Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs Other IDs Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	5700
Gene name Gene Name - the full gene name approved by the HGNC.	Proteasome 26S subunit, ATPase 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PSMC1
Synonyms (NCBI Gene) Gene synonyms aliases	NEDGTH, P26S4, RPT2, S4, p56
Chromosome Chromosome number	14
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	14q32.11
Summary Summary of gene provided in NCBI Entrez Gene.	The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits a

Show/Hide all(188)

miRTarBase ID	miRNA	Experiments	Reference
MIRT028792	hsa-miR-26b-5p	Microarray	19088304
MIRT051203	hsa-miR-16-5p	CLASH	23622248
MIRT038229	hsa-miR-342-5p	CLASH	23622248
MIRT649822	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT649821	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT649820	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT649819	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT649818	hsa-miR-539-5p	HITS-CLIP	23824327
MIRT649817	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT649816	hsa-miR-1200	HITS-CLIP	23824327
MIRT649815	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT649814	hsa-miR-580-3p	HITS-CLIP	23824327
MIRT649813	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT649812	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT649822	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT649821	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT649820	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT649819	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT649818	hsa-miR-539-5p	HITS-CLIP	23824327
MIRT649817	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT649816	hsa-miR-1200	HITS-CLIP	23824327
MIRT649815	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT649814	hsa-miR-580-3p	HITS-CLIP	23824327
MIRT649813	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT649812	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT649822	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT649821	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT649820	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT649819	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT649818	hsa-miR-539-5p	HITS-CLIP	23824327
MIRT649817	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT649816	hsa-miR-1200	HITS-CLIP	23824327
MIRT649815	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT649814	hsa-miR-580-3p	HITS-CLIP	23824327
MIRT649813	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT649812	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT649822	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT649821	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT649820	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT649819	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT649818	hsa-miR-539-5p	HITS-CLIP	23824327
MIRT649817	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT649816	hsa-miR-1200	HITS-CLIP	23824327
MIRT649815	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT649814	hsa-miR-580-3p	HITS-CLIP	23824327
MIRT649813	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT649812	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT1270291	hsa-miR-1265	CLIP-seq
MIRT1270292	hsa-miR-1285	CLIP-seq
MIRT1270293	hsa-miR-1292	CLIP-seq
MIRT1270294	hsa-miR-2052	CLIP-seq
MIRT1270295	hsa-miR-2277-3p	CLIP-seq
MIRT1270296	hsa-miR-3145-5p	CLIP-seq
MIRT1270297	hsa-miR-3187-5p	CLIP-seq
MIRT1270298	hsa-miR-326	CLIP-seq
MIRT1270299	hsa-miR-330-5p	CLIP-seq
MIRT1270300	hsa-miR-378g	CLIP-seq
MIRT1270301	hsa-miR-3941	CLIP-seq
MIRT1270302	hsa-miR-4307	CLIP-seq
MIRT1270303	hsa-miR-4471	CLIP-seq
MIRT1270304	hsa-miR-4486	CLIP-seq
MIRT1270305	hsa-miR-4502	CLIP-seq
MIRT1270306	hsa-miR-4639-5p	CLIP-seq
MIRT1270307	hsa-miR-4643	CLIP-seq
MIRT1270308	hsa-miR-466	CLIP-seq
MIRT1270309	hsa-miR-4672	CLIP-seq
MIRT1270310	hsa-miR-4789-3p	CLIP-seq
MIRT1270311	hsa-miR-487b	CLIP-seq
MIRT1270312	hsa-miR-508-5p	CLIP-seq
MIRT1270313	hsa-miR-548c-3p	CLIP-seq
MIRT1270314	hsa-miR-612	CLIP-seq
MIRT1270292	hsa-miR-1285	CLIP-seq
MIRT1270294	hsa-miR-2052	CLIP-seq
MIRT1270296	hsa-miR-3145-5p	CLIP-seq
MIRT1270297	hsa-miR-3187-5p	CLIP-seq
MIRT1270298	hsa-miR-326	CLIP-seq
MIRT1270299	hsa-miR-330-5p	CLIP-seq
MIRT2079451	hsa-miR-361-3p	CLIP-seq
MIRT1270300	hsa-miR-378g	CLIP-seq
MIRT1270301	hsa-miR-3941	CLIP-seq
MIRT1270302	hsa-miR-4307	CLIP-seq
MIRT1270304	hsa-miR-4486	CLIP-seq
MIRT2079452	hsa-miR-4494	CLIP-seq
MIRT1270307	hsa-miR-4643	CLIP-seq
MIRT1270308	hsa-miR-466	CLIP-seq
MIRT1270309	hsa-miR-4672	CLIP-seq
MIRT2079453	hsa-miR-4771	CLIP-seq
MIRT1270310	hsa-miR-4789-3p	CLIP-seq
MIRT1270311	hsa-miR-487b	CLIP-seq
MIRT1270312	hsa-miR-508-5p	CLIP-seq
MIRT1270314	hsa-miR-612	CLIP-seq
MIRT1270291	hsa-miR-1265	CLIP-seq
MIRT1270292	hsa-miR-1285	CLIP-seq
MIRT1270293	hsa-miR-1292	CLIP-seq
MIRT2305757	hsa-miR-1972	CLIP-seq
MIRT1270294	hsa-miR-2052	CLIP-seq
MIRT1270296	hsa-miR-3145-5p	CLIP-seq
MIRT1270297	hsa-miR-3187-5p	CLIP-seq
MIRT1270298	hsa-miR-326	CLIP-seq
MIRT1270299	hsa-miR-330-5p	CLIP-seq
MIRT2079451	hsa-miR-361-3p	CLIP-seq
MIRT1270300	hsa-miR-378g	CLIP-seq
MIRT1270301	hsa-miR-3941	CLIP-seq
MIRT1270302	hsa-miR-4307	CLIP-seq
MIRT1270303	hsa-miR-4471	CLIP-seq
MIRT1270304	hsa-miR-4486	CLIP-seq
MIRT1270306	hsa-miR-4639-5p	CLIP-seq
MIRT1270307	hsa-miR-4643	CLIP-seq
MIRT1270308	hsa-miR-466	CLIP-seq
MIRT1270309	hsa-miR-4672	CLIP-seq
MIRT2305758	hsa-miR-4717-5p	CLIP-seq
MIRT1270310	hsa-miR-4789-3p	CLIP-seq
MIRT1270311	hsa-miR-487b	CLIP-seq
MIRT1270312	hsa-miR-508-5p	CLIP-seq
MIRT1270313	hsa-miR-548c-3p	CLIP-seq
MIRT1270314	hsa-miR-612	CLIP-seq
MIRT1270291	hsa-miR-1265	CLIP-seq
MIRT1270292	hsa-miR-1285	CLIP-seq
MIRT1270293	hsa-miR-1292	CLIP-seq
MIRT2602956	hsa-miR-150	CLIP-seq
MIRT2602957	hsa-miR-188-5p	CLIP-seq
MIRT2305757	hsa-miR-1972	CLIP-seq
MIRT2602958	hsa-miR-204	CLIP-seq
MIRT1270294	hsa-miR-2052	CLIP-seq
MIRT2602959	hsa-miR-211	CLIP-seq
MIRT1270295	hsa-miR-2277-3p	CLIP-seq
MIRT2602960	hsa-miR-3127-5p	CLIP-seq
MIRT1270296	hsa-miR-3145-5p	CLIP-seq
MIRT1270297	hsa-miR-3187-5p	CLIP-seq
MIRT1270298	hsa-miR-326	CLIP-seq
MIRT1270299	hsa-miR-330-5p	CLIP-seq
MIRT2079451	hsa-miR-361-3p	CLIP-seq
MIRT1270300	hsa-miR-378g	CLIP-seq
MIRT1270301	hsa-miR-3941	CLIP-seq
MIRT2602961	hsa-miR-4270	CLIP-seq
MIRT1270302	hsa-miR-4307	CLIP-seq
MIRT2602962	hsa-miR-4441	CLIP-seq
MIRT2602963	hsa-miR-4461	CLIP-seq
MIRT1270303	hsa-miR-4471	CLIP-seq
MIRT1270304	hsa-miR-4486	CLIP-seq
MIRT1270305	hsa-miR-4502	CLIP-seq
MIRT1270306	hsa-miR-4639-5p	CLIP-seq
MIRT1270307	hsa-miR-4643	CLIP-seq
MIRT1270308	hsa-miR-466	CLIP-seq
MIRT1270309	hsa-miR-4672	CLIP-seq
MIRT2305758	hsa-miR-4717-5p	CLIP-seq
MIRT1270310	hsa-miR-4789-3p	CLIP-seq
MIRT1270311	hsa-miR-487b	CLIP-seq
MIRT1270312	hsa-miR-508-5p	CLIP-seq
MIRT2602964	hsa-miR-539	CLIP-seq
MIRT1270313	hsa-miR-548c-3p	CLIP-seq
MIRT2602965	hsa-miR-580	CLIP-seq
MIRT1270314	hsa-miR-612	CLIP-seq
MIRT1270291	hsa-miR-1265	CLIP-seq
MIRT1270292	hsa-miR-1285	CLIP-seq
MIRT1270293	hsa-miR-1292	CLIP-seq
MIRT2602956	hsa-miR-150	CLIP-seq
MIRT2602957	hsa-miR-188-5p	CLIP-seq
MIRT2602958	hsa-miR-204	CLIP-seq
MIRT1270294	hsa-miR-2052	CLIP-seq
MIRT2602959	hsa-miR-211	CLIP-seq
MIRT1270295	hsa-miR-2277-3p	CLIP-seq
MIRT2602960	hsa-miR-3127-5p	CLIP-seq
MIRT1270296	hsa-miR-3145-5p	CLIP-seq
MIRT1270297	hsa-miR-3187-5p	CLIP-seq
MIRT1270298	hsa-miR-326	CLIP-seq
MIRT1270299	hsa-miR-330-5p	CLIP-seq
MIRT2079451	hsa-miR-361-3p	CLIP-seq
MIRT1270300	hsa-miR-378g	CLIP-seq
MIRT1270301	hsa-miR-3941	CLIP-seq
MIRT2602961	hsa-miR-4270	CLIP-seq
MIRT1270302	hsa-miR-4307	CLIP-seq
MIRT2602962	hsa-miR-4441	CLIP-seq
MIRT2602963	hsa-miR-4461	CLIP-seq
MIRT1270303	hsa-miR-4471	CLIP-seq
MIRT1270304	hsa-miR-4486	CLIP-seq
MIRT1270305	hsa-miR-4502	CLIP-seq
MIRT1270306	hsa-miR-4639-5p	CLIP-seq
MIRT1270307	hsa-miR-4643	CLIP-seq
MIRT1270308	hsa-miR-466	CLIP-seq
MIRT1270309	hsa-miR-4672	CLIP-seq
MIRT1270310	hsa-miR-4789-3p	CLIP-seq
MIRT1270311	hsa-miR-487b	CLIP-seq
MIRT1270312	hsa-miR-508-5p	CLIP-seq
MIRT2602964	hsa-miR-539	CLIP-seq
MIRT1270313	hsa-miR-548c-3p	CLIP-seq
MIRT2602965	hsa-miR-580	CLIP-seq
MIRT1270314	hsa-miR-612	CLIP-seq

Show/Hide all(42)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000165	Process	MAPK cascade	TAS
GO:0000209	Process	Protein polyubiquitination	TAS
GO:0000502	Component	Proteasome complex	IDA	17323924
GO:0002223	Process	Stimulatory C-type lectin receptor signaling pathway	TAS
GO:0002479	Process	Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	TAS
GO:0003723	Function	RNA binding	HDA	22658674
GO:0005515	Function	Protein binding	IPI	9452483, 16189514, 16990800, 19060904, 19490896, 22901813, 23455924, 25416956, 26496610, 28514442, 29128334, 29636472, 31515488, 32296183, 32814053
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006457	Process	Protein folding	TAS
GO:0006521	Process	Regulation of cellular amino acid metabolic process	TAS
GO:0008540	Component	Proteasome regulatory particle, base subcomplex	IBA	21873635
GO:0010972	Process	Negative regulation of G2/M transition of mitotic cell cycle	TAS
GO:0016020	Component	Membrane	HDA	19946888
GO:0016579	Process	Protein deubiquitination	TAS
GO:0016887	Function	ATPase activity	ISS	1429620
GO:0017025	Function	TBP-class protein binding	IBA	21873635
GO:0022624	Component	Proteasome accessory complex	ISS
GO:0031145	Process	Anaphase-promoting complex-dependent catabolic process	TAS
GO:0031146	Process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	TAS
GO:0033209	Process	Tumor necrosis factor-mediated signaling pathway	TAS
GO:0036402	Function	Proteasome-activating ATPase activity	IBA	21873635
GO:0038061	Process	NIK/NF-kappaB signaling	TAS
GO:0038095	Process	Fc-epsilon receptor signaling pathway	TAS
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	TAS
GO:0043488	Process	Regulation of mRNA stability	TAS
GO:0043687	Process	Post-translational protein modification	TAS
GO:0050852	Process	T cell receptor signaling pathway	TAS
GO:0055085	Process	Transmembrane transport	TAS
GO:0060071	Process	Wnt signaling pathway, planar cell polarity pathway	TAS
GO:0061418	Process	Regulation of transcription from RNA polymerase II promoter in response to hypoxia	TAS
GO:0070498	Process	Interleukin-1-mediated signaling pathway	TAS
GO:0090090	Process	Negative regulation of canonical Wnt signaling pathway	TAS
GO:0090263	Process	Positive regulation of canonical Wnt signaling pathway	TAS
GO:1901215	Process	Negative regulation of neuron death	IEA
GO:1901800	Process	Positive regulation of proteasomal protein catabolic process	IEA
GO:1901990	Process	Regulation of mitotic cell cycle phase transition	TAS
GO:1902036	Process	Regulation of hematopoietic stem cell differentiation	TAS

MIM	HGNC	e!Ensembl
602706	9547	ENSG00000100764

Protein

UniProt ID

P62191

Protein name

26S proteasome regulatory subunit 4 (P26s4) (26S proteasome AAA-ATPase subunit RPT2) (Proteasome 26S subunit ATPase 1)

Protein function

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which

PDB

5GJQ , 5GJR , 5L4G , 5LN3 , 5M32 , 5T0C , 5T0G , 5T0H , 5T0I , 5T0J , 5VFP , 5VFQ , 5VFR , 5VFS , 5VFT , 5VFU , 5VGZ , 5VHF , 5VHH , 5VHI , 5VHJ , 5VHM , 5VHN , 5VHO , 5VHP , 5VHQ , 5VHR , 5VHS , 6MSB , 6MSD , 6MSG , 6MSH , 6MSJ , 6MSK , 6WJD , 6WJN , 7QXN , 7QXP , 7QXU , 7QXW , 7QXX , 7QY7 , 7QYA , 7QYB , 7W37 , 7W38 , 7W39 , 7W3A , 7W3B , 7W3C , 7W3F

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF16450	Prot_ATP_ID_OB	109 → 163	Proteasomal ATPase OB C-terminal domain	Domain
PF00004	AAA	222 → 355	ATPase family associated with various cellular activities (AAA)	Domain
PF17862	AAA_lid_3	377 → 421	AAA+ lid domain	Domain

Sequence

MGQSQSGGHGPGGGKKDDKDKKKKYEPPVPTRVGKKKKKTKGPDAASKLPLVTPHTQCRL
KLLKLERIKDYLLMEEEFIRNQEQMKPLEEKQEEERSKVDDLRGTPMSVGTLEEIIDDNH
AIVSTSVGSEHYVSILSFVDKDLLEPGCSVLLNHKVHAVIGVLMDDTDPLVTVMKVEKAP
QETYADIGGLDNQIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGPPGTGKTLLAKAVA
NQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAIGTKRYDSNSG
GEREIQRTMLELLNQLDGFDSRGDVKVIMATNRIETLDPALIRPGRIDRKIEFPLPDEKT
KKRIFQIHTSRMTLADDVTLDDLIMAKDDLSGADIKAICTEAGLMALRERRMKVTNEDFK
KSKENVLYKKQEGTPEGLYL

Sequence length

440

Interactions

View interactions

Show/Hide Unknown Diseases (2)

Disease term	Disease name	Source
Unknown
Neurodevelopmental Disorders	neurodevelopmental disorder	GenCC
Dementia	Dementia	GWAS

Show/Hide Text Mining Associations (12)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenocarcinoma of Lung	Associate	36091041
Anemia Hemolytic	Associate	36639418
Arthritis Rheumatoid	Associate	39342401
Ataxia Telangiectasia	Associate	19147735
Breast Neoplasms	Associate	34329194
Diabetes Mellitus Type 2	Associate	39342401
Hypertension	Associate	32664164
Ossification Heterotopic	Associate	34612770
Prostatic Neoplasms	Associate	22509301
Spondylitis Ankylosing	Inhibit	34612770
Urinary Bladder Neoplasms	Associate	38073378
Ventricular Remodeling	Associate	32664164

PSMC1 (proteasome 26S subunit, ATPase 1)