Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs Other IDs Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	5685
Gene name Gene Name - the full gene name approved by the HGNC.	Proteasome 20S subunit alpha 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PSMA4
Synonyms (NCBI Gene) Gene synonyms aliases	HC9, HsT17706, PSC9
Chromosome Chromosome number	15
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	15q25.1
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a core alpha subunit of the 20S proteosome, which is a highly ordered ring-shaped structure composed of four rings of 28 non-identical subunits. Proteasomes cleave peptides in an ATP- and ubiquitin-dependent manner. [provided by RefSeq,

Show/Hide all(133)

miRTarBase ID	miRNA	Experiments	Reference
MIRT049531	hsa-miR-92a-3p	CLASH	23622248
MIRT043029	hsa-miR-324-5p	CLASH	23622248
MIRT1270002	hsa-miR-142-5p	CLIP-seq
MIRT1270003	hsa-miR-208a	CLIP-seq
MIRT1270004	hsa-miR-208b	CLIP-seq
MIRT1270005	hsa-miR-3179	CLIP-seq
MIRT1270006	hsa-miR-338-5p	CLIP-seq
MIRT1270007	hsa-miR-4272	CLIP-seq
MIRT1270008	hsa-miR-4520a-3p	CLIP-seq
MIRT1270009	hsa-miR-4520b-3p	CLIP-seq
MIRT1270010	hsa-miR-4699-5p	CLIP-seq
MIRT1270011	hsa-miR-499-5p	CLIP-seq
MIRT1270012	hsa-miR-548a-5p	CLIP-seq
MIRT1270013	hsa-miR-548ab	CLIP-seq
MIRT1270014	hsa-miR-548ak	CLIP-seq
MIRT1270015	hsa-miR-548b-5p	CLIP-seq
MIRT1270016	hsa-miR-548c-5p	CLIP-seq
MIRT1270017	hsa-miR-548d-5p	CLIP-seq
MIRT1270018	hsa-miR-548h	CLIP-seq
MIRT1270019	hsa-miR-548i	CLIP-seq
MIRT1270020	hsa-miR-548j	CLIP-seq
MIRT1270021	hsa-miR-548k	CLIP-seq
MIRT1270022	hsa-miR-548l	CLIP-seq
MIRT1270023	hsa-miR-548w	CLIP-seq
MIRT1270024	hsa-miR-548y	CLIP-seq
MIRT1270025	hsa-miR-559	CLIP-seq
MIRT1270007	hsa-miR-4272	CLIP-seq
MIRT1270012	hsa-miR-548a-5p	CLIP-seq
MIRT1270013	hsa-miR-548ab	CLIP-seq
MIRT1270014	hsa-miR-548ak	CLIP-seq
MIRT1270015	hsa-miR-548b-5p	CLIP-seq
MIRT1270016	hsa-miR-548c-5p	CLIP-seq
MIRT1270017	hsa-miR-548d-5p	CLIP-seq
MIRT1270018	hsa-miR-548h	CLIP-seq
MIRT1270019	hsa-miR-548i	CLIP-seq
MIRT1270020	hsa-miR-548j	CLIP-seq
MIRT1270021	hsa-miR-548k	CLIP-seq
MIRT1270022	hsa-miR-548l	CLIP-seq
MIRT1270023	hsa-miR-548w	CLIP-seq
MIRT1270024	hsa-miR-548y	CLIP-seq
MIRT1270025	hsa-miR-559	CLIP-seq
MIRT2602776	hsa-miR-1260	CLIP-seq
MIRT2602777	hsa-miR-1260b	CLIP-seq
MIRT2602778	hsa-miR-188-3p	CLIP-seq
MIRT2602779	hsa-miR-203	CLIP-seq
MIRT2602780	hsa-miR-216b	CLIP-seq
MIRT2602781	hsa-miR-3117-3p	CLIP-seq
MIRT2602782	hsa-miR-3130-3p	CLIP-seq
MIRT2602783	hsa-miR-3156-3p	CLIP-seq
MIRT2602784	hsa-miR-3163	CLIP-seq
MIRT2602785	hsa-miR-3169	CLIP-seq
MIRT2602786	hsa-miR-3189-5p	CLIP-seq
MIRT2602787	hsa-miR-3190	CLIP-seq
MIRT2602788	hsa-miR-3614-3p	CLIP-seq
MIRT2602789	hsa-miR-3667-3p	CLIP-seq
MIRT2602790	hsa-miR-380	CLIP-seq
MIRT2602791	hsa-miR-384	CLIP-seq
MIRT2602792	hsa-miR-3911	CLIP-seq
MIRT2602793	hsa-miR-3920	CLIP-seq
MIRT2602794	hsa-miR-3921	CLIP-seq
MIRT2602795	hsa-miR-4297	CLIP-seq
MIRT2602796	hsa-miR-4301	CLIP-seq
MIRT2602797	hsa-miR-4446-5p	CLIP-seq
MIRT2602798	hsa-miR-4495	CLIP-seq
MIRT2602799	hsa-miR-4653-5p	CLIP-seq
MIRT2602800	hsa-miR-4668-3p	CLIP-seq
MIRT2602801	hsa-miR-4758-3p	CLIP-seq
MIRT2602802	hsa-miR-4759	CLIP-seq
MIRT2602803	hsa-miR-522	CLIP-seq
MIRT1270012	hsa-miR-548a-5p	CLIP-seq
MIRT1270013	hsa-miR-548ab	CLIP-seq
MIRT1270014	hsa-miR-548ak	CLIP-seq
MIRT1270015	hsa-miR-548b-5p	CLIP-seq
MIRT1270016	hsa-miR-548c-5p	CLIP-seq
MIRT1270017	hsa-miR-548d-5p	CLIP-seq
MIRT1270018	hsa-miR-548h	CLIP-seq
MIRT1270019	hsa-miR-548i	CLIP-seq
MIRT1270020	hsa-miR-548j	CLIP-seq
MIRT2602804	hsa-miR-548n	CLIP-seq
MIRT1270023	hsa-miR-548w	CLIP-seq
MIRT1270024	hsa-miR-548y	CLIP-seq
MIRT1270025	hsa-miR-559	CLIP-seq
MIRT2602805	hsa-miR-648	CLIP-seq
MIRT2602806	hsa-miR-676	CLIP-seq
MIRT2602807	hsa-miR-7	CLIP-seq
MIRT2602808	hsa-miR-711	CLIP-seq
MIRT2602809	hsa-miR-767-5p	CLIP-seq
MIRT2602776	hsa-miR-1260	CLIP-seq
MIRT2602777	hsa-miR-1260b	CLIP-seq
MIRT2602778	hsa-miR-188-3p	CLIP-seq
MIRT2602779	hsa-miR-203	CLIP-seq
MIRT2602780	hsa-miR-216b	CLIP-seq
MIRT2602781	hsa-miR-3117-3p	CLIP-seq
MIRT2602782	hsa-miR-3130-3p	CLIP-seq
MIRT2602783	hsa-miR-3156-3p	CLIP-seq
MIRT2602784	hsa-miR-3163	CLIP-seq
MIRT2602785	hsa-miR-3169	CLIP-seq
MIRT2602786	hsa-miR-3189-5p	CLIP-seq
MIRT2602787	hsa-miR-3190	CLIP-seq
MIRT2602788	hsa-miR-3614-3p	CLIP-seq
MIRT2602789	hsa-miR-3667-3p	CLIP-seq
MIRT2602790	hsa-miR-380	CLIP-seq
MIRT2602791	hsa-miR-384	CLIP-seq
MIRT2602792	hsa-miR-3911	CLIP-seq
MIRT2602793	hsa-miR-3920	CLIP-seq
MIRT2602794	hsa-miR-3921	CLIP-seq
MIRT2602795	hsa-miR-4297	CLIP-seq
MIRT2602796	hsa-miR-4301	CLIP-seq
MIRT2602797	hsa-miR-4446-5p	CLIP-seq
MIRT2602798	hsa-miR-4495	CLIP-seq
MIRT2602799	hsa-miR-4653-5p	CLIP-seq
MIRT2602800	hsa-miR-4668-3p	CLIP-seq
MIRT2602801	hsa-miR-4758-3p	CLIP-seq
MIRT2602802	hsa-miR-4759	CLIP-seq
MIRT2602803	hsa-miR-522	CLIP-seq
MIRT1270012	hsa-miR-548a-5p	CLIP-seq
MIRT1270013	hsa-miR-548ab	CLIP-seq
MIRT1270014	hsa-miR-548ak	CLIP-seq
MIRT1270015	hsa-miR-548b-5p	CLIP-seq
MIRT1270016	hsa-miR-548c-5p	CLIP-seq
MIRT1270017	hsa-miR-548d-5p	CLIP-seq
MIRT1270018	hsa-miR-548h	CLIP-seq
MIRT1270019	hsa-miR-548i	CLIP-seq
MIRT1270020	hsa-miR-548j	CLIP-seq
MIRT2602804	hsa-miR-548n	CLIP-seq
MIRT1270023	hsa-miR-548w	CLIP-seq
MIRT1270024	hsa-miR-548y	CLIP-seq
MIRT1270025	hsa-miR-559	CLIP-seq
MIRT2602805	hsa-miR-648	CLIP-seq
MIRT2602806	hsa-miR-676	CLIP-seq
MIRT2602807	hsa-miR-7	CLIP-seq
MIRT2602808	hsa-miR-711	CLIP-seq
MIRT2602809	hsa-miR-767-5p	CLIP-seq

Show/Hide all(30)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000502	Component	Proteasome complex	IDA	17323924
GO:0000502	Component	Proteasome complex	IEA
GO:0000502	Component	Proteasome complex	NAS	29636472
GO:0000502	Component	Proteasome complex	TAS	8811196
GO:0000932	Component	P-body	IEA
GO:0000932	Component	P-body	ISS
GO:0005515	Function	Protein binding	IPI	12376572, 14733938, 15225636, 15887188, 17948026, 19581590, 22801492, 25416956, 25599644, 25959826, 29568061, 29636472, 31473102, 32296183, 32814053, 33961781, 34702852, 35271311, 35858375
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	34711951
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IDA	34711951
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005839	Component	Proteasome core complex	IDA	34711951
GO:0005839	Component	Proteasome core complex	IEA
GO:0005839	Component	Proteasome core complex	ISS
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IEA
GO:0019773	Component	Proteasome core complex, alpha-subunit complex	IBA
GO:0019773	Component	Proteasome core complex, alpha-subunit complex	IDA	30133132
GO:0019773	Component	Proteasome core complex, alpha-subunit complex	IEA
GO:0019773	Component	Proteasome core complex, alpha-subunit complex	ISS
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IBA
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	NAS	19489727
GO:0051603	Process	Proteolysis involved in protein catabolic process	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867, 20458337

MIM	HGNC	e!Ensembl
176846	9533	ENSG00000041357

Protein

UniProt ID

P25789

Protein name

Proteasome subunit alpha type-4 (Macropain subunit C9) (Multicatalytic endopeptidase complex subunit C9) (Proteasome component C9) (Proteasome subunit L) (Proteasome subunit alpha-3) (alpha-3)

Protein function

Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with

PDB

4R3O , 4R67 , 5A0Q , 5GJQ , 5GJR , 5L4G , 5LE5 , 5LEX , 5LEY , 5LEZ , 5LF0 , 5LF1 , 5LF3 , 5LF4 , 5LF6 , 5LF7 , 5LN3 , 5M32 , 5T0C , 5T0G , 5T0H , 5T0I , 5T0J , 5VFO , 5VFP , 5VFQ , 5VFR , 5VFS , 5VFT , 5VFU , 6AVO , 6E5B , 6KWY , 6MSB , 6MSD , 6MSE , 6MSG , 6MSH , 6MSJ , 6MSK , 6R70 , 6REY , 6RGQ , 6WJD , 6WJN , 6XMJ , 7AWE , 7B12 , 7LXV , 7NAN , 7NAO

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF10584	Proteasome_A_N	5 → 27	Proteasome subunit A N-terminal signature	Family
PF00227	Proteasome	28 → 216	Proteasome subunit	Domain

Sequence

MSRRYDSRTTIFSPEGRLYQVEYAMEAIGHAGTCLGILANDGVLLAAERRNIHKLLDEVF
FSEKIYKLNEDMACSVAGITSDANVLTNELRLIAQRYLLQYQEPIPCEQLVTALCDIKQA
YTQFGGKRPFGVSLLYIGWDKHYGFQLYQSDPSGNYGGWKATCIGNNSAAAVSMLKQDYK
EGEMTLKSALALAIKVLNKTMDVSKLSAEKVEIATLTRENGKTVIRVLKQKEVEQLIKKH
EEEEAKAEREKKEKEQKEKDK

Sequence length

261

Interactions

View interactions

Show/Hide Unknown Diseases (2)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Dental caries	Dental caries	N/A	N/A	GWAS
Lung adenocarcinoma	Lung adenocarcinoma (conditioned on cigarettes per day)	N/A	N/A	GWAS

Show/Hide Text Mining Associations (18)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenocarcinoma of Lung	Associate	29486777
Aneurysm Ruptured	Stimulate	39181687
Aortic Aneurysm	Associate	35952493
Aortic Aneurysm Abdominal	Associate	35952493
Carcinoma Squamous Cell	Associate	29486777
Colorectal Neoplasms	Associate	25206290
Diabetes Mellitus Type 1	Associate	23637351
Graves Ophthalmopathy	Associate	36076300
Intracranial Aneurysm	Associate	35952493, 39181687
Lung Neoplasms	Associate	18385676, 18780872, 19789337, 20587604
Macular Degeneration	Associate	34629418
Neoplasms	Associate	19789337, 28181565
Parkinson Disease	Associate	37219663
Pulmonary Disease Chronic Obstructive	Associate	29422661
Small Cell Lung Carcinoma	Associate	29486777
Smoke Inhalation Injury	Associate	21436384
Stomach Neoplasms	Stimulate	27966459
Subarachnoid Hemorrhage	Associate	39181687

PSMA4 (proteasome 20S subunit alpha 4)