PPP2CA (protein phosphatase 2 catalytic subunit alpha)

Gene
Gene SNPs Transcription factors Other IDs
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5515
Gene name Gene Name - the full gene name approved by the HGNC.
Protein phosphatase 2 catalytic subunit alpha
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PPP2CA
Synonyms (NCBI Gene) Gene synonyms aliases
HJS3, NEDLBA, PP2Ac, PP2CA, PP2Calpha, RP-C
Chromosome Chromosome number
5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
5q31.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which
SNPs SNP information provided by dbSNP.
Gene SNPs Transcription factors Other IDs
Show/Hide all(14)
SNP ID Visualize variation Clinical significance Consequence
rs148071386 G>A Uncertain-significance, likely-pathogenic Coding sequence variant, stop gained, non coding transcript variant
rs764595667 C>G,T Likely-pathogenic Synonymous variant, coding sequence variant, missense variant, non coding transcript variant
rs864622012 AAG>-,AAGAAG Likely-pathogenic, uncertain-significance Coding sequence variant, non coding transcript variant, inframe deletion, inframe insertion
rs915349596 T>C Likely-pathogenic Non coding transcript variant, coding sequence variant, missense variant
rs1561733474 T>C Likely-pathogenic Non coding transcript variant, missense variant, coding sequence variant
miRNA miRNA information provided by mirtarbase database.
Gene SNPs Transcription factors Other IDs
Show/Hide all(840)
miRTarBase ID miRNA Experiments Reference
MIRT048079 hsa-miR-197-3p CLASH 23622248
MIRT043848 hsa-miR-340-3p CLASH 23622248
MIRT571790 hsa-miR-125a-5p PAR-CLIP 20371350
MIRT571789 hsa-miR-125b-5p PAR-CLIP 20371350
MIRT571787 hsa-miR-4319 PAR-CLIP 20371350
Transcription factors
Gene SNPs Transcription factors Other IDs
Show/Hide all(1)
Transcription factor Regulation Reference
CREB1 Activation 17526027
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene SNPs Transcription factors Other IDs
Show/Hide all(73)
GO ID Ontology Definition Evidence Reference
GO:0000159 Component Protein phosphatase type 2A complex IDA 17055435, 17174897
GO:0000159 Component Protein phosphatase type 2A complex IEA
GO:0000159 Component Protein phosphatase type 2A complex TAS 11007961
GO:0000278 Process Mitotic cell cycle IBA
GO:0000775 Component Chromosome, centromeric region IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene SNPs Transcription factors Other IDs
MIM HGNC e!Ensembl
176915 9299 ENSG00000113575
Protein
Gene SNPs Transcription factors Other IDs
UniProt ID P67775
Protein name Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PP2A-alpha) (EC 3.1.3.16) (Replication protein C) (RP-C)
Protein function Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events (PubMed:10801873, PubMed:12473674, PubMed:17245430, Pub
PDB 2IAE , 2IE3 , 2IE4 , 2NPP , 2NYL , 2NYM , 3C5W , 3DW8 , 3FGA , 3K7V , 3K7W , 3P71 , 4I5L , 4I5N , 4IYP , 4LAC , 4NY3 , 5W0W , 6NTS , 7CUN , 7K36 , 7PKS , 7SOY , 7YCX , 8RBX , 8RBZ , 8RC4 , 8SO0 , 8TTB , 8TWE , 8TWI , 8U1X , 8U89 , 8UWB , 8YJB
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00149 Metallophos 50 → 245 Calcineurin-like phosphoesterase Domain
Sequence
Sequence length 309
Interactions View interactions
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