Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5713
Gene name Gene Name - the full gene name approved by the HGNC.
Proteasome 26S subunit, non-ATPase 7
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PSMD7
Synonyms (NCBI Gene) Gene synonyms aliases
MOV34, P40, Rpn8, S12
Chromosome Chromosome number
16
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
16q23.1
Summary Summary of gene provided in NCBI Entrez Gene.
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits a
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT029210 hsa-miR-26b-5p Microarray 19088304
MIRT046509 hsa-miR-15b-5p CLASH 23622248
MIRT043500 hsa-miR-331-3p CLASH 23622248
MIRT075438 hsa-miR-30a-5p PAR-CLIP 20371350
MIRT075441 hsa-miR-30b-5p PAR-CLIP 20371350
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000165 Process MAPK cascade TAS
GO:0000209 Process Protein polyubiquitination TAS
GO:0000502 Component Proteasome complex IBA 21873635
GO:0000502 Component Proteasome complex IDA 17323924
GO:0002223 Process Stimulatory C-type lectin receptor signaling pathway TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
157970 9565 ENSG00000103035
Protein
UniProt ID P51665
Protein name 26S proteasome non-ATPase regulatory subunit 7 (26S proteasome regulatory subunit RPN8) (26S proteasome regulatory subunit S12) (Mov34 protein homolog) (Proteasome subunit p40)
Protein function Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which
PDB 2O95 , 2O96 , 5GJQ , 5GJR , 5L4K , 5LN3 , 5M32 , 5T0C , 5T0G , 5T0H , 5T0I , 5T0J , 5VFP , 5VFQ , 5VFR , 5VFS , 5VFT , 5VFU , 5VGZ , 5VHF , 5VHH , 5VHI , 5VHS , 6MSB , 6MSD , 6MSG , 6MSH , 6MSJ , 6MSK , 6WJD , 6WJN , 7QXN , 7QXP , 7QXU , 7QXW , 7QXX , 7QY7 , 7QYA , 7QYB , 7W37 , 7W38 , 7W39 , 7W3A , 7W3B , 7W3C , 7W3F , 7W3G , 7W3H , 7W3I , 7W3J , 7W3K
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01398 JAB 4 118 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Family
PF13012 MitMem_reg 166 277 Maintenance of mitochondrial structure and function Family
Sequence
Sequence length 324
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Restless Legs Syndrome Restless Legs Syndrome GWAS
Associations from Text Mining
Disease Name Relationship Type References
Arthritis Rheumatoid Associate 29848990
Breast Neoplasms Stimulate 34839279
Hypertension Associate 32664164
Neoplasms Associate 33687056
Squamous Cell Carcinoma of Head and Neck Stimulate 33687056
Stomach Neoplasms Stimulate 35037550
Ventricular Remodeling Associate 32664164