Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5567
Gene name Gene Name - the full gene name approved by the HGNC.
Protein kinase cAMP-activated catalytic subunit beta
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PRKACB
Synonyms (NCBI Gene) Gene synonyms aliases
CAFD2, PKA C-beta, PKACB
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p31.1
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the serine/threonine protein kinase family. The encoded protein is a catalytic subunit of cAMP (cyclic AMP)-dependent protein kinase, which mediates signalling though cAMP. cAMP signaling is important to a n
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT006806 hsa-miR-23b-3p Luciferase reporter assay, qRT-PCR 22449550
MIRT027986 hsa-miR-93-5p Sequencing 20371350
MIRT031110 hsa-miR-19b-3p Sequencing 20371350
MIRT006806 hsa-miR-23b-3p Luciferase reporter assay, Immunocytochemistry, Western blot 24916040
MIRT080186 hsa-miR-372-3p PAR-CLIP 21572407
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0000287 Function Magnesium ion binding IDA 12420224
GO:0000287 Function Magnesium ion binding IEA
GO:0001843 Process Neural tube closure IEA
GO:0003091 Process Renal water homeostasis TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
176892 9381 ENSG00000142875
Protein
UniProt ID P22694
Protein name cAMP-dependent protein kinase catalytic subunit beta (PKA C-beta) (EC 2.7.11.11)
Protein function Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs (PubMed:12420224, PubMed:21423175, PubMed:31112131). PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and reg
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase 44 298 Protein kinase domain Domain
Tissue specificity TISSUE SPECIFICITY: Isoform 1 is most abundant in the brain, with low level expression in kidney. Isoform 2 is predominantly expressed in thymus, spleen and kidney. Isoform 3 and isoform 4 are only expressed in the brain. {ECO:0000269|PubMed:11589697}.
Sequence
Sequence length 351
Interactions View interactions
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Breast cancer Breast cancer (male) N/A N/A GWAS
Ellis-Van Creveld Syndrome Ellis-van Creveld syndrome N/A N/A GenCC
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Acquired ichthyosis Associate 36303457
ACTH Secreting Pituitary Adenoma Associate 29669941
Adenocarcinoma Associate 36829221
Adenoma Associate 29669941
Adrenal Gland Neoplasms Associate 29669941
Alzheimer Disease Associate 29851783
Amebiasis Associate 28765971
Anencephaly Associate 24294386
Aphakia congenital primary Associate 29669941
Bile Duct Diseases Associate 31678302