Gene Gene information from NCBI Gene database.
Entrez ID 5520
Gene name Protein phosphatase 2 regulatory subunit Balpha
Gene symbol PPP2R2A
Synonyms (NCBI Gene)
B55B55AB55ALPHAPR52APR55APR55alpha
Chromosome 8
Chromosome location 8p21.2
Summary The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heter
miRNA miRNA information provided by mirtarbase database.
276
miRTarBase ID miRNA Experiments Reference
MIRT000490 hsa-miR-31-5p qRT-PCRLuciferase reporter assay 20237410
MIRT003191 hsa-miR-222-3p Luciferase reporter assayWestern blot 20103675
MIRT003191 hsa-miR-222-3p Luciferase reporter assayWestern blot 20103675
MIRT020735 hsa-miR-155-5p Proteomics 18668040
MIRT023787 hsa-miR-1-3p Proteomics 18668040
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
23
GO ID Ontology Definition Evidence Reference
GO:0000159 Component Protein phosphatase type 2A complex IBA
GO:0000159 Component Protein phosphatase type 2A complex IDA 1849734, 17245430
GO:0000159 Component Protein phosphatase type 2A complex IEA
GO:0005515 Function Protein binding IPI 9847399, 15761952, 17245430, 17529992, 17540176, 17632056, 18782753, 19156129, 19293187, 19915589, 20220139, 20711181, 25816751, 26496610, 26894577, 27173435, 27588481, 28330616, 28609714, 30595372, 30611118, 31046837, 32707033, 32814053, 33108758, 33961781, 34731788
GO:0005654 Component Nucleoplasm TAS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
604941 9304 ENSG00000221914
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P63151
Protein name Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (PP2A subunit B isoform B55-alpha) (B55) (PP2A subunit B isoform PR55-alpha) (PP2A subunit B isoform R2-alpha) (PP2A subunit B isoform alpha)
Protein function Substrate-recognition subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit (PubMed:1849734, PubMed:33108758). Involved in chromosome clustering during late mitosis by mediating dephos
PDB 3DW8 , 8SO0 , 8TTB , 8TWE
Family and domains
Tissue specificity TISSUE SPECIFICITY: Expressed in all tissues examined. {ECO:0000269|PubMed:1849734}.
Sequence
MAGAGGGNDIQWCFSQVKGAVDDDVAEADIISTVEFNHSGELLATGDKGGRVVIFQQEQE
NKIQSHSRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQKNAAQFLLSTNDKTIK
LWKISERDKRPEGYNLKEEDGRYRDPTTVTTLRVPVFRPMDLMVEASPRRIFANAHTYHI
NSISINSDYETYLSADDLRINLWHLEITDRSFNIVDIKPANMEELTEVITAAEFHPNSCN
TFVYSSSKGTIRLCDMRASALCDRHSKLFEEPEDPSNRSFFSEIISSISDVKFSHSGRYM
MTRDYLSVKIWDLNMENRPVETYQVHEYLRSKLCSLYENDCIFDKFECCWNGSDSVVMTG
SYNNFFRMFDRNTKRDITLEASRENNKPRTVLKPRKVCASGKRKKDEISVDSLDFNKKIL
HTAWHPKENIIAVATTNNLYIFQDKVN
Sequence length 447
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
28
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Acute myeloid leukemia Likely benign rs74731529 RCV005929945
Cervical cancer Likely benign rs74731529 RCV005929946
Gastric cancer Likely benign rs74731529 RCV005929947
Hereditary breast ovarian cancer syndrome Likely benign; Uncertain significance; Benign rs572866422, rs1413011339, rs116762879, rs111586207, rs372615585, rs17309515, rs17309592, rs74731529, rs2117424696, rs34109536, rs1205387644, rs142234242, rs3824232, rs3808565, rs372679014
View all (1 more)
RCV002226372
RCV002226373
RCV002226374
RCV002226375
RCV002226376
RCV002226377
RCV002226379
RCV002226380
RCV002226381
RCV002226382
RCV002226383
RCV002226384
RCV002226385
RCV002226386
RCV002226387
RCV002226388
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Ataxia Telangiectasia Associate 19430199
Breast Neoplasms Associate 19890961, 22522925, 25879784, 36781846
Carcinoma Hepatocellular Associate 35945177, 36378050
Carcinoma Non Small Cell Lung Associate 23959478, 32950569
Esophageal Squamous Cell Carcinoma Associate 36803971
Leukemia Associate 24858343, 27531894
Leukemia Myeloid Acute Associate 21660042, 24858343, 27531894
Lipoblastoma Associate 33097826
Lymphoma Large B Cell Diffuse Associate 27720936
Melanoma Associate 32767816