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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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O00231 |
| Protein name |
26S proteasome non-ATPase regulatory subunit 11 (26S proteasome regulatory subunit RPN6) (26S proteasome regulatory subunit S9) (26S proteasome regulatory subunit p44.5) |
| Protein function |
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which |
| PDB |
5GJQ
, 5GJR
, 5L4K
, 5LN3
, 5M32
, 5T0C
, 5T0G
, 5T0H
, 5T0I
, 5T0J
, 5VFP
, 5VFQ
, 5VFR
, 5VFS
, 5VFT
, 5VFU
, 5VGZ
, 5VHF
, 5VHH
, 5VHI
, 5VHS
, 6MSB
, 6MSD
, 6MSE
, 6MSG
, 6MSH
, 6MSJ
, 6MSK
, 6WJD
, 6WJN
, 7QXN
, 7QXP
, 7QXU
, 7QXW
, 7QXX
, 7QY7
, 7QYA
, 7QYB
, 7W37
, 7W38
, 7W39
, 7W3A
, 7W3B
, 7W3C
, 7W3F
, 7W3G
, 7W3H
, 7W3I
, 7W3J
, 7W3K
, 7W3M
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| Family and domains |
Pfam
| Accession |
ID |
Position in sequence |
Description |
Type |
| PF18055 |
RPN6_N |
12 → 129 |
26S proteasome regulatory subunit RPN6 N-terminal domain |
Domain |
| PF01399 |
PCI |
285 → 389 |
PCI domain |
Domain |
| PF18503 |
RPN6_C_helix |
393 → 419 |
26S proteasome subunit RPN6 C-terminal helix domain |
Domain |
|
| Tissue specificity |
TISSUE SPECIFICITY: Highly expressed in embryonic stem cells (ESCs). Expression decreases as ESCs differentiate. {ECO:0000269|PubMed:22972301}. |
| Sequence |
|
| Sequence length |
422 |
| Interactions |
View interactions |