Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5562
Gene name Gene Name - the full gene name approved by the HGNC.
Protein kinase AMP-activated catalytic subunit alpha 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PRKAA1
Synonyms (NCBI Gene) Gene synonyms aliases
AMPK, AMPK alpha 1, AMPKa1
Chromosome Chromosome number
5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
5p13.1
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5`-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT006742 hsa-miR-19b-3p Luciferase reporter assay 20190740
MIRT006742 hsa-miR-19b-3p Luciferase reporter assay 20190740
MIRT019393 hsa-miR-148b-3p Microarray 17612493
MIRT020218 hsa-miR-130b-3p Sequencing 20371350
MIRT021937 hsa-miR-128-3p Microarray 17612493
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000045 Process Autophagosome assembly IDA 28890335
GO:0000166 Function Nucleotide binding IEA
GO:0000785 Component Chromatin IEA
GO:0001666 Process Response to hypoxia NAS 8557660
GO:0002181 Process Cytoplasmic translation IDA 8706699, 34314702
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
602739 9376 ENSG00000132356
Protein
UniProt ID Q13131
Protein name 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11
Protein function Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:17307971, PubMed:17712357, PubMed:24563466, PubMed:37821951). In response to reducti
PDB 4RED , 4RER , 4REW , 5EZV , 6C9F , 6C9G , 6C9H , 6C9J , 7JHG , 7JHH , 7JIJ , 7M74
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase 27 279 Protein kinase domain Domain
PF16579 AdenylateSensor 406 503 Adenylate sensor of SNF1-like protein kinase Domain
Sequence
Sequence length 559
Interactions View interactions
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Duodenal Ulcer Duodenal ulcer N/A N/A GWAS
Gastric ulcer Gastric ulcer N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Acidosis Associate 35414794
Adenocarcinoma Inhibit 37670284
Adenocarcinoma of Lung Associate 24048094, 26715839, 28336923, 38203624, 38242874
Alzheimer Disease Associate 32444538, 34992508, 36035305
Arthritis Rheumatoid Associate 32692720
Ataxia Telangiectasia Associate 23800068
Atherosclerosis Associate 25354528
Birt Hogg Dube Syndrome Associate 19850877, 34031471
Breast Neoplasms Associate 19483724, 22363791, 22562547, 24359639, 24403860, 24488910, 26616021, 30653260, 31870119, 33632157, 34584194, 35674458, 37906431
Carcinogenesis Associate 22363791, 22801477, 24829520, 33219302, 33752745