PSMB11 (proteasome subunit beta 11)

Gene

• Entrez ID: 122706
• Gene name: Proteasome subunit beta 11
• Gene symbol: PSMB11
• Synonyms (NCBI Gene): BETA5T
• Chromosome: 14
• Chromosome location: 14q11.2
• Summary: Proteasomes generate peptides that are presented by major histocompatibility complex (MHC) I molecules to other cells of the immune system. Proteolysis is conducted by 20S proteasomes, complexes of 28 subunits arranged as a cylinder in 4 heteroheptameric

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1270080	hsa-miR-3617	CLIP-seq
MIRT1270081	hsa-miR-4252	CLIP-seq
MIRT1270082	hsa-miR-4311	CLIP-seq
MIRT1270083	hsa-miR-4318	CLIP-seq
MIRT1270084	hsa-miR-4693-5p	CLIP-seq
MIRT1270085	hsa-miR-4722-3p	CLIP-seq
MIRT1270086	hsa-miR-4725-5p	CLIP-seq
MIRT1270087	hsa-miR-4777-3p	CLIP-seq
MIRT1270088	hsa-miR-504	CLIP-seq
MIRT1270089	hsa-miR-641	CLIP-seq
MIRT1270090	hsa-miR-892a	CLIP-seq
MIRT2079431	hsa-miR-596	CLIP-seq
MIRT2079432	hsa-miR-642a	CLIP-seq
MIRT2079433	hsa-miR-671-5p	CLIP-seq
MIRT2305689	hsa-miR-127-5p	CLIP-seq
MIRT2305690	hsa-miR-143	CLIP-seq
MIRT2305691	hsa-miR-3134	CLIP-seq
MIRT2305692	hsa-miR-3148	CLIP-seq
MIRT2305693	hsa-miR-3688-3p	CLIP-seq
MIRT2305694	hsa-miR-3919	CLIP-seq
MIRT2305695	hsa-miR-4329	CLIP-seq
MIRT2305696	hsa-miR-4534	CLIP-seq
MIRT2305697	hsa-miR-4770	CLIP-seq
MIRT2305698	hsa-miR-4789-3p	CLIP-seq
MIRT2305699	hsa-miR-642b	CLIP-seq
MIRT2457328	hsa-miR-1275	CLIP-seq
MIRT2457329	hsa-miR-1587	CLIP-seq
MIRT2457330	hsa-miR-3151	CLIP-seq
MIRT2457331	hsa-miR-4417	CLIP-seq
MIRT2457332	hsa-miR-4447	CLIP-seq
MIRT2457333	hsa-miR-4472	CLIP-seq
MIRT2457334	hsa-miR-4492	CLIP-seq
MIRT2457335	hsa-miR-4498	CLIP-seq
MIRT2457336	hsa-miR-4525	CLIP-seq
MIRT2457337	hsa-miR-4656	CLIP-seq
MIRT2457338	hsa-miR-4665-5p	CLIP-seq
MIRT2457339	hsa-miR-4675	CLIP-seq
MIRT2457340	hsa-miR-4723-5p	CLIP-seq
MIRT2457341	hsa-miR-4741	CLIP-seq
MIRT2457342	hsa-miR-491-5p	CLIP-seq
MIRT2457343	hsa-miR-541	CLIP-seq
MIRT2457344	hsa-miR-625	CLIP-seq
MIRT2457345	hsa-miR-654-5p	CLIP-seq
MIRT2457346	hsa-miR-762	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000502	Component	Proteasome complex	IEA
GO:0004175	Function	Endopeptidase activity	IBA
GO:0004298	Function	Threonine-type endopeptidase activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	TAS
GO:0005839	Component	Proteasome core complex	IEA
GO:0006508	Process	Proteolysis	IDA	17540904
GO:0006508	Process	Proteolysis	IEA
GO:0008233	Function	Peptidase activity	IDA	17540904
GO:0008233	Function	Peptidase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0019774	Component	Proteasome core complex, beta-subunit complex	IBA
GO:0019774	Component	Proteasome core complex, beta-subunit complex	ISS
GO:0033077	Process	T cell differentiation in thymus	IEA
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IBA
GO:0043374	Process	CD8-positive, alpha-beta T cell differentiation	IEA
GO:0051603	Process	Proteolysis involved in protein catabolic process	IEA

Other IDs

• MIM: 611137
• HGNC: 31963
• e!Ensembl: ENSG00000222028

Protein

• UniProt ID: A5LHX3
• Protein name: Proteasome subunit beta type-11 (EC 3.4.25.1) (Proteasome subunit beta-5t)
• Protein function: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent pr
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00227	Proteasome	46 → 228	Proteasome subunit	Domain

• Sequence:

  MALQDVCKWQSPDTQGPSPHLPRAGGWAVPRGCDPQTFLQIHGPRLAHGTTTLAFRFRHG
  VIAAADTRSSCGSYVACPASCKVIPVHQHLLGTTSGTSADCATWYRVLQRELRLRELREG
  QLPSVASAAKLLSAMMSQYRGLDLCVATALCGWDRSGPELFYVYSDGTRLQGDIFSVGSG
  SPYAYGVLDRGYRYDMSTQEAYALARCAVAHATHRDAYSGGSVDLFHVRESGWEHVSRSD
  ACVLYVELQKLLEPEPEEDASHAHPEPATAHRAAEDRELSVGPGEVTPGDSRMPAGTETV
  

• Sequence length: 300