CLIP-seq
MIRT2079586	hsa-miR-3169	CLIP-seq
MIRT1270706	hsa-miR-3178	CLIP-seq
MIRT1270707	hsa-miR-330-3p	CLIP-seq
MIRT2305920	hsa-miR-34b	CLIP-seq
MIRT2305921	hsa-miR-3666	CLIP-seq
MIRT2305922	hsa-miR-3713	CLIP-seq
MIRT2079588	hsa-miR-3714	CLIP-seq
MIRT2079589	hsa-miR-4266	CLIP-seq
MIRT1270714	hsa-miR-4270	CLIP-seq
MIRT1270716	hsa-miR-4284	CLIP-seq
MIRT2305923	hsa-miR-4295	CLIP-seq
MIRT2305924	hsa-miR-4306	CLIP-seq
MIRT2305925	hsa-miR-4417	CLIP-seq
MIRT2079592	hsa-miR-4433	CLIP-seq
MIRT1270718	hsa-miR-4441	CLIP-seq
MIRT2079593	hsa-miR-4459	CLIP-seq
MIRT1270719	hsa-miR-4486	CLIP-seq
MIRT1270720	hsa-miR-4492	CLIP-seq
MIRT1270721	hsa-miR-4498	CLIP-seq
MIRT1270722	hsa-miR-4505	CLIP-seq
MIRT2305926	hsa-miR-454	CLIP-seq
MIRT2305927	hsa-miR-4644	CLIP-seq
MIRT1270724	hsa-miR-4656	CLIP-seq
MIRT1270726	hsa-miR-4675	CLIP-seq
MIRT1270727	hsa-miR-4679	CLIP-seq
MIRT2305928	hsa-miR-4685-5p	CLIP-seq
MIRT2079594	hsa-miR-4695-5p	CLIP-seq
MIRT2305929	hsa-miR-4712-5p	CLIP-seq
MIRT1270731	hsa-miR-4715-3p	CLIP-seq
MIRT2305930	hsa-miR-4722-3p	CLIP-seq
MIRT2079595	hsa-miR-4722-5p	CLIP-seq
MIRT1270734	hsa-miR-4741	CLIP-seq
MIRT2305931	hsa-miR-4742-3p	CLIP-seq
MIRT2079596	hsa-miR-4779	CLIP-seq
MIRT2305932	hsa-miR-4786-5p	CLIP-seq
MIRT2305933	hsa-miR-490-3p	CLIP-seq
MIRT1270737	hsa-miR-505	CLIP-seq
MIRT2305934	hsa-miR-518a-5p	CLIP-seq
MIRT2305935	hsa-miR-527	CLIP-seq
MIRT2305936	hsa-miR-545	CLIP-seq
MIRT2305937	hsa-miR-548aa	CLIP-seq
MIRT2305938	hsa-miR-548p	CLIP-seq
MIRT2079598	hsa-miR-651	CLIP-seq
MIRT2079599	hsa-miR-665	CLIP-seq
MIRT2305939	hsa-miR-718	CLIP-seq
MIRT1270742	hsa-miR-762	CLIP-seq
MIRT1270743	hsa-miR-766	CLIP-seq
MIRT2305940	hsa-miR-770-5p	CLIP-seq
MIRT2079601	hsa-miR-940	CLIP-seq
MIRT2079589	hsa-miR-4266	CLIP-seq
MIRT1270727	hsa-miR-4679	CLIP-seq
MIRT2079594	hsa-miR-4695-5p	CLIP-seq
MIRT2079596	hsa-miR-4779	CLIP-seq
MIRT2079598	hsa-miR-651	CLIP-seq
MIRT2079581	hsa-miR-1225-3p	CLIP-seq
MIRT2079582	hsa-miR-1233	CLIP-seq
MIRT2603161	hsa-miR-1236	CLIP-seq
MIRT2603162	hsa-miR-1253	CLIP-seq
MIRT2079583	hsa-miR-1273e	CLIP-seq
MIRT2079584	hsa-miR-1288	CLIP-seq
MIRT2305914	hsa-miR-185	CLIP-seq
MIRT2603163	hsa-miR-2355-5p	CLIP-seq
MIRT2603164	hsa-miR-3074-5p	CLIP-seq
MIRT2603165	hsa-miR-3124-3p	CLIP-seq
MIRT2603166	hsa-miR-3127-5p	CLIP-seq
MIRT2603167	hsa-miR-3160-5p	CLIP-seq
MIRT2079586	hsa-miR-3169	CLIP-seq
MIRT2603168	hsa-miR-3180-5p	CLIP-seq
MIRT1270707	hsa-miR-330-3p	CLIP-seq
MIRT2603169	hsa-miR-3691-3p	CLIP-seq
MIRT2079588	hsa-miR-3714	CLIP-seq
MIRT2603170	hsa-miR-3977	CLIP-seq
MIRT2603171	hsa-miR-3978	CLIP-seq
MIRT2079589	hsa-miR-4266	CLIP-seq
MIRT1270714	hsa-miR-4270	CLIP-seq
MIRT2305924	hsa-miR-4306	CLIP-seq
MIRT2079592	hsa-miR-4433	CLIP-seq
MIRT1270718	hsa-miR-4441	CLIP-seq
MIRT2079593	hsa-miR-4459	CLIP-seq
MIRT2603172	hsa-miR-452	CLIP-seq
MIRT2305927	hsa-miR-4644	CLIP-seq
MIRT2603173	hsa-miR-4676-3p	CLIP-seq
MIRT1270727	hsa-miR-4679	CLIP-seq
MIRT2305928	hsa-miR-4685-5p	CLIP-seq
MIRT2603174	hsa-miR-4693-5p	CLIP-seq
MIRT2079594	hsa-miR-4695-5p	CLIP-seq
MIRT1270731	hsa-miR-4715-3p	CLIP-seq
MIRT2079595	hsa-miR-4722-5p	CLIP-seq
MIRT2079596	hsa-miR-4779	CLIP-seq
MIRT2603175	hsa-miR-520a-5p	CLIP-seq
MIRT2603176	hsa-miR-525-5p	CLIP-seq
MIRT2603177	hsa-miR-605	CLIP-seq
MIRT2079598	hsa-miR-651	CLIP-seq
MIRT2079599	hsa-miR-665	CLIP-seq
MIRT2079601	hsa-miR-940	CLIP-seq
MIRT1270696	hsa-miR-10a	CLIP-seq
MIRT1270697	hsa-miR-10b	CLIP-seq
MIRT2079581	hsa-miR-1225-3p	CLIP-seq
MIRT2079582	hsa-miR-1233	CLIP-seq
MIRT2603161	hsa-miR-1236	CLIP-seq
MIRT2603162	hsa-miR-1253	CLIP-seq
MIRT2079583	hsa-miR-1273e	CLIP-seq
MIRT1270699	hsa-miR-1283	CLIP-seq
MIRT2079584	hsa-miR-1288	CLIP-seq
MIRT2305914	hsa-miR-185	CLIP-seq
MIRT2603163	hsa-miR-2355-5p	CLIP-seq
MIRT2603164	hsa-miR-3074-5p	CLIP-seq
MIRT2603165	hsa-miR-3124-3p	CLIP-seq
MIRT2603166	hsa-miR-3127-5p	CLIP-seq
MIRT2603167	hsa-miR-3160-5p	CLIP-seq
MIRT2079586	hsa-miR-3169	CLIP-seq
MIRT2603168	hsa-miR-3180-5p	CLIP-seq
MIRT1270709	hsa-miR-339-5p	CLIP-seq
MIRT1270711	hsa-miR-3613-3p	CLIP-seq
MIRT2603169	hsa-miR-3691-3p	CLIP-seq
MIRT2079588	hsa-miR-3714	CLIP-seq
MIRT2603170	hsa-miR-3977	CLIP-seq
MIRT2603171	hsa-miR-3978	CLIP-seq
MIRT1270714	hsa-miR-4270	CLIP-seq
MIRT2305924	hsa-miR-4306	CLIP-seq
MIRT1270717	hsa-miR-4421	CLIP-seq
MIRT1270718	hsa-miR-4441	CLIP-seq
MIRT2079593	hsa-miR-4459	CLIP-seq
MIRT2603172	hsa-miR-452	CLIP-seq
MIRT2305927	hsa-miR-4644	CLIP-seq
MIRT2603173	hsa-miR-4676-3p	CLIP-seq
MIRT1270728	hsa-miR-4684-5p	CLIP-seq
MIRT2305928	hsa-miR-4685-5p	CLIP-seq
MIRT2603174	hsa-miR-4693-5p	CLIP-seq
MIRT1270731	hsa-miR-4715-3p	CLIP-seq
MIRT2079595	hsa-miR-4722-5p	CLIP-seq
MIRT1270733	hsa-miR-4725-5p	CLIP-seq
MIRT1270736	hsa-miR-504	CLIP-seq
MIRT2603175	hsa-miR-520a-5p	CLIP-seq
MIRT2603176	hsa-miR-525-5p	CLIP-seq
MIRT1270740	hsa-miR-593	CLIP-seq
MIRT2603177	hsa-miR-605	CLIP-seq
MIRT2079599	hsa-miR-665	CLIP-seq
MIRT2079601	hsa-miR-940	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003713	Function	Transcription coactivator activity	ISS	10567574
GO:0005515	Function	Protein binding	IPI	16189514, 19490896, 21516116, 25009770, 25416956, 31515488, 32296183, 32814053, 33961781, 35271311
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	ISS	10567574
GO:0005737	Component	Cytoplasm	IBA
GO:0005829	Component	Cytosol	TAS
GO:0005838	Component	Proteasome regulatory particle	NAS	9653651
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	NAS	9653651
GO:0008540	Component	Proteasome regulatory particle, base subcomplex	IDA	19490896
GO:0032024	Process	Positive regulation of insulin secretion	ISS	10567574
GO:0043425	Function	BHLH transcription factor binding	ISS	10567574
GO:0045893	Process	Positive regulation of DNA-templated transcription	ISS	10567574, 16293776
GO:0046676	Process	Negative regulation of insulin secretion	ISS	16099819
GO:0070682	Process	Proteasome regulatory particle assembly	IBA
GO:0070682	Process	Proteasome regulatory particle assembly	IEA
GO:0070682	Process	Proteasome regulatory particle assembly	IMP	19490896

Other IDs

• MIM: 603146
• HGNC: 9567
• e!Ensembl: ENSG00000110801

Protein

• UniProt ID: O00233
• Protein name: 26S proteasome non-ATPase regulatory subunit 9 (26S proteasome regulatory subunit p27)
• Protein function: Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). During the base subcomplex assembly is part of an intermediate PSMD9:PSMC6:PSMC3 module, also known as m
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF18265	Nas2_N	23 → 102	Nas2 N_terminal domain	Domain
  PF17820	PDZ_6	138 → 194	PDZ domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in all tissues tested, highly expressed in liver and kidney.
• Sequence:

  MSDEEARQSGGSSQAGVVTVSDVQELMRRKEEIEAQIKANYDVLESQKGIGMNEPLVDCE
  GYPRSDVDLYQVRTARHNIICLQNDHKAVMKQVEEALHQLHARDKEKQARDMAEAHKEAM
  SRKLGQSESQGPPRAFAKVNSISPGSPASIAGLQVDDEIVEFGSVNTQNFQSLHNIGSVV
  QHSEGKPLNVTVIRRGEKHQLRLVPTRWAGKGLLGCNIIPLQR

• Sequence length: 223