Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs Other IDs Associated diseases
Entrez ID	5688
Gene name	Proteasome 20S subunit alpha 7
Gene symbol	PSMA7
Synonyms (NCBI Gene)	C6HEL-S-276HSPCRC6-1XAPC7
Chromosome	20
Chromosome location	20q13.33
Summary	The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits a

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Show/Hide all (151)

miRTarBase ID	miRNA	Experiments	Reference
MIRT049617	hsa-miR-92a-3p	CLASH	23622248
MIRT041274	hsa-miR-193b-3p	CLASH	23622248
MIRT040706	hsa-miR-92b-3p	CLASH	23622248
MIRT456028	hsa-miR-6768-3p	PAR-CLIP	23592263
MIRT456027	hsa-miR-4694-3p	PAR-CLIP	23592263
MIRT456026	hsa-miR-224-3p	PAR-CLIP	23592263
MIRT456025	hsa-miR-522-3p	PAR-CLIP	23592263
MIRT456024	hsa-miR-4789-3p	PAR-CLIP	23592263
MIRT456023	hsa-miR-4643	PAR-CLIP	23592263
MIRT456022	hsa-miR-3688-3p	PAR-CLIP	23592263
MIRT456021	hsa-miR-6733-3p	PAR-CLIP	23592263
MIRT456020	hsa-miR-4302	PAR-CLIP	23592263
MIRT456019	hsa-miR-1-3p	PAR-CLIP	23592263
MIRT456018	hsa-miR-206	PAR-CLIP	23592263
MIRT456017	hsa-miR-613	PAR-CLIP	23592263
MIRT456016	hsa-miR-1257	PAR-CLIP	23592263
MIRT456015	hsa-miR-466	PAR-CLIP	23592263
MIRT456014	hsa-miR-3978	PAR-CLIP	23592263
MIRT456016	hsa-miR-1257	PAR-CLIP	26701625
MIRT456016	hsa-miR-1257	PAR-CLIP	26701625
MIRT456016	hsa-miR-1257	PAR-CLIP	26701625
MIRT456016	hsa-miR-1257	PAR-CLIP	26701625
MIRT456016	hsa-miR-1257	PAR-CLIP	26701625
MIRT456016	hsa-miR-1257	PAR-CLIP	26701625
MIRT456019	hsa-miR-1-3p	PAR-CLIP	26701625
MIRT456019	hsa-miR-1-3p	PAR-CLIP	26701625
MIRT456019	hsa-miR-1-3p	PAR-CLIP	26701625
MIRT456019	hsa-miR-1-3p	PAR-CLIP	26701625
MIRT456019	hsa-miR-1-3p	PAR-CLIP	26701625
MIRT456019	hsa-miR-1-3p	PAR-CLIP	26701625
MIRT456018	hsa-miR-206	PAR-CLIP	26701625
MIRT456018	hsa-miR-206	PAR-CLIP	26701625
MIRT456018	hsa-miR-206	PAR-CLIP	26701625
MIRT456018	hsa-miR-206	PAR-CLIP	26701625
MIRT456018	hsa-miR-206	PAR-CLIP	26701625
MIRT456018	hsa-miR-206	PAR-CLIP	26701625
MIRT456026	hsa-miR-224-3p	PAR-CLIP	26701625
MIRT456026	hsa-miR-224-3p	PAR-CLIP	26701625
MIRT456026	hsa-miR-224-3p	PAR-CLIP	26701625
MIRT456026	hsa-miR-224-3p	PAR-CLIP	26701625
MIRT456026	hsa-miR-224-3p	PAR-CLIP	26701625
MIRT456026	hsa-miR-224-3p	PAR-CLIP	26701625
MIRT456022	hsa-miR-3688-3p	PAR-CLIP	26701625
MIRT456022	hsa-miR-3688-3p	PAR-CLIP	26701625
MIRT456022	hsa-miR-3688-3p	PAR-CLIP	26701625
MIRT456022	hsa-miR-3688-3p	PAR-CLIP	26701625
MIRT456022	hsa-miR-3688-3p	PAR-CLIP	26701625
MIRT456022	hsa-miR-3688-3p	PAR-CLIP	26701625
MIRT456014	hsa-miR-3978	PAR-CLIP	26701625
MIRT456014	hsa-miR-3978	PAR-CLIP	26701625
MIRT456014	hsa-miR-3978	PAR-CLIP	26701625
MIRT456014	hsa-miR-3978	PAR-CLIP	26701625
MIRT456014	hsa-miR-3978	PAR-CLIP	26701625
MIRT456014	hsa-miR-3978	PAR-CLIP	26701625
MIRT456020	hsa-miR-4302	PAR-CLIP	26701625
MIRT456020	hsa-miR-4302	PAR-CLIP	26701625
MIRT456020	hsa-miR-4302	PAR-CLIP	26701625
MIRT456020	hsa-miR-4302	PAR-CLIP	26701625
MIRT456020	hsa-miR-4302	PAR-CLIP	26701625
MIRT456020	hsa-miR-4302	PAR-CLIP	26701625
MIRT456023	hsa-miR-4643	PAR-CLIP	26701625
MIRT456023	hsa-miR-4643	PAR-CLIP	26701625
MIRT456023	hsa-miR-4643	PAR-CLIP	26701625
MIRT456023	hsa-miR-4643	PAR-CLIP	26701625
MIRT456023	hsa-miR-4643	PAR-CLIP	26701625
MIRT456023	hsa-miR-4643	PAR-CLIP	26701625
MIRT456015	hsa-miR-466	PAR-CLIP	26701625
MIRT456015	hsa-miR-466	PAR-CLIP	26701625
MIRT456015	hsa-miR-466	PAR-CLIP	26701625
MIRT456015	hsa-miR-466	PAR-CLIP	26701625
MIRT456015	hsa-miR-466	PAR-CLIP	26701625
MIRT456015	hsa-miR-466	PAR-CLIP	26701625
MIRT456027	hsa-miR-4694-3p	PAR-CLIP	26701625
MIRT456027	hsa-miR-4694-3p	PAR-CLIP	26701625
MIRT456027	hsa-miR-4694-3p	PAR-CLIP	26701625
MIRT456027	hsa-miR-4694-3p	PAR-CLIP	26701625
MIRT456027	hsa-miR-4694-3p	PAR-CLIP	26701625
MIRT456027	hsa-miR-4694-3p	PAR-CLIP	26701625
MIRT456024	hsa-miR-4789-3p	PAR-CLIP	26701625
MIRT456024	hsa-miR-4789-3p	PAR-CLIP	26701625
MIRT456024	hsa-miR-4789-3p	PAR-CLIP	26701625
MIRT456024	hsa-miR-4789-3p	PAR-CLIP	26701625
MIRT456024	hsa-miR-4789-3p	PAR-CLIP	26701625
MIRT456024	hsa-miR-4789-3p	PAR-CLIP	26701625
MIRT456025	hsa-miR-522-3p	PAR-CLIP	26701625
MIRT456025	hsa-miR-522-3p	PAR-CLIP	26701625
MIRT456025	hsa-miR-522-3p	PAR-CLIP	26701625
MIRT456025	hsa-miR-522-3p	PAR-CLIP	26701625
MIRT456025	hsa-miR-522-3p	PAR-CLIP	26701625
MIRT456025	hsa-miR-522-3p	PAR-CLIP	26701625
MIRT456017	hsa-miR-613	PAR-CLIP	26701625
MIRT456017	hsa-miR-613	PAR-CLIP	26701625
MIRT456017	hsa-miR-613	PAR-CLIP	26701625
MIRT456017	hsa-miR-613	PAR-CLIP	26701625
MIRT456017	hsa-miR-613	PAR-CLIP	26701625
MIRT456017	hsa-miR-613	PAR-CLIP	26701625
MIRT456021	hsa-miR-6733-3p	PAR-CLIP	26701625
MIRT456021	hsa-miR-6733-3p	PAR-CLIP	26701625
MIRT456021	hsa-miR-6733-3p	PAR-CLIP	26701625
MIRT456021	hsa-miR-6733-3p	PAR-CLIP	26701625
MIRT456021	hsa-miR-6733-3p	PAR-CLIP	26701625
MIRT456021	hsa-miR-6733-3p	PAR-CLIP	26701625
MIRT456028	hsa-miR-6768-3p	PAR-CLIP	26701625
MIRT456028	hsa-miR-6768-3p	PAR-CLIP	26701625
MIRT456028	hsa-miR-6768-3p	PAR-CLIP	26701625
MIRT456028	hsa-miR-6768-3p	PAR-CLIP	26701625
MIRT456028	hsa-miR-6768-3p	PAR-CLIP	26701625
MIRT456028	hsa-miR-6768-3p	PAR-CLIP	26701625
MIRT456016	hsa-miR-1257	PAR-CLIP	27292025
MIRT456019	hsa-miR-1-3p	PAR-CLIP	27292025
MIRT456018	hsa-miR-206	PAR-CLIP	27292025
MIRT456026	hsa-miR-224-3p	PAR-CLIP	27292025
MIRT456022	hsa-miR-3688-3p	PAR-CLIP	27292025
MIRT456014	hsa-miR-3978	PAR-CLIP	27292025
MIRT456020	hsa-miR-4302	PAR-CLIP	27292025
MIRT456023	hsa-miR-4643	PAR-CLIP	27292025
MIRT456015	hsa-miR-466	PAR-CLIP	27292025
MIRT456027	hsa-miR-4694-3p	PAR-CLIP	27292025
MIRT456024	hsa-miR-4789-3p	PAR-CLIP	27292025
MIRT456025	hsa-miR-522-3p	PAR-CLIP	27292025
MIRT456017	hsa-miR-613	PAR-CLIP	27292025
MIRT456021	hsa-miR-6733-3p	PAR-CLIP	27292025
MIRT456028	hsa-miR-6768-3p	PAR-CLIP	27292025
MIRT456028	hsa-miR-6768-3p	PAR-CLIP	23592263
MIRT456027	hsa-miR-4694-3p	PAR-CLIP	23592263
MIRT456026	hsa-miR-224-3p	PAR-CLIP	23592263
MIRT456025	hsa-miR-522-3p	PAR-CLIP	23592263
MIRT456024	hsa-miR-4789-3p	PAR-CLIP	23592263
MIRT456023	hsa-miR-4643	PAR-CLIP	23592263
MIRT456022	hsa-miR-3688-3p	PAR-CLIP	23592263
MIRT456021	hsa-miR-6733-3p	PAR-CLIP	23592263
MIRT456020	hsa-miR-4302	PAR-CLIP	23592263
MIRT456019	hsa-miR-1-3p	PAR-CLIP	23592263
MIRT456018	hsa-miR-206	PAR-CLIP	23592263
MIRT456017	hsa-miR-613	PAR-CLIP	23592263
MIRT456016	hsa-miR-1257	PAR-CLIP	23592263
MIRT456015	hsa-miR-466	PAR-CLIP	23592263
MIRT456014	hsa-miR-3978	PAR-CLIP	23592263
MIRT1270057	hsa-miR-1	CLIP-seq
MIRT1270058	hsa-miR-190	CLIP-seq
MIRT1270059	hsa-miR-190b	CLIP-seq
MIRT1270060	hsa-miR-3673	CLIP-seq
MIRT1270061	hsa-miR-522	CLIP-seq
MIRT1270057	hsa-miR-1	CLIP-seq
MIRT1270060	hsa-miR-3673	CLIP-seq
MIRT1270061	hsa-miR-522	CLIP-seq
MIRT1270057	hsa-miR-1	CLIP-seq
MIRT1270058	hsa-miR-190	CLIP-seq
MIRT1270059	hsa-miR-190b	CLIP-seq
MIRT1270060	hsa-miR-3673	CLIP-seq
MIRT1270061	hsa-miR-522	CLIP-seq

Show/Hide all (27)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000502	Component	Proteasome complex	IDA	17323924
GO:0000502	Component	Proteasome complex	IEA
GO:0000502	Component	Proteasome complex	NAS	29636472
GO:0000502	Component	Proteasome complex	TAS	8811196
GO:0005515	Function	Protein binding	IPI	12376572, 14733938, 15225636, 16251969, 16990800, 17948026, 19416853, 21900206, 21988832, 25599644, 25959826, 28514442, 29568061, 29636472, 31473102, 32296183, 32814053, 33961781, 34702852, 35271311, 35858375
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	34711951
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IDA	34711951
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005839	Component	Proteasome core complex	IDA	34711951
GO:0005839	Component	Proteasome core complex	IEA
GO:0005839	Component	Proteasome core complex	ISS
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IEA
GO:0019773	Component	Proteasome core complex, alpha-subunit complex	IBA
GO:0019773	Component	Proteasome core complex, alpha-subunit complex	IDA	30133132
GO:0019773	Component	Proteasome core complex, alpha-subunit complex	IEA
GO:0019773	Component	Proteasome core complex, alpha-subunit complex	ISS
GO:0042802	Function	Identical protein binding	IPI	15225636, 17948026
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IBA
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	NAS	19489727
GO:0051603	Process	Proteolysis involved in protein catabolic process	IEA
GO:0070062	Component	Extracellular exosome	HDA	20458337, 23533145

MIM	HGNC	e!Ensembl
606607	9536	ENSG00000101182

O14818

Protein name

Proteasome subunit alpha type-7 (Proteasome subunit RC6-1) (Proteasome subunit XAPC7) (Proteasome subunit alpha-4) (alpha-4)

Protein function

Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with

PDB

4R3O , 4R67 , 5A0Q , 5GJQ , 5GJR , 5L4G , 5LE5 , 5LEX , 5LEY , 5LEZ , 5LF0 , 5LF1 , 5LF3 , 5LF4 , 5LF6 , 5LF7 , 5LN3 , 5M32 , 5T0C , 5T0G , 5T0H , 5T0I , 5T0J , 5VFO , 5VFP , 5VFQ , 5VFR , 5VFS , 5VFT , 5VFU , 6AVO , 6E5B , 6KWY , 6MSB , 6MSD , 6MSE , 6MSG , 6MSH , 6MSJ , 6MSK , 6R70 , 6REY , 6RGQ , 6WJD , 6WJN , 6XMJ , 7AWE , 7B12 , 7LXV , 7NAN , 7NAO

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF10584	Proteasome_A_N	3 → 25	Proteasome subunit A N-terminal signature	Family
PF00227	Proteasome	26 → 211	Proteasome subunit	Domain

Sequence

MSYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGVRGRDIVVLGVEKKSVAKLQDERTVR
KICALDDNVCMAFAGLTADARIVINRARVECQSHRLTVEDPVTVEYITRYIASLKQRYTQ
SNGRRPFGISALIVGFDFDGTPRLYQTDPSGTYHAWKANAIGRGAKSVREFLEKNYTDEA
IETDDLTIKLVIKALLEVVQSGGKNIELAVMRRDQSLKILNPEEIEKYVAEIEKEKEENE
KKKQKKAS

Sequence length

248

Interactions

View interactions

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
PSMA7-related disorder	Uncertain significance	rs2516191700	RCV003397203
Variant of unknown significance	Uncertain significance	rs2145664821	RCV000033110

Show/Hide Text Mining Associations (15)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Arthritis Rheumatoid	Associate	39342401
Breast Neoplasms	Associate	34604955
Carcinoma Squamous Cell	Associate	37369480
Colorectal Neoplasms	Stimulate	23839082
Diabetes Mellitus Type 2	Inhibit	39342401
Lung Diseases	Associate	17586700, 21707890
Lung Diseases Interstitial	Associate	25344067
Neoplasm Metastasis	Associate	38211649
Neoplasms	Associate	23839082, 37369480
Neoplasms	Stimulate	38211649
Prostatic Neoplasms	Associate	19893039
Pulmonary Alveolar Proteinosis Acquired	Associate	21707890
Stomach Neoplasms	Stimulate	27966459
Urinary Bladder Neoplasms	Stimulate	38211649
Wiskott Aldrich Syndrome	Associate	27237736

PSMA7 (proteasome 20S subunit alpha 7)