Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs Other IDs
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	28227
Gene name Gene Name - the full gene name approved by the HGNC.	Protein phosphatase 2 regulatory subunit B''beta
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PPP2R3B
Synonyms (NCBI Gene) Gene synonyms aliases	NYREN8, PPP2R3L, PPP2R3LY, PR48, PR70
Chromosome Chromosome number	X\|Y
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	X;Y
Summary Summary of gene provided in NCBI Entrez Gene.	Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subu

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miRTarBase ID	miRNA	Experiments	Reference
MIRT024826	hsa-miR-215-5p	Microarray	19074876
MIRT026231	hsa-miR-192-5p	Microarray	19074876
MIRT739549	hsa-miR-1285	CLIP-seq
MIRT1257761	hsa-miR-3150a-3p	CLIP-seq
MIRT1257762	hsa-miR-3175	CLIP-seq
MIRT739548	hsa-miR-3187-5p	CLIP-seq
MIRT739553	hsa-miR-326	CLIP-seq
MIRT739554	hsa-miR-330-5p	CLIP-seq
MIRT739551	hsa-miR-378g	CLIP-seq
MIRT1257763	hsa-miR-3960	CLIP-seq
MIRT1257764	hsa-miR-4467	CLIP-seq
MIRT739552	hsa-miR-4486	CLIP-seq
MIRT739547	hsa-miR-4736	CLIP-seq
MIRT1257765	hsa-miR-491-5p	CLIP-seq
MIRT739550	hsa-miR-612	CLIP-seq
MIRT1257766	hsa-miR-939	CLIP-seq
MIRT739549	hsa-miR-1285	CLIP-seq
MIRT739548	hsa-miR-3187-5p	CLIP-seq
MIRT739553	hsa-miR-326	CLIP-seq
MIRT739554	hsa-miR-330-5p	CLIP-seq
MIRT739551	hsa-miR-378g	CLIP-seq
MIRT739552	hsa-miR-4486	CLIP-seq
MIRT739547	hsa-miR-4736	CLIP-seq
MIRT739550	hsa-miR-612	CLIP-seq
MIRT739549	hsa-miR-1285	CLIP-seq
MIRT739548	hsa-miR-3187-5p	CLIP-seq
MIRT739553	hsa-miR-326	CLIP-seq
MIRT739554	hsa-miR-330-5p	CLIP-seq
MIRT739551	hsa-miR-378g	CLIP-seq
MIRT739552	hsa-miR-4486	CLIP-seq
MIRT739547	hsa-miR-4736	CLIP-seq
MIRT739550	hsa-miR-612	CLIP-seq
MIRT739549	hsa-miR-1285	CLIP-seq
MIRT739548	hsa-miR-3187-5p	CLIP-seq
MIRT739553	hsa-miR-326	CLIP-seq
MIRT739554	hsa-miR-330-5p	CLIP-seq
MIRT739551	hsa-miR-378g	CLIP-seq
MIRT739552	hsa-miR-4486	CLIP-seq
MIRT739547	hsa-miR-4736	CLIP-seq
MIRT739550	hsa-miR-612	CLIP-seq
MIRT739549	hsa-miR-1285	CLIP-seq
MIRT739548	hsa-miR-3187-5p	CLIP-seq
MIRT739553	hsa-miR-326	CLIP-seq
MIRT739554	hsa-miR-330-5p	CLIP-seq
MIRT739551	hsa-miR-378g	CLIP-seq
MIRT739552	hsa-miR-4486	CLIP-seq
MIRT739547	hsa-miR-4736	CLIP-seq
MIRT739550	hsa-miR-612	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000159	Component	Protein phosphatase type 2A complex	IBA	21873635
GO:0000159	Component	Protein phosphatase type 2A complex	ISS
GO:0005509	Function	Calcium ion binding	IEA
GO:0005515	Function	Protein binding	IPI	9847399, 21516116, 25416956, 27812135, 32296183
GO:0005634	Component	Nucleus	TAS	10629059
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005829	Component	Cytosol	IDA
GO:0006470	Process	Protein dephosphorylation	IBA	21873635
GO:0006470	Process	Protein dephosphorylation	ISS
GO:0007050	Process	Cell cycle arrest	TAS	10629059
GO:0019888	Function	Protein phosphatase regulator activity	IBA	21873635
GO:0019888	Function	Protein phosphatase regulator activity	ISS
GO:0043666	Process	Regulation of phosphoprotein phosphatase activity	IEA

MIM	HGNC	e!Ensembl
300339	13417	ENSG00000167393

Protein

UniProt ID

Q9Y5P8

Protein name

Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta (PP2A subunit B isoform PR48) (Protein phosphatase 2A 48 kDa regulatory subunit)

Protein function

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment.

PDB

4I5L , 4I5N , 4MEW

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF17958	EF-hand_13	212 → 301	EF-hand domain	Domain
PF13499	EF-hand_7	316 → 418	EF-hand domain pair	Domain

Sequence

MPPGKVLQPVLKMKVDELFLYWLSEASTQRMLQDCLRRIKAPGRDQPTPGDGEQPGAWPT
APLAAPRPSGLEPPGTPGPGPALPLGAASSPRNAPHVRGTRRSAGTRVVQTRKEEPLPPA
TSQSIPTFYFPRGRPQDSVNVDAVISKIESTFARFPHERATMDDMGLVAKACGCPLYWKG
PLFYGAGGERTGSVSVHKFVAMWRKILQNCHDDAAKFVHLLMSPGCNYLVQEDFVPFLQD
VVNTHPGLSFLKEASEFHSRYITTVIQRIFYAVNRSWSGRITCAELRRSSFLQNVALLEE
EADINQLTEFFSYEHFYVIYCKFWELDTDHDLLIDADDLARHNDHALSTKMIDRIFSGAV
TRGRKVQKEGKISYADFVWFLISEEDKKTPTSIEYWFRCMDLDGDGALSMFELEYFYEEQ
CRRLDSMAIEALPFQDCLCQMLDLVKPRTEGKITLQDLKRCKLANVFFDTFFNIEKYLDH
EQKEQISLLRDGDSGGPELSDWEKYAAEEYDILVAEETAGEPWEDGFEAELSPVEQKLSA
LRSPLAQRPFFEAPSPLGAVDLYEYACGDEDLEPL

Sequence length

575

Interactions

View interactions

PPP2R3B (protein phosphatase 2 regulatory subunit B''beta)