Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs Other IDs
Entrez ID	5694
Gene name	Proteasome 20S subunit beta 6
Gene symbol	PSMB6
Synonyms (NCBI Gene)	DELTALMPY
Chromosome	17
Chromosome location	17p13.2
Summary	The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta

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miRTarBase ID	miRNA	Experiments	Reference
MIRT049356	hsa-miR-92a-3p	CLASH	23622248
MIRT048307	hsa-miR-107	CLASH	23622248
MIRT038619	hsa-miR-185-3p	CLASH	23622248
MIRT2079448	hsa-miR-4477a	CLIP-seq
MIRT2305739	hsa-miR-137	CLIP-seq
MIRT2305740	hsa-miR-153	CLIP-seq
MIRT2305741	hsa-miR-25	CLIP-seq
MIRT2305742	hsa-miR-28-3p	CLIP-seq
MIRT2305743	hsa-miR-32	CLIP-seq
MIRT2305744	hsa-miR-363	CLIP-seq
MIRT2305745	hsa-miR-367	CLIP-seq
MIRT2305746	hsa-miR-448	CLIP-seq
MIRT2305747	hsa-miR-450b-5p	CLIP-seq
MIRT2305748	hsa-miR-4711-5p	CLIP-seq
MIRT2305749	hsa-miR-4761-3p	CLIP-seq
MIRT2305750	hsa-miR-507	CLIP-seq
MIRT2305751	hsa-miR-513a-3p	CLIP-seq
MIRT2305752	hsa-miR-557	CLIP-seq
MIRT2305753	hsa-miR-92a	CLIP-seq
MIRT2305754	hsa-miR-92b	CLIP-seq
MIRT2305739	hsa-miR-137	CLIP-seq
MIRT2305740	hsa-miR-153	CLIP-seq
MIRT2602936	hsa-miR-1915	CLIP-seq
MIRT2305741	hsa-miR-25	CLIP-seq
MIRT2305742	hsa-miR-28-3p	CLIP-seq
MIRT2305743	hsa-miR-32	CLIP-seq
MIRT2305744	hsa-miR-363	CLIP-seq
MIRT2305745	hsa-miR-367	CLIP-seq
MIRT2079448	hsa-miR-4477a	CLIP-seq
MIRT2305746	hsa-miR-448	CLIP-seq
MIRT2305747	hsa-miR-450b-5p	CLIP-seq
MIRT2305748	hsa-miR-4711-5p	CLIP-seq
MIRT2602937	hsa-miR-4726-3p	CLIP-seq
MIRT2305749	hsa-miR-4761-3p	CLIP-seq
MIRT2305750	hsa-miR-507	CLIP-seq
MIRT2305751	hsa-miR-513a-3p	CLIP-seq
MIRT2305752	hsa-miR-557	CLIP-seq
MIRT2305753	hsa-miR-92a	CLIP-seq
MIRT2305754	hsa-miR-92b	CLIP-seq
MIRT2305739	hsa-miR-137	CLIP-seq
MIRT2305740	hsa-miR-153	CLIP-seq
MIRT2602936	hsa-miR-1915	CLIP-seq
MIRT2305741	hsa-miR-25	CLIP-seq
MIRT2305742	hsa-miR-28-3p	CLIP-seq
MIRT2305743	hsa-miR-32	CLIP-seq
MIRT2305744	hsa-miR-363	CLIP-seq
MIRT2305745	hsa-miR-367	CLIP-seq
MIRT2079448	hsa-miR-4477a	CLIP-seq
MIRT2305746	hsa-miR-448	CLIP-seq
MIRT2305747	hsa-miR-450b-5p	CLIP-seq
MIRT2305748	hsa-miR-4711-5p	CLIP-seq
MIRT2602937	hsa-miR-4726-3p	CLIP-seq
MIRT2305749	hsa-miR-4761-3p	CLIP-seq
MIRT2305750	hsa-miR-507	CLIP-seq
MIRT2305751	hsa-miR-513a-3p	CLIP-seq
MIRT2305752	hsa-miR-557	CLIP-seq
MIRT2305753	hsa-miR-92a	CLIP-seq
MIRT2305754	hsa-miR-92b	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000502	Component	Proteasome complex	IDA	17323924
GO:0000502	Component	Proteasome complex	IEA
GO:0000502	Component	Proteasome complex	NAS	29636472
GO:0004175	Function	Endopeptidase activity	IBA
GO:0004175	Function	Endopeptidase activity	NAS	8066462
GO:0004298	Function	Threonine-type endopeptidase activity	IEA
GO:0005515	Function	Protein binding	IPI	14733938, 17948026, 28514442, 31473102, 32296183, 32814053, 33961781, 35271311
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	34711951
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IDA	34711951
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	IDA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005839	Component	Proteasome core complex	IDA	34711951
GO:0005839	Component	Proteasome core complex	IEA
GO:0005839	Component	Proteasome core complex	ISS
GO:0006508	Process	Proteolysis	IEA
GO:0008233	Function	Peptidase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0019774	Component	Proteasome core complex, beta-subunit complex	IBA
GO:0019774	Component	Proteasome core complex, beta-subunit complex	ISS
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IBA
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	NAS	19489727
GO:0045296	Function	Cadherin binding	HDA	25468996
GO:0051603	Process	Proteolysis involved in protein catabolic process	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867, 20458337

MIM	HGNC	e!Ensembl
600307	9543	ENSG00000142507

P28072

Protein name

Proteasome subunit beta type-6 (EC 3.4.25.1) (Macropain delta chain) (Multicatalytic endopeptidase complex delta chain) (Proteasome delta chain) (Proteasome subunit Y) (Proteasome subunit beta-1) (beta-1)

Protein function

Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with

PDB

4R3O , 4R67 , 5A0Q , 5GJQ , 5GJR , 5L4G , 5LE5 , 5LEX , 5LEY , 5LEZ , 5LF0 , 5LF1 , 5LF3 , 5LF4 , 5LF6 , 5LF7 , 5LN3 , 5M32 , 5T0C , 5T0G , 5T0H , 5T0I , 5T0J , 5VFO , 5VFP , 5VFQ , 5VFR , 5VFS , 5VFT , 5VFU , 6KWY , 6MSB , 6MSD , 6MSE , 6MSG , 6MSH , 6MSJ , 6MSK , 6R70 , 6REY , 6RGQ , 6WJD , 6WJN , 6XMJ , 7LXV , 7NAN , 7NAO , 7NAP , 7NAQ , 7NHT , 7PG9

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00227	Proteasome	31 → 213	Proteasome subunit	Domain

Sequence

MAATLLAARGAGPAPAWGPEAFTPDWESREVSTGTTIMAVQFDGGVVLGADSRTTTGSYI
ANRVTDKLTPIHDRIFCCRSGSAADTQAVADAVTYQLGFHSIELNEPPLVHTAASLFKEM
CYRYREDLMAGIIIAGWDPQEGGQVYSVPMGGMMVRQSFAIGGSGSSYIYGYVDATYREG
MTKEECLQFTANALALAMERDGSSGGVIRLAAIAESGVERQVLLGDQIPKFAVATLPPA

Sequence length

239

Interactions

View interactions

PSMB6 (proteasome 20S subunit beta 6)