Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs Other IDs Associated diseases
Entrez ID	5502
Gene name	Protein phosphatase 1 regulatory inhibitor subunit 1A
Gene symbol	PPP1R1A
Synonyms (NCBI Gene)	I1IPP1
Chromosome	12
Chromosome location	12q13.2

143

Show/Hide all (143)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018310	hsa-miR-335-5p	Microarray	18185580
MIRT038385	hsa-miR-296-3p	CLASH	23622248
MIRT519160	hsa-miR-4678	HITS-CLIP	21572407
MIRT519159	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT519158	hsa-miR-4469	HITS-CLIP	21572407
MIRT519157	hsa-miR-331-5p	HITS-CLIP	21572407
MIRT519156	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT519155	hsa-miR-6509-5p	HITS-CLIP	21572407
MIRT519154	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT519160	hsa-miR-4678	PAR-CLIP	21572407
MIRT519159	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT552112	hsa-miR-3126-3p	PAR-CLIP	21572407
MIRT552111	hsa-miR-1298-3p	PAR-CLIP	21572407
MIRT552110	hsa-miR-1285-3p	PAR-CLIP	21572407
MIRT552109	hsa-miR-3187-5p	PAR-CLIP	21572407
MIRT552108	hsa-miR-5189-5p	PAR-CLIP	21572407
MIRT552107	hsa-miR-612	PAR-CLIP	21572407
MIRT552106	hsa-miR-6860	PAR-CLIP	21572407
MIRT552104	hsa-miR-4486	PAR-CLIP	21572407
MIRT552105	hsa-miR-378g	PAR-CLIP	21572407
MIRT519157	hsa-miR-331-5p	PAR-CLIP	21572407
MIRT519156	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT552103	hsa-miR-3924	PAR-CLIP	21572407
MIRT519155	hsa-miR-6509-5p	PAR-CLIP	21572407
MIRT519154	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT519160	hsa-miR-4678	PAR-CLIP	23446348
MIRT519159	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT519158	hsa-miR-4469	PAR-CLIP	23446348
MIRT519157	hsa-miR-331-5p	PAR-CLIP	23446348
MIRT519156	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT519155	hsa-miR-6509-5p	PAR-CLIP	23446348
MIRT519154	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT737207	hsa-miR-3922-5p	Luciferase reporter assayqRT-PCR	31797701
MIRT519160	hsa-miR-4678	HITS-CLIP	21572407
MIRT519159	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT519158	hsa-miR-4469	HITS-CLIP	21572407
MIRT519157	hsa-miR-331-5p	HITS-CLIP	21572407
MIRT519156	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT519155	hsa-miR-6509-5p	HITS-CLIP	21572407
MIRT519154	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT519160	hsa-miR-4678	PAR-CLIP	21572407
MIRT519159	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT552112	hsa-miR-3126-3p	PAR-CLIP	21572407
MIRT552111	hsa-miR-1298-3p	PAR-CLIP	21572407
MIRT552110	hsa-miR-1285-3p	PAR-CLIP	21572407
MIRT552109	hsa-miR-3187-5p	PAR-CLIP	21572407
MIRT552108	hsa-miR-5189-5p	PAR-CLIP	21572407
MIRT552107	hsa-miR-612	PAR-CLIP	21572407
MIRT552106	hsa-miR-6860	PAR-CLIP	21572407
MIRT552104	hsa-miR-4486	PAR-CLIP	21572407
MIRT552105	hsa-miR-378g	PAR-CLIP	21572407
MIRT519157	hsa-miR-331-5p	PAR-CLIP	21572407
MIRT519156	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT552103	hsa-miR-3924	PAR-CLIP	21572407
MIRT519155	hsa-miR-6509-5p	PAR-CLIP	21572407
MIRT519154	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT519160	hsa-miR-4678	PAR-CLIP	23446348
MIRT519159	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT519158	hsa-miR-4469	PAR-CLIP	23446348
MIRT519157	hsa-miR-331-5p	PAR-CLIP	23446348
MIRT519156	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT519155	hsa-miR-6509-5p	PAR-CLIP	23446348
MIRT519154	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT1256308	hsa-miR-106a	CLIP-seq
MIRT1256309	hsa-miR-106b	CLIP-seq
MIRT1256310	hsa-miR-1252	CLIP-seq
MIRT1256311	hsa-miR-1321	CLIP-seq
MIRT1256312	hsa-miR-140-3p	CLIP-seq
MIRT1256313	hsa-miR-145	CLIP-seq
MIRT1256314	hsa-miR-17	CLIP-seq
MIRT1256315	hsa-miR-186	CLIP-seq
MIRT1256316	hsa-miR-20a	CLIP-seq
MIRT1256317	hsa-miR-20b	CLIP-seq
MIRT1256318	hsa-miR-214	CLIP-seq
MIRT1256319	hsa-miR-2861	CLIP-seq
MIRT1256320	hsa-miR-3152-5p	CLIP-seq
MIRT1256321	hsa-miR-3153	CLIP-seq
MIRT1256322	hsa-miR-3194-3p	CLIP-seq
MIRT1256323	hsa-miR-338-3p	CLIP-seq
MIRT1256324	hsa-miR-3619-5p	CLIP-seq
MIRT1256325	hsa-miR-3925-3p	CLIP-seq
MIRT1256326	hsa-miR-3977	CLIP-seq
MIRT1256327	hsa-miR-4270	CLIP-seq
MIRT1256328	hsa-miR-4291	CLIP-seq
MIRT1256329	hsa-miR-4297	CLIP-seq
MIRT1256330	hsa-miR-4441	CLIP-seq
MIRT1256331	hsa-miR-4459	CLIP-seq
MIRT1256332	hsa-miR-4480	CLIP-seq
MIRT1256333	hsa-miR-4530	CLIP-seq
MIRT1256334	hsa-miR-4649-3p	CLIP-seq
MIRT1256335	hsa-miR-4659a-3p	CLIP-seq
MIRT1256336	hsa-miR-4659b-3p	CLIP-seq
MIRT1256337	hsa-miR-4695-5p	CLIP-seq
MIRT1256338	hsa-miR-4716-3p	CLIP-seq
MIRT1256339	hsa-miR-4728-5p	CLIP-seq
MIRT1256340	hsa-miR-4739	CLIP-seq
MIRT1256341	hsa-miR-4753-3p	CLIP-seq
MIRT1256342	hsa-miR-4756-5p	CLIP-seq
MIRT1256343	hsa-miR-4757-5p	CLIP-seq
MIRT1256344	hsa-miR-519d	CLIP-seq
MIRT1256345	hsa-miR-625	CLIP-seq
MIRT1256346	hsa-miR-665	CLIP-seq
MIRT1256347	hsa-miR-760	CLIP-seq
MIRT1256348	hsa-miR-761	CLIP-seq
MIRT1256349	hsa-miR-765	CLIP-seq
MIRT1256350	hsa-miR-766	CLIP-seq
MIRT1256351	hsa-miR-767-3p	CLIP-seq
MIRT1256352	hsa-miR-922	CLIP-seq
MIRT1256353	hsa-miR-93	CLIP-seq
MIRT1256354	hsa-miR-942	CLIP-seq
MIRT1556829	hsa-miR-15a	CLIP-seq
MIRT1556830	hsa-miR-15b	CLIP-seq
MIRT1556831	hsa-miR-16	CLIP-seq
MIRT1556832	hsa-miR-195	CLIP-seq
MIRT1256318	hsa-miR-214	CLIP-seq
MIRT1556833	hsa-miR-3613-3p	CLIP-seq
MIRT1256324	hsa-miR-3619-5p	CLIP-seq
MIRT1556834	hsa-miR-424	CLIP-seq
MIRT1556835	hsa-miR-4722-5p	CLIP-seq
MIRT1556836	hsa-miR-4768-3p	CLIP-seq
MIRT1556837	hsa-miR-497	CLIP-seq
MIRT1256348	hsa-miR-761	CLIP-seq
MIRT2075494	hsa-miR-1207-3p	CLIP-seq
MIRT2075495	hsa-miR-1207-5p	CLIP-seq
MIRT1256313	hsa-miR-145	CLIP-seq
MIRT2075496	hsa-miR-1827	CLIP-seq
MIRT1256323	hsa-miR-338-3p	CLIP-seq
MIRT2075497	hsa-miR-3714	CLIP-seq
MIRT1256325	hsa-miR-3925-3p	CLIP-seq
MIRT1256327	hsa-miR-4270	CLIP-seq
MIRT2075498	hsa-miR-4436b-3p	CLIP-seq
MIRT1256330	hsa-miR-4441	CLIP-seq
MIRT2075499	hsa-miR-4453	CLIP-seq
MIRT1256331	hsa-miR-4459	CLIP-seq
MIRT1256333	hsa-miR-4530	CLIP-seq
MIRT2075500	hsa-miR-4538	CLIP-seq
MIRT2075501	hsa-miR-4763-3p	CLIP-seq
MIRT1256350	hsa-miR-766	CLIP-seq
MIRT2302160	hsa-miR-3124-3p	CLIP-seq
MIRT1256323	hsa-miR-338-3p	CLIP-seq
MIRT1256333	hsa-miR-4530	CLIP-seq
MIRT1256335	hsa-miR-4659a-3p	CLIP-seq
MIRT1256336	hsa-miR-4659b-3p	CLIP-seq

Show/Hide all (7)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004864	Function	Protein phosphatase inhibitor activity	IEA
GO:0004865	Function	Protein serine/threonine phosphatase inhibitor activity	TAS	8611507
GO:0005515	Function	Protein binding	IPI	11564868, 28514442, 33961781
GO:0005737	Component	Cytoplasm	IBA
GO:0005977	Process	Glycogen metabolic process	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0035556	Process	Intracellular signal transduction	IBA

MIM	HGNC	e!Ensembl
613246	9286	ENSG00000135447

Q13522

Protein name

Protein phosphatase 1 regulatory subunit 1A (Protein phosphatase inhibitor 1) (I-1) (IPP-1)

Protein function

Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins th

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05395	DARPP-32	3 → 166	Protein phosphatase inhibitor 1/DARPP-32	Family

Sequence

MEQDNSPRKIQFTVPLLEPHLDPEAAEQIRRRRPTPATLVLTSDQSSPEIDEDRIPNPHL
KSTLAMSPRQRKKMTRITPTMKELQMMVEHHLGQQQQGEEPEGAAESTETQESRPPGIPD
TEVESRLGTSGTAKKTAECIPKTHERGSKEPSTKEPSTHIPPLDSKGANSV

Sequence length

171

Interactions

View interactions

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Low-frequency hearing loss	Conflicting classifications of pathogenicity	rs202211027	RCV002246210
Low-frequency sensorineural hearing impairment	Conflicting classifications of pathogenicity	rs202211027	RCV002246210
Rosette-forming glioneuronal tumor	Uncertain significance	rs1064792893	RCV000487426

Show/Hide Text Mining Associations (4)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Carcinoma Renal Cell	Associate	32883362
Colorectal Neoplasms	Associate	37596405
Diabetes Mellitus Type 2	Associate	29185012, 32705173
Heart Failure	Associate	18192322, 18698139

PPP1R1A (protein phosphatase 1 regulatory inhibitor subunit 1A)