PRKCQ (protein kinase C theta)

Gene
Gene SNPs Transcription factors Other IDs Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5588
Gene name Gene Name - the full gene name approved by the HGNC.
Protein kinase C theta
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PRKCQ
Synonyms (NCBI Gene) Gene synonyms aliases
PRKCT, nPKC-theta
Chromosome Chromosome number
10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
10p15.1
Summary Summary of gene provided in NCBI Entrez Gene.
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved
SNPs SNP information provided by dbSNP.
Gene SNPs Transcription factors Other IDs Associated diseases
Show/Hide all(1)
SNP ID Visualize variation Clinical significance Consequence
rs2236379 G>A,C Pathogenic Coding sequence variant, missense variant
miRNA miRNA information provided by mirtarbase database.
Gene SNPs Transcription factors Other IDs Associated diseases
Show/Hide all(12)
miRTarBase ID miRNA Experiments Reference
MIRT1263387 hsa-miR-3659 CLIP-seq
MIRT1263388 hsa-miR-4658 CLIP-seq
MIRT1263389 hsa-miR-4758-5p CLIP-seq
MIRT1263390 hsa-miR-574-5p CLIP-seq
MIRT1263391 hsa-miR-622 CLIP-seq
Transcription factors
Gene SNPs Transcription factors Other IDs Associated diseases
Show/Hide all(1)
Transcription factor Regulation Reference
RUNX1 Unknown 21252065
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene SNPs Transcription factors Other IDs Associated diseases
Show/Hide all(40)
GO ID Ontology Definition Evidence Reference
GO:0001558 Process Regulation of cell growth NAS 8444877
GO:0001772 Component Immunological synapse IEA
GO:0004672 Function Protein kinase activity TAS
GO:0004674 Function Protein serine/threonine kinase activity EXP 16356856
GO:0004674 Function Protein serine/threonine kinase activity IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene SNPs Transcription factors Other IDs Associated diseases
MIM HGNC e!Ensembl
600448 9410 ENSG00000065675
Protein
Gene SNPs Transcription factors Other IDs Associated diseases
UniProt ID Q04759
Protein name Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta)
Protein function Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non-redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and surv
PDB 1XJD , 2ENJ , 2ENN , 2ENZ , 2JED , 4Q9Z , 4RA5 , 5F9E
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00130 C1_1 160 → 212 Phorbol esters/diacylglycerol binding domain (C1 domain) Domain
PF00130 C1_1 232 → 284 Phorbol esters/diacylglycerol binding domain (C1 domain) Domain
PF00069 Pkinase 380 → 634 Protein kinase domain Domain
PF00433 Pkinase_C 655 → 696 Protein kinase C terminal domain Family
Tissue specificity TISSUE SPECIFICITY: Expressed in skeletal muscle, T-cells, megakaryoblastic cells and platelets. {ECO:0000269|PubMed:7686153}.
Sequence 
MSPFLRIGLSNFDCGSCQSCQGEAVNPYCAVLVKEYVESENGQMYIQKKPTMYPPWDSTF
DAHINKGRVMQIIVKGKNVDLISETTVELYSLAERCRKNNGKTEIWLELKPQGRMLMNAR
YFLEMSDTKDMNEFETEGFFALHQRRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFV
WGLNKQGYQCRQCNAAIHKKCIDKVIAKCTGSAINSRETMFHKERFKIDMPHRFKVYNYK
SPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTKVANLCGINQKLMAEALAMIESTQQ
ARCLRDTEQIFREGPVEIGLPCSIKNEARPPCLPTPGKREPQGISWESPLDEVDKMCHLP
EPELNKERPSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDD
DVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSR
ATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFC
GTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPR
WLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFD
CSNFDKEFLNEKPRLSFADRALINSMDQNMFRNFSFMNPGMERLIS
Sequence length 706
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene SNPs Transcription factors Other IDs Associated diseases
Show/Hide Unknown Diseases (8)
Unknown
Disease term Disease name Evidence References Source
Eczema Eczema GWAS
Asthma Asthma GWAS
Rheumatoid arthritis Rheumatoid arthritis GWAS
Inflammatory Bowel Disease Inflammatory Bowel Disease GWAS
Show/Hide Text Mining Associations (49)
Associations from Text Mining
Disease Name Relationship Type References
Acute Kidney Injury Associate 33863396
Adenocarcinoma of Lung Associate 35029906
Alopecia Associate 31908401
Angioedema Inhibit 23838604
Angioedema Associate 23838604, 32080354
Arthritis Juvenile Associate 19674979, 28990043
Arthritis Rheumatoid Associate 19503088
Asthma Associate 34741802
Autoimmune Diseases Associate 26784953, 31908401
Breast Neoplasms Associate 24319668, 24891615, 40597019