Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs Other IDs Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	5634
Gene name Gene Name - the full gene name approved by the HGNC.	Phosphoribosyl pyrophosphate synthetase 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PRPS2
Synonyms (NCBI Gene) Gene synonyms aliases	PRSII
Chromosome Chromosome number	X
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	Xp22.2
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a phosphoribosyl pyrophosphate synthetase that plays a central role in the synthesis of purines and pyrimidines. The encoded protein catalyzes the synthesis of 5-phosphoribosyl 1-pyrophosphate from ATP and D-ribose 5-phosphate. Alternate

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miRTarBase ID	miRNA	Experiments	Reference
MIRT024389	hsa-miR-215-5p	Microarray	19074876
MIRT026537	hsa-miR-192-5p	Microarray	19074876
MIRT029585	hsa-miR-26b-5p	Microarray	19088304
MIRT1266009	hsa-miR-103a	CLIP-seq
MIRT1266010	hsa-miR-107	CLIP-seq
MIRT1266011	hsa-miR-1178	CLIP-seq
MIRT1266012	hsa-miR-1265	CLIP-seq
MIRT1266013	hsa-miR-2392	CLIP-seq
MIRT1266014	hsa-miR-3673	CLIP-seq
MIRT1266015	hsa-miR-4310	CLIP-seq
MIRT1266016	hsa-miR-4775	CLIP-seq
MIRT1266017	hsa-miR-590-3p	CLIP-seq
MIRT1266018	hsa-miR-651	CLIP-seq
MIRT1266009	hsa-miR-103a	CLIP-seq
MIRT1266010	hsa-miR-107	CLIP-seq
MIRT1266019	hsa-miR-1202	CLIP-seq
MIRT1266020	hsa-miR-15a	CLIP-seq
MIRT1266021	hsa-miR-15b	CLIP-seq
MIRT1266022	hsa-miR-16	CLIP-seq
MIRT1266023	hsa-miR-195	CLIP-seq
MIRT1266024	hsa-miR-224	CLIP-seq
MIRT1266025	hsa-miR-300	CLIP-seq
MIRT1266026	hsa-miR-3133	CLIP-seq
MIRT1266027	hsa-miR-3140-3p	CLIP-seq
MIRT1266028	hsa-miR-3145-5p	CLIP-seq
MIRT1266029	hsa-miR-3156-5p	CLIP-seq
MIRT1266030	hsa-miR-323-5p	CLIP-seq
MIRT1266031	hsa-miR-3622a-3p	CLIP-seq
MIRT1266032	hsa-miR-3622b-3p	CLIP-seq
MIRT1266033	hsa-miR-3647-3p	CLIP-seq
MIRT1266034	hsa-miR-3692	CLIP-seq
MIRT1266035	hsa-miR-381	CLIP-seq
MIRT1266036	hsa-miR-3972	CLIP-seq
MIRT1266037	hsa-miR-3973	CLIP-seq
MIRT1266038	hsa-miR-424	CLIP-seq
MIRT1266015	hsa-miR-4310	CLIP-seq
MIRT1266039	hsa-miR-4317	CLIP-seq
MIRT1266040	hsa-miR-4427	CLIP-seq
MIRT1266041	hsa-miR-4502	CLIP-seq
MIRT1266042	hsa-miR-451b	CLIP-seq
MIRT1266043	hsa-miR-4520a-3p	CLIP-seq
MIRT1266044	hsa-miR-4520b-3p	CLIP-seq
MIRT1266045	hsa-miR-4666-3p	CLIP-seq
MIRT1266046	hsa-miR-4668-3p	CLIP-seq
MIRT1266047	hsa-miR-4698	CLIP-seq
MIRT1266048	hsa-miR-4700-3p	CLIP-seq
MIRT1266049	hsa-miR-4776-3p	CLIP-seq
MIRT1266050	hsa-miR-483-3p	CLIP-seq
MIRT1266051	hsa-miR-486-5p	CLIP-seq
MIRT1266052	hsa-miR-497	CLIP-seq
MIRT1266053	hsa-miR-520d-5p	CLIP-seq
MIRT1266054	hsa-miR-524-5p	CLIP-seq
MIRT1266055	hsa-miR-542-3p	CLIP-seq
MIRT1266056	hsa-miR-548a-5p	CLIP-seq
MIRT1266057	hsa-miR-548ab	CLIP-seq
MIRT1266058	hsa-miR-548ak	CLIP-seq
MIRT1266059	hsa-miR-548b-5p	CLIP-seq
MIRT1266060	hsa-miR-548c-5p	CLIP-seq
MIRT1266061	hsa-miR-548d-5p	CLIP-seq
MIRT1266062	hsa-miR-548h	CLIP-seq
MIRT1266063	hsa-miR-548i	CLIP-seq
MIRT1266064	hsa-miR-548j	CLIP-seq
MIRT1266065	hsa-miR-548n	CLIP-seq
MIRT1266066	hsa-miR-548t	CLIP-seq
MIRT1266067	hsa-miR-548w	CLIP-seq
MIRT1266068	hsa-miR-548y	CLIP-seq
MIRT1266069	hsa-miR-559	CLIP-seq
MIRT1266070	hsa-miR-628-5p	CLIP-seq
MIRT1266071	hsa-miR-665	CLIP-seq
MIRT1266072	hsa-miR-876-3p	CLIP-seq
MIRT1266009	hsa-miR-103a	CLIP-seq
MIRT1266010	hsa-miR-107	CLIP-seq
MIRT1266012	hsa-miR-1265	CLIP-seq
MIRT2078191	hsa-miR-1284	CLIP-seq
MIRT1266020	hsa-miR-15a	CLIP-seq
MIRT1266021	hsa-miR-15b	CLIP-seq
MIRT1266022	hsa-miR-16	CLIP-seq
MIRT1266023	hsa-miR-195	CLIP-seq
MIRT2078192	hsa-miR-203	CLIP-seq
MIRT2078193	hsa-miR-208a	CLIP-seq
MIRT2078194	hsa-miR-208b	CLIP-seq
MIRT1266013	hsa-miR-2392	CLIP-seq
MIRT1266030	hsa-miR-323-5p	CLIP-seq
MIRT2078195	hsa-miR-361-5p	CLIP-seq
MIRT2078196	hsa-miR-3617	CLIP-seq
MIRT2078197	hsa-miR-3658	CLIP-seq
MIRT1266014	hsa-miR-3673	CLIP-seq
MIRT1266034	hsa-miR-3692	CLIP-seq
MIRT2078198	hsa-miR-3941	CLIP-seq
MIRT1266037	hsa-miR-3973	CLIP-seq
MIRT1266038	hsa-miR-424	CLIP-seq
MIRT2078199	hsa-miR-4307	CLIP-seq
MIRT1266015	hsa-miR-4310	CLIP-seq
MIRT1266042	hsa-miR-451b	CLIP-seq
MIRT2078200	hsa-miR-4645-3p	CLIP-seq
MIRT2078201	hsa-miR-466	CLIP-seq
MIRT2078202	hsa-miR-4672	CLIP-seq
MIRT2078203	hsa-miR-4699-3p	CLIP-seq
MIRT2078204	hsa-miR-4729	CLIP-seq
MIRT1266016	hsa-miR-4775	CLIP-seq
MIRT1266052	hsa-miR-497	CLIP-seq
MIRT2078205	hsa-miR-499-5p	CLIP-seq
MIRT1266055	hsa-miR-542-3p	CLIP-seq
MIRT2078206	hsa-miR-548u	CLIP-seq
MIRT1266017	hsa-miR-590-3p	CLIP-seq
MIRT2078207	hsa-miR-641	CLIP-seq
MIRT1266018	hsa-miR-651	CLIP-seq
MIRT1266071	hsa-miR-665	CLIP-seq
MIRT1266072	hsa-miR-876-3p	CLIP-seq
MIRT1266009	hsa-miR-103a	CLIP-seq
MIRT1266010	hsa-miR-107	CLIP-seq
MIRT1266019	hsa-miR-1202	CLIP-seq
MIRT1266012	hsa-miR-1265	CLIP-seq
MIRT2304661	hsa-miR-150	CLIP-seq
MIRT1266020	hsa-miR-15a	CLIP-seq
MIRT1266021	hsa-miR-15b	CLIP-seq
MIRT1266022	hsa-miR-16	CLIP-seq
MIRT1266023	hsa-miR-195	CLIP-seq
MIRT1266024	hsa-miR-224	CLIP-seq
MIRT1266013	hsa-miR-2392	CLIP-seq
MIRT1266025	hsa-miR-300	CLIP-seq
MIRT2304662	hsa-miR-3122	CLIP-seq
MIRT1266027	hsa-miR-3140-3p	CLIP-seq
MIRT1266029	hsa-miR-3156-5p	CLIP-seq
MIRT2304663	hsa-miR-320e	CLIP-seq
MIRT1266030	hsa-miR-323-5p	CLIP-seq
MIRT1266014	hsa-miR-3673	CLIP-seq
MIRT1266034	hsa-miR-3692	CLIP-seq
MIRT1266035	hsa-miR-381	CLIP-seq
MIRT2304664	hsa-miR-3913-5p	CLIP-seq
MIRT1266036	hsa-miR-3972	CLIP-seq
MIRT1266038	hsa-miR-424	CLIP-seq
MIRT2078199	hsa-miR-4307	CLIP-seq
MIRT1266015	hsa-miR-4310	CLIP-seq
MIRT2304665	hsa-miR-4474-3p	CLIP-seq
MIRT1266041	hsa-miR-4502	CLIP-seq
MIRT2304666	hsa-miR-450b-3p	CLIP-seq
MIRT1266042	hsa-miR-451b	CLIP-seq
MIRT2078200	hsa-miR-4645-3p	CLIP-seq
MIRT1266045	hsa-miR-4666-3p	CLIP-seq
MIRT1266016	hsa-miR-4775	CLIP-seq
MIRT1266049	hsa-miR-4776-3p	CLIP-seq
MIRT1266052	hsa-miR-497	CLIP-seq
MIRT1266053	hsa-miR-520d-5p	CLIP-seq
MIRT1266054	hsa-miR-524-5p	CLIP-seq
MIRT1266055	hsa-miR-542-3p	CLIP-seq
MIRT2078206	hsa-miR-548u	CLIP-seq
MIRT1266017	hsa-miR-590-3p	CLIP-seq
MIRT1266018	hsa-miR-651	CLIP-seq
MIRT2304667	hsa-miR-659	CLIP-seq
MIRT1266071	hsa-miR-665	CLIP-seq
MIRT2304668	hsa-miR-759	CLIP-seq
MIRT2304669	hsa-miR-769-3p	CLIP-seq
MIRT1266072	hsa-miR-876-3p	CLIP-seq
MIRT1266024	hsa-miR-224	CLIP-seq
MIRT1266011	hsa-miR-1178	CLIP-seq
MIRT2601679	hsa-miR-1245b-5p	CLIP-seq
MIRT2601680	hsa-miR-1278	CLIP-seq
MIRT2601681	hsa-miR-1281	CLIP-seq
MIRT2078191	hsa-miR-1284	CLIP-seq
MIRT2601682	hsa-miR-1295	CLIP-seq
MIRT2601683	hsa-miR-181a	CLIP-seq
MIRT2601684	hsa-miR-181b	CLIP-seq
MIRT2601685	hsa-miR-181c	CLIP-seq
MIRT2601686	hsa-miR-181d	CLIP-seq
MIRT2078192	hsa-miR-203	CLIP-seq
MIRT2601687	hsa-miR-223	CLIP-seq
MIRT1266024	hsa-miR-224	CLIP-seq
MIRT2601688	hsa-miR-3119	CLIP-seq
MIRT1266026	hsa-miR-3133	CLIP-seq
MIRT2601689	hsa-miR-3142	CLIP-seq
MIRT2601690	hsa-miR-3200-5p	CLIP-seq
MIRT2601691	hsa-miR-337-3p	CLIP-seq
MIRT1266031	hsa-miR-3622a-3p	CLIP-seq
MIRT1266032	hsa-miR-3622b-3p	CLIP-seq
MIRT2601692	hsa-miR-362-5p	CLIP-seq
MIRT2601693	hsa-miR-3665	CLIP-seq
MIRT1266034	hsa-miR-3692	CLIP-seq
MIRT2601694	hsa-miR-382	CLIP-seq
MIRT1266037	hsa-miR-3973	CLIP-seq
MIRT2601695	hsa-miR-4251	CLIP-seq
MIRT2601696	hsa-miR-4262	CLIP-seq
MIRT2601697	hsa-miR-4329	CLIP-seq
MIRT1266043	hsa-miR-4520a-3p	CLIP-seq
MIRT1266044	hsa-miR-4520b-3p	CLIP-seq
MIRT2601698	hsa-miR-4528	CLIP-seq
MIRT2601699	hsa-miR-4661-5p	CLIP-seq
MIRT1266048	hsa-miR-4700-3p	CLIP-seq
MIRT2601700	hsa-miR-4715-5p	CLIP-seq
MIRT2601701	hsa-miR-4724-3p	CLIP-seq
MIRT2601702	hsa-miR-4724-5p	CLIP-seq
MIRT2601703	hsa-miR-4766-5p	CLIP-seq
MIRT1266051	hsa-miR-486-5p	CLIP-seq
MIRT2601704	hsa-miR-488	CLIP-seq
MIRT2601705	hsa-miR-500b	CLIP-seq
MIRT2601706	hsa-miR-501-5p	CLIP-seq
MIRT2601707	hsa-miR-513a-3p	CLIP-seq
MIRT2601708	hsa-miR-520g	CLIP-seq
MIRT2601709	hsa-miR-520h	CLIP-seq
MIRT2601710	hsa-miR-548a-3p	CLIP-seq
MIRT2601711	hsa-miR-548c-3p	CLIP-seq
MIRT2601712	hsa-miR-548e	CLIP-seq
MIRT2601713	hsa-miR-548f	CLIP-seq
MIRT2601714	hsa-miR-548k	CLIP-seq
MIRT2601715	hsa-miR-657	CLIP-seq
MIRT2601716	hsa-miR-936	CLIP-seq
MIRT2078191	hsa-miR-1284	CLIP-seq
MIRT2601683	hsa-miR-181a	CLIP-seq
MIRT2601684	hsa-miR-181b	CLIP-seq
MIRT2601685	hsa-miR-181c	CLIP-seq
MIRT2601686	hsa-miR-181d	CLIP-seq
MIRT2601690	hsa-miR-3200-5p	CLIP-seq
MIRT2601691	hsa-miR-337-3p	CLIP-seq
MIRT2601692	hsa-miR-362-5p	CLIP-seq
MIRT2601693	hsa-miR-3665	CLIP-seq
MIRT2601695	hsa-miR-4251	CLIP-seq
MIRT2601696	hsa-miR-4262	CLIP-seq
MIRT2601697	hsa-miR-4329	CLIP-seq
MIRT2601698	hsa-miR-4528	CLIP-seq
MIRT2601699	hsa-miR-4661-5p	CLIP-seq
MIRT2601705	hsa-miR-500b	CLIP-seq
MIRT2601706	hsa-miR-501-5p	CLIP-seq
MIRT2601710	hsa-miR-548a-3p	CLIP-seq
MIRT2601711	hsa-miR-548c-3p	CLIP-seq
MIRT2601712	hsa-miR-548e	CLIP-seq
MIRT2601713	hsa-miR-548f	CLIP-seq
MIRT2601715	hsa-miR-657	CLIP-seq

Show/Hide all(23)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000287	Function	Magnesium ion binding	IEA
GO:0002189	Component	Ribose phosphate diphosphokinase complex	IBA	21873635
GO:0004749	Function	Ribose phosphate diphosphokinase activity	IBA	21873635
GO:0004749	Function	Ribose phosphate diphosphokinase activity	ISS
GO:0005515	Function	Protein binding	IPI	25416956, 26496610, 31515488, 32814053
GO:0005524	Function	ATP binding	IBA	21873635
GO:0005524	Function	ATP binding	ISS
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0006015	Process	5-phosphoribose 1-diphosphate biosynthetic process	IBA	21873635
GO:0006015	Process	5-phosphoribose 1-diphosphate biosynthetic process	IEA
GO:0006139	Process	Nucleobase-containing compound metabolic process	TAS	2538352
GO:0006164	Process	Purine nucleotide biosynthetic process	IBA	21873635
GO:0006167	Process	AMP biosynthetic process	IEA
GO:0009116	Process	Nucleoside metabolic process	IEA
GO:0016208	Function	AMP binding	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016310	Process	Phosphorylation	IEA
GO:0019003	Function	GDP binding	IEA
GO:0030246	Function	Carbohydrate binding	IEA
GO:0031100	Process	Animal organ regeneration	IEA
GO:0042802	Function	Identical protein binding	IPI	25416956
GO:0042803	Function	Protein homodimerization activity	ISS
GO:0043531	Function	ADP binding	IEA

MIM	HGNC	e!Ensembl
311860	9465	ENSG00000101911

Protein

UniProt ID

P11908

Protein name

Ribose-phosphate pyrophosphokinase 2 (EC 2.7.6.1) (PPRibP) (Phosphoribosyl pyrophosphate synthase II) (PRS-II)

Protein function

Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.

PDB

7YK1 , 8YI9

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13793	Pribosyltran_N	4 → 120	N-terminal domain of ribose phosphate pyrophosphokinase	Domain
PF14572	Pribosyl_synth	200 → 314	Phosphoribosyl synthetase-associated domain	Domain

Sequence

MPNIVLFSGSSHQDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGC
GEINDNLMELLIMINACKIASSSRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAG
ADHIITMDLHASQIQGFFDIPVDNLYAEPAVLQWIRENIAEWKNCIIVSPDAGGAKRVTS
IADRLNVEFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAG
ATKVYAILTHGIFSGPAISRINNAAFEAVVVTNTIPQEDKMKHCTKIQVIDISMILAEAI
RRTHNGESVSYLFSHVPL

Sequence length

318

Interactions

View interactions

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Systemic lupus erythematosus	Systemic lupus erythematosus			GWAS

Show/Hide Text Mining Associations (6)

Disease Name	Relationship Type	References
Associations from Text Mining
Burkitt Lymphoma	Associate	32391636
Colorectal Neoplasms	Associate	30908912
Graves Ophthalmopathy	Associate	37884559
Melanoma	Associate	18677108
Neoplasms	Associate	23807417, 27448979, 28811348
Neuroblastoma	Associate	27448979

PRPS2 (phosphoribosyl pyrophosphate synthetase 2)