Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs Other IDs
Entrez ID	5704
Gene name	Proteasome 26S subunit, ATPase 4
Gene symbol	PSMC4
Synonyms (NCBI Gene)	MIP224RPT3S6TBP-7TBP7
Chromosome	19
Chromosome location	19q13.2
Summary	The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits a

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miRTarBase ID	miRNA	Experiments	Reference
MIRT029325	hsa-miR-26b-5p	Microarray	19088304
MIRT051335	hsa-miR-15a-5p	CLASH	23622248
MIRT046684	hsa-miR-222-3p	CLASH	23622248
MIRT046684	hsa-miR-222-3p	CLASH	23622248
MIRT043323	hsa-miR-331-3p	CLASH	23622248
MIRT036915	hsa-miR-877-3p	CLASH	23622248
MIRT697079	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT697078	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT697077	hsa-miR-940	HITS-CLIP	23313552
MIRT697076	hsa-miR-3929	HITS-CLIP	23313552
MIRT697075	hsa-miR-4419b	HITS-CLIP	23313552
MIRT697074	hsa-miR-4478	HITS-CLIP	23313552
MIRT697073	hsa-miR-5690	HITS-CLIP	23313552
MIRT697072	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT697071	hsa-miR-6746-5p	HITS-CLIP	23313552
MIRT697070	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT697069	hsa-miR-1827	HITS-CLIP	23313552
MIRT697068	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT697067	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT697066	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT697065	hsa-miR-6811-3p	HITS-CLIP	23313552
MIRT697064	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT697063	hsa-miR-4281	HITS-CLIP	23313552
MIRT697062	hsa-miR-7977	HITS-CLIP	23313552
MIRT697061	hsa-miR-6771-5p	HITS-CLIP	23313552
MIRT697060	hsa-miR-133a-3p	HITS-CLIP	23313552
MIRT697059	hsa-miR-665	HITS-CLIP	23313552
MIRT697079	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT697078	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT697077	hsa-miR-940	HITS-CLIP	23313552
MIRT697076	hsa-miR-3929	HITS-CLIP	23313552
MIRT697075	hsa-miR-4419b	HITS-CLIP	23313552
MIRT697074	hsa-miR-4478	HITS-CLIP	23313552
MIRT697073	hsa-miR-5690	HITS-CLIP	23313552
MIRT697072	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT697071	hsa-miR-6746-5p	HITS-CLIP	23313552
MIRT697070	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT697069	hsa-miR-1827	HITS-CLIP	23313552
MIRT697068	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT697067	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT697066	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT697065	hsa-miR-6811-3p	HITS-CLIP	23313552
MIRT697064	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT697063	hsa-miR-4281	HITS-CLIP	23313552
MIRT697062	hsa-miR-7977	HITS-CLIP	23313552
MIRT697061	hsa-miR-6771-5p	HITS-CLIP	23313552
MIRT697060	hsa-miR-133a-3p	HITS-CLIP	23313552
MIRT697059	hsa-miR-665	HITS-CLIP	23313552

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000502	Component	Proteasome complex	IDA	17323924
GO:0000502	Component	Proteasome complex	IEA
GO:0000502	Component	Proteasome complex	NAS	29636472
GO:0000502	Component	Proteasome complex	TAS	8603043
GO:0001824	Process	Blastocyst development	IEA
GO:0005515	Function	Protein binding	IPI	12525503, 16189514, 16990800, 17292836, 19490896, 21988832, 22078707, 24338975, 25416956, 26496610, 27342858, 29128334, 29636472, 29804830, 29892012, 32296183, 32814053, 33961781, 35271311
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006508	Process	Proteolysis	TAS	8603043
GO:0008540	Component	Proteasome regulatory particle, base subcomplex	IBA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016887	Function	ATP hydrolysis activity	IEA
GO:0022624	Component	Proteasome accessory complex	IEA
GO:0022624	Component	Proteasome accessory complex	ISS
GO:0036064	Component	Ciliary basal body	IDA
GO:0036402	Function	Proteasome-activating activity	IBA
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IBA
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	NAS	19489727
GO:1901800	Process	Positive regulation of proteasomal protein catabolic process	IEA

MIM	HGNC	e!Ensembl
602707	9551	ENSG00000013275

P43686

Protein name

26S proteasome regulatory subunit 6B (26S proteasome AAA-ATPase subunit RPT3) (MB67-interacting protein) (MIP224) (Proteasome 26S subunit ATPase 4) (Tat-binding protein 7) (TBP-7)

Protein function

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which

PDB

2DVW , 5GJQ , 5GJR , 5L4G , 5LN3 , 5M32 , 5T0C , 5T0G , 5T0H , 5T0I , 5T0J , 5VFP , 5VFQ , 5VFR , 5VFS , 5VFT , 5VFU , 5VGZ , 5VHF , 5VHH , 5VHI , 5VHJ , 5VHM , 5VHN , 5VHO , 5VHP , 5VHQ , 5VHR , 5VHS , 6MSB , 6MSD , 6MSE , 6MSG , 6MSH , 6MSJ , 6MSK , 6WJD , 6WJN , 7QXN , 7QXP , 7QXU , 7QXW , 7QXX , 7QY7 , 7QYA , 7QYB , 7W37 , 7W38 , 7W39 , 7W3A , 7W3B

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF16450	Prot_ATP_ID_OB	89 → 144	Proteasomal ATPase OB C-terminal domain	Domain
PF00004	AAA	202 → 335	ATPase family associated with various cellular activities (AAA)	Domain
PF17862	AAA_lid_3	357 → 401	AAA+ lid domain	Domain

Sequence

MEEIGILVEKAQDEIPALSVSRPQTGLSFLGPEPEDLEDLYSRYKKLQQELEFLEVQEEY
IKDEQKNLKKEFLHAQEEVKRIQSIPLVIGQFLEAVDQNTAIVGSTTGSNYYVRILSTID
RELLKPNASVALHKHSNALVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREA
VELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYL
GEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFD
QNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDL
EDYVARPDKISGADINSICQESGMLAVRENRYIVLAKDFEKAYKTVIKKDEQEHEFYK

Sequence length

418

Interactions

View interactions

PSMC4 (proteasome 26S subunit, ATPase 4)