Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs Other IDs
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	221823
Gene name Gene Name - the full gene name approved by the HGNC.	Phosphoribosyl pyrophosphate synthetase 1 like 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PRPS1L1
Synonyms (NCBI Gene) Gene synonyms aliases	PRPS1, PRPS3, PRPSL, PRS-III
Chromosome Chromosome number	7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	7p21.1
Summary Summary of gene provided in NCBI Entrez Gene.	This intronless gene is specifically expressed in the testis, and encodes a protein that is highly homologous to the two subunits of phosphoribosylpyrophosphate synthetase encoded by human X-linked genes, PRPS1 and PRPS2. These enzymes convert pyrimidine,

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miRTarBase ID	miRNA	Experiments	Reference
MIRT573879	hsa-miR-376c-3p	PAR-CLIP	20371350
MIRT573878	hsa-miR-3155a	PAR-CLIP	20371350
MIRT573877	hsa-miR-3155b	PAR-CLIP	20371350
MIRT573876	hsa-miR-484	PAR-CLIP	20371350
MIRT573875	hsa-miR-4772-5p	PAR-CLIP	20371350
MIRT573874	hsa-miR-4534	PAR-CLIP	20371350
MIRT573872	hsa-miR-8082	PAR-CLIP	20371350
MIRT573873	hsa-miR-3134	PAR-CLIP	20371350
MIRT573871	hsa-miR-221-3p	PAR-CLIP	20371350
MIRT573870	hsa-miR-222-3p	PAR-CLIP	20371350
MIRT521631	hsa-miR-4459	PAR-CLIP	23446348
MIRT521632	hsa-miR-6087	PAR-CLIP	23446348
MIRT521630	hsa-miR-377-5p	PAR-CLIP	23446348
MIRT521628	hsa-miR-6086	PAR-CLIP	23446348
MIRT521629	hsa-miR-658	PAR-CLIP	23446348
MIRT521627	hsa-miR-25-5p	PAR-CLIP	23446348
MIRT521626	hsa-miR-4497	PAR-CLIP	23446348
MIRT521625	hsa-miR-455-3p	PAR-CLIP	23446348
MIRT521623	hsa-miR-6516-5p	PAR-CLIP	23446348
MIRT443318	hsa-miR-548a-5p	PAR-CLIP	22100165
MIRT443317	hsa-miR-548ab	PAR-CLIP	22100165
MIRT443316	hsa-miR-548ad-5p	PAR-CLIP	22100165
MIRT443315	hsa-miR-548ae-5p	PAR-CLIP	22100165
MIRT443314	hsa-miR-548ak	PAR-CLIP	22100165
MIRT443313	hsa-miR-548am-5p	PAR-CLIP	22100165
MIRT443312	hsa-miR-548ap-5p	PAR-CLIP	22100165
MIRT443311	hsa-miR-548aq-5p	PAR-CLIP	22100165
MIRT443310	hsa-miR-548ar-5p	PAR-CLIP	22100165
MIRT443309	hsa-miR-548as-5p	PAR-CLIP	22100165
MIRT443308	hsa-miR-548au-5p	PAR-CLIP	22100165
MIRT443307	hsa-miR-548ay-5p	PAR-CLIP	22100165
MIRT443306	hsa-miR-548b-5p	PAR-CLIP	22100165
MIRT443305	hsa-miR-548bb-5p	PAR-CLIP	22100165
MIRT443304	hsa-miR-548c-5p	PAR-CLIP	22100165
MIRT443303	hsa-miR-548d-5p	PAR-CLIP	22100165
MIRT443302	hsa-miR-548h-5p	PAR-CLIP	22100165
MIRT443301	hsa-miR-548i	PAR-CLIP	22100165
MIRT443300	hsa-miR-548j-5p	PAR-CLIP	22100165
MIRT443299	hsa-miR-548o-5p	PAR-CLIP	22100165
MIRT443298	hsa-miR-548w	PAR-CLIP	22100165
MIRT443297	hsa-miR-548y	PAR-CLIP	22100165
MIRT443296	hsa-miR-559	PAR-CLIP	22100165
MIRT573879	hsa-miR-376c-3p	PAR-CLIP	20371350
MIRT573878	hsa-miR-3155a	PAR-CLIP	20371350
MIRT573877	hsa-miR-3155b	PAR-CLIP	20371350
MIRT573876	hsa-miR-484	PAR-CLIP	20371350
MIRT573875	hsa-miR-4772-5p	PAR-CLIP	20371350
MIRT573874	hsa-miR-4534	PAR-CLIP	20371350
MIRT573872	hsa-miR-8082	PAR-CLIP	20371350
MIRT573873	hsa-miR-3134	PAR-CLIP	20371350
MIRT573871	hsa-miR-221-3p	PAR-CLIP	20371350
MIRT573870	hsa-miR-222-3p	PAR-CLIP	20371350
MIRT521631	hsa-miR-4459	PAR-CLIP	23446348
MIRT521632	hsa-miR-6087	PAR-CLIP	23446348
MIRT521630	hsa-miR-377-5p	PAR-CLIP	23446348
MIRT521628	hsa-miR-6086	PAR-CLIP	23446348
MIRT521629	hsa-miR-658	PAR-CLIP	23446348
MIRT521627	hsa-miR-25-5p	PAR-CLIP	23446348
MIRT521626	hsa-miR-4497	PAR-CLIP	23446348
MIRT521625	hsa-miR-455-3p	PAR-CLIP	23446348
MIRT521623	hsa-miR-6516-5p	PAR-CLIP	23446348
MIRT443318	hsa-miR-548a-5p	PAR-CLIP	22100165
MIRT443317	hsa-miR-548ab	PAR-CLIP	22100165
MIRT443316	hsa-miR-548ad-5p	PAR-CLIP	22100165
MIRT443315	hsa-miR-548ae-5p	PAR-CLIP	22100165
MIRT443314	hsa-miR-548ak	PAR-CLIP	22100165
MIRT443313	hsa-miR-548am-5p	PAR-CLIP	22100165
MIRT443312	hsa-miR-548ap-5p	PAR-CLIP	22100165
MIRT443311	hsa-miR-548aq-5p	PAR-CLIP	22100165
MIRT443310	hsa-miR-548ar-5p	PAR-CLIP	22100165
MIRT443309	hsa-miR-548as-5p	PAR-CLIP	22100165
MIRT443308	hsa-miR-548au-5p	PAR-CLIP	22100165
MIRT443307	hsa-miR-548ay-5p	PAR-CLIP	22100165
MIRT443306	hsa-miR-548b-5p	PAR-CLIP	22100165
MIRT443305	hsa-miR-548bb-5p	PAR-CLIP	22100165
MIRT443304	hsa-miR-548c-5p	PAR-CLIP	22100165
MIRT443303	hsa-miR-548d-5p	PAR-CLIP	22100165
MIRT443302	hsa-miR-548h-5p	PAR-CLIP	22100165
MIRT443301	hsa-miR-548i	PAR-CLIP	22100165
MIRT443300	hsa-miR-548j-5p	PAR-CLIP	22100165
MIRT443299	hsa-miR-548o-5p	PAR-CLIP	22100165
MIRT443298	hsa-miR-548w	PAR-CLIP	22100165
MIRT443297	hsa-miR-548y	PAR-CLIP	22100165
MIRT443296	hsa-miR-559	PAR-CLIP	22100165

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000287	Function	Magnesium ion binding	IEA
GO:0002189	Component	Ribose phosphate diphosphokinase complex	IBA	21873635
GO:0004749	Function	Ribose phosphate diphosphokinase activity	IBA	21873635
GO:0004749	Function	Ribose phosphate diphosphokinase activity	ISS
GO:0004749	Function	Ribose phosphate diphosphokinase activity	NAS	2168892
GO:0005524	Function	ATP binding	IBA	21873635
GO:0005524	Function	ATP binding	ISS
GO:0005575	Component	Cellular_component	ND
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0006015	Process	5-phosphoribose 1-diphosphate biosynthetic process	IBA	21873635
GO:0006015	Process	5-phosphoribose 1-diphosphate biosynthetic process	IEA
GO:0006164	Process	Purine nucleotide biosynthetic process	IBA	21873635
GO:0008584	Process	Male gonad development	IEA
GO:0009116	Process	Nucleoside metabolic process	IEA
GO:0009156	Process	Ribonucleoside monophosphate biosynthetic process	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016310	Process	Phosphorylation	IEA
GO:0042803	Function	Protein homodimerization activity	ISS

MIM	HGNC	e!Ensembl
611566	9463	ENSG00000229937

Protein

UniProt ID

P21108

Protein name

Ribose-phosphate pyrophosphokinase 3 (EC 2.7.6.1) (Phosphoribosyl pyrophosphate synthase 1-like 1) (PRPS1-like 1) (Phosphoribosyl pyrophosphate synthase III) (PRS-III)

Protein function

Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13793	Pribosyltran_N	4 → 120	N-terminal domain of ribose phosphate pyrophosphokinase	Domain
PF14572	Pribosyl_synth	199 → 314	Phosphoribosyl synthetase-associated domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Testis.

Sequence

MPNIKIFSGSSHQDLSQKIADRLGLELGKVVTKKFSNQETCVEIDESVRGEDVYIVQSGC
GEINDSLMELLIMINACKIASASRVTAVIPCFPYARQDKKDKSRSPISAKLVANMLSIAG
ADHIITMDLHASQIQGFFDIPVDNLYAEPTVLKWIRENIPEWKNCIIVSPDAGGAKRVTS
IADQLNVDFALIHKERKKANEVDCIVLVGDVNDRVAILVDDMADTCVTICLAADKLLSAG
ATRVYAILTHGIFSGPAISRINTACFEAVVVTNTIPQDEKMKHCSKIRVIDISMILAEAI
RRTHNGESVSYLFSHVPL

Sequence length

318

Interactions

View interactions

PRPS1L1 (phosphoribosyl pyrophosphate synthetase 1 like 1)