PPP2R5A (protein phosphatase 2 regulatory subunit B'alpha)

Gene

• Entrez ID: 5525
• Gene name: Protein phosphatase 2 regulatory subunit B'alpha
• Gene symbol: PPP2R5A
• Synonyms (NCBI Gene): B56A, B56alpha, PR61A
• Chromosome: 1
• Chromosome location: 1q32.3
• Summary: The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common het

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT004602	hsa-miR-1-3p	Luciferase reporter assay, Western blot	19131648
MIRT016181	hsa-miR-590-3p	Sequencing	20371350
MIRT018236	hsa-miR-335-5p	Microarray	18185580
MIRT042199	hsa-miR-484	CLASH	23622248
MIRT439913	ebv-miR-BART7-3p	HITS-CLIP	22473208
MIRT439913	ebv-miR-BART7-3p	HITS-CLIP	22473208
MIRT1257908	hsa-miR-1	CLIP-seq
MIRT1257909	hsa-miR-1202	CLIP-seq
MIRT1257910	hsa-miR-1298	CLIP-seq
MIRT1257911	hsa-miR-19a	CLIP-seq
MIRT1257912	hsa-miR-19b	CLIP-seq
MIRT1257913	hsa-miR-2052	CLIP-seq
MIRT1257914	hsa-miR-2054	CLIP-seq
MIRT1257915	hsa-miR-206	CLIP-seq
MIRT1257916	hsa-miR-2276	CLIP-seq
MIRT1257917	hsa-miR-2278	CLIP-seq
MIRT1257918	hsa-miR-3120-3p	CLIP-seq
MIRT1257919	hsa-miR-3148	CLIP-seq
MIRT1257920	hsa-miR-3673	CLIP-seq
MIRT1257921	hsa-miR-3692	CLIP-seq
MIRT1257922	hsa-miR-3972	CLIP-seq
MIRT1257923	hsa-miR-4328	CLIP-seq
MIRT1257924	hsa-miR-4464	CLIP-seq
MIRT1257925	hsa-miR-4468	CLIP-seq
MIRT1257926	hsa-miR-4502	CLIP-seq
MIRT1257927	hsa-miR-4540	CLIP-seq
MIRT1257928	hsa-miR-455-5p	CLIP-seq
MIRT1257929	hsa-miR-4652-3p	CLIP-seq
MIRT1257930	hsa-miR-4668-5p	CLIP-seq
MIRT1257931	hsa-miR-4677-3p	CLIP-seq
MIRT1257932	hsa-miR-4679	CLIP-seq
MIRT1257933	hsa-miR-4738-3p	CLIP-seq
MIRT1257934	hsa-miR-4748	CLIP-seq
MIRT1257935	hsa-miR-4771	CLIP-seq
MIRT1257936	hsa-miR-4775	CLIP-seq
MIRT1257937	hsa-miR-4790-3p	CLIP-seq
MIRT1257938	hsa-miR-4797-5p	CLIP-seq
MIRT1257939	hsa-miR-579	CLIP-seq
MIRT1257940	hsa-miR-582-5p	CLIP-seq
MIRT1257941	hsa-miR-587	CLIP-seq
MIRT1257942	hsa-miR-613	CLIP-seq
MIRT1257943	hsa-miR-642b	CLIP-seq
MIRT1257944	hsa-miR-656	CLIP-seq
MIRT1257945	hsa-miR-664	CLIP-seq
MIRT1257946	hsa-miR-944	CLIP-seq
MIRT1257908	hsa-miR-1	CLIP-seq
MIRT1257909	hsa-miR-1202	CLIP-seq
MIRT1257947	hsa-miR-1254	CLIP-seq
MIRT1257948	hsa-miR-1270	CLIP-seq
MIRT1257949	hsa-miR-1323	CLIP-seq
MIRT1257950	hsa-miR-197	CLIP-seq
MIRT1257913	hsa-miR-2052	CLIP-seq
MIRT1257914	hsa-miR-2054	CLIP-seq
MIRT1257915	hsa-miR-206	CLIP-seq
MIRT1257951	hsa-miR-2113	CLIP-seq
MIRT1257952	hsa-miR-218	CLIP-seq
MIRT1257916	hsa-miR-2276	CLIP-seq
MIRT1257953	hsa-miR-3116	CLIP-seq
MIRT1257918	hsa-miR-3120-3p	CLIP-seq
MIRT1257954	hsa-miR-3156-5p	CLIP-seq
MIRT1257955	hsa-miR-3187-3p	CLIP-seq
MIRT1257956	hsa-miR-3199	CLIP-seq
MIRT1257957	hsa-miR-338-5p	CLIP-seq
MIRT1257958	hsa-miR-3613-3p	CLIP-seq
MIRT1257959	hsa-miR-361-3p	CLIP-seq
MIRT1257960	hsa-miR-3664-5p	CLIP-seq
MIRT1257920	hsa-miR-3673	CLIP-seq
MIRT1257921	hsa-miR-3692	CLIP-seq
MIRT1257922	hsa-miR-3972	CLIP-seq
MIRT1257961	hsa-miR-4254	CLIP-seq
MIRT1257962	hsa-miR-4318	CLIP-seq
MIRT1257923	hsa-miR-4328	CLIP-seq
MIRT1257963	hsa-miR-4422	CLIP-seq
MIRT1257964	hsa-miR-4529-5p	CLIP-seq
MIRT1257927	hsa-miR-4540	CLIP-seq
MIRT1257965	hsa-miR-4648	CLIP-seq
MIRT1257966	hsa-miR-4654	CLIP-seq
MIRT1257967	hsa-miR-4683	CLIP-seq
MIRT1257968	hsa-miR-4699-5p	CLIP-seq
MIRT1257969	hsa-miR-4714-5p	CLIP-seq
MIRT1257970	hsa-miR-4769-5p	CLIP-seq
MIRT1257936	hsa-miR-4775	CLIP-seq
MIRT1257937	hsa-miR-4790-3p	CLIP-seq
MIRT1257971	hsa-miR-495	CLIP-seq
MIRT1257972	hsa-miR-520d-5p	CLIP-seq
MIRT1257973	hsa-miR-524-5p	CLIP-seq
MIRT1257974	hsa-miR-548o	CLIP-seq
MIRT1257940	hsa-miR-582-5p	CLIP-seq
MIRT1257941	hsa-miR-587	CLIP-seq
MIRT1257975	hsa-miR-607	CLIP-seq
MIRT1257942	hsa-miR-613	CLIP-seq
MIRT1257976	hsa-miR-620	CLIP-seq
MIRT1257977	hsa-miR-636	CLIP-seq
MIRT1257978	hsa-miR-767-3p	CLIP-seq
MIRT1257979	hsa-miR-888	CLIP-seq
MIRT1257908	hsa-miR-1	CLIP-seq
MIRT2075986	hsa-miR-101	CLIP-seq
MIRT2075987	hsa-miR-1296	CLIP-seq
MIRT2075988	hsa-miR-1321	CLIP-seq
MIRT2075989	hsa-miR-144	CLIP-seq
MIRT1257950	hsa-miR-197	CLIP-seq
MIRT1257911	hsa-miR-19a	CLIP-seq
MIRT1257912	hsa-miR-19b	CLIP-seq
MIRT1257913	hsa-miR-2052	CLIP-seq
MIRT1257914	hsa-miR-2054	CLIP-seq
MIRT1257915	hsa-miR-206	CLIP-seq
MIRT1257916	hsa-miR-2276	CLIP-seq
MIRT2075990	hsa-miR-2682	CLIP-seq
MIRT2075991	hsa-miR-2909	CLIP-seq
MIRT1257918	hsa-miR-3120-3p	CLIP-seq
MIRT2075992	hsa-miR-3126-5p	CLIP-seq
MIRT2075993	hsa-miR-3152-5p	CLIP-seq
MIRT2075994	hsa-miR-3180-5p	CLIP-seq
MIRT1257955	hsa-miR-3187-3p	CLIP-seq
MIRT2075995	hsa-miR-3194-3p	CLIP-seq
MIRT1257956	hsa-miR-3199	CLIP-seq
MIRT2075996	hsa-miR-330-3p	CLIP-seq
MIRT2075997	hsa-miR-34a	CLIP-seq
MIRT2075998	hsa-miR-34c-5p	CLIP-seq
MIRT1257920	hsa-miR-3673	CLIP-seq
MIRT1257921	hsa-miR-3692	CLIP-seq
MIRT2075999	hsa-miR-4292	CLIP-seq
MIRT2076000	hsa-miR-4308	CLIP-seq
MIRT1257962	hsa-miR-4318	CLIP-seq
MIRT1257923	hsa-miR-4328	CLIP-seq
MIRT2076001	hsa-miR-4419a	CLIP-seq
MIRT2076002	hsa-miR-4433	CLIP-seq
MIRT2076003	hsa-miR-4459	CLIP-seq
MIRT2076004	hsa-miR-4461	CLIP-seq
MIRT1257924	hsa-miR-4464	CLIP-seq
MIRT2076005	hsa-miR-4473	CLIP-seq
MIRT2076006	hsa-miR-4477b	CLIP-seq
MIRT2076007	hsa-miR-449a	CLIP-seq
MIRT2076008	hsa-miR-449b	CLIP-seq
MIRT2076009	hsa-miR-449c	CLIP-seq
MIRT1257926	hsa-miR-4502	CLIP-seq
MIRT2076010	hsa-miR-4504	CLIP-seq
MIRT2076011	hsa-miR-4510	CLIP-seq
MIRT1257964	hsa-miR-4529-5p	CLIP-seq
MIRT1257927	hsa-miR-4540	CLIP-seq
MIRT1257928	hsa-miR-455-5p	CLIP-seq
MIRT1257965	hsa-miR-4648	CLIP-seq
MIRT1257966	hsa-miR-4654	CLIP-seq
MIRT2076012	hsa-miR-4728-5p	CLIP-seq
MIRT2076013	hsa-miR-4739	CLIP-seq
MIRT2076014	hsa-miR-4742-3p	CLIP-seq
MIRT1257934	hsa-miR-4748	CLIP-seq
MIRT2076015	hsa-miR-4756-5p	CLIP-seq
MIRT2076016	hsa-miR-4768-3p	CLIP-seq
MIRT1257970	hsa-miR-4769-5p	CLIP-seq
MIRT2076017	hsa-miR-4774-3p	CLIP-seq
MIRT1257936	hsa-miR-4775	CLIP-seq
MIRT1257937	hsa-miR-4790-3p	CLIP-seq
MIRT2076018	hsa-miR-512-3p	CLIP-seq
MIRT2076019	hsa-miR-520a-5p	CLIP-seq
MIRT2076020	hsa-miR-520f	CLIP-seq
MIRT2076021	hsa-miR-525-5p	CLIP-seq
MIRT2076022	hsa-miR-549	CLIP-seq
MIRT1257939	hsa-miR-579	CLIP-seq
MIRT1257942	hsa-miR-613	CLIP-seq
MIRT1257979	hsa-miR-888	CLIP-seq
MIRT1257946	hsa-miR-944	CLIP-seq
MIRT1257951	hsa-miR-2113	CLIP-seq
MIRT2302607	hsa-miR-103a	CLIP-seq
MIRT2302608	hsa-miR-107	CLIP-seq
MIRT2302609	hsa-miR-1301	CLIP-seq
MIRT1257918	hsa-miR-3120-3p	CLIP-seq
MIRT2302610	hsa-miR-3125	CLIP-seq
MIRT2302611	hsa-miR-3129-3p	CLIP-seq
MIRT1257955	hsa-miR-3187-3p	CLIP-seq
MIRT2302612	hsa-miR-3916	CLIP-seq
MIRT2302613	hsa-miR-4302	CLIP-seq
MIRT1257924	hsa-miR-4464	CLIP-seq
MIRT2302614	hsa-miR-4519	CLIP-seq
MIRT1257964	hsa-miR-4529-5p	CLIP-seq
MIRT1257927	hsa-miR-4540	CLIP-seq
MIRT1257934	hsa-miR-4748	CLIP-seq
MIRT2302615	hsa-miR-5047	CLIP-seq
MIRT1257941	hsa-miR-587	CLIP-seq
MIRT2302616	hsa-miR-605	CLIP-seq
MIRT1257918	hsa-miR-3120-3p	CLIP-seq
MIRT1257955	hsa-miR-3187-3p	CLIP-seq
MIRT1257957	hsa-miR-338-5p	CLIP-seq
MIRT1257964	hsa-miR-4529-5p	CLIP-seq
MIRT2302616	hsa-miR-605	CLIP-seq
MIRT1257943	hsa-miR-642b	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000159	Component	Protein phosphatase type 2A complex	IBA
GO:0000159	Component	Protein phosphatase type 2A complex	IDA	17245430
GO:0000159	Component	Protein phosphatase type 2A complex	IEA
GO:0000159	Component	Protein phosphatase type 2A complex	IMP	21075214
GO:0000775	Component	Chromosome, centromeric region	IEA
GO:0005515	Function	Protein binding	IPI	7592815, 9847399, 15380617, 16097049, 16541025, 17245430, 17540176, 18782753, 21878643, 24157919, 26496610, 27880917, 28330616, 28514442, 30595372, 32296183, 32707033, 32814053, 33961781, 35271311, 37219487
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005694	Component	Chromosome	IEA
GO:0005737	Component	Cytoplasm	IDA	21075214
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	TAS	8703017
GO:0005813	Component	Centrosome	IDA	24157919
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA	15569306
GO:0007165	Process	Signal transduction	IEA
GO:0019210	Function	Kinase inhibitor activity	IMP	21075214
GO:0019888	Function	Protein phosphatase regulator activity	IDA	24157919
GO:0019888	Function	Protein phosphatase regulator activity	IEA
GO:0019888	Function	Protein phosphatase regulator activity	TAS	8703017
GO:0019900	Function	Kinase binding	IPI	21075214
GO:0030018	Component	Z disc	IDA	19131648
GO:0030018	Component	Z disc	IEA
GO:0031430	Component	M band	IEA
GO:0031430	Component	M band	ISS	18782775
GO:0072542	Function	Protein phosphatase activator activity	IMP	21075214
GO:1903077	Process	Negative regulation of protein localization to plasma membrane	IMP	21075214

Other IDs

• MIM: 601643
• HGNC: 9309
• e!Ensembl: ENSG00000066027

Protein

• UniProt ID: Q15172
• Protein name: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform (PP2A B subunit isoform B'-alpha) (PP2A B subunit isoform B56-alpha) (PP2A B subunit isoform PR61-alpha) (PR61alpha) (PP2A B subunit isoform R5-alpha)
• Protein function: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment.
• PDB: 6NTS, 8SZK
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01603	B56	56 → 462	Protein phosphatase 2A regulatory B subunit (B56 family)	Family

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed with the highest expression in heart and skeletal muscle.
• Sequence:

  MSSSSPPAGAASAAISASEKVDGFTRKSVRKAQRQKRSQGSSQFRSQGSQAELHPLPQLK
  DATSNEQQELFCQKLQQCCILFDFMDSVSDLKSKEIKRATLNELVEYVSTNRGVIVESAY
  SDIVKMISANIFRTLPPSDNPDFDPEEDEPTLEASWPHIQLVYEFFLRFLESPDFQPSIA
  KRYIDQKFVQQLLELFDSEDPRERDFLKTVLHRIYGKFLGLRAFIRKQINNIFLRFIYET
  EHFNGVAELLEILGSIINGFALPLKAEHKQFLMKVLIPMHTAKGLALFHAQLAYCVVQFL
  EKDTTLTEPVIRGLLKFWPKTCSQKEVMFLGEIEEILDVIEPTQFKKIEEPLFKQISKCV
  SSSHFQVAERALYFWNNEYILSLIEENIDKILPIMFASLYKISKEHWNPTIVALVYNVLK
  TLMEMNGKLFDDLTSSYKAERQREKKKELEREELWKKLEELKLKKALEKQNSAYNMHSIL
  SNTSAE

• Sequence length: 486