Gene Gene information from NCBI Gene database.
Entrez ID 5562
Gene name Protein kinase AMP-activated catalytic subunit alpha 1
Gene symbol PRKAA1
Synonyms (NCBI Gene)
AMPKAMPK alpha 1AMPKa1
Chromosome 5
Chromosome location 5p13.1
Summary The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5`-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK
miRNA miRNA information provided by mirtarbase database.
1167
miRTarBase ID miRNA Experiments Reference
MIRT006742 hsa-miR-19b-3p Luciferase reporter assay 20190740
MIRT006742 hsa-miR-19b-3p Luciferase reporter assay 20190740
MIRT019393 hsa-miR-148b-3p Microarray 17612493
MIRT020218 hsa-miR-130b-3p Sequencing 20371350
MIRT021937 hsa-miR-128-3p Microarray 17612493
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
193
GO ID Ontology Definition Evidence Reference
GO:0000045 Process Autophagosome assembly IDA 28890335
GO:0000166 Function Nucleotide binding IEA
GO:0000785 Component Chromatin IEA
GO:0001666 Process Response to hypoxia NAS 8557660
GO:0002181 Process Cytoplasmic translation IDA 8706699, 34314702
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
602739 9376 ENSG00000132356
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q13131
Protein name 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11
Protein function Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:17307971, PubMed:17712357, PubMed:24563466, PubMed:37821951). In response to reducti
PDB 4RED , 4RER , 4REW , 5EZV , 6C9F , 6C9G , 6C9H , 6C9J , 7JHG , 7JHH , 7JIJ , 7M74
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase 27 279 Protein kinase domain Domain
PF16579 AdenylateSensor 406 503 Adenylate sensor of SNF1-like protein kinase Domain
Sequence
Sequence length 559
Interactions View interactions