PRPS2 (phosphoribosyl pyrophosphate synthetase 2)

Gene

• Entrez ID: 5634
• Gene name: Phosphoribosyl pyrophosphate synthetase 2
• Gene symbol: PRPS2
• Synonyms (NCBI Gene): PRSII
• Chromosome: X
• Chromosome location: Xp22.2
• Summary: This gene encodes a phosphoribosyl pyrophosphate synthetase that plays a central role in the synthesis of purines and pyrimidines. The encoded protein catalyzes the synthesis of 5-phosphoribosyl 1-pyrophosphate from ATP and D-ribose 5-phosphate. Alternate

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT024389	hsa-miR-215-5p	Microarray	19074876
MIRT026537	hsa-miR-192-5p	Microarray	19074876
MIRT029585	hsa-miR-26b-5p	Microarray	19088304
MIRT1266009	hsa-miR-103a	CLIP-seq
MIRT1266010	hsa-miR-107	CLIP-seq
MIRT1266011	hsa-miR-1178	CLIP-seq
MIRT1266012	hsa-miR-1265	CLIP-seq
MIRT1266013	hsa-miR-2392	CLIP-seq
MIRT1266014	hsa-miR-3673	CLIP-seq
MIRT1266015	hsa-miR-4310	CLIP-seq
MIRT1266016	hsa-miR-4775	CLIP-seq
MIRT1266017	hsa-miR-590-3p	CLIP-seq
MIRT1266018	hsa-miR-651	CLIP-seq
MIRT1266009	hsa-miR-103a	CLIP-seq
MIRT1266010	hsa-miR-107	CLIP-seq
MIRT1266019	hsa-miR-1202	CLIP-seq
MIRT1266020	hsa-miR-15a	CLIP-seq
MIRT1266021	hsa-miR-15b	CLIP-seq
MIRT1266022	hsa-miR-16	CLIP-seq
MIRT1266023	hsa-miR-195	CLIP-seq
MIRT1266024	hsa-miR-224	CLIP-seq
MIRT1266025	hsa-miR-300	CLIP-seq
MIRT1266026	hsa-miR-3133	CLIP-seq
MIRT1266027	hsa-miR-3140-3p	CLIP-seq
MIRT1266028	hsa-miR-3145-5p	CLIP-seq
MIRT1266029	hsa-miR-3156-5p	CLIP-seq
MIRT1266030	hsa-miR-323-5p	CLIP-seq
MIRT1266031	hsa-miR-3622a-3p	CLIP-seq
MIRT1266032	hsa-miR-3622b-3p	CLIP-seq
MIRT1266033	hsa-miR-3647-3p	CLIP-seq
MIRT1266034	hsa-miR-3692	CLIP-seq
MIRT1266035	hsa-miR-381	CLIP-seq
MIRT1266036	hsa-miR-3972	CLIP-seq
MIRT1266037	hsa-miR-3973	CLIP-seq
MIRT1266038	hsa-miR-424	CLIP-seq
MIRT1266015	hsa-miR-4310	CLIP-seq
MIRT1266039	hsa-miR-4317	CLIP-seq
MIRT1266040	hsa-miR-4427	CLIP-seq
MIRT1266041	hsa-miR-4502	CLIP-seq
MIRT1266042	hsa-miR-451b	CLIP-seq
MIRT1266043	hsa-miR-4520a-3p	CLIP-seq
MIRT1266044	hsa-miR-4520b-3p	CLIP-seq
MIRT1266045	hsa-miR-4666-3p	CLIP-seq
MIRT1266046	hsa-miR-4668-3p	CLIP-seq
MIRT1266047	hsa-miR-4698	CLIP-seq
MIRT1266048	hsa-miR-4700-3p	CLIP-seq
MIRT1266049	hsa-miR-4776-3p	CLIP-seq
MIRT1266050	hsa-miR-483-3p	CLIP-seq
MIRT1266051	hsa-miR-486-5p	CLIP-seq
MIRT1266052	hsa-miR-497	CLIP-seq
MIRT1266053	hsa-miR-520d-5p	CLIP-seq
MIRT1266054	hsa-miR-524-5p	CLIP-seq
MIRT1266055	hsa-miR-542-3p	CLIP-seq
MIRT1266056	hsa-miR-548a-5p	CLIP-seq
MIRT1266057	hsa-miR-548ab	CLIP-seq
MIRT1266058	hsa-miR-548ak	CLIP-seq
MIRT1266059	hsa-miR-548b-5p	CLIP-seq
MIRT1266060	hsa-miR-548c-5p	CLIP-seq
MIRT1266061	hsa-miR-548d-5p	CLIP-seq
MIRT1266062	hsa-miR-548h	CLIP-seq
MIRT1266063	hsa-miR-548i	CLIP-seq
MIRT1266064	hsa-miR-548j	CLIP-seq
MIRT1266065	hsa-miR-548n	CLIP-seq
MIRT1266066	hsa-miR-548t	CLIP-seq
MIRT1266067	hsa-miR-548w	CLIP-seq
MIRT1266068	hsa-miR-548y	CLIP-seq
MIRT1266069	hsa-miR-559	CLIP-seq
MIRT1266070	hsa-miR-628-5p	CLIP-seq
MIRT1266071	hsa-miR-665	CLIP-seq
MIRT1266072	hsa-miR-876-3p	CLIP-seq
MIRT1266009	hsa-miR-103a	CLIP-seq
MIRT1266010	hsa-miR-107	CLIP-seq
MIRT1266012	hsa-miR-1265	CLIP-seq
MIRT2078191	hsa-miR-1284	CLIP-seq
MIRT1266020	hsa-miR-15a	CLIP-seq
MIRT1266021	hsa-miR-15b	CLIP-seq
MIRT1266022	hsa-miR-16	CLIP-seq
MIRT1266023	hsa-miR-195	CLIP-seq
MIRT2078192	hsa-miR-203	CLIP-seq
MIRT2078193	hsa-miR-208a	CLIP-seq
MIRT2078194	hsa-miR-208b	CLIP-seq
MIRT1266013	hsa-miR-2392	CLIP-seq
MIRT1266030	hsa-miR-323-5p	CLIP-seq
MIRT2078195	hsa-miR-361-5p	CLIP-seq
MIRT2078196	hsa-miR-3617	CLIP-seq
MIRT2078197	hsa-miR-3658	CLIP-seq
MIRT1266014	hsa-miR-3673	CLIP-seq
MIRT1266034	hsa-miR-3692	CLIP-seq
MIRT2078198	hsa-miR-3941	CLIP-seq
MIRT1266037	hsa-miR-3973	CLIP-seq
MIRT1266038	hsa-miR-424	CLIP-seq
MIRT2078199	hsa-miR-4307	CLIP-seq
MIRT1266015	hsa-miR-4310	CLIP-seq
MIRT1266042	hsa-miR-451b	CLIP-seq
MIRT2078200	hsa-miR-4645-3p	CLIP-seq
MIRT2078201	hsa-miR-466	CLIP-seq
MIRT2078202	hsa-miR-4672	CLIP-seq
MIRT2078203	hsa-miR-4699-3p	CLIP-seq
MIRT2078204	hsa-miR-4729	CLIP-seq
MIRT1266016	hsa-miR-4775	CLIP-seq
MIRT1266052	hsa-miR-497	CLIP-seq
MIRT2078205	hsa-miR-499-5p	CLIP-seq
MIRT1266055	hsa-miR-542-3p	CLIP-seq
MIRT2078206	hsa-miR-548u	CLIP-seq
MIRT1266017	hsa-miR-590-3p	CLIP-seq
MIRT2078207	hsa-miR-641	CLIP-seq
MIRT1266018	hsa-miR-651	CLIP-seq
MIRT1266071	hsa-miR-665	CLIP-seq
MIRT1266072	hsa-miR-876-3p	CLIP-seq
MIRT1266009	hsa-miR-103a	CLIP-seq
MIRT1266010	hsa-miR-107	CLIP-seq
MIRT1266019	hsa-miR-1202	CLIP-seq
MIRT1266012	hsa-miR-1265	CLIP-seq
MIRT2304661	hsa-miR-150	CLIP-seq
MIRT1266020	hsa-miR-15a	CLIP-seq
MIRT1266021	hsa-miR-15b	CLIP-seq
MIRT1266022	hsa-miR-16	CLIP-seq
MIRT1266023	hsa-miR-195	CLIP-seq
MIRT1266024	hsa-miR-224	CLIP-seq
MIRT1266013	hsa-miR-2392	CLIP-seq
MIRT1266025	hsa-miR-300	CLIP-seq
MIRT2304662	hsa-miR-3122	CLIP-seq
MIRT1266027	hsa-miR-3140-3p	CLIP-seq
MIRT1266029	hsa-miR-3156-5p	CLIP-seq
MIRT2304663	hsa-miR-320e	CLIP-seq
MIRT1266030	hsa-miR-323-5p	CLIP-seq
MIRT1266014	hsa-miR-3673	CLIP-seq
MIRT1266034	hsa-miR-3692	CLIP-seq
MIRT1266035	hsa-miR-381	CLIP-seq
MIRT2304664	hsa-miR-3913-5p	CLIP-seq
MIRT1266036	hsa-miR-3972	CLIP-seq
MIRT1266038	hsa-miR-424	CLIP-seq
MIRT2078199	hsa-miR-4307	CLIP-seq
MIRT1266015	hsa-miR-4310	CLIP-seq
MIRT2304665	hsa-miR-4474-3p	CLIP-seq
MIRT1266041	hsa-miR-4502	CLIP-seq
MIRT2304666	hsa-miR-450b-3p	CLIP-seq
MIRT1266042	hsa-miR-451b	CLIP-seq
MIRT2078200	hsa-miR-4645-3p	CLIP-seq
MIRT1266045	hsa-miR-4666-3p	CLIP-seq
MIRT1266016	hsa-miR-4775	CLIP-seq
MIRT1266049	hsa-miR-4776-3p	CLIP-seq
MIRT1266052	hsa-miR-497	CLIP-seq
MIRT1266053	hsa-miR-520d-5p	CLIP-seq
MIRT1266054	hsa-miR-524-5p	CLIP-seq
MIRT1266055	hsa-miR-542-3p	CLIP-seq
MIRT2078206	hsa-miR-548u	CLIP-seq
MIRT1266017	hsa-miR-590-3p	CLIP-seq
MIRT1266018	hsa-miR-651	CLIP-seq
MIRT2304667	hsa-miR-659	CLIP-seq
MIRT1266071	hsa-miR-665	CLIP-seq
MIRT2304668	hsa-miR-759	CLIP-seq
MIRT2304669	hsa-miR-769-3p	CLIP-seq
MIRT1266072	hsa-miR-876-3p	CLIP-seq
MIRT1266024	hsa-miR-224	CLIP-seq
MIRT1266011	hsa-miR-1178	CLIP-seq
MIRT2601679	hsa-miR-1245b-5p	CLIP-seq
MIRT2601680	hsa-miR-1278	CLIP-seq
MIRT2601681	hsa-miR-1281	CLIP-seq
MIRT2078191	hsa-miR-1284	CLIP-seq
MIRT2601682	hsa-miR-1295	CLIP-seq
MIRT2601683	hsa-miR-181a	CLIP-seq
MIRT2601684	hsa-miR-181b	CLIP-seq
MIRT2601685	hsa-miR-181c	CLIP-seq
MIRT2601686	hsa-miR-181d	CLIP-seq
MIRT2078192	hsa-miR-203	CLIP-seq
MIRT2601687	hsa-miR-223	CLIP-seq
MIRT1266024	hsa-miR-224	CLIP-seq
MIRT2601688	hsa-miR-3119	CLIP-seq
MIRT1266026	hsa-miR-3133	CLIP-seq
MIRT2601689	hsa-miR-3142	CLIP-seq
MIRT2601690	hsa-miR-3200-5p	CLIP-seq
MIRT2601691	hsa-miR-337-3p	CLIP-seq
MIRT1266031	hsa-miR-3622a-3p	CLIP-seq
MIRT1266032	hsa-miR-3622b-3p	CLIP-seq
MIRT2601692	hsa-miR-362-5p	CLIP-seq
MIRT2601693	hsa-miR-3665	CLIP-seq
MIRT1266034	hsa-miR-3692	CLIP-seq
MIRT2601694	hsa-miR-382	CLIP-seq
MIRT1266037	hsa-miR-3973	CLIP-seq
MIRT2601695	hsa-miR-4251	CLIP-seq
MIRT2601696	hsa-miR-4262	CLIP-seq
MIRT2601697	hsa-miR-4329	CLIP-seq
MIRT1266043	hsa-miR-4520a-3p	CLIP-seq
MIRT1266044	hsa-miR-4520b-3p	CLIP-seq
MIRT2601698	hsa-miR-4528	CLIP-seq
MIRT2601699	hsa-miR-4661-5p	CLIP-seq
MIRT1266048	hsa-miR-4700-3p	CLIP-seq
MIRT2601700	hsa-miR-4715-5p	CLIP-seq
MIRT2601701	hsa-miR-4724-3p	CLIP-seq
MIRT2601702	hsa-miR-4724-5p	CLIP-seq
MIRT2601703	hsa-miR-4766-5p	CLIP-seq
MIRT1266051	hsa-miR-486-5p	CLIP-seq
MIRT2601704	hsa-miR-488	CLIP-seq
MIRT2601705	hsa-miR-500b	CLIP-seq
MIRT2601706	hsa-miR-501-5p	CLIP-seq
MIRT2601707	hsa-miR-513a-3p	CLIP-seq
MIRT2601708	hsa-miR-520g	CLIP-seq
MIRT2601709	hsa-miR-520h	CLIP-seq
MIRT2601710	hsa-miR-548a-3p	CLIP-seq
MIRT2601711	hsa-miR-548c-3p	CLIP-seq
MIRT2601712	hsa-miR-548e	CLIP-seq
MIRT2601713	hsa-miR-548f	CLIP-seq
MIRT2601714	hsa-miR-548k	CLIP-seq
MIRT2601715	hsa-miR-657	CLIP-seq
MIRT2601716	hsa-miR-936	CLIP-seq
MIRT2078191	hsa-miR-1284	CLIP-seq
MIRT2601683	hsa-miR-181a	CLIP-seq
MIRT2601684	hsa-miR-181b	CLIP-seq
MIRT2601685	hsa-miR-181c	CLIP-seq
MIRT2601686	hsa-miR-181d	CLIP-seq
MIRT2601690	hsa-miR-3200-5p	CLIP-seq
MIRT2601691	hsa-miR-337-3p	CLIP-seq
MIRT2601692	hsa-miR-362-5p	CLIP-seq
MIRT2601693	hsa-miR-3665	CLIP-seq
MIRT2601695	hsa-miR-4251	CLIP-seq
MIRT2601696	hsa-miR-4262	CLIP-seq
MIRT2601697	hsa-miR-4329	CLIP-seq
MIRT2601698	hsa-miR-4528	CLIP-seq
MIRT2601699	hsa-miR-4661-5p	CLIP-seq
MIRT2601705	hsa-miR-500b	CLIP-seq
MIRT2601706	hsa-miR-501-5p	CLIP-seq
MIRT2601710	hsa-miR-548a-3p	CLIP-seq
MIRT2601711	hsa-miR-548c-3p	CLIP-seq
MIRT2601712	hsa-miR-548e	CLIP-seq
MIRT2601713	hsa-miR-548f	CLIP-seq
MIRT2601715	hsa-miR-657	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000287	Function	Magnesium ion binding	IEA
GO:0004749	Function	Ribose phosphate diphosphokinase activity	IBA
GO:0004749	Function	Ribose phosphate diphosphokinase activity	IEA
GO:0004749	Function	Ribose phosphate diphosphokinase activity	ISS
GO:0004749	Function	Ribose phosphate diphosphokinase activity	TAS	2538352
GO:0005515	Function	Protein binding	IPI	25416956, 25910212, 26496610, 28514442, 31515488, 32296183, 32814053, 33961781
GO:0005524	Function	ATP binding	IEA
GO:0005524	Function	ATP binding	ISS
GO:0005737	Component	Cytoplasm	IBA
GO:0005829	Component	Cytosol	IEA
GO:0006015	Process	5-phosphoribose 1-diphosphate biosynthetic process	IBA
GO:0006015	Process	5-phosphoribose 1-diphosphate biosynthetic process	IEA
GO:0006098	Process	Pentose-phosphate shunt	IEA
GO:0006139	Process	Nucleobase-containing compound metabolic process	IEA
GO:0006139	Process	Nucleobase-containing compound metabolic process	TAS	2538352
GO:0006164	Process	Purine nucleotide biosynthetic process	IBA
GO:0009156	Process	Ribonucleoside monophosphate biosynthetic process	IEA
GO:0009165	Process	Nucleotide biosynthetic process	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0042802	Function	Identical protein binding	IPI	25416956
GO:0042803	Function	Protein homodimerization activity	ISS
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 311860
• HGNC: 9465
• e!Ensembl: ENSG00000101911

Protein

• UniProt ID: P11908
• Protein name: Ribose-phosphate pyrophosphokinase 2 (EC 2.7.6.1) (PPRibP) (Phosphoribosyl pyrophosphate synthase II) (PRS-II)
• Protein function: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
• PDB: 7YK1, 8YI9
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13793	Pribosyltran_N	4 → 120	N-terminal domain of ribose phosphate pyrophosphokinase	Domain
  PF14572	Pribosyl_synth	200 → 314	Phosphoribosyl synthetase-associated domain	Domain

• Sequence:

  MPNIVLFSGSSHQDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGC
  GEINDNLMELLIMINACKIASSSRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAG
  ADHIITMDLHASQIQGFFDIPVDNLYAEPAVLQWIRENIAEWKNCIIVSPDAGGAKRVTS
  IADRLNVEFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAG
  ATKVYAILTHGIFSGPAISRINNAAFEAVVVTNTIPQEDKMKHCTKIQVIDISMILAEAI
  RRTHNGESVSYLFSHVPL

• Sequence length: 318