Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs Other IDs
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	5525
Gene name Gene Name - the full gene name approved by the HGNC.	Protein phosphatase 2 regulatory subunit B'alpha
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PPP2R5A
Synonyms (NCBI Gene) Gene synonyms aliases	B56A, B56alpha, PR61A
Chromosome Chromosome number	1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	1q32.3
Summary Summary of gene provided in NCBI Entrez Gene.	The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common het

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miRTarBase ID	miRNA	Experiments	Reference
MIRT004602	hsa-miR-1-3p	Luciferase reporter assay, Western blot	19131648
MIRT016181	hsa-miR-590-3p	Sequencing	20371350
MIRT018236	hsa-miR-335-5p	Microarray	18185580
MIRT042199	hsa-miR-484	CLASH	23622248
MIRT439913	ebv-miR-BART7-3p	HITS-CLIP	22473208
MIRT439913	ebv-miR-BART7-3p	HITS-CLIP	22473208
MIRT1257908	hsa-miR-1	CLIP-seq
MIRT1257909	hsa-miR-1202	CLIP-seq
MIRT1257910	hsa-miR-1298	CLIP-seq
MIRT1257911	hsa-miR-19a	CLIP-seq
MIRT1257912	hsa-miR-19b	CLIP-seq
MIRT1257913	hsa-miR-2052	CLIP-seq
MIRT1257914	hsa-miR-2054	CLIP-seq
MIRT1257915	hsa-miR-206	CLIP-seq
MIRT1257916	hsa-miR-2276	CLIP-seq
MIRT1257917	hsa-miR-2278	CLIP-seq
MIRT1257918	hsa-miR-3120-3p	CLIP-seq
MIRT1257919	hsa-miR-3148	CLIP-seq
MIRT1257920	hsa-miR-3673	CLIP-seq
MIRT1257921	hsa-miR-3692	CLIP-seq
MIRT1257922	hsa-miR-3972	CLIP-seq
MIRT1257923	hsa-miR-4328	CLIP-seq
MIRT1257924	hsa-miR-4464	CLIP-seq
MIRT1257925	hsa-miR-4468	CLIP-seq
MIRT1257926	hsa-miR-4502	CLIP-seq
MIRT1257927	hsa-miR-4540	CLIP-seq
MIRT1257928	hsa-miR-455-5p	CLIP-seq
MIRT1257929	hsa-miR-4652-3p	CLIP-seq
MIRT1257930	hsa-miR-4668-5p	CLIP-seq
MIRT1257931	hsa-miR-4677-3p	CLIP-seq
MIRT1257932	hsa-miR-4679	CLIP-seq
MIRT1257933	hsa-miR-4738-3p	CLIP-seq
MIRT1257934	hsa-miR-4748	CLIP-seq
MIRT1257935	hsa-miR-4771	CLIP-seq
MIRT1257936	hsa-miR-4775	CLIP-seq
MIRT1257937	hsa-miR-4790-3p	CLIP-seq
MIRT1257938	hsa-miR-4797-5p	CLIP-seq
MIRT1257939	hsa-miR-579	CLIP-seq
MIRT1257940	hsa-miR-582-5p	CLIP-seq
MIRT1257941	hsa-miR-587	CLIP-seq
MIRT1257942	hsa-miR-613	CLIP-seq
MIRT1257943	hsa-miR-642b	CLIP-seq
MIRT1257944	hsa-miR-656	CLIP-seq
MIRT1257945	hsa-miR-664	CLIP-seq
MIRT1257946	hsa-miR-944	CLIP-seq
MIRT1257908	hsa-miR-1	CLIP-seq
MIRT1257909	hsa-miR-1202	CLIP-seq
MIRT1257947	hsa-miR-1254	CLIP-seq
MIRT1257948	hsa-miR-1270	CLIP-seq
MIRT1257949	hsa-miR-1323	CLIP-seq
MIRT1257950	hsa-miR-197	CLIP-seq
MIRT1257913	hsa-miR-2052	CLIP-seq
MIRT1257914	hsa-miR-2054	CLIP-seq
MIRT1257915	hsa-miR-206	CLIP-seq
MIRT1257951	hsa-miR-2113	CLIP-seq
MIRT1257952	hsa-miR-218	CLIP-seq
MIRT1257916	hsa-miR-2276	CLIP-seq
MIRT1257953	hsa-miR-3116	CLIP-seq
MIRT1257918	hsa-miR-3120-3p	CLIP-seq
MIRT1257954	hsa-miR-3156-5p	CLIP-seq
MIRT1257955	hsa-miR-3187-3p	CLIP-seq
MIRT1257956	hsa-miR-3199	CLIP-seq
MIRT1257957	hsa-miR-338-5p	CLIP-seq
MIRT1257958	hsa-miR-3613-3p	CLIP-seq
MIRT1257959	hsa-miR-361-3p	CLIP-seq
MIRT1257960	hsa-miR-3664-5p	CLIP-seq
MIRT1257920	hsa-miR-3673	CLIP-seq
MIRT1257921	hsa-miR-3692	CLIP-seq
MIRT1257922	hsa-miR-3972	CLIP-seq
MIRT1257961	hsa-miR-4254	CLIP-seq
MIRT1257962	hsa-miR-4318	CLIP-seq
MIRT1257923	hsa-miR-4328	CLIP-seq
MIRT1257963	hsa-miR-4422	CLIP-seq
MIRT1257964	hsa-miR-4529-5p	CLIP-seq
MIRT1257927	hsa-miR-4540	CLIP-seq
MIRT1257965	hsa-miR-4648	CLIP-seq
MIRT1257966	hsa-miR-4654	CLIP-seq
MIRT1257967	hsa-miR-4683	CLIP-seq
MIRT1257968	hsa-miR-4699-5p	CLIP-seq
MIRT1257969	hsa-miR-4714-5p	CLIP-seq
MIRT1257970	hsa-miR-4769-5p	CLIP-seq
MIRT1257936	hsa-miR-4775	CLIP-seq
MIRT1257937	hsa-miR-4790-3p	CLIP-seq
MIRT1257971	hsa-miR-495	CLIP-seq
MIRT1257972	hsa-miR-520d-5p	CLIP-seq
MIRT1257973	hsa-miR-524-5p	CLIP-seq
MIRT1257974	hsa-miR-548o	CLIP-seq
MIRT1257940	hsa-miR-582-5p	CLIP-seq
MIRT1257941	hsa-miR-587	CLIP-seq
MIRT1257975	hsa-miR-607	CLIP-seq
MIRT1257942	hsa-miR-613	CLIP-seq
MIRT1257976	hsa-miR-620	CLIP-seq
MIRT1257977	hsa-miR-636	CLIP-seq
MIRT1257978	hsa-miR-767-3p	CLIP-seq
MIRT1257979	hsa-miR-888	CLIP-seq
MIRT1257908	hsa-miR-1	CLIP-seq
MIRT2075986	hsa-miR-101	CLIP-seq
MIRT2075987	hsa-miR-1296	CLIP-seq
MIRT2075988	hsa-miR-1321	CLIP-seq
MIRT2075989	hsa-miR-144	CLIP-seq
MIRT1257950	hsa-miR-197	CLIP-seq
MIRT1257911	hsa-miR-19a	CLIP-seq
MIRT1257912	hsa-miR-19b	CLIP-seq
MIRT1257913	hsa-miR-2052	CLIP-seq
MIRT1257914	hsa-miR-2054	CLIP-seq
MIRT1257915	hsa-miR-206	CLIP-seq
MIRT1257916	hsa-miR-2276	CLIP-seq
MIRT2075990	hsa-miR-2682	CLIP-seq
MIRT2075991	hsa-miR-2909	CLIP-seq
MIRT1257918	hsa-miR-3120-3p	CLIP-seq
MIRT2075992	hsa-miR-3126-5p	CLIP-seq
MIRT2075993	hsa-miR-3152-5p	CLIP-seq
MIRT2075994	hsa-miR-3180-5p	CLIP-seq
MIRT1257955	hsa-miR-3187-3p	CLIP-seq
MIRT2075995	hsa-miR-3194-3p	CLIP-seq
MIRT1257956	hsa-miR-3199	CLIP-seq
MIRT2075996	hsa-miR-330-3p	CLIP-seq
MIRT2075997	hsa-miR-34a	CLIP-seq
MIRT2075998	hsa-miR-34c-5p	CLIP-seq
MIRT1257920	hsa-miR-3673	CLIP-seq
MIRT1257921	hsa-miR-3692	CLIP-seq
MIRT2075999	hsa-miR-4292	CLIP-seq
MIRT2076000	hsa-miR-4308	CLIP-seq
MIRT1257962	hsa-miR-4318	CLIP-seq
MIRT1257923	hsa-miR-4328	CLIP-seq
MIRT2076001	hsa-miR-4419a	CLIP-seq
MIRT2076002	hsa-miR-4433	CLIP-seq
MIRT2076003	hsa-miR-4459	CLIP-seq
MIRT2076004	hsa-miR-4461	CLIP-seq
MIRT1257924	hsa-miR-4464	CLIP-seq
MIRT2076005	hsa-miR-4473	CLIP-seq
MIRT2076006	hsa-miR-4477b	CLIP-seq
MIRT2076007	hsa-miR-449a	CLIP-seq
MIRT2076008	hsa-miR-449b	CLIP-seq
MIRT2076009	hsa-miR-449c	CLIP-seq
MIRT1257926	hsa-miR-4502	CLIP-seq
MIRT2076010	hsa-miR-4504	CLIP-seq
MIRT2076011	hsa-miR-4510	CLIP-seq
MIRT1257964	hsa-miR-4529-5p	CLIP-seq
MIRT1257927	hsa-miR-4540	CLIP-seq
MIRT1257928	hsa-miR-455-5p	CLIP-seq
MIRT1257965	hsa-miR-4648	CLIP-seq
MIRT1257966	hsa-miR-4654	CLIP-seq
MIRT2076012	hsa-miR-4728-5p	CLIP-seq
MIRT2076013	hsa-miR-4739	CLIP-seq
MIRT2076014	hsa-miR-4742-3p	CLIP-seq
MIRT1257934	hsa-miR-4748	CLIP-seq
MIRT2076015	hsa-miR-4756-5p	CLIP-seq
MIRT2076016	hsa-miR-4768-3p	CLIP-seq
MIRT1257970	hsa-miR-4769-5p	CLIP-seq
MIRT2076017	hsa-miR-4774-3p	CLIP-seq
MIRT1257936	hsa-miR-4775	CLIP-seq
MIRT1257937	hsa-miR-4790-3p	CLIP-seq
MIRT2076018	hsa-miR-512-3p	CLIP-seq
MIRT2076019	hsa-miR-520a-5p	CLIP-seq
MIRT2076020	hsa-miR-520f	CLIP-seq
MIRT2076021	hsa-miR-525-5p	CLIP-seq
MIRT2076022	hsa-miR-549	CLIP-seq
MIRT1257939	hsa-miR-579	CLIP-seq
MIRT1257942	hsa-miR-613	CLIP-seq
MIRT1257979	hsa-miR-888	CLIP-seq
MIRT1257946	hsa-miR-944	CLIP-seq
MIRT1257951	hsa-miR-2113	CLIP-seq
MIRT2302607	hsa-miR-103a	CLIP-seq
MIRT2302608	hsa-miR-107	CLIP-seq
MIRT2302609	hsa-miR-1301	CLIP-seq
MIRT1257918	hsa-miR-3120-3p	CLIP-seq
MIRT2302610	hsa-miR-3125	CLIP-seq
MIRT2302611	hsa-miR-3129-3p	CLIP-seq
MIRT1257955	hsa-miR-3187-3p	CLIP-seq
MIRT2302612	hsa-miR-3916	CLIP-seq
MIRT2302613	hsa-miR-4302	CLIP-seq
MIRT1257924	hsa-miR-4464	CLIP-seq
MIRT2302614	hsa-miR-4519	CLIP-seq
MIRT1257964	hsa-miR-4529-5p	CLIP-seq
MIRT1257927	hsa-miR-4540	CLIP-seq
MIRT1257934	hsa-miR-4748	CLIP-seq
MIRT2302615	hsa-miR-5047	CLIP-seq
MIRT1257941	hsa-miR-587	CLIP-seq
MIRT2302616	hsa-miR-605	CLIP-seq
MIRT1257918	hsa-miR-3120-3p	CLIP-seq
MIRT1257955	hsa-miR-3187-3p	CLIP-seq
MIRT1257957	hsa-miR-338-5p	CLIP-seq
MIRT1257964	hsa-miR-4529-5p	CLIP-seq
MIRT2302616	hsa-miR-605	CLIP-seq
MIRT1257943	hsa-miR-642b	CLIP-seq

Show/Hide all(24)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000159	Component	Protein phosphatase type 2A complex	IBA	21873635
GO:0000159	Component	Protein phosphatase type 2A complex	IDA	17245430
GO:0000775	Component	Chromosome, centromeric region	IEA
GO:0004721	Function	Phosphoprotein phosphatase activity	IDA	24157919
GO:0005515	Function	Protein binding	IPI	7592815, 9847399, 15380617, 16097049, 16541025, 17245430, 17540176, 18782753, 21878643, 24157919, 26496610, 28330616, 28514442, 30595372, 32296183, 32814053
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005737	Component	Cytoplasm	IDA	21075214
GO:0005813	Component	Centrosome	IDA	24157919
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	IDA
GO:0006470	Process	Protein dephosphorylation	IBA	21873635
GO:0006470	Process	Protein dephosphorylation	IDA	24157919
GO:0007165	Process	Signal transduction	IEA
GO:0016020	Component	Membrane	IDA	15569306
GO:0019888	Function	Protein phosphatase regulator activity	TAS	8703017
GO:0019900	Function	Kinase binding	IPI	21075214
GO:0030018	Component	Z disc	IDA	19131648
GO:0031430	Component	M band	ISS	18782775
GO:0031952	Process	Regulation of protein autophosphorylation	IBA	21873635
GO:0035307	Process	Positive regulation of protein dephosphorylation	IMP	21075214
GO:0043666	Process	Regulation of phosphoprotein phosphatase activity	IEA
GO:0072542	Function	Protein phosphatase activator activity	IBA	21873635
GO:0090219	Process	Negative regulation of lipid kinase activity	IMP	21075214
GO:1903077	Process	Negative regulation of protein localization to plasma membrane	IMP	21075214

MIM	HGNC	e!Ensembl
601643	9309	ENSG00000066027

Protein

UniProt ID

Q15172

Protein name

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform (PP2A B subunit isoform B'-alpha) (PP2A B subunit isoform B56-alpha) (PP2A B subunit isoform PR61-alpha) (PR61alpha) (PP2A B subunit isoform R5-alpha)

Protein function

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment.

PDB

6NTS , 8SZK

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01603	B56	56 → 462	Protein phosphatase 2A regulatory B subunit (B56 family)	Family

Tissue specificity

TISSUE SPECIFICITY: Widely expressed with the highest expression in heart and skeletal muscle.

Sequence

MSSSSPPAGAASAAISASEKVDGFTRKSVRKAQRQKRSQGSSQFRSQGSQAELHPLPQLK
DATSNEQQELFCQKLQQCCILFDFMDSVSDLKSKEIKRATLNELVEYVSTNRGVIVESAY
SDIVKMISANIFRTLPPSDNPDFDPEEDEPTLEASWPHIQLVYEFFLRFLESPDFQPSIA
KRYIDQKFVQQLLELFDSEDPRERDFLKTVLHRIYGKFLGLRAFIRKQINNIFLRFIYET
EHFNGVAELLEILGSIINGFALPLKAEHKQFLMKVLIPMHTAKGLALFHAQLAYCVVQFL
EKDTTLTEPVIRGLLKFWPKTCSQKEVMFLGEIEEILDVIEPTQFKKIEEPLFKQISKCV
SSSHFQVAERALYFWNNEYILSLIEENIDKILPIMFASLYKISKEHWNPTIVALVYNVLK
TLMEMNGKLFDDLTSSYKAERQREKKKELEREELWKKLEELKLKKALEKQNSAYNMHSIL
SNTSAE

Sequence length

486

Interactions

View interactions

PPP2R5A (protein phosphatase 2 regulatory subunit B'alpha)